Mitochondrial RNase H1 activity regulates R-loop homeostasis to maintain genome integrity and enable early embryogenesis in Arabidopsis

RNase H1C collaborates with ssDNA binding proteins WHY1/3 and recombinase RecA1 to fulfill the DNA damage repair in Arabidopsis chloroplasts

(2021) Wenjie Wang et al.   NUCLEIC ACIDS RESEARCH

RHON1 Co-transcriptionally Resolves R-Loops for Arabidopsis Chloroplast Genome Maintenance

(2020) Zhuo Yang et al.   Cell Reports

RNase H1 directs origin-specific initiation of DNA replication in human mitochondria

(2019) Viktor Posse et al.   PLoS Genetics

R-Loops as Cellular Regulators and Genomic Threats

(2019) Madzia P. Crossley et al.   MOLECULAR CELL

The mitochondrial R-loop

(2019) Ian J Holt   NUCLEIC ACIDS RESEARCH

ALBA protein complex reads genic R-loops to maintain genome stability in Arabidopsis

(2019) Wei Yuan et al.   Science Advances

RNases H: Structure and mechanism

(2019) Malwina Hyjek et al.   DNA REPAIR

R Loops: From Physiological to Pathological Roles

(2019) Tatiana García-Muse et al.   CELL

Correction of Persistent Errors in Arabidopsis Reference Mitochondrial Genomes

(2018) Daniel B. Sloan et al.   PLANT CELL

EARLY FLOWERING IN SHORT DAYS (EFS) regulates the seed size in Arabidopsis

(2018) Lingling Cheng et al.   Science China-Life Sciences

Human Rad52 Promotes XPG-Mediated R-loop Processing to Initiate Transcription-Associated Homologous Recombination Repair

(2018) Takaaki Yasuhara et al.   CELL

A two-nuclease pathway involving RNase H1 is required for primer removal at human mitochondrial OriL

(2018) Ali Al-Behadili et al.   NUCLEIC ACIDS RESEARCH

Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation

(2018) Shuai Zhao et al.   CELL RESEARCH

Human mitochondrial degradosome prevents harmful mitochondrial R loops and mitochondrial genome instability

(2018) Sonia Silva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNase H1 Cooperates with DNA Gyrases to Restrict R-Loops and Maintain Genome Integrity in Arabidopsis Chloroplasts

(2017) Zhuo Yang et al.   PLANT CELL

Functional divergence of chloroplast Cpn60α subunits during Arabidopsis embryo development

(2017) Xiaolong Ke et al.   PLoS Genetics

Transient RNA-DNA Hybrids Are Required for Efficient Double-Strand Break Repair

(2016) Corina Ohle et al.   CELL

ViableRNaseH1knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver function

(2016) Walt F. Lima et al.   NUCLEIC ACIDS RESEARCH

Pathological ribonuclease H1 causes R-loop depletion and aberrant DNA segregation in mitochondria

(2016) Gokhan Akman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RNASEH1 Mutations Impair mtDNA Replication and Cause Adult-Onset Mitochondrial Encephalomyopathy

(2015) Aurelio Reyes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Yin and Yang of R-loop biology

(2015) Lorenzo Costantino et al.   CURRENT OPINION IN CELL BIOLOGY

Ribonuclease J is required for chloroplast and embryo development in Arabidopsis

(2015) Hongyu Chen et al.   JOURNAL OF EXPERIMENTAL BOTANY

R loops: new modulators of genome dynamics and function

(2015) José M. Santos-Pereira et al.   NATURE REVIEWS GENETICS

An improved method with a wider applicability to isolate plant mitochondria for mtDNA extraction

(2015) Zaheer Ahmed et al.   Plant Methods

Role for RNA:DNA hybrids in origin-independent replication priming in a eukaryotic system

(2015) Ruth Stuckey et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Primer retention owing to the absence of RNase H1 is catastrophic for mitochondrial DNA replication

(2015) J. Bradley Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The massive mitochondrial genome of the angiospermSilene noctiflorais evolving by gain or loss of entire chromosomes

(2015) Zhiqiang Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Egg cell-specific promoter-controlled CRISPR/Cas9 efficiently generates homozygous mutants for multiple target genes in Arabidopsis in a single generation

(2015) Zhi-Ping Wang et al.   GENOME BIOLOGY

Minireview: DNA replication in plant mitochondria

(2014) John D. Cupp et al.   MITOCHONDRION

Plastid encoded RNA polymerase activity and expression of photosynthesis genes required for embryo and seed development in Arabidopsis

(2014) Dmitry Kremnev et al.   Frontiers in Plant Science

Male Sterility and Fertility Restoration in Crops

(2013) Letian Chen et al.   Annual Review of Plant Biology

Mitochondrial DNA Rearrangements in Health and Disease-A Comprehensive Study

(2013) Joana Damas et al.   HUMAN MUTATION

A reevaluation of dual-targeting of proteins to mitochondria and chloroplasts

(2012) Christopher Carrie et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Preparation of plant cells for transmission electron microscopy to optimize immunogold labeling of carbohydrate and protein epitopes

(2012) Sarah M Wilson et al.   Nature Protocols

A RAD52-like single-stranded DNA binding protein affects mitochondrial DNA repair by recombination

(2012) Sabina Janicka et al.   PLANT JOURNAL

RecA-Dependent DNA Repair Results in Increased Heteroplasmy of the Arabidopsis Mitochondrial Genome

(2012) M. Miller-Messmer et al.   PLANT PHYSIOLOGY

Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis

(2011) Jaime I Davila et al.   BMC BIOLOGY

FastCloning: a highly simplified, purification-free, sequence- and ligation-independent PCR cloning method

(2011) Chaokun Li et al.   BMC BIOTECHNOLOGY

Dual targeting of mitochondrial proteins: Mechanism, regulation and function

(2010) Ohad Yogev et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Mitochondrial protein import: from proteomics to functional mechanisms

(2010) Oliver Schmidt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Recombination and the maintenance of plant organelle genome stability

(2010) Alexandre Maréchal et al.   NEW PHYTOLOGIST

Crystal Structures of DNA-Whirly Complexes and Their Role inArabidopsisOrganelle Genome Repair

(2010) Laurent Cappadocia et al.   PLANT CELL

Ribonuclease H: the enzymes in eukaryotes

(2009) Susana M. Cerritelli et al.   FEBS Journal

Diversity of the Arabidopsis Mitochondrial Genome Occurs via Nuclear-Controlled Recombination Activity

(2009) Maria P. Arrieta-Montiel et al.   GENETICS