Developmental Neurotoxicity of Environmentally Relevant Pharmaceuticals and Mixtures Thereof in a Zebrafish Embryo Behavioural Test

Zygotic exposure to venlafaxine disrupts cortisol stress axis activity in multiple generations of zebrafish

(2021) William A. Thompson et al.   ENVIRONMENTAL POLLUTION

Epidemiology of Autism Spectrum Disorders: A Review of Worldwide Prevalence Estimates Since 2014

(2020) Flavia Chiarotti et al.   Brain Sciences

Time-, dose- and transgenerational effects of fluoxetine on the behavioural responses of zebrafish to a conspecific alarm substance

(2020) Asma Al Shuraiqi et al.   ENVIRONMENTAL POLLUTION

Varying the exposure period and duration of neuroactive pharmaceuticals and their metabolites modulates effects on the visual motor response in zebrafish (Danio rerio) larvae

(2019) Irvin J. Huang et al.   NEUROTOXICOLOGY AND TERATOLOGY

Temporal and Geographical Variability of Prevalence and Incidence of Autism Spectrum Disorder Diagnoses in Children in Catalonia, Spain

(2019) Laura Pérez‐Crespo et al.   Autism Research

Antidepressants with different mechanisms of action show different chronopharmacological profiles in the tail suspension test in mice

(2019) Hiroshi Kawai et al.   CHRONOBIOLOGY INTERNATIONAL

Effects of antidepressants with different modes of action on early life stages of fish and amphibians

(2019) Pavla Sehonova et al.   ENVIRONMENTAL POLLUTION

Environmental concentration of fluoxetine disturbs larvae behavior and increases the defense response at molecular level in zebrafish (Danio rerio)

(2019) Marco Parolini et al.   ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH

Fluoxetine modulates the transcription of genes involved in serotonin, dopamine and adrenergic signalling in zebrafish embryos

(2018) V. Cunha et al.   CHEMOSPHERE

Expression of the eight GABAA receptor α subunits in the developing zebrafish central nervous system

(2018) Bryan Monesson-Olson et al.   PLoS One

Design and validation of an ontology-driven animal-free testing strategy for developmental neurotoxicity testing

(2018) Ellen V.S. Hessel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Strategies to improve the regulatory assessment of developmental neurotoxicity (DNT) using in vitro methods

(2018) Anna Bal-Price et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Head skeleton malformations in zebrafish (Danio rerio) to assess adverse effects of mixtures of compounds

(2018) Yvonne C. M. Staal et al.   ARCHIVES OF TOXICOLOGY

Exposure to low concentration of fluoxetine affects development, behaviour and acetylcholinesterase activity of zebrafish embryos

(2018) Natália Oliveira de Farias et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Transgenerational hypocortisolism and behavioral disruption are induced by the antidepressant fluoxetine in male zebrafish Danio rerio

(2018) Marilyn N. Vera-Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Venlafaxine in Embryos Stimulates Neurogenesis and Disrupts Larval Behavior in Zebrafish

(2017) William A. Thompson et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

The influence of aripiprazole and venlafaxine on the antidepressant-like effect observed in prenatally stressed rats (animal model of depression)

(2017) P Ratajczak et al.   HUMAN & EXPERIMENTAL TOXICOLOGY

Dysregulation of autism-associated synaptic proteins by psychoactive pharmaceuticals at environmental concentrations

(2017) Gaurav Kaushik et al.   NEUROSCIENCE LETTERS

Developing and applying the adverse outcome pathway concept for understanding and predicting neurotoxicity

(2017) Anna Bal-Price et al.   NEUROTOXICOLOGY

Reference compounds for alternative test methods to indicate developmental neurotoxicity (DNT) potential of chemicals: Example lists and criteria for their selection and use_suppl

(2017) Michael Aschner   ALTEX-Alternatives to Animal Experimentation

Comparative safety of antiepileptic drugs for neurological development in children exposed during pregnancy and breast feeding: a systematic review and network meta-analysis

(2017) Areti Angeliki Veroniki et al.   BMJ Open

Psychoactive pharmaceuticals at environmental concentrations induce in vitro gene expression associated with neurological disorders

(2016) Gaurav Kaushik et al.   BMC GENOMICS

Safety of Selective Serotonin Reuptake Inhibitors in Pregnancy: A Review of Current Evidence

(2016) Sura Alwan et al.   CNS DRUGS

Environmental concentration of carbamazepine accelerates fish embryonic development and disturbs larvae behavior

(2016) Liyuan Qiang et al.   ECOTOXICOLOGY

Changes in Neurotransmitter Profiles during Early Zebrafish (Danio rerio) Development and after Pesticide Exposure

(2016) Sara Tufi et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

CRED: Criteria for reporting and evaluating ecotoxicity data

(2016) Caroline T.A. Moermond et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Effects of carbamazepine on cortisol levels and behavioral responses to stress in the fish Jenynsia multidentata

(2016) Emilia Calcagno et al.   PHYSIOLOGY & BEHAVIOR

Occurrence and spatial distribution of 158 pharmaceuticals, drugs of abuse and related metabolites in offshore seawater

(2016) Nikiforos A. Alygizakis et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Markers of murine embryonic and neural stem cells, neurons and astrocytes: reference points for developmental neurotoxicity testing

(2016) Philipp Kuegler   ALTEX-Alternatives to Animal Experimentation

Placental Transfer of Antidepressant Medications: Implications for Postnatal Adaptation Syndrome

(2015) Grace Ewing et al.   CLINICAL PHARMACOKINETICS

Prevalence and incidence of attention-deficit/hyperactivity disorder in Slovenian children and adolescents: a database study from a national perspective

(2015) Matej Štuhec et al.   CROATIAN MEDICAL JOURNAL

Development of a SPE-HPLC–MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples

(2015) Robert Gurke et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

An adverse outcome pathway framework for neural tube and axial defects mediated by modulation of retinoic acid homeostasis

(2015) Elisa C.M. Tonk et al.   REPRODUCTIVE TOXICOLOGY

Effects of the antidepressant venlafaxine on fish brain serotonin and predation behavior

(2014) Joseph H. Bisesi et al.   AQUATIC TOXICOLOGY

The Antidepressant Venlafaxine Disrupts Brain Monoamine Levels and Neuroendocrine Responses to Stress in Rainbow Trout

(2014) Nataliya Melnyk-Lamont et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Neurobehavioural effects of developmental toxicity

(2014) Philippe Grandjean et al.   LANCET NEUROLOGY

Antidepressant Use in Pregnancy and the Risk of Cardiac Defects

(2014) Krista F. Huybrechts et al.   NEW ENGLAND JOURNAL OF MEDICINE

Gaining translational momentum: More zebrafish models for neuroscience research

(2014) Allan V. Kalueff et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Zebrafish embryotoxicity test for developmental (neuro)toxicity: Demo case of an integrated screening approach system using anti-epileptic drugs

(2014) Anna Beker van Woudenberg et al.   REPRODUCTIVE TOXICOLOGY

Developmental neurotoxicity – Challenges in the 21st Century and In Vitro Opportunities

(2014) Lena Smirnova   ALTEX-Alternatives to Animal Experimentation

Behavioral and neurogenomic transcriptome changes in wild-derived zebrafish with fluoxetine treatment

(2013) Ryan Y Wong et al.   BMC GENOMICS

Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS

(2013) André Lajeunesse et al.   Chemistry Central Journal

The adverse outcome pathway concept: A pragmatic tool in toxicology

(2013) Mathieu Vinken   TOXICOLOGY

Teratogenic Potential of Antiepileptic Drugs in the Zebrafish Model

(2013) Sung Hak Lee et al.   Biomed Research International

Psychoactive Pharmaceuticals Induce Fish Gene Expression Profiles Associated with Human Idiopathic Autism

(2012) Michael A. Thomas et al.   PLoS One

Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water

(2012) Cindy M. de Jongh et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Gene-class analysis of expression patterns induced by psychoactive pharmaceutical exposure in fathead minnow (Pimephales promelas) indicates induction of neuronal systems

(2011) Michael A. Thomas et al.   COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY

Temporal control of a dendritogenesis-linked gene via REST-dependent regulation of nuclear factor I occupancy

(2011) Wei Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Selective Serotonin Reuptake Inhibitors and Risk for Major Congenital Anomalies

(2011) Heli Malm et al.   OBSTETRICS AND GYNECOLOGY

Relative embryotoxicity of two classes of chemicals in a modified zebrafish embryotoxicity test and comparison with their in vivo potencies

(2011) Sanne A.B. Hermsen et al.   TOXICOLOGY IN VITRO

Acute effects of triclosan, diclofenac and carbamazepine on feeding performance of Japanese medaka fish (Oryzias latipes)

(2010) Mohamed Nassef et al.   CHEMOSPHERE

Antidepressants and their metabolites in municipal wastewater, and downstream exposure in an urban watershed

(2010) Chris D. Metcalfe et al.   ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY

Locomotor activity in zebrafish embryos: A new method to assess developmental neurotoxicity

(2010) Ingrid W.T. Selderslaghs et al.   NEUROTOXICOLOGY AND TERATOLOGY

Removal of pharmaceuticals during wastewater treatment and environmental risk assessment using hazard indexes

(2009) Meritxell Gros et al.   ENVIRONMENT INTERNATIONAL

Childhood Lead Poisoning: Conservative Estimates of the Social and Economic Benefits of Lead Hazard Control

(2009) Elise Gould   ENVIRONMENTAL HEALTH PERSPECTIVES

Placental Transfer of SSRI and SNRI Antidepressants and Effects on the Neonate

(2009) J. Rampono et al.   PHARMACOPSYCHIATRY

Trace Analysis of Antidepressant Pharmaceuticals and Their Select Degradates in Aquatic Matrixes by LC/ESI/MS/MS

(2008) Melissa M. Schultz et al.   ANALYTICAL CHEMISTRY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols