Analysis of Age-Dependent Alterations in Excitability Properties of CA1 Pyramidal Neurons in an APPPS1 Model of Alzheimer’s Disease

Fibrillar Aβ triggers microglial proteome alterations and dysfunction in Alzheimer mouse models

(2020) Laura Sebastian Monasor et al.   eLife

APP Family Regulates Neuronal Excitability and Synaptic Plasticity but Not Neuronal Survival

(2020) Sang Hun Lee et al.   NEURON

Anti-Inflammatory Treatment with FTY720 Starting after Onset of Symptoms Reverses Synaptic Deficits in an AD Mouse Model

(2020) Georgia-Ioanna Kartalou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Genistein Inhibits Aβ25–35-Induced Neuronal Death with Changes in the Electrophysiological Properties of Voltage-Gated Sodium and Potassium Channels

(2019) Yu-xiang Wang et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Modulating Human Memory via Entrainment of Brain Oscillations

(2019) Simon Hanslmayr et al.   TRENDS IN NEUROSCIENCES

Amyloid β-Induced Upregulation of Nav1.6 Underlies Neuronal Hyperactivity in Tg2576 Alzheimer’s Disease Mouse Model

(2019) Roselia Ciccone et al.   Scientific Reports

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding

(2019) Paula A. Pousinha et al.   Cell Reports

Imbalance between firing homeostasis and synaptic plasticity drives early-phase Alzheimer’s disease

(2018) Boaz Styr et al.   NATURE NEUROSCIENCE

The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow

(2018) Rosanna Migliore et al.   PLoS Computational Biology

Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity

(2018) Gaël Barthet et al.   Nature Communications

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

(2017) Paula A Pousinha et al.   eLife

Early Alterations of Hippocampal Neuronal Firing Induced by Abeta42

(2016) Daniela Gavello et al.   CEREBRAL CORTEX

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

The autism-associated MET receptor tyrosine kinase engages early neuronal growth mechanism and controls glutamatergic circuits development in the forebrain

(2016) Y Peng et al.   MOLECULAR PSYCHIATRY

Amyloid precursor protein modulates Nav1.6 sodium channel currents through a Go-coupled JNK pathway

(2016) Shao Li et al.   Scientific Reports

Amyloid Precursor Protein Enhances Nav1.6 Sodium Channel Cell Surface Expression

(2015) Chao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Altered hippocampal information coding and network synchrony in APP-PS1 mice

(2015) Sebastien Cayzac et al.   NEUROBIOLOGY OF AGING

Amyloid-β(25-35) Modulates the Expression of GirK and KCNQ Channel Genes in the Hippocampus

(2015) Jennifer Mayordomo-Cava et al.   PLoS One

Altered intrinsic excitability of hippocampal CA1 pyramidal neurons in aged PDAPP mice

(2015) Francesco Tamagnini et al.   Frontiers in Cellular Neuroscience

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Dendritic Structural Degeneration Is Functionally Linked to Cellular Hyperexcitability in a Mouse Model of Alzheimer’s Disease

(2014) Zuzana Šišková et al.   NEURON

Alterations in hippocampal network oscillations and theta-gamma coupling arise before Aβ overproduction in a mouse model of Alzheimer's disease

(2013) Romain Goutagny et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Amyloid β peptides modify the expression of antioxidant repair enzymes and a potassium channel in the septohippocampal system

(2013) Jorge Durán-González et al.   NEUROBIOLOGY OF AGING

Characterization of altered intrinsic excitability in hippocampal CA1 pyramidal cells of the Aβ-overproducing PDAPP mouse

(2013) T.L. Kerrigan et al.   NEUROPHARMACOLOGY

Changes in Amyloid-  and Tau in the Cerebrospinal Fluid of Transgenic Mice Overexpressing Amyloid Precursor Protein

(2013) L. F. Maia et al.   Science Translational Medicine

Inhibitory Interneuron Deficit Links Altered Network Activity and Cognitive Dysfunction in Alzheimer Model

(2012) Laure Verret et al.   CELL

Glucagon-Like Peptide-1 Cleavage Product GLP-1(9-36) Amide Rescues Synaptic Plasticity and Memory Deficits in Alzheimer's Disease Model Mice

(2012) T. Ma et al.   JOURNAL OF NEUROSCIENCE

Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations

(2012) Michele Migliore et al.   PLoS One

Critical role of soluble amyloid-  for early hippocampal hyperactivity in a mouse model of Alzheimer's disease

(2012) M. A. Busche et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

APP and APLP2 are essential at PNS and CNS synapses for transmission, spatial learning and LTP

(2011) Sascha W Weyer et al.   EMBO JOURNAL

Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease

(2011) Jon T. Brown et al.   NEUROBIOLOGY OF AGING

Changes in the physiology of CA1 hippocampal pyramidal neurons in preplaque CRND8 mice

(2011) Robert Wykes et al.   NEUROBIOLOGY OF AGING

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?

(2011) Cristina Marchetti et al.   REVIEWS IN THE NEUROSCIENCES

Probing the Biology of Alzheimer's Disease in Mice

(2010) Karen H. Ashe et al.   NEURON

Synaptic Plasticity in the Hippocampus of a APP/PS1 Mouse Model of Alzheimer's Disease Is Impaired in Old but Not Young Mice

(2010) Simon Gengler et al.   PLoS One

Seizures in Alzheimer Disease

(2009) Nikolaos Scarmeas et al.   ARCHIVES OF NEUROLOGY

Mechanisms underlying basal and learning-related intrinsic excitability in a mouse model of Alzheimer's disease

(2009) C.C. Kaczorowski et al.   NEUROBIOLOGY OF AGING

Early-Onset and Robust Amyloid Pathology in a New Homozygous Mouse Model of Alzheimer's Disease

(2009) Antje Willuweit et al.   PLoS One

 -Secretase Heterogeneity in the Aph1 Subunit: Relevance for Alzheimer's Disease

(2009) L. Serneels et al.   SCIENCE

Relevance of Transgenic Mouse Models to Human Alzheimer Disease

(2008) Debbi A. Morrissette et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clusters of Hyperactive Neurons Near Amyloid Plaques in a Mouse Model of Alzheimer's Disease

(2008) M. A. Busche et al.   SCIENCE