The heme synthesis-export system regulates the tricarboxylic acid cycle flux and oxidative phosphorylation

The Multifaceted Role of Heme in Cancer

(2020) Veronica Fiorito et al.   Frontiers in Oncology

Investigating the Connection Between Endogenous Heme Accumulation and COX2 Activity in Cancer Cells

(2019) Francesca Destefanis et al.   Frontiers in Oncology

Expression of the feline leukemia virus subgroup C receptors in normal and neoplastic urothelium of the urinary bladder of cattle associated with bovine papillomavirus infection

(2019) Valeria Russo et al.   VETERINARY MICROBIOLOGY

Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism

(2019) Jiyoung Lee et al.   NATURE

BACH1 Stabilization by Antioxidants Stimulates Lung Cancer Metastasis

(2019) Clotilde Wiel et al.   CELL

Heme and sensory neuropathy

(2019) Francesca Bertino et al.   PAIN

Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells

(2018) Saar Vandekeere et al.   Cell Metabolism

Iron metabolism gene expression and prognostic features of hepatocellular carcinoma

(2018) Ying Shen et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Akt‐mediated phosphorylation of MICU1 regulates mitochondrial Ca2+ levels and tumor growth

(2018) Saverio Marchi et al.   EMBO JOURNAL

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma

(2017) Valentina Audrito et al.   JNCI-Journal of the National Cancer Institute

Use of luciferase probes to measure ATP in living cells and animals

(2017) Giampaolo Morciano et al.   Nature Protocols

The emerging role and targetability of the TCA cycle in cancer metabolism

(2017) Nicole M. Anderson et al.   Protein & Cell

Nicotinamide Phosphoribosyltransferase (NAMPT) as a Therapeutic Target in BRAF-Mutated Metastatic Melanoma

(2017) Valentina Audrito et al.   JNCI-Journal of the National Cancer Institute

Synthesis, delivery and regulation of eukaryotic heme and Fe–S cluster cofactors

(2016) Dulmini P. Barupala et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Update review of the acute porphyrias

(2016) Penelope E. Stein et al.   BRITISH JOURNAL OF HAEMATOLOGY

Novel Mechanisms for Heme-dependent Degradation of ALAS1 Protein as a Component of Negative Feedback Regulation of Heme Biosynthesis

(2016) Yoshiko Kubota et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in the Heme Exporter FLVCR1 Cause Sensory Neurodegeneration with Loss of Pain Perception

(2016) Deborah Chiabrando et al.   PLoS Genetics

Crucial Role of FLVCR1a in the Maintenance of Intestinal Heme Homeostasis

(2015) Veronica Fiorito et al.   ANTIOXIDANTS & REDOX SIGNALING

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

(2015) S. Mercurio et al.   HAEMATOLOGICA

Coordinate expression of heme and globin is essential for effective erythropoiesis

(2015) Raymond T. Doty et al.   JOURNAL OF CLINICAL INVESTIGATION

BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis

(2015) Quan Wan et al.   Database-The Journal of Biological Databases and Curation

Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest

(2015) Michela Capello et al.   Oncotarget

The heme exporter Flvcr1 regulates expansion and differentiation of committed erythroid progenitors by controlling intracellular heme accumulation

(2015) S. Mercurio et al.   HAEMATOLOGICA

Heme Exporter FLVCR1a Regulates Heme Synthesis and Degradation and Controls Activity of Cytochromes P450

(2014) Francesca Vinchi et al.   GASTROENTEROLOGY

MICU1 and MICU2 Finely Tune the Mitochondrial Ca2+ Uniporter by Exerting Opposite Effects on MCU Activity

(2014) Maria Patron et al.   MOLECULAR CELL

Heme in pathophysiology: a matter of scavenging, metabolism and trafficking across cell membranes

(2014) Deborah Chiabrando et al.   Frontiers in Pharmacology

Subcellular calcium measurements in mammalian cells using jellyfish photoprotein aequorin-based probes

(2013) Massimo Bonora et al.   Nature Protocols

Structure, function, and assembly of heme centers in mitochondrial respiratory complexes

(2012) Hyung J. Kim et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

The mitochondrial heme exporter FLVCR1b mediates erythroid differentiation

(2012) Deborah Chiabrando et al.   JOURNAL OF CLINICAL INVESTIGATION

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Control of intracellular heme levels: Heme transporters and heme oxygenases

(2011) Anwar A. Khan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Aminolevulinic Acid (ALA) as a Prodrug in Photodynamic Therapy of Cancer

(2011) Małgorzata Wachowska et al.   MOLECULES

Haem oxygenase is synthetically lethal with the tumour suppressor fumarate hydratase

(2011) Christian Frezza et al.   NATURE

A kinetic assay of mitochondrial ADP–ATP exchange rate in permeabilized cells

(2010) Hibiki Kawamata et al.   ANALYTICAL BIOCHEMISTRY

Kinetics and Specificity of Feline Leukemia Virus Subgroup C Receptor (FLVCR) Export Function and Its Dependence on Hemopexin

(2010) Zhantao Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis

(2010) Yingdi Wang et al.   NATURE

Mutated K-rasAsp12promotes tumourigenesis inApcMinmice more in the large than the small intestines, with synergistic effects between K-rasandWntpathways

(2009) Feijun Luo et al.   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

Differential regulation of human ALAS1 mRNA and protein levels by heme and cobalt protoporphyrin

(2008) Jianyu Zheng et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Adenine Nucleotide Translocator Transports Haem Precursors into Mitochondria

(2008) Motoki Azuma et al.   PLoS One

A Heme Export Protein Is Required for Red Blood Cell Differentiation and Iron Homeostasis

(2008) S. B. Keel et al.   SCIENCE