Evaluating the impact of age on immune checkpoint therapy biomarkers

An integrative analysis of the age-associated multi-omic landscape across cancers

(2021) Kasit Chatsirisupachai et al.   Nature Communications

NK cells for cancer immunotherapy

(2020) Noriko Shimasaki et al.   NATURE REVIEWS DRUG DISCOVERY

The Human Tumor Atlas Network: Charting Tumor Transitions across Space and Time at Single-Cell Resolution

(2020) Orit Rozenblatt-Rosen et al.   CELL

Interplay of somatic alterations and immune infiltration modulates response to PD-1 blockade in advanced clear cell renal cell carcinoma

(2020) David A. Braun et al.   NATURE MEDICINE

Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden

(2020) Tao Qing et al.   Nature Communications

A single-cell transcriptomic atlas characterizes ageing tissues in the mouse

(2020)   NATURE

Unveiling the immune infiltrate modulation in cancer and response to immunotherapy by MIXTURE—an enhanced deconvolution method

(2020) Elmer A Fernández et al.   BRIEFINGS IN BIOINFORMATICS

Molecular and pharmacological modulators of the tumor immune contexture revealed by deconvolution of RNA-seq data

(2019) Francesca Finotello et al.   Genome Medicine

Targeting of M2-like tumor-associated macrophages with a melittin-based pro-apoptotic peptide

(2019) Chanju Lee et al.   Journal for ImmunoTherapy of Cancer

Natural Killer Cells Suppress T Cell-Associated Tumor Immune Evasion

(2019) Andrew J. Freeman et al.   Cell Reports

Association of Age with Efficacy of Immunotherapy in Metastatic Melanoma

(2019) Varsha Jain et al.   ONCOLOGIST

TCR Repertoire Diversity of Peripheral PD-1+CD8+ T Cells Predicts Clinical Outcomes after Immunotherapy in Patients with Non–Small Cell Lung Cancer

(2019) Jiefei Han et al.   Cancer Immunology Research

WNT Signaling in Tumors: The Way to Evade Drugs and Immunity

(2019) Elena Martin-Orozco et al.   Frontiers in Immunology

DNA Methylation Patterns Separate Senescence from Transformation Potential and Indicate Cancer Risk

(2018) Wenbing Xie et al.   CANCER CELL

Interferon Gamma Messenger RNA Signature in Tumor Biopsies Predicts Outcomes in Patients with Non–Small Cell Lung Carcinoma or Urothelial Cancer Treated with Durvalumab

(2018) Brandon W. Higgs et al.   CLINICAL CANCER RESEARCH

Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations

(2018) Curtis H. Kugel et al.   CLINICAL CANCER RESEARCH

Considerations for successful cancer immunotherapy in aged hosts

(2018) Vincent Hurez et al.   EXPERIMENTAL GERONTOLOGY

The Immune Landscape of Cancer

(2018) Vésteinn Thorsson et al.   IMMUNITY

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?

(2018) Tamas Fulop et al.   Frontiers in Immunology

PD-L1 expression is regulated by both DNA methylation and NF-kB during EMT signaling in non-small cell lung carcinoma

(2018) A. Asgarova et al.   OncoImmunology

Efficacy of PD-1 & PD-L1 inhibitors in older adults: a meta-analysis

(2018) Rawad Elias et al.   Journal for ImmunoTherapy of Cancer

Targeting Macrophages in Cancer: From Bench to Bedside

(2018) Ashleigh R. Poh et al.   Frontiers in Oncology

Comprehensive transcriptome profiling in elderly cancer patients reveals aging-altered immune cells and immune checkpoints

(2018) Yingcheng Wu et al.   INTERNATIONAL JOURNAL OF CANCER

The Changing Landscape of Naive T Cell Receptor Repertoire With Human Aging

(2018) Evgeny S. Egorov et al.   Frontiers in Immunology

PD-L1 methylation regulates PD-L1 expression and is associated with melanoma survival

(2018) Goran Micevic et al.   Pigment Cell & Melanoma Research

Pan-tumor genomic biomarkers for PD-1 checkpoint blockade–based immunotherapy

(2018) Razvan Cristescu et al.   SCIENCE

Genomics of response to immune checkpoint therapies for cancer: implications for precision medicine

(2018) Jake R. Conway et al.   Genome Medicine

Immune checkpoint inhibitors and elderly people: A review

(2017) Amaury Daste et al.   EUROPEAN JOURNAL OF CANCER

Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers

(2017) Aaron M. Goodman et al.   MOLECULAR CANCER THERAPEUTICS

Genetic effects on gene expression across human tissues

(2017) François Aguet et al.   NATURE

Tumor Mutational Burden and Response Rate to PD-1 Inhibition

(2017) Mark Yarchoan et al.   NEW ENGLAND JOURNAL OF MEDICINE

Contribution of epigenetic mechanisms to variation in cancer risk among tissues

(2017) Michael Klutstein et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stem cell divisions, somatic mutations, cancer etiology, and cancer prevention

(2017) Cristian Tomasetti et al.   SCIENCE

Analysis of 100,000 human cancer genomes reveals the landscape of tumor mutational burden

(2017) Zachary R. Chalmers et al.   Genome Medicine

The somatic mutation profiles of 2,433 breast cancers refines their genomic and transcriptomic landscapes

(2016) Bernard Pereira et al.   Nature Communications

Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment

(2016) Larisa V. Kovtonyuk et al.   Frontiers in Immunology

PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy

(2015) S. P. Patel et al.   MOLECULAR CANCER THERAPEUTICS

Robust enumeration of cell subsets from tissue expression profiles

(2015) Aaron M Newman et al.   NATURE METHODS

Age-Related Decrease in TCR Repertoire Diversity Measured with Deep and Normalized Sequence Profiling

(2014) O. V. Britanova et al.   JOURNAL OF IMMUNOLOGY

Unleashing the immune system: PD-1 and PD-Ls in the pre-treatment tumor microenvironment and correlation with response to PD-1/PD-L1 blockade

(2014) Janis M Taube   OncoImmunology

Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment

(2014) Theerawut Chanmee et al.   Cancers

MiTCR: software for T-cell receptor sequencing data analysis

(2013) Dmitriy A Bolotin et al.   NATURE METHODS

DNA methylation age of human tissues and cell types

(2013) Steve Horvath   GENOME BIOLOGY

A DNA hypermethylation module for the stem/progenitor cell signature of cancer

(2012) H. Easwaran et al.   GENOME RESEARCH

Molecular signatures database (MSigDB) 3.0

(2011) A. Liberzon et al.   BIOINFORMATICS

Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus

(2008) Eric J. Yager et al.   JOURNAL OF EXPERIMENTAL MEDICINE