Mineralocorticoid receptors dampen glucocorticoid receptor sensitivity to stress via regulation of FKBP5

The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice

(2021) Alexander S. Häusl et al.   MOLECULAR PSYCHIATRY

Identification of mineralocorticoid receptor target genes in the mouse hippocampus

(2019) Lisa T.C.M. van Weert et al.   JOURNAL OF NEUROENDOCRINOLOGY

Deconstructing the Gestalt: Mechanisms of Fear, Threat, and Trauma Memory Encoding

(2019) Stephanie A. Maddox et al.   NEURON

Epigenetic upregulation of FKBP5 by aging and stress contributes to NF-κB–driven inflammation and cardiovascular risk

(2019) Anthony S. Zannas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Novel role for mineralocorticoid receptors in control of a neuronal phenotype

(2019) Katharine E. McCann et al.   MOLECULAR PSYCHIATRY

Importance of the brain corticosteroid receptor balance in metaplasticity, cognitive performance and neuro-inflammation

(2018) E.R. de Kloet et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Molecular Diversity and Specializations among the Cells of the Adult Mouse Brain

(2018) Arpiar Saunders et al.   CELL

Brain circuit dysfunction in post-traumatic stress disorder: from mouse to man

(2018) Robert J. Fenster et al.   NATURE REVIEWS NEUROSCIENCE

Hsp90 and FKBP51: complex regulators of psychiatric diseases

(2017) Marangelie Criado-Marrero et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Brain mineralocorticoid receptor function in control of salt balance and stress-adaptation

(2017) Edo Ronald de Kloet et al.   PHYSIOLOGY & BEHAVIOR

Forebrain glutamatergic, but not GABAergic, neurons mediate anxiogenic effects of the glucocorticoid receptor

(2016) J Hartmann et al.   MOLECULAR PSYCHIATRY

HPA axis in major depression: cortisol, clinical symptomatology and genetic variation predict cognition

(2016) J Keller et al.   MOLECULAR PSYCHIATRY

Acute stress enhances heterodimerization and binding of corticosteroid receptors at glucocorticoid target genes in the hippocampus

(2016) Karen R. Mifsud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Approaches to Hypothalamic-Pituitary-Adrenal Axis Regulation

(2015) Melinda G Arnett et al.   NEUROPSYCHOPHARMACOLOGY

Glucocorticoid and mineralocorticoid receptor polymorphisms and recurrence of major depressive disorder

(2015) Florian Hardeveld et al.   PSYCHONEUROENDOCRINOLOGY

Depletion of FKBP51 in Female Mice Shapes HPA Axis Activity

(2014) Lianne Hoeijmakers et al.   PLoS One

Deletion of the forebrain mineralocorticoid receptor impairs social discrimination and decision-making in male, but not in female mice

(2014) Judith P. ter Horst et al.   Frontiers in Behavioral Neuroscience

Disrupting Hypothalamic Glucocorticoid Receptors Causes HPA Axis Hyperactivity and Excess Adiposity

(2013) Gloria Laryea et al.   MOLECULAR ENDOCRINOLOGY

Glucocorticoid and mineralocorticoid receptor expression in the human hippocampus in major depressive disorder

(2012) Adriana Medina et al.   JOURNAL OF PSYCHIATRIC RESEARCH

An anatomically comprehensive atlas of the adult human brain transcriptome

(2012) Michael J. Hawrylycz et al.   NATURE

Allele-specific FKBP5 DNA demethylation mediates gene–childhood trauma interactions

(2012) Torsten Klengel et al.   NATURE NEUROSCIENCE

Stress or no stress: Mineralocorticoid receptors in the forebrain regulate behavioral adaptation

(2012) J.P. ter Horst et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Differences in FKBP51 Regulation Following Chronic Social Defeat Stress Correlate with Individual Stress Sensitivity: Influence of Paroxetine Treatment

(2012) Klaus V Wagner et al.   NEUROPSYCHOPHARMACOLOGY

Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour

(2012) A.P. Harris et al.   PSYCHONEUROENDOCRINOLOGY

FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

(2011) Chadi Touma et al.   BIOLOGICAL PSYCHIATRY

The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress

(2011) Jakob Hartmann et al.   NEUROPHARMACOLOGY

Expression and Regulation of the Fkbp5 Gene in the Adult Mouse Brain

(2011) Sebastian H. Scharf et al.   PLoS One

A New Anti-Depressive Strategy for the Elderly: Ablation of FKBP5/FKBP51

(2011) John C. O'Leary et al.   PLoS One

A common and functional mineralocorticoid receptor haplotype enhances optimism and protects against depression in females

(2011) M D Klok et al.   Translational Psychiatry

Chronic Corticosterone Exposure Increases Expression and Decreases Deoxyribonucleic Acid Methylation ofFkbp5in Mice

(2010) Richard S. Lee et al.   ENDOCRINOLOGY

Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?

(2010) Michael S. Fanselow et al.   NEURON

Differential Impact of Tetratricopeptide Repeat Proteins on the Steroid Hormone Receptors

(2010) Jan-Philip Schülke et al.   PLoS One

Effects of stress throughout the lifespan on the brain, behaviour and cognition

(2009) Sonia J. Lupien et al.   NATURE REVIEWS NEUROSCIENCE

Neural regulation of endocrine and autonomic stress responses

(2009) Yvonne M. Ulrich-Lai et al.   NATURE REVIEWS NEUROSCIENCE

The brain and the stress axis: The neural correlates of cortisol regulation in response to stress

(2009) Katarina Dedovic et al.   NEUROIMAGE

Brain development under stress: Hypotheses of glucocorticoid actions revisited

(2009) Melly S. Oitzl et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

(2009) Elisabeth B. Binder   PSYCHONEUROENDOCRINOLOGY

The Role of the Forebrain Glucocorticoid Receptor in Acute and Chronic Stress

(2008) Amy R. Furay et al.   ENDOCRINOLOGY

Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls

(2008) Marcus Ising et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults

(2008) Elisabeth B. Binder   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION