Mammalian target of rapamycin (mTOR) complex 2 regulates filamin A-dependent focal adhesion dynamics and cell migration

Exon skipping causes atypical phenotypes associated with a loss-of-function mutation in FLNA by restoring its protein function

(2015) Hirotsugu Oda et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Significance of filamin A in mTORC2 function in glioblastoma

(2015) Naphat Chantaravisoot et al.   Molecular Cancer

Current treatment strategies for inhibiting mTOR in cancer

(2015) Francesca Chiarini et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

RICTOR involvement in the PI3K/AKT pathway regulation in melanocytes and melanoma

(2015) Florence Laugier et al.   Oncotarget

Making new contacts: the mTOR network in metabolism and signalling crosstalk

(2014) Mitsugu Shimobayashi et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Targeting of mTORC2 prevents cell migration and promotes apoptosis in breast cancer

(2012) Haiyan Li et al.   BREAST CANCER RESEARCH AND TREATMENT

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

Brefeldin A-inhibited Guanine Exchange Factor 2 Regulates Filamin A Phosphorylation and Neuronal Migration

(2012) J. Zhang et al.   JOURNAL OF NEUROSCIENCE

Integrins in Cell Migration

(2011) A. Huttenlocher et al.   Cold Spring Harbor Perspectives in Biology

The filamins

(2011) Fumihiko Nakamura et al.   Cell Adhesion & Migration

Genetic Dissection of the Oncogenic mTOR Pathway Reveals Druggable Addiction to Translational Control via 4EBP-eIF4E

(2010) Andrew C. Hsieh et al.   CANCER CELL

Fat Cell-Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism

(2010) A. Kumar et al.   DIABETES

Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion

(2010) Yingjie Xu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cell adhesion: integrating cytoskeletal dynamics and cellular tension

(2010) J. Thomas Parsons et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Filamins in cell signaling, transcription and organ development

(2010) Alex-Xianghua Zhou et al.   TRENDS IN CELL BIOLOGY

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

(2009) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Filamin A Is Essential for Active Cell Stiffening but not Passive Stiffening under External Force

(2009) K.E. Kasza et al.   BIOPHYSICAL JOURNAL

Phosphorylation Facilitates the Integrin Binding of Filamin under Force

(2009) Harvey S. Chen et al.   BIOPHYSICAL JOURNAL

Absence of Filamin A Prevents Cells from Responding to Stiffness Gradients on Gels Coated with Collagen but not Fibronectin

(2009) Fitzroy J. Byfield et al.   BIOPHYSICAL JOURNAL

Specific Activation of mTORC1 by Rheb G-proteinin VitroInvolves Enhanced Recruitment of Its Substrate Protein

(2009) Tatsuhiro Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

(2009) Carson C. Thoreen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Regulation Mechanism for the Auto-Inhibition of Binding of Human Filamin A to Integrin

(2009) Ulla Pentikäinen et al.   JOURNAL OF MOLECULAR BIOLOGY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

mTOR complex 2 in adipose tissue negatively controls whole-body growth

(2009) N. Cybulski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

Filamin A is a novel caveolin-1-dependent target in IGF-I-stimulated cancer cell migration

(2008) Dana Ravid et al.   EXPERIMENTAL CELL RESEARCH

Filamin A regulates cell spreading and survival via β1 integrins

(2007) Hugh Kim et al.   EXPERIMENTAL CELL RESEARCH