PDX1 dynamically regulates pancreatic ductal adenocarcinoma initiation and maintenance

Cancer statistics, 2016

(2016) Rebecca L. Siegel et al.   CA-A CANCER JOURNAL FOR CLINICIANS

TGF-β Tumor Suppression through a Lethal EMT

(2016) Charles J. David et al.   CELL

Genomic analyses identify molecular subtypes of pancreatic cancer

(2016) Peter Bailey et al.   NATURE

Diabetes Caused by Elastase-Cre-Mediated Pdx1 Inactivation in Mice

(2016) Sota Kodama et al.   Scientific Reports

Pdx1 regulates pancreas tubulogenesis and E-cadherin expression

(2015) Leilani Marty-Santos et al.   DEVELOPMENT

Regulation of Cellular Identity in Cancer

(2015) Nilotpal Roy et al.   DEVELOPMENTAL CELL

The acinar differentiation determinant PTF1A inhibits initiation of pancreatic ductal adenocarcinoma

(2015) Nathan M Krah et al.   eLife

Vertically integrated translational studies of PDX1 as a therapeutic target for pancreatic cancer via a novel bifunctional RNAi platform

(2014) J Wu et al.   CANCER GENE THERAPY

Projecting Cancer Incidence and Deaths to 2030: The Unexpected Burden of Thyroid, Liver, and Pancreas Cancers in the United States

(2014) L. Rahib et al.   CANCER RESEARCH

Pdx1 Maintains β Cell Identity and Function by Repressing an α Cell Program

(2014) Tao Gao et al.   Cell Metabolism

The chromatin regulator Brg1 suppresses formation of intraductal papillary mucinous neoplasm and pancreatic ductal adenocarcinoma

(2014) Guido von Figura et al.   NATURE CELL BIOLOGY

Analysis of the tumor-initiating and metastatic capacity of PDX1-positive cells from the adult pancreas

(2014) Irene Ischenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatiotemporal patterns of multipotentiality in Ptf1a-expressing cells during pancreas organogenesis and injury-induced facultative restoration

(2013) F. C. Pan et al.   DEVELOPMENT

Nr5a2heterozygosity sensitises to, and cooperates with, inflammation inKRasG12V-driven pancreatic tumourigenesis

(2013) Marta Flandez et al.   GUT

Nr5a2 maintains acinar cell differentiation and constrains oncogenic Kras-mediated pancreatic neoplastic initiation

(2013) Guido von Figura et al.   GUT

Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA

(2013) Michelle T. Paulsen et al.   METHODS

HOXB7 promotes invasion and predicts survival in pancreatic adenocarcinoma

(2012) Anne Nguyen Kovochich et al.   CANCER

Identification of Sox9-Dependent Acinar-to-Ductal Reprogramming as the Principal Mechanism for Initiation of Pancreatic Ductal Adenocarcinoma

(2012) Janel L. Kopp et al.   CANCER CELL

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

(2012) Charles Y. Lin et al.   CELL

Maintenance of acinar cell organization is critical to preventing Kras-induced acinar-ductal metaplasia

(2012) G Shi et al.   ONCOGENE

Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy

(2011) Eric A Collisson et al.   NATURE MEDICINE

Pdx1 Expression in Pancreatic Precursor Lesions and Neoplasms

(2011) Jason Y. Park et al.   APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY

Loss of FOXA1/2 Is Essential for the Epithelial-to-Mesenchymal Transition in Pancreatic Cancer

(2010) Y. Song et al.   CANCER RESEARCH

β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

(2010) John P. Morris et al.   JOURNAL OF CLINICAL INVESTIGATION

Distant metastasis occurs late during the genetic evolution of pancreatic cancer

(2010) Shinichi Yachida et al.   NATURE

The basics of epithelial-mesenchymal transition

(2009) Raghu Kalluri et al.   JOURNAL OF CLINICAL INVESTIGATION

PDX-1 Acts as a Potential Molecular Target for Treatment of Human Pancreatic Cancer

(2009) Shihe Liu et al.   PANCREAS

Trp53 Deletion Stimulates the Formation of Metastatic Pancreatic Tumors

(2008) Jennifer P. Morton et al.   AMERICAN JOURNAL OF PATHOLOGY

pdx-1 function is specifically required in embryonic β cells to generate appropriate numbers of endocrine cell types and maintain glucose homeostasis

(2008) Maureen Gannon et al.   DEVELOPMENTAL BIOLOGY

Notch and Kras reprogram pancreatic acinar cells to ductal intraepithelial neoplasia

(2008) J.-P. De La O et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice

(2008) N. Habbe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA