Article
Pharmacology & Pharmacy
Long He, Shuting Wen, Zhuotai Zhong, Senhui Weng, Qilong Jiang, Hong Mi, Fengbin Liu
Summary: The combination of 5-ASA and SAHA showed lower toxicity and alleviated inflammation more effectively in the treatment of UC. One possible mechanism of synergy is the synergistic inhibition of the NF-kB signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Hossein Shahdadi Sardou, Fatemeh Sadeghi, Hadi Afrasiabi Garekani, Abbas Akhgari, Amir Hossein Jafarian, Mohammadreza Abbaspour, Ali Nokhodchi
Summary: The aim of this study was to evaluate and optimize the combination of time and pH-dependent polymers as a single coating for the design of the colon-specific drug delivery system of 5-aminosalicylic acid (5-ASA) pellets. The ratio of ES:EL:EC of 33:52:15 w/w at a coating level of 7% was discovered as the optimum coating for the delivery of 5-ASA matrix pellets to the colon.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Surgery
J. A. Bunce, B. Doleman, J. N. Lund, G. M. Tierney
Summary: This study investigated the impact of surgeon subspeciality on outcomes after emergency laparotomy for inflammatory bowel disease (IBD). It found that colorectal surgeons had significantly better outcomes in terms of mortality and length of stay for the least urgent category of IBD emergency laparotomies. However, this association was not seen in more urgent cases.
WORLD JOURNAL OF SURGERY
(2023)
Article
Pediatrics
Maya Ruban, Adam Slavick, Achiya Amir, Amir Ben-Tov, Hadar Moran-Lev, Yael Weintraub, Adi Anafy, Shlomi Cohen, Anat Yerushalmy-Feler
Summary: The rate of a positive family history of IBD in the pediatric IBD population is increasing, and patients with a positive family history are more likely to have a severe phenotype, receive more nutritional therapy, and less corticosteroids. Patients with a negative family history may require intensified biologic therapy.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Biochemistry & Molecular Biology
Javier Conde, Marlene Schwarzfischer, Egle Katkeviciute, Janine Hafliger, Anna Niechcial, Nathalie Brillant, Roberto Manzini, Katharina Babler, Kirstin Atrott, Silvia Lang, Michael Scharl
Summary: This study investigated the interaction between the food additive TiO2 and the IBD risk gene Ptpn2 in the development of intestinal inflammation. Results showed that TiO2 exacerbated intestinal inflammation in Ptpn2 deficient mice by impacting the differentiation of intestinal macrophages. Furthermore, TiO2 was found to induce the secretion of IL-1 beta and suppress the expression of IL-10 in macrophages through different signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Ohad Atia, Ramit Magen Rimon, Natan Ledderman, Shira Greenfeld, Revital Kariv, Yiska Loewenberg Weisband, Ron Shaoul, Eran Matz, Shmuel Odes, Idan Goren, Henit Yanai, Iris Dotan, Dan Turner
Summary: A nationwide study in Israel showed that 18% of patients with UC do not receive maintenance treatment, and half of them remain untreated after 3 years. The outcomes of untreated patients were similar to those of treated patients. Further research is needed to explore the role of NMT in UC.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pharmacology & Pharmacy
Snjezana Cuzic, Maja Antolic, Anja Ognjenovic, Darija Stupin-Polancec, Adriana Petrinic Grba, Boska Hrvacic, Miroslava Dominis Kramaric, Sanja Musladin, Lidija Pozgaj, Ivo Zlatar, Denis Polancec, Gorana Aralica, Marko Banic, Marija Urek, Brankica Mijandrusic Sincic, Aleksandar Cubranic, Ines Glojnaric, Martina Bosnar, Vesna Erakovic Haber
Summary: This study explored the expression of claudins in human disease and two different animal models of IBD. The diverse alterations in claudin expression by epithelial and inflammatory cells were recorded in IBD and both animal models. The results suggest that claudins are not exclusively expressed by epithelial cells, and changes in claudin mRNA levels should be interpreted in the context of overall tissue alterations.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Tyler Atagozli, David E. Elliott, Mirac Nedim Ince
Summary: Helminths are multicellular invertebrates that live in the gut of vertebrate animals, including humans. They can cause pathology and require treatment, but can also have commensal or symbiotic relationships with their hosts. Epidemiological data suggests that helminth exposure may provide protection against immune disorders, such as allergies and autoimmune illnesses.
Article
Biochemistry & Molecular Biology
Nikolas Dovrolis, Anastasia Moschoviti, Smaragdi Fessatou, George Karamanolis, George Kolios, Maria Gazouli
Summary: This study examines the role of the microbiome in the onset of pediatric inflammatory bowel disease (IBD). Through analyzing the microbiota of nine IBD families, specific patterns of microbial taxa were identified among patients and their families. The results suggest a potential role of maternal factors in the establishment and modulation of the early life microbiome.
Article
Gastroenterology & Hepatology
Christopher Ma, Jurij Hanzel, Remo Panaccione, William J. Sandborn, Geert R. D'Haens, Vineet Ahuja, Raja Atreya, Charles N. Bernstein, Peter Bossuyt, Brian Bressler, Robert Bryant, Benjamin Cohen, Jean-Frederic Colombel, Silvio Danese, Axel Dignass, Marla C. Dubinsky, Phillip R. Fleshner, Richard B. Gearry, Stephen B. Hanauer, Ailsa Hart, Paulo Gustavo Kotze, Torsten Kucharzik, Peter L. Lakatos, Rupert W. Leong, Fernando Magro, Julian Panes, Laurent Peyrin-Biroulet, Zhihua Ran, Miguel Regueiro, Siddharth Singh, Antonino Spinelli, A. Hillary Steinhart, Simon P. Travis, C. Janneke van der Woude, Bruce Yacyshyn, Takayuki Yamamoto, Matthieu Allez, Willem A. Bemelman, Amy L. Lightner, Edouard Louis, David T. Rubin, Ellen J. Scherl, Corey A. Siegel, Mark S. Silverberg, Severine Vermeire, Claire E. Parker, Stefanie C. McFarlane, Leonardo Guizzetti, Michelle Smith, Niels Vande Casteele, Brian G. Feagan, Vipul Jairath
Summary: This study establishes a core outcome set for randomized controlled trials of CD and UC through a multidisciplinary collaboration involving patients and clinical experts. Candidate outcome domains and measures were generated from literature reviews and patient engagement. The study highlights the importance of harmonizing endpoints for drug development in inflammatory bowel disease.
Article
Multidisciplinary Sciences
Rahel Bianchi, Barry Mamadou-Pathe, Roland von Kanel, Rene Roth, Philipp Schreiner, Jean-Benoit Rossel, Sabine Burk, Babara Dora, Patrizia Kloth, Andreas Rickenbacher, Matthias Turina, Thomas Greuter, Benjamin Misselwitz, Michael Scharl, Gerhard Rogler, Luc Biedermann
Summary: This study examined the impact of ostomy formation on disease progression, psychological well-being, and working capacity in patients with inflammatory bowel disease. The results showed that patients with ostomy had lower disease activity, similar psychological well-being compared to patients without ostomy, and only a modest impact on working capacity.
Article
Gastroenterology & Hepatology
Wan-Jie Gu, Fei-Long Ning, Hao-Ran Jin, Zhe-Ming Zhao, Jun Lyu, Jun-Peng Pei, Shi-Yi Cao, Yong-Ji Zeng, Masanobu Abe, Kazuhiro Nishiyama, Chun-Dong Zhang
Summary: This study examined the burden and trends of IBD in 5 Asian countries, the United States, and the United Kingdom, and found significant variations in incidence and death rates between these countries over the past 3 decades.
DISEASES OF THE COLON & RECTUM
(2023)
Article
Medicine, Research & Experimental
Lianxiang Luo, Suzhou Zhang, Nuoqing Guo, Huizhen Li, Shasha He
Summary: This study identified the significantly down-regulated expression of ACSF2, a ferroptosis-related gene, in ulcerative colitis through bioinformatics analysis. ACSF2 is significantly associated with immune-related pathways and is expected to play an important role in mediating ferroptosis and inflammation, making it a potential target for further research and treatment of ulcerative colitis.
Article
Gastroenterology & Hepatology
Giuseppe Biscaglia, Anna Latiano, Stefano Castellana, Rosanna Fontana, Annamaria Gentile, Tiziana Latiano, Giuseppe Corritore, Anna Panza, Marianna Nardella, Giuseppina Martino, Fabrizio Bossa, Francesco Perri, Tommaso Mazza, Angelo Andriulli, Orazio Palmieri
Summary: This study investigated germline alterations in patients with inflammatory bowel disease (IBD)-associated colorectal cancer (CRC). The results showed that a significant proportion of IBD patients with CRC had pathogenic variants in cancer-related genes. Those with pathogenic variants had earlier onset of high-grade dysplasia or CRC compared to patients with benign or unidentified variants. Screening for these genes could help identify IBD patients who require more intensive surveillance for early detection of dysplastic changes.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Pathology
Zhiyan Fu, Michel Kmeid, Soe Htet Arker, Georgi Lukose, Edward C. Lee, Gregory Y. Lauwers, Hwajeong Lee
Summary: This study aimed to identify histologic features of diverted colon segments in IBD patients and found that severe inflammatory activity, mucosal atrophy, and transmural inflammation were significantly greater in IBD patients compared to non-IBD cases. The inflammatory activity, presence of ulcer(s), IMLAs, TMLAs, and transmural inflammation in diverted colon segments of IBD patients may reflect the severity of underlying IBD.