Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Eradicating mesothelin-positive human gastric and pancreatic tumors in xenograft models with optimized anti-mesothelin antibody–drug conjugates from synthetic antibody libraries
Authors
Keywords
-
Journal
Scientific Reports
Volume 11, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-07-29
DOI
10.1038/s41598-021-94902-1
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- A panel of anti-influenza virus nucleoprotein antibodies selected from phage-displayed synthetic antibody libraries with rapid diagnostic capability to distinguish diverse influenza virus subtypes
- (2020) Chung-Ming Yu et al. Scientific Reports
- Protein Solubility Predictions Using the CamSol Method in the Study of Protein Homeostasis
- (2019) Pietro Sormanni et al. Cold Spring Harbor Perspectives in Biology
- Noninvasive assessment of characteristics of novel anti-HER2 antibodies by molecular imaging in a human gastric cancer xenograft-bearing mouse model
- (2018) Wei-Ying Kuo et al. Scientific Reports
- Effective binding to protein antigens by antibodies from antibody libraries designed with enhanced protein recognition propensities
- (2018) Jhih-Wei Jian et al. mAbs
- Antibody-drug conjugates with HER2-targeting antibodies from synthetic antibody libraries are highly potent against HER2-positive human gastric tumor in xenograft models
- (2018) Wei-Ying Kuo et al. mAbs
- Peritoneal dissemination of ovarian cancer: role of MUC16-mesothelin interaction and implications for treatment
- (2017) Ricardo Coelho et al. Expert Review of Anticancer Therapy
- Modeling and docking of antibody structures with Rosetta
- (2017) Brian D Weitzner et al. Nature Protocols
- Strategies and challenges for the next generation of antibody–drug conjugates
- (2017) Alain Beck et al. NATURE REVIEWS DRUG DISCOVERY
- Amatuximab and novel agents targeting mesothelin for solid tumors
- (2017) Paolo Baldo et al. OncoTargets and Therapy
- High throughput discovery of influenza virus neutralizing antibodies from phage-displayed synthetic antibody libraries
- (2017) Ing-Chien Chen et al. Scientific Reports
- Mesothelin Immunotherapy for Cancer: Ready for Prime Time?
- (2016) Raffit Hassan et al. JOURNAL OF CLINICAL ONCOLOGY
- Hydrophobic interaction chromatography for the characterization of monoclonal antibodies and related products
- (2016) Szabolcs Fekete et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
- Phase I Study of DMOT4039A, an Antibody-Drug Conjugate Targeting Mesothelin, in Patients with Unresectable Pancreatic or Platinum-Resistant Ovarian Cancer
- (2016) C. D. Weekes et al. MOLECULAR CANCER THERAPEUTICS
- High throughput cytotoxicity screening of anti-HER2 immunotoxins conjugated with antibody fragments from phage-displayed synthetic antibody libraries
- (2016) Shin-Chen Hou et al. Scientific Reports
- High mesothelin expression in advanced lung adenocarcinoma is associated with KRAS mutations and a poor prognosis
- (2015) Anish Thomas et al. Oncotarget
- Predominant structural configuration of natural antibody repertoires enables potent antibody responses against protein antigens
- (2015) Hong-Sen Chen et al. Scientific Reports
- Discovering neutralizing antibodies targeting the stem epitope of H1N1 influenza hemagglutinin with synthetic phage-displayed antibody libraries
- (2015) Chao-Ping Tung et al. Scientific Reports
- Mesothelin expression is associated with poor outcomes in breast cancer
- (2014) Yun R. Li et al. BREAST CANCER RESEARCH AND TREATMENT
- Anetumab Ravtansine: A Novel Mesothelin-Targeting Antibody-Drug Conjugate Cures Tumors with Heterogeneous Target Expression Favored by Bystander Effect
- (2014) S. Golfier et al. MOLECULAR CANCER THERAPEUTICS
- An Antimesothelin-Monomethyl Auristatin E Conjugate with Potent Antitumor Activity in Ovarian, Pancreatic, and Mesothelioma Models
- (2014) S. J. Scales et al. MOLECULAR CANCER THERAPEUTICS
- Efficacy of RG7787, a Next-Generation Mesothelin-Targeted Immunotoxin, against Triple-Negative Breast and Gastric Cancers
- (2014) C. Alewine et al. MOLECULAR CANCER THERAPEUTICS
- Origins of specificity and affinity in antibody–protein interactions
- (2014) Hung-Pin Peng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mesothelin Expression Is a Prognostic Factor in Cholangiocellular Carcinoma
- (2013) Ryohei Nomura et al. INTERNATIONAL SURGERY
- Antibody Variable Domain Interface and Framework Sequence Requirements for Stability and Function by High-Throughput Experiments
- (2013) Hung-Ju Hsu et al. STRUCTURE
- Loop-Sequence Features and Stability Determinants in Antibody Variable Domains by High-Throughput Experiments
- (2013) Hung-Ju Chang et al. STRUCTURE
- Mesothelin Binding to CA125/MUC16 Promotes Pancreatic Cancer Cell Motility and Invasion via MMP-7 Activation
- (2013) Shih-Hsun Chen et al. Scientific Reports
- CellMiner: A Web-Based Suite of Genomic and Pharmacologic Tools to Explore Transcript and Drug Patterns in the NCI-60 Cell Line Set
- (2012) W. C. Reinhold et al. CANCER RESEARCH
- Coexpression of MUC16 and mesothelin is related to the invasion process in pancreatic ductal adenocarcinoma
- (2012) Atsushi Shimizu et al. CANCER SCIENCE
- Mesothelin Overexpression Promotes Mesothelioma Cell Invasion and MMP-9 Secretion in an Orthotopic Mouse Model and in Epithelioid Pleural Mesothelioma Patients
- (2012) E. L. Servais et al. CLINICAL CANCER RESEARCH
- Intracellular localization of mesothelin predicts patient prognosis of extrahepatic bile duct cancer
- (2012) FUTOSHI KAWAMATA et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Recognition of Mesothelin by the Therapeutic Antibody MORAb-009
- (2012) Jichun Ma et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Rationalization and Design of the Complementarity Determining Region Sequences in an Antibody-Antigen Recognition Interface
- (2012) Chung-Ming Yu et al. PLoS One
- A Novel Survival-Based Tissue Microarray of Pancreatic Cancer Validates MUC1 and Mesothelin as Biomarkers
- (2012) Jordan M. Winter et al. PLoS One
- Mesothelin confers pancreatic cancer cell resistance to TNF-α-induced apoptosis through Akt/PI3K/NF-κB activation and IL-6/Mcl-1 overexpression
- (2011) Uddalak Bharadwaj et al. Molecular Cancer
- A novel high-affinity human monoclonal antibody to mesothelin
- (2010) Mitchell Ho et al. INTERNATIONAL JOURNAL OF CANCER
- A New Clustering of Antibody CDR Loop Conformations
- (2010) Benjamin North et al. JOURNAL OF MOLECULAR BIOLOGY
- High mesothelin correlates with chemoresistance and poor survival in epithelial ovarian carcinoma
- (2009) W-F Cheng et al. BRITISH JOURNAL OF CANCER
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started