Article
Optics
K. Berezin, K. N. Dvoretskii, V. V. Nechaev, A. Novoselova, A. M. Likhter, I. T. Shagautdinova, E. Grabarchuk, V. V. Tuchin
Summary: This paper investigates the interaction between five immersion agents and collagen peptide, predicting their optical clearing potential for rat skin and optical clearing efficiency for human skin. It also discusses the reasons for significant differences in optical clearing parameters among immersion agents in the same molecular group.
OPTICS AND SPECTROSCOPY
(2021)
Review
Plant Sciences
Mathilde Heriche, Christine Arnould, Daniel Wipf, Pierre-Emmanuel Courty
Summary: Understanding plant organ structure and physiology requires high-resolution 3D imaging, but plant tissues are opaque to light, making it difficult to study them using optical microscopes. Over the past 20 years, progress has been made in developing plant clearing protocols (CPs) through an improved classification system based on their physical and optical parameters. Combining CPs with new microscopy methods is a successful approach with promising future applications in plant science research.
TRENDS IN PLANT SCIENCE
(2022)
Article
Chemistry, Analytical
Xiaoling Su, Deying Chen, Liang Li, Lanjuan Li
Summary: The study demonstrates that perfusion can significantly alter the liver metabolome, recommending the use of non-perfused liver for comprehensive liver metabolomics analysis for high coverage.
ANALYTICA CHIMICA ACTA
(2021)
Article
Physics, Multidisciplinary
Nicola Molinari, Yu Xie, Ian Leifer, Aris Marcolongo, Mordechai Kornbluth, Boris Kozinsky
Summary: The method uses spectral decomposition of short-time ionic displacement covariance to accelerate computations of ionic conductivity and reduce uncertainty. It demonstrates robustness through mathematical and numerical proofs, and is applied to realistic electrolyte materials.
PHYSICAL REVIEW LETTERS
(2021)
Review
Pharmacology & Pharmacy
Valery V. Tuchin, Elina A. Genina, Elena S. Tuchina, Anna Svetlakova, Yulia Svenskaya
Summary: This review presents principles and novelties in the field of tissue optical clearing technology, as well as application for optical monitoring of drug delivery and effective antimicrobial phototherapy. Various methods and kinetics of delivery of photodynamic agents, nanoantibiotics and their mixtures with OCAs into the tissue depth are analyzed in the context of antimicrobial and antifungal phototherapy. The prospects of a new TOC technology for effective killing of pathogens are discussed based on in vitro and in vivo studies of antimicrobial phototherapies.
ADVANCED DRUG DELIVERY REVIEWS
(2022)
Article
Astronomy & Astrophysics
J. Martin Laming
Summary: The first critical fast Mach number for a magnetohydrodynamic shock is defined as the Mach number where the shock transitions from subcritical to supercritical behavior, marked by the reflection of ions from the shock front. We revisit the calculations and find that the contributions from accelerated particles are insignificant, but the presence of associated waves has a more significant effect.
ASTROPHYSICAL JOURNAL
(2022)
Article
Engineering, Biomedical
Ni Zhang, Xiaowei Li, Daniel M. Czajkowsky, Hepeng Zhang, Mohammad Shah Alam, Zhifeng Shao
Summary: Using the EERS technique, efficient immuno-labeling of thick clarified tissues can be achieved in a short period of time with minimal tissue damage and lower antibody requirement compared to conventional methods. The implementation of EERS is expected to significantly accelerate the application of tissue clearing techniques in various research areas.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2021)
Article
Optics
Xionggui Tang, Wenjing Rong, Yi Shen
Summary: Optical centrifuge driven by optical force from the transverse phase gradient of light is a novel tool for optically manipulating small particles. Experimental results demonstrate its high performance in clearing and separating nanoparticles. It offers a new way for versatile optical manipulation in microfluidic systems, with advantages of high speed, flexible design, and ease of control.
OPTICS AND LASERS IN ENGINEERING
(2023)
Article
Biochemical Research Methods
Krzysztof M. Ocetkiewicz, Cezary Czaplewski, Henryk Krawczyk, Agnieszka G. Lipska, Adam Liwo, Jerzy Proficz, Adam K. Sieradzan, Pawel Czarnul
Summary: The UNRES-GPU package has been implemented on GPUs and achieved significant speed-up for large protein systems. It is capable of simulating large protein systems at the millisecond time scale.
Review
Nanoscience & Nanotechnology
Enming Song, Ya Huang, Ningge Huang, Yongfeng Mei, Xinge Yu, John A. Rogers
Summary: Microsystem technologies offer various capabilities for evaluating the mechanical properties of soft biological tissues, with potential applications in medical research and clinical diagnosis. Recent progress includes the development of tissue-compliant designs and improvements in assessing elastic moduli at different scales and depths. These technologies have clinical utility in monitoring tissue changes and identifying diseased tissues.
MICROSYSTEMS & NANOENGINEERING
(2022)
Article
Chemistry, Physical
M. Lundborg, J. Lidmar, B. Hess
Summary: The accelerated weight histogram method is an enhanced sampling technique that efficiently explores free energy landscapes and can be used for sampling alchemical transformations, easy to use and can be combined with other reaction coordinates.
JOURNAL OF CHEMICAL PHYSICS
(2021)
Article
Multidisciplinary Sciences
Ewelina Lorenc, Luca Varinelli, Matteo Chighizola, Silvia Brich, Federica Pisati, Marcello Guaglio, Dario Baratti, Marcello Deraco, Manuela Gariboldi, Alessandro Podesta
Summary: Peritoneal metastases (PM) are a common and lethal route of dissemination for colorectal cancer (CRC). In this study, we used atomic force microscopy (AFM) to investigate the elastic properties of extracellular matrix (ECM) in PM derived from human samples. We found that PM progression is associated with stiffening of ECM, increased cancer associated fibroblasts (CAF) activity, and increased deposition and crosslinking in neoplastic matrices. We also observed softer regions in neoplastic ECMs. Our findings suggest that local changes in the ECM contribute to the growth and spread of metastatic cells from the tumor.
SCIENTIFIC REPORTS
(2023)
Article
Engineering, Chemical
Jian-Sin Liou, Jia-Hong Cheng, Yi-Ru Wei, Ching-Yao Chen
Summary: This study experimentally investigates the MHD bubbly jet generated by high current density and analyzes the size distribution and motion of bubbles. The results show that the mean size of bubbles is dependent on the current density and can be divided into two regimes: electrochemistry regime and flow regime.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2023)
Article
Multidisciplinary Sciences
Yan Zheng, Chen Li, Chuanxin Zhang, Jiajie He, Xue Jiang, Dean Ta
Summary: This study designs a planar metalens operating at megahertz and experimentally demonstrates its distinct thermal effect on biological tissues, providing a feasible approach for the practical biomedical application of acoustic metalens.
Article
Multidisciplinary Sciences
Chunxiang Wang, Yingdan Wu, Xiaoguang Dong, Milena Armacki, Metin Sitti
Summary: Compared with conventional medical imaging, implanted electronic sensors can continuously monitor advanced physiological properties of soft biological tissues. However, they are invasive and could cause inflammation. Here, we propose a minimally invasive method using wireless miniature soft robots to sense tissue physiological properties in situ. By controlling robot-tissue interaction with external magnetic fields, tissue properties can be recovered precisely from robot shape and magnetic fields, as visualized by medical imaging. We demonstrate that the robot can traverse tissues with multimodal locomotion and sense adhesion, pH, and viscoelasticity on ex vivo porcine and mice gastrointestinal tissues, tracked by x-ray or ultrasound imaging.
Article
Biology
M. Desmond Ramirez, Todd H. Oakley
JOURNAL OF EXPERIMENTAL BIOLOGY
(2015)
Article
Evolutionary Biology
M. Desmond Ramirez, Autum N. Pairett, M. Sabrina Pankey, Jeanne M. Serb, Daniel I. Speiser, Andrew J. Swafford, Todd H. Oakley
GENOME BIOLOGY AND EVOLUTION
(2016)
Article
Biochemistry & Molecular Biology
Natasha Picciani, Jamie R. Kerlin, Noemie Sierra, Andrew J. M. Swafford, M. Desmond Ramirez, Nickellaus G. Roberts, Johanna T. Cannon, Marymegan Daly, Todd H. Oakley
Review
Neurosciences
M. Desmond Ramirez, Daniel I. Speiser, M. Sabrina Pankey, Todd H. Oakley
VISUAL NEUROSCIENCE
(2011)
Article
Marine & Freshwater Biology
James H. Peniston, Emily A. Ellis, Celia K. C. Churchill, M. Desmond Ramirez, Todd H. Oakley
JOURNAL OF CRUSTACEAN BIOLOGY
(2019)