Article
Biochemistry & Molecular Biology
Aspen T. Reese, Sarah R. Phillips, Leah A. Owens, Emily M. Venable, Kevin E. Langergraber, Zarin P. Machanda, John C. Mitani, Martin N. Muller, David P. Watts, Richard W. Wrangham, Tony L. Goldberg, Melissa Emery Thompson, Rachel N. Carmody
Summary: Research found significant variations in gut microbiota of wild chimpanzees at different ages, different from the patterns observed in humans. Chimpanzee infants have similar microbial compositions to human infants, but show higher diversity compared to older conspecifics.
Article
Medical Laboratory Technology
Abdurrahman Coskun, Anna Carobene, Ozlem Demirelce, Michele Mussap, Federica Braga, Ebru Sezer, Aasne Karine Aarsand, Sverre Sandberg, Pilar Fernandez Calle, Jorge Diaz-Garzon, Metincan Erkaya, Cihan Coskun, Esila Nur Erol, Hunkar Dag, Bill Bartlett, Mustafa Serteser, Niels Jonker, Ibrahim Unsal
Summary: In this study, BV estimates for 22 AAs were provided based on a large sample size, and it was found that there are differences in CVI estimates between males and females for most AAs, which has implications for the clinical interpretation and use of AAs.
CLINICA CHIMICA ACTA
(2024)
Review
Biochemistry & Molecular Biology
Olimpia Mora-Janiszewska, Anna Faryniak-Zuzak, Dorota Darmochwal-Kolarz
Summary: Gestational diabetes mellitus (GDM) is a significant global problem that induces diabetogenic and obesogenic changes in an offspring's DNA through epigenetic mechanisms. Alterations in microbiota play a crucial role in this process. Identification of specific epigenetic marks may provide key solutions for personalized medicine. This manuscript summarizes available data on epigenetic changes among women with GDM and their offspring, in relation to microbiome alterations.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Qi Zhao, Jian-Feng Huang, Yan Cheng, Man-Yun Dai, Wei-Feng Zhu, Xiu-Wei Yang, Frank J. Gonzalez, Fei Li
Summary: This study found that alterations in gut microbiota are linked to testicular dysfunction through disruption of polyamine metabolism. The diversity and dynamics of the gut microbiota may be considered as a therapeutic option to prevent male infertility.
Review
Cell Biology
Fangyu Zhou, Xin Wang, Lingjun Wang, Xin Sun, Guiqin Tan, Wenwen Wei, Guangbing Zheng, Xiaomin Ma, Dan Tian, Hongsong Yu
Summary: This article reviews the role of genetics, epigenetics, cellular immunology, and gut microbiota in the pathogenic mechanism of Graves' disease, which may lead to the development of novel therapeutic strategies and providing promising therapeutic targets.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Dermatology
Harsimran Bajwa, Mohsen Baghchechi, Mahasin Mujahid, Mi-Suk Kang Dufour, Sinead M. Langan, Katrina Abuabara
Summary: The association between socioeconomic position and atopic dermatitis is inconsistent, and it may vary depending on patient and study characteristics. Studies conducted in Europe, among children, and based on self-report of eczema were more likely to find a positive association with socioeconomic position.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2022)
Review
Cell Biology
Emma Wagg, Fiona M. Blyth, Robert G. Cumming, Saman Khalatbari-Soltani
Summary: This systematic review found a positive association between educational level and income/wealth with healthy ageing, while evidence regarding occupational position was inconclusive. The study highlights the importance of addressing inequalities through integrated health and social policies and strategies.
AGEING RESEARCH REVIEWS
(2021)
Article
Public, Environmental & Occupational Health
Emily M. Mann, Kristiann C. Heesch, Jerome N. Rachele, Nicola W. Burton, Gavin Turrell
Summary: This study explores the relationship between individual socioeconomic position (SEP), neighborhood disadvantage, and mental well-being in middle-aged adults. Findings indicate that lower education, inability to work, unemployment, and low-income households are associated with lower levels of mental well-being. Additionally, residents of the most disadvantaged neighborhoods have lower levels of mental well-being compared to those living in the least disadvantaged neighborhoods.
Article
Immunology
Gavyn Chern Wei Bee, Kristen L. Lokken-Toyli, Stephen T. Yeung, Lucie Rodriguez, Tonia Zangari, Exene E. Anderson, Sourav Ghosh, Carla V. Rothlin, Petter Brodin, Kamal M. Khanna, Jeffrey N. Weiser
Summary: In early life, neonatal neutrophils show enhanced CD11b-dependent opsonophagocytosis, leading to improved protection against Streptococcus pneumoniae (Spn). The augmented function of neonatal neutrophils is mediated by higher CD11b surface expression and dampened efferocytosis, resulting in more CD11bhi aged neutrophils in peripheral blood. Experimentally impairing efferocytosis later in life increases CD11bhi neutrophils and improves protection against Spn.
Article
Neurosciences
Jon Walbrin, Jorge Almeida, Kami Koldewyn
Summary: This study used fMRI to investigate the neural basis of recognizing and understanding others' social interactions using biological motion. The results showed that adults rely more on body and dynamic social interaction processing, while children rely more on mental state inferences.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Psychology, Developmental
Miao Qian, Gail D. Heyman, Paul C. Quinn, Francoise A. Messi, Genyue Fu, Kang Lee
Summary: The study found that implicit pro-Black/anti-other-race biases are present at age 4, while anti-Black/pro-other-race biases are observed among 9- to 30-year-olds. In addition, explicit pro-Black/anti-other-race biases that were present at age 4 are no longer evident by age 7.
DEVELOPMENTAL PSYCHOLOGY
(2021)
Article
Neurosciences
Emma Lindgren, Josephine Sorenson, Carina Wattmo, Ingemar Kareholt, Katarina Nagga
Summary: This registry-based study found significant differences in dementia diagnostics, treatment, and care between foreign-born and Swedish-born individuals. These differences were more pronounced with lower country level socioeconomic position, indicating a need for further research on equity in dementia care.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Malthe Faurschou Wandall-Holm, Mads Albrecht Andersen, Mathias Due Buron, Melinda Magyari
Summary: Danish patients with MS are at a higher risk of losing all income from earnings and at a much higher risk of receiving disability pension compared with healthy controls.
FRONTIERS IN NEUROLOGY
(2022)
Editorial Material
Multidisciplinary Sciences
Jonathan B. Lynch, Elaine Y. Hsiao
Summary: The gut microbiota regulates neurobiological activity in various animal lineages by interacting with neurotransmitters and other neuromodulatory molecules in the host. Recent research has established evidence for microbiota-neurotransmitter connections, but there are still outstanding questions and gaps in our current understanding that may guide future advances in the field of microbiota-nervous system interactions.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2023)
Article
Public, Environmental & Occupational Health
Kimberly D. Martin, Gloria L. Beckles, Chengyi Wu, Leslie A. McClure, April P. Carson, Aleena Bennett, Kai McKeever Bullard, M. Maria Glymour, Fred Unverzagt, Solveig Cunningham, Giuseppina Imperatore, Virginia J. Howard
Summary: This study found that low childhood socioeconomic position was associated with Type 2 diabetes incidence among African Americans but not among white participants. Cumulative socioeconomic position had an impact on T2DM incidence for both racial groups, and social mobility also affected the risk of diabetes.
PREVENTIVE MEDICINE
(2021)
Editorial Material
Medicine, General & Internal
Peter Bergman
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Fisheries
Jinjin Zhang, Wentao Wang, Shufei Liang, Rui Shao, Wenkai Shi, Gudmundur H. Gudmundsson, Peter Bergman, Qinghui Ai, Kangsen Mai, Min Wan
Summary: Short-chain fatty acids (SCFAs) promote the expression of IL-22 in fish macrophages, enhancing their bactericidal activity. Feeding turbot with sodium butyrate (NaB) reduces mortality after bacterial infection and increases IL-22 expression and bactericidal activity in macrophages. Treatment with NaB also promotes the expression of beta-defensins in zebrafish, although this effect is reduced in IL-22 mutant fish. Macrophages are identified as a cell source of IL-22 production in vivo.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Microbiology
Maria Batool, Ciara Keating, Sundus Javed, Arshan Nasir, Muhammad Muddassar, Umer Zeeshan Ijaz
Summary: Antimicrobial resistance (AMR) is a global public health concern, particularly affecting low- and middle-income countries. This study aimed to link microbial assembly and covariates to gut microbiome structure and evaluate antimicrobial gene prevalence using PICRUSt2. The researchers analyzed the microbial profiles of healthy adults in Pakistan and found that drinking tap water was the main contributor to increased AMR signatures in the Pakistani cohort. They also observed abnormal gut microbial signatures in smokers and identified smoking and age as factors impacting the microbial community structure in this cohort.
Letter
Medicine, General & Internal
Peter Bergman
JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Environmental Sciences
Suniti Singh, Ciara Keating, Umer Zeeshan Ijaz, Francis Hassard
Summary: This study compares anaerobic microbiomes degrading long chain fatty acids (LCFA) at low temperatures and finds that inoculum characteristics significantly influence species richness, species evenness, and beta diversity patterns. Additionally, certain bacterial genera were found to play a prominent role in LCFA degradation under low temperatures.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Israr Aziz, Zobia Noreen, Umer Zeeshan Ijaz, Ozan Gundogdu, Muhammad Haroon Hamid, Nazir Muhammad, Abdullah Khan, Habib Bokhari
Summary: Stunted growth is a global challenge in low- and middle-income countries for children under age 5. This study investigated the association between pathogenic E. coli strains and the gut microbiota of stunted children. Stool samples from 64 children were analyzed for E. coli characterization and microbial community profiling. The study found that different pathotypes of E. coli were present, with the most prevalent being EPEC. Microbial diversity and certain bacteria were found to be altered in stunted children.
SCIENTIFIC REPORTS
(2023)
Article
Microbiology
Lydia Bach, Asha Ram, Umer Z. Ijaz, Thomas J. Evans, Daniel T. Haydon, Jan Lindstrom
Summary: Smoking is associated with increased risk of respiratory infections due to alteration of smokers' microbiota. However, the study found that the ecological stability properties of smokers' microbiota are not different from those of nonsmokers, suggesting that the increased risk of respiratory infections in smokers may be more related to changes in the immune system rather than ecological changes in the microbial communities.
MICROBIOLOGY SPECTRUM
(2023)
Article
Biotechnology & Applied Microbiology
Valentine Okonkwo, Fabien Cholet, Umer Z. Ijaz, Thammarat Koottatep, Tatchai Pussayanavin, Chongrak Polpraset, William T. Sloan, Stephanie Connelly, Cindy J. Smith
Summary: Antimicrobial resistance poses a serious global health threat, and septic tanks in Thailand are found to be a source of this resistance. The abundance of the intI1 gene, a proxy for antimicrobial resistance, was monitored in conventional and solar septic tanks in Thailand. It was found that the gene abundance was highest in influent, lowest in the effluent of solar septic tanks, and 31% to 42% of the gene was removed by the conventional septic tank. Different primers used for quantification of the gene could lead to different interpretations of antimicrobial resistance risk. The F3-R3 primer is recommended for standardization in future studies.
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
(2023)
Article
Environmental Sciences
Simon Mills, Thi Phi Yen Nguyen, Umer Zeeshan Ijaz, Piet N. L. Lens
Summary: In this study, the effects of long-term bioreactor (un)stability on resistance to shock loads were evaluated. The results showed that the reactor with stable operation performed better in terms of resistance to a sudden increase in organic loading rate, despite having lower microbial community diversity. The operation history of a reactor plays a crucial role in determining its ability to withstand environmental perturbations.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2023)
Article
Cell Biology
Thomas R. R. Muller, Takuya Sekine, Darya Trubach, Julia Niessl, Puran Chen, Peter Bergman, Ola Blennow, Lotta Hansson, Stephan Mielke, Piotr Nowak, Jan Vesterbacka, Mira Akber, Anna Olofsson, Susana Patricia Amaya Hernandez, Yu Gao, Curtis Cai, Gunnar Soderdahl, C. I. Edvard Smith, Anders Osterborg, Karin Lore, Margaret Sallberg Chen, Per Ljungman, Hans-Gustaf Ljunggren, Annika C. C. Karlsson, Sunil Kumar Saini, Soo Aleman, Marcus Buggert
Summary: Suboptimal immunity to SARS-CoV-2 mRNA vaccination is common in immunodeficient individuals. T cell responses were assessed in 279 individuals with different immunodeficiencies and healthy controls before and after booster vaccination, as well as after Omicron infection. Robust and persistent Omicron-reactive T cell responses were observed, which increased significantly after booster vaccination and correlated with antibody titers in all patient groups. Additional vaccine doses effectively countered poor vaccination responsiveness in immunocompromised or elderly individuals.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Nikolaos Panagiotou, Dagmara McGuinness, Armand M. G. Jaminon, Barend Mees, Colin Selman, Leon Schurgers, Paul G. Shiels
Summary: Extracellular vesicles (EVs) secreted by cells play a role in repairing cellular and tissue damage. Microvesicles (MVs) from stem cell regulatory cells have been found to enhance the repair of human dermal fibroblasts (HDFs) and mesenchymal stem cells (MSCs) under stress, but this effect is age and stress specific. These findings provide insights into the roles of EVs in tissue repair and ageing.
Article
Engineering, Civil
Marta Vignola, Jeanine Lenselink, Dominic Quinn, Umer Zeeshan Ijaz, Ryan Pereira, William T. Sloan, Stephanie Connelly, Graeme Moore, Caroline Gauchotte-Lindsay, Cindy J. Smith
Summary: This study investigated the abilities of microbial communities from different parts of a biofilter to process DOM. The bottom community showed the highest growth rate on DOM and had a higher preference for complex DOM fractions. The higher relative abundance of the Curvibacter genus in the bottom community suggests its crucial role in degrading complex DOM fractions.
AQUA-WATER INFRASTRUCTURE ECOSYSTEMS AND SOCIETY
(2023)
Article
Green & Sustainable Science & Technology
Paolo Dessi, Claribel Buenano-Vargas, Santiago Martinez-Sosa, Simon Mills, Anna Trego, Umer Z. Ijaz, Deepak Pant, Sebastia Puig, Vincent O'Flaherty, Pau Farras
Summary: The industrial adoption of microbial electrosynthesis (MES) is hindered by high overpotentials and inefficient cell designs. In this study, a mixed microbial consortium was adapted for acetate production from bicarbonate under saline conditions. The enriched communities were used as inoculum in three-chamber cells and achieved high acetate production rates with Coulombic efficiency. The experiment also demonstrated that connecting multiple cells in series can significantly increase the production rates.
ENVIRONMENTAL SCIENCE AND ECOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Rhea Aqueel, Ayesha Badar, Nazish Roy, Qandeel Mushtaq, Aimen Fatima Ali, Aftab Bashir, Umer Zeeshan Ijaz, Kauser Abdulla Malik
Summary: The failure of breeding strategies has led scientists to explore the microbiome for modulating plant defense mechanisms against Cotton Leaf Curl Disease (CLCuD). The study discovered that Pseudomonas inhabits the rhizosphere while Bacillus is predominantly found in the phyllosphere of CLCuD-resistant cotton varieties. By applying specific strains isolated from resistant cotton, the researchers successfully suppressed CLCuD in susceptible cotton.
NPJ BIOFILMS AND MICROBIOMES
(2023)
Review
Surgery
Elizabeth K. Day, Norman J. Galbraith, Hester J. T. Ward, Campbell S. Roxburgh
Summary: This article performs a systematic review to explore the volume-outcome relationship in intra-abdominal robotic-assisted surgery. The study identifies the minimum volume standards for maintaining quality and cost-effectiveness. The findings suggest that in centers with a low annual case volume, involving multiple surgeons in performing the procedures may lead to worse outcomes.
JOURNAL OF ROBOTIC SURGERY
(2023)