Article
Clinical Neurology
Junchi Li, Yongjie Li, Wei Shu
Summary: This study presents a case report of a 57-year-old male patient who developed post-traumatic trigeminal neuropathic pain (PTNP) and secondary hemifacial dystonia after orbital trauma. Peripheral nerve stimulation (PNS) was performed to relieve the patient's neuropathic pain and dystonia, with successful results. The findings highlight the potential benefits of PNS in treating PTNP and dystonia and discuss the underlying therapeutic mechanism.
FRONTIERS IN NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Steven Char, Max Y. Jin, Vinicius Tieppo Francio, Nasir Hussain, Eric J. Wang, Mahmoud Morsi, Vwaire Orhurhu, Larry J. Prokop, Adam Fink, Ryan S. D'Souza
Summary: This review synthesized data from prospective studies on the efficacy of peripheral nerve stimulation (PNS) for neuropathic pain. The results showed that there is limited and low-quality evidence supporting the effectiveness of PNS for peripheral neuropathic pain, with modest improvement in pain and neurological function. Only PNS for phantom limb pain had moderate level evidence.
Article
Anesthesiology
Timothy R. Deer, Christopher A. Gilmore, Mehul J. Desai, Sean C. Li, Michael J. DePalma, Thomas J. Hopkins, Abram H. Burgher, David A. Spinner, Steven P. Cohen, Meredith J. McGee, Joseph W. Boggs
Summary: The study demonstrated the potential of percutaneous PNS as a minimally invasive and nondestructive alternative for chronic back pain management. Significant reductions in pain intensity and improvements in functional outcomes were reported by majority of participants after 2 months with PNS, with clinically meaningful improvements sustained up to 5 months after treatment.
Review
Biochemistry & Molecular Biology
Clayton Busch, Olivia Smith, Tristan Weaver, Jayesh Vallabh, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) is a widely used interventional pain treatment modality for chronic lower extremity pain. Despite the lack of large prospective evidence, PNS has shown potential for improving pain scores, functionality, and opioid consumption, making it a viable option for patients with chronic lower extremity pain.
Article
Clinical Neurology
Alaa Abd-Elsayed, Mitchell K. Keith, Nancy N. Cao, Kenneth J. Fiala, Joshua M. Martens
Summary: This study suggests the potential role of PNS therapy in improving pain levels in patients with various neuropathies. However, further research is needed to evaluate the efficacy of PNS therapy for pain management and complications associated with PNS device placements.
Review
Anesthesiology
Jijun Xu, Zhuo Sun, Jiang Wu, Maunak Rana, Joshua Garza, Alyssa C. Zhu, Krishnan Chakravarthy, Alaa Abd-Elsayed, Ellen Rosenquist, Hersimren Basi, Paul Christo, Jianguo Cheng
Summary: PNS may be effective in managing chronic headaches, postamputation pain, chronic pelvic pain, and chronic low back and lower extremity pain.
Review
Biochemistry & Molecular Biology
Lady Christine Ong Sio, Brian Hom, Shuchita Garg, Alaa Abd-Elsayed
Summary: Peripheral nerve stimulation (PNS) has been widely used for treating chronic pain, although its mechanism of action remains largely unknown. The gate control theory proposed by Melzack and Wall in the 1960s has been the mainstay for understanding its mechanism. This review article discusses the mechanism of action, safety, and effectiveness of PNS in treating chronic pain, as well as current PNS devices available in the market.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Anesthesiology
Marc A. Huntoon, Konstantin Slavin, Jonathan M. Hagedorn, Nathan D. Crosby, Joseph W. Boggs
Summary: This retrospective study evaluated the effectiveness of a 60-day percutaneous peripheral nerve stimulation (PNS) treatment based on a large real-world database. The results showed that temporary PNS treatment can provide significant pain relief in various pain indications, with a majority of patients achieving the desired level of relief. These findings are important for clinical practice.
Review
Clinical Neurology
Ryan S. D'Souza, Max Y. Y. Jin, Alaa Abd-Elsayed
Summary: The purpose of this systematic review is to evaluate the efficacy of peripheral nerve stimulation (PNS) for the treatment of low back pain (LBP). The review found that PNS may provide modest to moderate pain relief in patients with LBP, although the evidence is currently limited.
CURRENT PAIN AND HEADACHE REPORTS
(2023)
Article
Clinical Neurology
Can Sarica, Christian Iorio-Morin, David H. Aguirre-Padilla, Michelle Paff, Samuelle-Arianne Villeneuve, Artur Vetkas, Kazuaki Yamamoto, Nardin Samuel, Vanessa Milano, Aaron Loh, Brendan Santyr, Ajmal Zemmar, Andres M. Lozano, Mojgan Hodaie
Summary: This study systematically reviewed the literature on peripheral nerve field stimulation (PNFS) for trigeminal pain and found that PNFS can provide effective long-term pain control for patients with trigeminal pain.
JOURNAL OF NEUROSURGERY
(2022)
Article
Multidisciplinary Sciences
Benjamin U. Hoffman, Yoshichika Baba, Stephen A. Lee, Chi-Kun Tong, Elisa E. Konofagou, Ellen A. Lumpkin
Summary: This study successfully modulated the activity of peripheral neurons using targeted ultrasound stimulation and electrophysiology in mouse ex vivo skin-saphenous nerve preparations. The findings showed that high-intensity, millisecond ultrasound pulses reliably evoked action potentials in peripheral neurons, and there was a discrete range of parameters capable of exciting different types of neurons. Additionally, ultrasound stimulation could be targeted to cutaneous receptive fields or peripheral nerves, expanding the therapeutic range of ultrasound-based peripheral neuromodulation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Anesthesiology
Michelle Liu, Naum Shaparin, Singh Nair, Ryung S. Kim, Jacob R. Hascalovici
Summary: In some patients, diagnostic MBB procedures may lead to prolonged relief of CLBP symptoms. Shorter duration of back pain symptoms and unilateral back pain are significantly associated with this phenomenon.
Article
Medicine, Research & Experimental
Steven Mach, Saba Javed, Grant H. Chen, Billy K. Huh
Summary: This case series demonstrates the use of temporary percutaneous peripheral nerve stimulation (PNS) as a bridge therapy to treat myeloma-related back pain and allow patients to complete their course of radiation. PNS effectively treats low back pain secondary to myeloma-related spinal lesions.
Review
Clinical Neurology
Natalie H. Strand, Ryan D'Souza, Christopher Wie, Stephen Covington, Moustafa Maita, John Freeman, Jillian Maloney
Summary: This review article examines the mechanism of action of peripheral nerve stimulation (PNS) in pain management, recent literature from 2018 to 2021, and clinical outcomes. The review found that PNS may activate and modulate higher CNS centers, extend neuromodulatory effects into the spinal columns, and impact endogenous neurotransmitters and the plasticity of NMDA pathways.
CURRENT PAIN AND HEADACHE REPORTS
(2021)
Review
Clinical Neurology
Alan D. Kaye, Sasha Ridgell, E. Saunders Alpaugh, Aya Mouhaffel, Aaron J. Kaye, Elyse M. Cornett, Azam A. Chami, Rutvij Shah, Bruce M. Dixon, Omar Viswanath, Ivan Urits, Amber N. Edinoff, Richard D. Urman
Summary: Peripheral nerve stimulation is gaining popularity as a potential treatment for chronic pain, including post-surgical pain and chronic shoulder pain. Studies have shown significant improvement in knee and back pain treatment with peripheral nerve stimulation, leading to a reduction in opioid use. More research is needed to fully understand the long-term risks and benefits of this treatment modality.
Review
Medicine, Research & Experimental
Steven Char, Ross A. Barman, Timothy R. Deer, Jonathan M. Hagedorn
Summary: Chronic neuropathic groin pain is a challenging condition with multiple identified etiologies. Advances in neuromodulation technology, particularly DRG stimulation, have provided benefits for patients with refractory chronic pain. Prospective randomized controlled studies are needed to further evaluate the effectiveness of DRG stimulation for chronic groin pain.
Article
Medicine, Research & Experimental
Christopher Gilligan, Willem Volschenk, Marc Russo, Matthew Green, Christopher Gilmore, Vivek Mehta, Kristiaan Deckers, Kris De Smedt, Usman Latif, Peter Georgius, Jonathan Gentile, Bruce Mitchell, Meredith Langhorst, Frank Huygen, Ganesan Baranidharan, Vikas Patel, Eugene Mironer, Edgar Ross, Alexios Carayannopoulos, Salim Hayek, Ashish Gulve, Jean-Pierre Van Buyten, Antoine Tohmeh, Jeffrey Fischgrund, Shivanand Lad, Farshad Ahadian, Timothy Deer, William Klemme, Richard Rauck, James Rathmell, Greg Maislin, Jan Pieter Heemels, Sam Eldabe
Summary: This study followed up with 204 patients implanted with a restorative neurostimulation system and found that after two years, 76% of patients experienced substantial, clinically meaningful improvements in pain, disability, or both.
Review
Anesthesiology
Mehul J. Desai, Sargoon Nepaul
Summary: This article provides a narrative review of three clinical entities of cluneal neuropathy, including superior, middle, and inferior cluneal neuralgia. It also discusses the challenges in diagnosis and treatment, and the treatment methods such as nerve blocks, ablative techniques, neuromodulation, and surgical decompression.
Editorial Material
Clinical Neurology
Timothy Deer, Alaa Abd-Elsayed, Krishnan Chakravarthy, Joshua M. Rosenow, Steven Falowski, Erika Petersen, Julie Pilitsis, Corey Hunter, Dawood Sayed, Michael E. Schatman
JOURNAL OF PAIN RESEARCH
(2023)
Editorial Material
Anesthesiology
Timothy R. Deer, Peter S. Staats, Sudhir Diwan, Amol Soin, Konstantin V. Slavin, Douglas P. Beall, Christopher J. Gilligan
Article
Clinical Neurology
Timothy Deer, Anuj Shah, Konstantin Slavin, Kevin E. Vorenkamp, Shalini Shah, Michael Leong, W. Porter McRoberts
Summary: Peripheral nerve stimulation (PNS) has gained interest due to advancements in imaging techniques and the availability of minimally invasive stimulation systems. However, PNS requires unique technical requirements and skills compared to other pain management procedures. This article aims to educate about the differences and help patients and healthcare providers make informed decisions.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Medicine, Research & Experimental
Timothy Deer, Christopher Gilligan, Steven Falowski, Mehul Desai, Julie Pilitsis, Jessica Jameson, Susan Moeschler, Robert Heros, Edward Tavel, Anne Christopher, Denis Patterson, Sayed Wahezi, Jacqueline Weisbein, Ajay Antony, Robert Funk, Mohab Ibrahim, Chi Lim, Derron Wilson, Michael Fishell, Keith Scarfo, David Dickerson, Edward Braun, Patrick Buchanan, Robert M. Levy, Nathan Miller, Jonathan Duncan, Jijun Xu, Kenneth Candido, Scott Kreiner, Marie E. Fahey, James Yue
Summary: The study demonstrates that spinal cord stimulation is effective in relieving chronic low back pain and improving pain-related disability and quality of life in patients. It also suggests that it may lead to reduced opioid use and other treatments.
Article
Anesthesiology
Nagy A. Mekhail, Robert M. Levy, Timothy R. Deer, Leonardo Kapural, Sean Li, Kasra Amirdelfan, Jason E. Pope, Corey W. Hunter, Steven M. Rosen, Shrif J. Costandi, Steven M. Falowski, Abram H. Burgher, Christopher A. Gilmore, Farooq A. Qureshi, Peter S. Staats, James Scowcroft, Tory Mcjunkin, Jonathan Carlson, Christopher K. Kim, Michael Yang, Thomas Stauss, Erika A. Petersen, Jonathan M. Hagedorn, Richard Rauck, Jan W. Kallewaard, Ganesan Baranidharan, Rod S. Taylor, Lawrence Poree, Dan Brounstein, Rui Duarte, Gerrit E. Gmel, Robert Gorman, Ian Gould, Erin Hanson, Dean M. Karantonis, Abeer Khurram, Angela Leitner, Dave Mugan, Milan Obradovic, Zhonghua Ouyang, John Parker, Peter Single, Nicole Soliday, E. V. O. K. E. Study Grp EVOKE Study Grp
Summary: This study compared the effects of evoked compound action potential (ECAP)-controlled, closed-loop spinal cord stimulation (SCS) with fixed-output, open-loop SCS after 36 months of implantation. The results showed that ECAP-controlled closed-loop SCS was more effective than open-loop SCS in reducing back and leg pain, and it also improved holistic treatment response.
REGIONAL ANESTHESIA AND PAIN MEDICINE
(2023)
Article
Anesthesiology
Timothy R. Deer, Timothy B. Chafin, Shrif J. Costandi, Huaguang Qu, Christopher Kim, Navdeep Jassal, Kiran Patel, Aaron Calodney
Summary: The MOTION study aims to evaluate the impact of percutaneous image-guided lumbar decompression as a first-line treatment for patients with lumbar spinal stenosis and neurogenic claudication. The study compared the combination of the mild procedure and conventional medical management to conventional medical management alone, using objective and patient-reported outcome measures. The results showed significant improvements in all outcome measures for the mild + CMM group compared to the CMM-Alone group, and demonstrated the durability and safety of the mild procedure.
Article
Clinical Neurology
Thomas Hedman, James Yu, Harwant Singh, Timothy Deer
Summary: This study evaluated the safety and efficacy of a genipin-based implant for treating discogenic chronic low back pain (CLBP) through IRB-approved prospective studies in two countries. The results showed that the device could effectively improve pain and disability, enhance joint stability, and had no serious adverse events. This study merits further randomized clinical trials.
JOURNAL OF PAIN RESEARCH
(2023)
Correction
Clinical Neurology
A. Abd-Sayed, K. Fiala, J. Weisbein
JOURNAL OF PAIN RESEARCH
(2023)
Article
Clinical Neurology
Timothy Sowder, Dawood Sayed, Tyler Concannon, Scott H. Pew, Natalie H. Strand, Alaa Abd-Elsayed, Christopher S. Wie, Daniel E. Gomez Ramos, Ahmed M. Raslan, Timothy R. Deer
Summary: Radiofrequency ablation (RFA) is a treatment method used for various conditions, but it may have an impact on patients with implanted medical devices. This review focuses on establishing guidelines to assist physicians in safely managing implanted devices during RFA procedures.
JOURNAL OF PAIN RESEARCH
(2023)
Article
Clinical Neurology
Erika A. Petersen, Timothy R. Deer, Stana Bojanic, Lauren R. Sankary, Natalie H. Strand, Adnan Al Kaisy, Frank Huygen, Dawood Sayed, Monique Steegers, Paul Verrills, Michael E. Schatman
Summary: The COVID-19 pandemic exposed the lack of preparedness in conducting research and completing ongoing projects in the field of pain medicine during a global crisis. The ASPN Research Group has provided guidance for conducting clinical trials in emergency or disaster situations, utilizing governmental guidance, scientific best practices, and expert opinion. This analysis fills a gap in the current literature and offers protocols to improve patient safety and efficacy in future disasters and infectious disease outbreaks.
JOURNAL OF PAIN RESEARCH
(2023)
Review
Anesthesiology
Lindsay Burke, Mehul J. Desai
Summary: This narrative review aims to analyze the incidence and risk factors of pocket pain in SCS patients, in order to guide treatment options and reduce its occurrence. Currently, there is a lack of primary literature on this topic, highlighting the need for large-scale, high-quality prospective or randomized controlled trials.
Article
Anesthesiology
Andrew Wondra, Shelly Gulhar, Mason D. Brestle, Jiling Chou, Mehul J. Desai
Summary: Radiofrequency ablation (RFA) is commonly used for treating chronic pain by damaging neural tissues. This study evaluated RFA lesion areas and lesion continuity using different gauge probes, providing recommendations for clinical practice.