Journal
GENE EXPRESSION PATTERNS
Volume 20, Issue 1, Pages 22-31Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gep.2015.11.001
Keywords
Joint; Microarray; Molecular marker; mRNA in situ hybridization
Categories
Funding
- Department of Biotechnology, India (DBT) [BT/PR11202/MED/32/46/2008, BT/IN/DENMARK/02/PDN/2011]
- Danish Strategic Research Council [10-093757]
- Ministry of Human Resource Development (MHRD), India
- Council of Scientific & Industrial Research (CSIR), India
Ask authors/readers for more resources
Articular cartilage present at the ends of appendicular skeletal elements provides friction-less movement to the synovial joints and any damage to this tissue can lead to a degenerative disease of joint called osteoarthritis. During past two decades although many genes e.g., Gdf5, Wnt9a, Noggin etc. have been identified and characterized in joint development, still a comprehensive understanding of molecular network(s) operational in articular cartilage morphogenesis is far from being drawn. Here we report identification of 36 genes (19 from literature survey and 17 from microarray analysis) that are expressed in developing chicken phalangeal joints in a spatiotemporally dynamic manner. For both these set of genes across the time window investigated we observed three kinds of expression patterns: early, late and constant. The early expressed genes are invariably expressed in a domain broader than the interzone while the late expressed genes are expressed in restricted spatial domains. The comprehensive expression analysis presented in this report provides a candidate list of molecular players involved in articular cartilage differentiation and/or maintenance. (C) 2015 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available