Curcumin and Its Potential Impact on Microbiota

Curcumin is one of the most frequently researched herbal substances; however, it has been reported to have a poor bioavailability and fast metabolism, which has led to doubts about its effectiveness. Curcumin has antioxidant and anti-inflammatory effects, and has demonstrated favorable health effects. Nevertheless, well-reported in vivo pharmacological activities of curcumin are limited by its poor solubility, bioavailability, and pharmacokinetic profile. The bidirectional interactions between curcumin and gut microbiota play key roles in understanding the ambiguity between the bioavailability and biological activity of curcumin, including its wider health impact.

Automated summary

Curcumin, a widely researched herbal substance, has antioxidant and anti-inflammatory effects, but its effectiveness is limited by its poor bioavailability and fast metabolism. Understanding the bidirectional interactions between curcumin and gut microbiota is crucial for its biological activity and wider health impact.