Article
Cell Biology
Anran Zhang, Jinpo Yang, Chao Ma, Feng Li, Huan Luo
Summary: This study established a novel 15-gene signature related to ferroptosis, which accurately predicts the prognosis of LUAD and is associated with specific immune cells. The findings demonstrate the independent prognostic value of this gene signature in patients with LUAD.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Richard Molnar, Laszlo Szabo, Andras Tomesz, Arpad Deutsch, Richard Darago, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Ferenc Budan, Istvan Kiss
Summary: This study investigated the effects of olive oil and TFAs on the expression patterns of miRs and mTOR in mouse liver, spleen, and kidney. Olive oil showed protective, antioxidant, and anti-inflammatory effects, while TFAs exhibited damaging, inflammatory, and carcinogenic properties. The results suggest the presence of negative feedback regulatory mechanisms between these dietary components.
Article
Multidisciplinary Sciences
Erika Cione, Antonio Siniscalchi, Pietro Gangemi, Lucio Cosco, Manuela Colosimo, Federico Longhini, Filippo Luciani, Giovambattista De Sarro, Liberato Berrino, Bruno D'Agostino, Luca Gallelli
Summary: The multifunctional role of neuron-specific enolase (NSE) in lung diseases, particularly in COVID-19 patients, was explored in this study. Higher NSE levels were detected in COVID-19 patients compared to controls, and a significant increase in dyspnea severity was observed within the COVID-19 patient group. These findings suggest the potential for NSE as a clinical marker of disease progression in COVID-19.
Article
Biochemistry & Molecular Biology
Hend Baghoum, Hend Alahmed, Mahmood Hachim, Abiola Senok, Nour Jalaleddine, Saba Al Heialy
Summary: Microgravity is a potential strategy for developing cancer therapies, particularly in lung cancer. This study demonstrates the influence of microgravity on cellular processes and the migratory capacity of lung cancer cells. It identifies differentially expressed genes associated with the prognosis of lung cancer under simulated microgravity and highlights the potential of these genes as tumor suppressor biomarkers. The study also reveals the ability of microgravity to revert the epithelial-to-mesenchymal transition phenotype and suggests new therapeutic opportunities for lung cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Holly Holliday, Jessica Yang, Eoin Dodson, Iva Nikolic, Alvin Kamili, Madeleine Wheatley, Niantao Deng, Sarah Alexandrou, Thomas P. Davis, Maria Kavallaris, C. Elizabeth Caldon, Joshua McCarroll, Katleen De Preter, Pieter Mestdagh, Glenn M. Marshall, Kaylene J. Simpson, Jamie Fletcher, Alexander Swarbrick
Summary: This study discovered that miR-99b-5p, miR-380-3p, and miR-485-3p enhance the chemotherapeutic effects of doxorubicin in high-risk neuroblastoma. These miRNAs are often lost in patients and their low expression predicts poor survival outcomes.
Review
Immunology
Yingying Xing, Guojing Ruan, Haiwei Ni, Hai Qin, Simiao Chen, Xinyue Gu, Jiamin Shang, Yantong Zhou, Xi Tao, Lufeng Zheng
Summary: MiRNA plays multifarious roles in tumor progression by regulating the tumor immune microenvironment, impacting the function of immune cells and tumor cells. Investigating the role of miRNA can elucidate the mechanisms of interaction between immune cells and tumor cells, with potential use as a predictor of immune disorders in tumor progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Shigeo Hisamori, Junko Mukohyama, Sanjay Koul, Takanori Hayashi, Michael Evan Rothenberg, Masao Maeda, Taichi Isobe, Luis Enrique Valencia Salazar, Xin Qian, Darius Michael Johnston, Dalong Qian, Kaiqin Lao, Naoya Asai, Yoshihiro Kakeji, Vincenzo Alessandro Gennarino, Debashis Sahoo, Piero Dalerba, Yohei Shimono
Summary: In this study, it was found that the coordinated upregulation of miR-200c and miR-203 in colon epithelial cells is associated with terminal differentiation and plays a role in controlling the expansion capacity and stem cell properties of epithelial cells by suppressing BMI1 expression.
JOURNAL OF GASTROENTEROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yongan Song, Leonardo Kelava, Istvan Kiss
Summary: Lung cancer, particularly lung adenocarcinoma (LUAD), is a major public health challenge and the leading cause of cancer-related deaths worldwide. MicroRNAs (miRNAs) have crucial roles in gene regulation and their involvement in cancer is extensively studied. However, there is a gap in the literature regarding the specific role of miRNAs in LUAD. This review provides an inclusive overview of the research conducted on miRNAs in the context of LUAD, highlighting their potential diagnostic, prognostic, and therapeutic implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Ming Dong, Zifan Tang, Steven Hicks, Weihua Guan
Summary: This study developed a RCA-coupled platform using large glass nanopores for profiling mTBI-related miRNAs, which shows promise as an accessible alternative for the clinical diagnosis of mTBI using salivary miRNAs.
ANALYTICAL CHEMISTRY
(2022)
Article
Environmental Sciences
Li Shi, Lingfang Feng, Yan Tong, Junlin Jia, Tao Li, Jing Wang, Zhaoqiang Jiang, Min Yu, Hailing Xia, Qi Jin, Xiyi Jiang, Yongran Cheng, Li Ju, Jiaqi Liu, Quan Zhang, Jianlin Lou
Summary: The study identified differentially expressed miRNAs in the DNA damage response induced by Cr (VI) exposure, indicating potential roles of several miRNAs in cell apoptosis and DDR.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Oncology
Shanying Gui, W. Quinn O'Neill, Theodoros N. Teknos, Quintin Pan
Summary: This study found that IGJ is a robust and independent prognostic biomarker for disease-specific mortality in HPV+ HNSCC. Patients with low IGJ have a significantly increased risk of disease-specific death and can effectively identify early disease-specific mortality.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Biochemistry & Molecular Biology
Tahani Bakhsh, Safiah Alhazmi, Najla Ali Alburae, Ali Farsi, Faisal Alzahrani, Hani Choudhry, Ahmed Bahieldin
Summary: Colorectal cancer is a common type of cancer worldwide, and early diagnosis is crucial for effective treatment. Current blood biomarkers for CRC diagnosis are not accurate enough. Studies have found that specific miRNAs in extracellular vesicles can be used as noninvasive biomarkers for the screening and diagnosis of CRC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Bo Yang, Lin-Lin Ji, Hong-Liang Xu, Xiao-Ping Li, Hong-Gang Zhou, Ting Xiao, Xiao-He Li, Zhou-Yong Gao, Jian-Zhong Li, Wei-Dong Zhang, Guang-Shun Wang, Ming-Jiang Li
Summary: The study investigated the expression of zc3h12d in LUAD and its relationships with clinical features, prognosis, immune infiltration, etc. Results showed that zc3h12d expression was significantly elevated in LUAD, closely related to pathological features and survival, and influenced by methylation levels. Additionally, zc3h12d may serve as a potential biomarker for prognosis and immune-related therapeutic targeting in LUAD.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Chemistry, Analytical
Jingjing Zhang, Fenglian Guo, Jingfeng Zhu, Zhimei He, Lin Hao, Lixing Weng, Lianhui Wang, Jie Chao
Summary: An electrochemiluminescence immunosensor based on metal-organic framework nanospheres and DNA tetrahedral probes was developed for the detection of bladder cancer marker CFHR1. The sensor showed high sensitivity and stable emission, and was able to accurately distinguish between bladder cancer patients and healthy samples in urine.
ANALYTICAL CHEMISTRY
(2023)
Article
Immunology
Wuguang Chang, Hongmu Li, Leqi Zhong, Tengfei Zhu, Zenghao Chang, Wei Ou, Siyu Wang
Summary: This study reveals the prognostic value of copper metabolism-related genes in lung adenocarcinoma and their potential role in guiding immunotherapy. The low-risk group exhibits longer overall survival and higher immune cell infiltration levels, suggesting potential benefits from immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Mohammad A. Gholampour, Saeid Abroun, Rienk Nieuwland, Seyed J. Mowla, Sara Soudi
Summary: The study showed that treatment with hypoxic MSC-EVs and normoxic MSC-EVs significantly prolonged the survival rate, increased platelet counts, and ameliorated BM hypoplasia in a mouse model of AA. The effects of MSC-EVs were mediated by T cell suppression and inhibition of interferon-gamma and tumor necrosis factor-alpha production. Additionally, there was an association between reduced pro-inflammatory cytokine levels and decreased splenocyte viability in vitro.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Oncology
Somayeh Sadat Mehrnia, Bijan Hashemi, Seyed Javad Mowla, Maryam Nikkhah, Azim Arbabi
Summary: This study demonstrated that AS1411 aptamer enhanced the delivery of gold nanoparticles to cancer cells, leading to increased radiation-induced cancer cell death. The sensitization effect was particularly significant for breast cancer cells and mammosphere cells, suggesting potential for future clinical applications in cancer treatment.
RADIATION ONCOLOGY
(2021)
Review
Cell Biology
Fatemeh Mirzadeh Azad, Isabelle Laurence Polignano, Valentina Proserpio, Salvatore Oliviero
Summary: Long noncoding RNAs play a crucial role in stem cell maintenance and differentiation, exhibiting diverse functions through interactions with proteins, DNA, and RNA. This heterogeneity in function enhances the capabilities of the lncRNome toolkit but also poses challenges in predicting the functions of novel lncRNAs.
TRENDS IN CELL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Parichehr Maleki, Seyed Javad Mowla, Mohammad Taheri, Soudeh Ghafouri-Fard, Jamshid Raheb
Summary: The study evaluated the impact of down-regulation of LINK-A in non-small cell lung carcinoma cell lines, revealing that LINK-A significantly affects cell survival, proliferation, and migration, and may act as an oncogene in NSCLC.
SCIENTIFIC REPORTS
(2021)
Article
Genetics & Heredity
Arman Moradi, Majid Maleki, Zahra Ghaemmaghami, Zahra Khajali, Feridoun Noohi, Maryam Hosseini Moghadam, Samira Kalyinia, Seyed Javad Mowla, Nabil G. Seidah, Mahshid Malakootian
Summary: Genetic mutations in LDLR and PCSK9 genes exhibit diversity in Iranian patients with FH, potentially leading to the development of FH and early-onset CAD. A pathogenic mutation in the LDLR gene was found to be cosegregated in a family. Genetic testing and reports on nucleotide alterations are limited in the Iranian population.
FRONTIERS IN GENETICS
(2021)
Editorial Material
Biochemistry & Molecular Biology
Leila Montazeri, Maryam Mohajeri, Hossein Baharvand, Rouhollah Fathi, Valeria Poli, Sara Kazemi, Fattaneh Pahlavan, Solmaz Kouhestani, Firoozeh Ahmadi, Seyed Javad Mowla
Summary: This report showcases the successful experiences of the Executive Boards of these two congresses in overcoming the challenges brought about by the COVID-19 pandemic. By utilizing different virtual setting components, they have created a suitable model for future virtual events, inspiring people to turn threats into opportunities.
Review
Biochemistry & Molecular Biology
Naeim Ehtesham, Shahnaz Shahrbanian, Mohammad Valadiathar, Seyed Javad Mowla
Summary: This study investigates the impact of exercise on miRNA expression in individuals with obesity, highlighting the role of miRNAs in obesity and exercise adaptation mechanisms. Further research is needed to fully understand the underlying molecular pathways.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Afsaneh Malekzadeh Shafaroudi, Ali Sharifi-Zarchi, Saeid Rahmani, Nahid Nafissi, Seyed Javad Mowla, Andrea Lauria, Salvatore Oliviero, Maryam M. Matin
Summary: Studies have revealed the significant downregulation of the C1orf132 long transcript in breast cancer, along with the identification of its promoter that has a notable impact on the expression of miR-29c, subsequently influencing cell migration ability.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Sogol Ghanbari, Adel Salimi, Saeid Rahmani, Nahid Nafissi, Ali Sharifi-Zarchi, Seyed Javad Mowla
Summary: In this study, a multi-component scoring system was used to identify the most stable miRNA, hsa-miR-361-5p, in breast tissues using TCGA miRNA-Seq data. This miRNA was recommended as a suitable reference gene for miRNA expression studies in breast cancer. Furthermore, the commonly used IC hsa-miR-16-5p was shown to be unsuitable for breast cancer studies.
Article
Multidisciplinary Sciences
Karim Rahimi, Annette C. Fuechtbauer, Fardin Fathi, Seyed Javad Mowla, Ernst-Martin Fuechtbauer
Summary: MiR-302/367 is a significant miRNA cluster that induces and maintains pluripotency. Research on the transcriptional control and processing of the miR-302 host-gene in mice reveals that it is regulated through alternative splicing, polyadenylation, and nuclear export.
SCIENTIFIC REPORTS
(2021)
Review
Allergy
Zahra Salehi, Bibi Fatemeh Nobakht Motlagh Ghoochani, Yazdan Hasani Nourian, Sadegh Azimzadeh Jamalkandi, Mostafa Ghanei
Summary: The effects of nicotine and cigarette smoke on various diseases, including COVID-19 infection, are being discussed. Current data suggests that smokers have a higher risk of COVID-19 infection due to the overexpression of viral entry receptors. However, epidemiological reports indicate a lower incidence of COVID-19 in smokers. Nicotine has dual effects, both inflammatory and anti-inflammatory. The study investigates the effect of nicotine on various cells involved in COVID-19 infection.
ALLERGY ASTHMA AND CLINICAL IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Fatemeh Mirzadeh Azad, Eduard A. Struys, Victoria Wingert, Luciana Hannibal, Ken Mills, Joop H. Jansen, Daniel B. Longley, Hendrik G. Stunnenberg, Yaser Atlasi
Summary: Understanding the mechanisms of epigenetic regulation in ESCs is crucial for stem cell and developmental biology. In this study, the identification of Spic as a marker of ground state pluripotency and its role in controlling 1C metabolism and histone marks highlight the importance of auxiliary TFs in linking cellular metabolism to epigenetic regulation in ESCs.
Review
Immunology
Mostafa Ghanei, Ali Mohabattalab, Kiarash Fartash, Narjes Kolahchi, Alireza Khakdaman, Hooman Kaghazian, Abolfazl Bagheri
Summary: Widespread public vaccination is essential for ensuring health and preventing deaths, and the development of the COVID-19 vaccine exemplifies this. Vaccine development is a complex process that requires firm-level capabilities, infrastructure, long-term planning, and stable policies. With the global demand for vaccines during the pandemic, the national capability to produce vaccines is crucial. This paper examines factors at the firm and policy levels that influence the COVID-19 vaccine development process in Iran, drawing lessons for vaccine development in developing countries.
CLINICAL AND EXPERIMENTAL VACCINE RESEARCH
(2023)
Article
Medicine, General & Internal
Parisa Mehdizadeh, Mostafa Ghanei, Abolghasem Pourreza, Ali Akbari-sari, Batool Mousavi, Rajabali Daroudi
Summary: This study investigated the healthcare utilization and expenditures among Iranian survivors of sulfur mustard exposure during the Iran-Iraq war. The results showed that the survivors had high utilization rates and corresponding costs. Disability, age, and severity of injury were identified as important factors influencing healthcare utilization.
ARCHIVES OF IRANIAN MEDICINE
(2022)
Article
Urology & Nephrology
Maria Zahiri, Mansoureh Movahedin, Seyed Javad Mowla, Mehrdad Noruzinia, Morteza Koruji, Mohammad Reza Nowroozi, Zahra Bashiri
Summary: The study found that the use of testicular cell suspension in group IV led to a significant increase in the number and diameter of colonies, as well as an increase in the expression of germ-specific genes and a decrease in the expression levels of pluripotency genes.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.