Journal
GENE
Volume 592, Issue 2, Pages 325-330Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2016.07.006
Keywords
ErbB2; Neonatal; Cardiomyocyte; Proliferation
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Funding
- National Natural Science Foundation of China [81200192]
- AHA Scientist Development Grant [13SDG17060010]
- Ellison Medical Foundation (EMF) New Scholar Grant [AG-NS-1064-13]
- NIH/NHLBI [R00 HL109079]
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It has been long recognized that the mammalian heart loses its proliferative capacity soon after birth, yet, the molecular basis of this loss of cardiac proliferation postnatally is largely unknown. In this study, we found that cardiac ErbB2, a member of the epidermal growth factor receptor family, exhibits a rapid and dramatic decline in expression at the neonatal stage. We further demonstrate that conditional ablation of ErbB2 in the ventricular myocardium results in upregulation of negative cell cycle regulators and a significant reduction in cardiomyocyte proliferation during the narrow neonatal proliferative time window. Together, our data reveal a positive correlation between the expression levels of ErbB2 with neonatal cardiomyocyte proliferation and suggest that reduction in cardiac ErbB2 expression may contribute to the loss of postnatal cardiomyocyte proliferative capacity. (C) 2016 Elsevier B.V. All rights reserved.
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