Journal
GENE
Volume 575, Issue 2, Pages 264-269Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.gene.2015.09.009
Keywords
Bombyx mori; Cytoplasmic polyhedrosis virus; MicroRINA; IBP2
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Funding
- National Natural Science Foundation of China [31502016]
- Natural Science Foundation of Jiangsu Province, China [BK20141286]
- Third Batch of Oversea Training for Outstanding University Teachers of Jiangsu Province, China
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Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) is a major viral pathogen of silkworm and remains a big challenge to the sericultural industry. Insulin-related peptide binding protein 2 (IBP2) gene, induced by BmCPV infection may play an important role in B. mori immune response. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the post-transcriptional level and play an important role in various processes, including immunity and antiviral response. In this study, we identified IBP2 as one of the targets for miR-278-3p by using luciferase reporter assay. Overexpression of miR-278-3p negatively regulates the expression of IBP2 in silkworm larvae and positively regulates the mRNA transcript level of BmCPV. Our results suggest that miR-278-3p may play an important role in BmCPV replication. It's the first report on bmo-miRNAs in response to BmCPV infection and could provide a new clue to explore the molecular mechanism of BmCPV infection and host immunity. (C) 2015 Elsevier B.V. All rights reserved.
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