Article
Cell Biology
Ruowen Gong, Ruyi Han, Xiaonan Zhuang, Wenyi Tang, Gezhi Xu, Lei Zhang, Jihong Wu, Jun Ma
Summary: miR-375 alleviates cell proliferation and angiogenesis in retinal microvascular endothelial cells, potentially providing new therapeutic targets for retinal diseases.
Article
Biochemistry & Molecular Biology
Jingjin Li, Mengjiang Liu, Bin Zeng, Zhonghai Wang
Summary: The study found that Propofol significantly inhibited the proliferation of HCC cells and induced apoptosis by regulating the miR-105/JAK2/STAT3 signaling pathway. Therefore, Propofol may serve as a new therapeutic agent for HCC.
Article
Oncology
Chuigong Yu, Yu Fan, Yu Zhang, Lupeng Liu, Gang Guo
Summary: This study demonstrated that LINC00893 suppresses the progression of prostate cancer cells through targeting the miR-3173-5p/SOCS3/JAK2/STAT3 signaling axis. This finding uncovers a novel tumor-suppressor role of LINC00893 in prostate cancer and suggests its potential as a targeted therapy strategy.
CANCER CELL INTERNATIONAL
(2022)
Article
Nanoscience & Nanotechnology
Lai Pan, Chenyi Zhang, Haizheng Zhang, Ting Ke, Mengyao Bian, Yuxuan Yang, Lili Chen, Jingyi Tan
Summary: This study found that exosomal miR-5134-5p derived from osteoclasts inhibits osteoblastic proliferation and differentiation via the JAK2/STAT3 pathway, exacerbating periodontal tissue inflammation and alveolar bone resorption in mice with experimental periodontitis.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Laiwei Wu, Guoqiang Huang, Huifeng Hong, Xiangzhou Xu, Xiaohe Lu, Jing Li
Summary: This study investigated the function of miR-452-5p in retinoblastoma (RB) and found that it promoted cell proliferation and invasion through the SOCS3/JAK2/STAT3 signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Liheng Li, Chengjiang Xiao, Ke He, Guoan Xiang
Summary: The study revealed that circ_0072088 is highly expressed in HCC, promoting proliferation, migration, and invasion of liver cancer cells while inhibiting apoptosis. It activates the JAK2/STAT3 signaling pathway by serving as a molecular sponge of miR-375.
Article
Medicine, Research & Experimental
Yawei Hu, Xinle Luo, Jianhua Zhou, Shaochu Chen, Ming Gong, Yue Deng, Hao Zhang
Summary: The study demonstrated that Piperlongumine (PL) effectively inhibits the growth, migration, invasion, and promotes apoptosis of osteosarcoma cells by downregulating the SOCS3-mediated JAK2/STAT3 pathway.
Article
Clinical Neurology
Xiaowang Guo, Xiaoyan Shen, Zhijun Yong
Summary: The study demonstrated that miR-101 can protect neuronal cells from apoptosis and ischemic brain injury by regulating the JAK2/STAT3 signaling pathway, suggesting that miR-101 might be a potential target for the treatment of ischemic stroke.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Cell Biology
Wei Dong, Jin Chen, Yadong Wang, Junfei Weng, Xingxiang Du, Xu Fang, Wenyu Liu, Tao Long, Jiaxiang You, Wensheng Wang, Xiaoping Peng
Summary: This study aims to elucidate the potential mechanism of miR-206 in septic cardiomyopathy (SCM). The results showed that miR-206 protected cardiomyocytes from LPS-induced inflammatory injuries via targeting the USP33/JAK2/STAT3 signaling pathway, which might be a novel target for SCM treatment.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang
Summary: Liver cancer is a common malignancy with drug resistance being a major challenge in treatment. This study demonstrates that Dihydrotanshinone (DHTS) can inhibit the growth of hepatocellular carcinoma by suppressing the JAK2/STAT3 signaling pathway, suggesting its potential as a chemotherapeutic agent.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Zheng Ma, Yun Chen, Ju Qiu, Rui Guo, Keli Cai, Yan Zheng, Yuyao Zhang, Xueqing Li, Linsen Zan, Anning Li
Summary: In this study, a novel circRNA, circBTBD7, was identified to inhibit adipogenesis in bovine adipocytes by binding to miR-183 and regulating SMAD4 expression.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Jiahui Zhou, Zhiyue Li, Qun Zhao, Tianding Wu, Qiancheng Zhao, Yong Cao
Summary: The study demonstrated that SNHG1 regulated cell viability, apoptosis, and autophagy in an in vitro spinal cord injury model by activating the Jak2/stat3 pathway through sponging miR-362-3p.
NEUROCHEMICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Hui Wang, Mei Ma, Yuying Li, Jinxin Liu, Chao Sun, Shengnan Liu, Yiruo Ma, Ying Yan, Zhili Tang, Siyi Shen, Jing Yu, Yuting Wu, Jingjing Jiang, Li Wang, Zi-Bing Jin, Hao Ying, Yan Li
Summary: miR-183 and miR-96 have been demonstrated as master coordinators of fuel selection and metabolic homeostasis by modulating glucose utilization and fat catabolism in skeletal muscle. Their loss enhances oxidative phenotype and alters substrate utilization in mice, potentially offering therapeutic targets for obesity and glucose metabolism induced by high-fat diet.
Article
Biochemistry & Molecular Biology
Li Gao, Yu-xin Liu, Yu-zhi Zhou, Xue-mei Qin
Summary: More and more evidence suggests that metabolic reprogramming is closely linked to Alzheimer's disease (AD). The switch from oxidative phosphorylation to glycolysis worsens microglia-mediated inflammation. Baicalein has been shown to inhibit neuroinflammation in BV-2 microglial cells treated with LPS, but its mechanism of action in relation to glycolysis is unclear. Our results demonstrate that baicalein significantly reduces the levels of nitric oxide (NO), interleukin-6 (IL-6), prostaglandin-2 (PGE2), and tumor necrosis factor (TNF-alpha) in LPS-treated BV-2 cells. H-1-NMR metabolomics analysis reveals that baicalein decreases the levels of lactic acid and pyruvate, and effectively regulates the glycolytic pathway. Further investigation reveals that baicalein inhibits the activity of glycolysis-related enzymes and suppresses STAT3 phosphorylation and c-Myc expression. By using a STAT3 activator, RO8191, we found that baicalein hinders the increase in STAT3 phosphorylation and c-Myc expression triggered by RO8191, and also inhibits the elevated levels of 6-PFK, PK, and LDH caused by RO8191. In conclusion, these findings suggest that baicalein alleviates neuroinflammation in LPS-treated BV-2 cells by inhibiting glycolysis through the STAT3/c-Myc pathway.
NEUROCHEMICAL RESEARCH
(2023)
Article
Cell Biology
Hai-Yan Yang
Summary: The study elucidates the role of miR-133b in oxidative stress injury of trophoblasts in preeclampsia by activating the JAK2/STAT3 pathway to promote cell migration and invasion.
JOURNAL OF MOLECULAR HISTOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Yaxiong Guo, Junjie Ma, Haibing Wang, Feihong Ye, Liangbin Xiong, Hongwei Lei, Zuojun Tan
Summary: Nickel oxide (NiOx) is an ideal hole selective material (HSM) for perovskite photovoltaics due to its stability and low cost. By employing a lithium-doping strategy, the electronic levels of NiOx can be tuned to match the perovskite active layer, leading to increased open-circuit voltage values and power conversion efficiencies in perovskite solar cells. Additionally, a PN4N interlayer strategy helps reduce interfacial density of defect sites and trap-assisted recombination, contributing to lower energy loss across the perovskite/NiOx interface and facilitating charge transport process.
ADVANCED MATERIALS INTERFACES
(2021)
Article
Biotechnology & Applied Microbiology
Jihui Zhang, Hongwei Lei, Xiu Li
Summary: Gout is a common form of arthritis that may involve oxidative stress and NLRP3 inflammasome. S14G-HNG may have potential benefits against gout arthritis, particularly in its anti-inflammatory effects.
Article
Medicine, Research & Experimental
Hong-Wei Lei, Bi-Run Huang, Jie Cai, Cheng-Ming Li, Chun-Bo Shang, Zhi-Yang Liao, Zheng-Dong Wan
Summary: This study demonstrates the therapeutic effect of CXCR4 antagonist AMD3100 combined with TACE in a rat model of HCC. The combination treatment reduces tumor volume and microvessel density, while promoting HCC cell apoptosis and reducing cell proliferation.
KAOHSIUNG JOURNAL OF MEDICAL SCIENCES
(2022)
Article
Engineering, Environmental
Zhengchun Wang, Chang Shi, Ziyi Wang, Lan Xiao, Tong Wu, Xueli Yu, Liang Ma, Xiangbai Chen, Jiliang Zhang, Hongwei Lei, Pingli Qin
Summary: The study introduces the use of Fe2-xMgxO3 for passivating the perovskite/SnO2 interface in perovskite solar cells (PSCs). The interaction between perovskite and Fe2-xMgxO3 promotes uniform perovskite photoactive layer and enhances electron transfer, leading to higher efficiency in solar energy conversion.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Lei Hongwei, Li Juan, Xu Xiaoying, Fan Zhijun
Summary: This study aims to investigate the role of miR-106b-5p in cervical cancer (CC). The expression of miR-106b-5p was found to be down-regulated in CC tissues compared to normal tissues. Overexpression of miR-106b-5p inhibited CC cell proliferation, migration, and invasion, while miR-106b-5p inhibitor had the opposite effects. Furthermore, miR-106b-5p was shown to negatively regulate FGF4 expression, suggesting its involvement in CC growth and metastasis inhibition.
Article
Engineering, Environmental
Wenkai Li, Hongwei Lei, Yun Han, Ming Lei, Tianlong Zheng
Summary: Truck-wash facilities are popular on construction sites, but the treatment of suspended solids and pathogenic bacteria in truck-wash wastewater remains challenging. This study investigated the wastewater characteristics, bacterial communities, and distribution of pathogenic bacteria in three-stage sedimentation basins on four construction sites. The results showed high concentrations of suspended solids and bacteria in truck-wash wastewater, and the presence of pathogenic bacteria was detected. Traditional three-stage sedimentation basins need to be simplified and improved to enhance the removal efficiency, and practical technologies for controlling suspended solids and pathogenic bacteria should be further studied.
JOURNAL OF ENVIRONMENTAL ENGINEERING
(2022)
Article
Green & Sustainable Science & Technology
Wenkai Li, Ming Lei, Yun Han, Tianlong Zheng, Yingqun Ma, Mingjie Xu, Wenjun Wu, Po Gao, Hongwei Lei
Summary: In this study, unpowered baffle rural sewage reactors were established and operated with different construction wastes to achieve the cooperative governance of rural sewage and rural construction wastes. The results showed that the construction wastes had a significant removal effect on COD and SS, and the different removal effects were mainly influenced by their physicochemical characteristics rather than bacterial community characteristics. This study provided an effective and low-cost method for the co-governance of rural sewage and rural construction wastes, which is suitable for rural areas and has development potential.
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gang Wen, Hongwei Lei, Baochang Qi, Shao Duan, Zunyu Xiao, Chaozhe Han, Yifei Xia, Chengwei Jing, Jianyu Liu, Chao Li
Summary: The purpose of this study was to develop an imaging probe, IRDye-680RD-OX40 mAb, for noninvasive imaging and optical imaging of rheumatoid arthritis (RA). The probe exhibited high specificity in detecting OX40-positive responses in early RA. The results suggest that this optical probe has the potential to be an ideal tool for RA imaging.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Article
Surgery
Zheng-Dong Wan, Jie Cai, Bi-Run Huang, Cheng-Ming Li, Chun -Bo Shang, Hong -Wei Lei
Summary: English Summary: The article introduces the symptoms and treatment methods of median arcuate ligament syndrome (MALS), highlighting the challenging diagnosis and treatment of MALS. A case of MALS is presented, with detailed description of the patient's recovery after surgical treatment. The article aims to provide reference for the diagnosis and treatment of MALS.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Nanoscience & Nanotechnology
Ziyi Wang, Wuchen Xiang, Chang Shi, Shuping Xiao, Rui Wu, Xueli Yu, Liang Ma, Zhongli Qin, Hongwei Lei, Xiangbai Chen, Guojia Fang, Pingli Qin
Summary: Manipulating the interface between Spiro-OMeTAD and perovskite using copper acetylacetonate can improve the stability and performance of perovskite solar cells by constructing ligand bridges and suppressing interface defects.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Physical
Xiaoyan Li, Junzhe Shi, Jianjun Chen, Zuojun Tan, Hongwei Lei
Summary: Lead halide perovskite has limitations in practical applications due to the presence of toxic lead, leading scientists to search for low-toxic and stable alternatives. Lead-free double perovskite has shown promising results and two types based on different Pb substitution strategies have been reviewed in this paper. The research progress and prospects of lead-free double perovskite photodetectors in the past three years have been summarized, and possible pathways for improving device performance have been proposed.
Article
Materials Science, Multidisciplinary
Yaling Lei, Xiaoyan Li, Jingying Liang, Junzhe Shi, Yunhao Wei, Pingli Qin, Hong Tao, Jianjun Chen, Zuojun Tan, Hongwei Lei
Summary: In this work, oxygen-doped graphitic carbon nitride (g-C3N4-O) was introduced as an additive in the SnO2 electron transport layer (ETL) to optimize the traps at the ETL/perovskite interface. The interaction between g-C3N4-O and SnO2 effectively reduced the uncoordinated Sn dangling bonds and -OH groups, which are the main deep-traps at the ETL/perovskite interface. The trap-engineered PVSCs exhibited improved electrical properties, including matched energy band alignment, enhanced electron transport, and prolonged carrier lifetime. As a result, g-C3N4-O modified binary PVSCs achieved a champion power conversion efficiency of over 21% and demonstrated high environmental stability.
JOURNAL OF MATERIALS CHEMISTRY C
(2023)
Article
Nanoscience & Nanotechnology
Haiyu Guan, Yaling Lei, Qing Chen, Jiao Ding, Hongwei Lei, Yaxiong Guo, Zuojun Tan, Fu Xiang
Summary: In this study, nitrogen-doped carbon quantum dots (N-CDs) were synthesized from walnut shell waste and used to modify the electron transport layer (ETL) in perovskite solar cells (PVSCs). The N-CDs improved the crystallinity and inhibited the formation of defects in the PVSCs, resulting in improved power conversion efficiency.
JOURNAL OF NANO RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Jorim Okoth Obila, Hongwei Lei, Elijah Omolo Ayieta, Alex Awuor Ogacho, Bernard O. Aduda, Feng Wang
Summary: The introduction of anilinium hypophosphite (AHP) as a co-additive has successfully improved the structural and optoelectronic properties of tin-absorber perovskite, leading to enhanced efficiency and stability of solar cells.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Materials Science, Multidisciplinary
Keli Shi, Risheng Jin, Shihua Huang, Hongwei Lei, Pei Dai, Dan Chi, Weifeng Zhang, Gui Yu
Summary: ITIC-type non-fullerene acceptors (NFAs) offer advantages over fullerene derivative molecules in organic photovoltaics, with enhanced absorption coefficient, broadened spectral photoresponse, efficient exciton dissociation, and tunable energy levels. The combination of pentacene and ITIC in a bi-layer heterojunction demonstrates high performance in organic phototransistors, enhancing light detection range and limits. The results indicate that ITIC-type NFAs could serve as highly efficient alternative acceptors for high-performance OHPTs.
JOURNAL OF MATERIALS CHEMISTRY C
(2021)