Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease
Published 2021 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Small-molecule suppression of calpastatin degradation reduces neuropathology in models of Huntington’s disease
Authors
Keywords
-
Journal
Nature Communications
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-09-06
DOI
10.1038/s41467-021-25651-y
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects
- (2019) Yuanyuan Zhao et al. Nature Communications
- Dynamin-like protein 1 cleavage by calpain in Alzheimer’s disease
- (2019) Sirui Jiang et al. AGING CELL
- CHIR-99021 regulates mitochondrial remodelling via β-catenin signalling and miRNA expression during endodermal differentiation
- (2019) Yuejiao Ma et al. JOURNAL OF CELL SCIENCE
- Mitochondrial membrane potential
- (2018) Ljubava D. Zorova et al. ANALYTICAL BIOCHEMISTRY
- Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease
- (2018) Jonasz Jeremiasz Weber et al. NEUROPHARMACOLOGY
- Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia
- (2018) Florence F. Wagner et al. Science Translational Medicine
- Drp1/Fis1-mediated mitochondrial fragmentation leads to lysosomal dysfunction in cardiac models of Huntington's disease
- (2018) A.U. Joshi et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Huntington's disease: a clinical review
- (2017) P. McColgan et al. EUROPEAN JOURNAL OF NEUROLOGY
- Mitostasis in Neurons: Maintaining Mitochondria in an Extended Cellular Architecture
- (2017) Thomas Misgeld et al. NEURON
- Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects
- (2016) Florence F. Wagner et al. ACS Chemical Biology
- Calpastatin overexpression reduces oxidative stress-induced mitochondrial impairment and cell death in human neuroblastoma SH-SY5Y cells by decreasing calpain and calcineurin activation, induction of mitochondrial fission and destruction of mitochondrial fusion
- (2016) Kulvadee Tangmansakulchai et al. MITOCHONDRION
- Calpain-1 and Calpain-2: The Yin and Yang of Synaptic Plasticity and Neurodegeneration
- (2016) Michel Baudry et al. TRENDS IN NEUROSCIENCES
- VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington’s disease
- (2016) Xing Guo et al. Nature Communications
- Calpain-mediated cleavage of DARPP-32 in Alzheimer's disease
- (2015) Kwangmin Cho et al. AGING CELL
- Decreased glycogen synthase kinase-3 levels and activity contribute to Huntington's disease
- (2015) Marta Fernández-Nogales et al. HUMAN MOLECULAR GENETICS
- Lineage conversion induced by pluripotency factors involves transient passage through an iPSC stage
- (2015) Ori Bar-Nur et al. NATURE BIOTECHNOLOGY
- Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity
- (2014) F M Menzies et al. CELL DEATH AND DIFFERENTIATION
- Mitochondrial Dynamics in the Regulation of Nutrient Utilization and Energy Expenditure
- (2013) Marc Liesa et al. Cell Metabolism
- Inhibition of mitochondrial fragmentation diminishes Huntington’s disease–associated neurodegeneration
- (2013) Xing Guo et al. JOURNAL OF CLINICAL INVESTIGATION
- Calpains, mitochondria, and apoptosis
- (2012) M. A. Smith et al. CARDIOVASCULAR RESEARCH
- Shaping the role of mitochondria in the pathogenesis of Huntington's disease
- (2012) Veronica Costa et al. EMBO JOURNAL
- Calpastatin reduces calpain and caspase activation in methamphetamine-induced toxicity in human neuroblastoma SH-SY5Y cultured cells
- (2012) Wilasinee Suwanjang et al. NEUROSCIENCE LETTERS
- Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease
- (2011) U. P. Shirendeb et al. HUMAN MOLECULAR GENETICS
- Energy deficit in Huntington disease: why it matters
- (2011) Fanny Mochel et al. JOURNAL OF CLINICAL INVESTIGATION
- Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity
- (2011) Wenjun Song et al. NATURE MEDICINE
- PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease
- (2011) Ming-Chang Chiang et al. NEUROBIOLOGY OF DISEASE
- AKT Kinase Activity Is Required for Lithium to Modulate Mood-Related Behaviors in Mice
- (2011) Jen Q Pan et al. NEUROPSYCHOPHARMACOLOGY
- Dynamic regulation of mitochondrial fission through modification of the dynamin-related protein Drp1
- (2010) Chuang-Rung Chang et al. Annals of the New York Academy of Sciences
- Huntington's disease: from molecular pathogenesis to clinical treatment
- (2010) Christopher A Ross et al. LANCET NEUROLOGY
- Tetrabenazine is neuroprotective in Huntington's disease mice
- (2010) Hongyu Wang et al. Molecular Neurodegeneration
- Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease
- (2010) Austen J. Milnerwood et al. TRENDS IN NEUROSCIENCES
- Universal sample preparation method for proteome analysis
- (2009) Jacek R Wiśniewski et al. NATURE METHODS
- Systematic behavioral evaluation of Huntington's disease transgenic and knock-in mouse models
- (2009) Liliana Menalled et al. NEUROBIOLOGY OF DISEASE
- Dopaminergic and Glutamatergic Signaling Crosstalk in Huntington's Disease Neurodegeneration: The Role of p25/Cyclin-Dependent Kinase 5
- (2008) P. Paoletti et al. JOURNAL OF NEUROSCIENCE
- Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
- (2008) Rachel A. Hanna et al. NATURE
- The ground state of embryonic stem cell self-renewal
- (2008) Qi-Long Ying et al. NATURE
- Dephosphorylation by calcineurin regulates translocation of Drp1 to mitochondria
- (2008) G. M. Cereghetti et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowBecome a Peeref-certified reviewer
The Peeref Institute provides free reviewer training that teaches the core competencies of the academic peer review process.
Get Started