Journal
NATURE COMMUNICATIONS
Volume 12, Issue 1, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41467-021-25449-y
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Funding
- National Natural Science Foundation of China [21672148, 21871181]
- Shanghai Municipal Education Commission [2019-01-07-00-02-E00029]
- Shanghai Municipal Committee of Science and Technology [18ZR1447600, 20JC1416800]
- 111 Innovation and Talent Recruitment Base on Photochemical and Energy Materials [D18020]
- Shanghai Engineering Research Center of Green Energy Chemical Engineering [18DZ2254200]
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The study presents an efficient strategy for synthesizing peptides, achieving enantioselective transamination through multiple imitation of transaminases with high yields and excellent enantioselectivity. This method is particularly suitable for synthesizing peptides made of unnatural amino acids.
Peptides are important compounds with broad applications in many areas. Asymmetric transamination of alpha-keto amides can provide an efficient strategy to synthesize peptides, however, the process has not been well developed yet and still remains a great challenge in both enzymatic and catalytic chemistry. For biological transamination, the high activity is attributed to manifold structural and electronic factors of transaminases. Based on the concept of multiple imitation of transaminases, here we report N-quaternized axially chiral pyridoxamines 1 for enantioselective transamination of alpha-keto amides, to produce various peptides in good yields with excellent enantio- and diastereoselectivities. The reaction is especially attractive for the synthesis of peptides made of unnatural amino acids since it doesn't need great efforts to make chiral unnatural amino acids before amide bond formation.
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