Article
Immunology
Ji Hyeon Ryu, Jisu Park, Bo-Young Kim, Yeonye Kim, Nam Gyun Kim, Yong-Il Shin
Summary: This study investigates the effects and mechanisms of photobiomodulation (PBM) on fibroblast-like synoviocytes (FLSs) from rheumatoid arthritis (RA) patients and a mouse model of collagen-induced arthritis (CIA). PBM significantly reduced proliferation, migration, and invasion of RA-FLSs, and inhibited synovial inflammation and cartilage degradation in the CIA model. PBM therapy also showed a synergistic effect when combined with methotrexate (MTX), a disease-modifying anti-rheumatic drug (DMARD).
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Yu-Wei Chang, Ling-Chien Hung, Yu-Cheng Chen, Wen-Hung Wang, Chun-Yu Lin, Hsin-Han Tzeng, Jau-Ling Suen, Yen-Hsu Chen
Summary: Insulin may reduce inflammation by regulating the NLRP3 inflammasome, as demonstrated in in vivo models, providing evidence for its potential immunomodulatory role in anti-inflammation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Physiology
Michael R. Odom, Francis M. Hughes, Huixia Jin, J. Todd Purves
Summary: This study demonstrates that NLRP3-mediated inflammation is responsible for urothelial barrier damage in type 1 diabetic female Akita mice with an overactive bladder. Eliminating the NLRP3 gene in these diabetic mice prevented barrier damage as a result of diabetes. By the time female Akita mice develop an underactive phenotype, the urothelial barrier has been restored, suggesting that inflammation is a critical causative factor early in the development of diabetic bladder dysfunction.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Article
Endocrinology & Metabolism
Hongye Chang, Hongjuan Chang, Tuanjie Cheng, Garrick D. Lee, Xiaoping Chen, Kunqing Qi
Summary: This study investigated the role of miR-23a-3p in pyroptosis caused by NLRP3 inflammatory body activation in type 2 diabetes mellitus. The results showed that targeting NEK7 by miR-23a-3p could reduce NLRP3-induced pyroptosis and alleviate liver and kidney injuries in type 2 diabetes mellitus.
JOURNAL OF DIABETES INVESTIGATION
(2021)
Review
Biochemistry & Molecular Biology
Julia Barczuk, Natalia Siwecka, Weronika Lusa, Wioletta Rozpedek-Kaminska, Ewa Kucharska, Ireneusz Majsterek
Summary: Alzheimer's disease is the most common cause of dementia and a major therapeutic challenge. Aggregates of A beta and Tau proteins trigger a neuroinflammatory response and the formation of inflammasomes, particularly the NLRP3 inflammasome which plays a crucial role in AD pathology. Inhibitors of NLRP3 have shown promising results in reducing Tau and A beta aggregates and cognitive impairment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Kuyas Hekimler Oeztuerk, Guelin Oezdamar Uenal
Summary: Variants in the NLRP3 gene are associated with bipolar I disorder (BPI) and may serve as potential risk factors. Two novel splice-site variants were detected in BPI patients and showed significant associations with certain phenotypic traits.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Pharmacology & Pharmacy
Xiaoke Yang, Bo Chen, Mingyue Zhang, Shengqian Xu, Zongwen Shuai
Summary: The study explored the association between TTP gene polymorphisms and mRNA levels with RA susceptibility in Chinese populations. The results indicated that the T allele of rs3746083 in the TTP gene increased susceptibility to RA, with a significant difference found under the dominant model. However, the association of rs251864 with RA was not statistically significant. Furthermore, TTP expression levels were significantly reduced in RA patients, supporting its potential involvement in RA pathogenesis.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Akinobu Nakata, Yuji Nadatani, Toshio Watanabe, Yuji Matsumoto, Satoshi Kosaka, Akira Higashimori, Koji Otani, Shuhei Hosomi, Fumio Tanaka, Noriko Kamata, Koichi Taira, Yasuaki Nagami, Tetsuya Tanigawa, Yasuhiro Fujiwara
Summary: The study revealed that NLRP3 inflammasome plays a crucial role in 5-FU-induced small intestinal mucositis, possibly exacerbating the disease through IL-1 beta maturation.
Article
Plant Sciences
Min Liu, Xiangwen Meng, Zihua Xuan, Simeng Chen, Jin Wang, Zhiluo Chen, Jiayu Wang, Xiaoyi Jia
Summary: In this study, it was found that Er Miao San (EMS) treatment could reduce macrophage polarization to the M1 inflammatory phenotype by downregulating the miRNA-33/NLRP3 pathway in rats with adjuvant arthritis (AA). EMS also increased the levels of anti-inflammatory cytokines IL-10 and TGF-beta, and decreased the levels of pro-inflammatory cytokines IL-1 beta and TNF-alpha.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Lei Chong, Haiyan Li, Lili Zhu, Gang Yu
Summary: Obese asthma, characterized by increasing asthma occurrence in both adults and children, is strongly associated with obesity as a major risk factor for asthma with considerable effects on the lungs. Research has shown that the NLRP3 inflammasome, mediated by mtROS, plays a role in obese asthma. Leptin may promote airway inflammation by upregulating the mtROS-NLRP3 inflammasome signaling pathway in airway epithelial cells, while the mitochondrial-targeted antioxidant mitoQ shows potential as a treatment for obese asthma.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Immunology
Matthew K. Mcelwee, Thamotharampillai Dileepan, Shawn A. Mahmud, Marc K. Jenkins
Summary: This study found that HLA-DR-bound citrullinated peptides are not neo-antigens and can induce varying degrees of immune tolerance. This may pose a barrier to rheumatoid arthritis.
JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Nanoscience & Nanotechnology
Guowei Shen, Shichang Yan, Siyuan Shen, Feng Liang, Shouyun Xiao, Yunpeng Zhang, Yongtao Zhang, Huimin Ding
Summary: This study found that curculigoside has the potential to aid cartilage restoration in osteoarthritis patients by inhibiting the NLRP3 pathway.
JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
(2023)
Article
Plant Sciences
Zhenya Liu, Zirui Ren, Lunyi Yan, Feng Li
Summary: Members of the LRR superfamily play critical roles in biological processes. Accurately predicting the number and location of LRR units in proteins is a challenging task. In this study, we introduce DeepLRR, a method based on CNN model and LRR features, which outperforms existing methods in predicting LRR units. DeepLRR has also been used to annotate LRR-RLK genes in plant genomes and explore their evolutionary relationships and domain compositions.
Review
Immunology
Huihui Chen, Jie Zha, Runyan Tang, Guochun Chen
Summary: Research has shown that dysfunctional immune cells play a role in the development of autoimmune diseases. The T cell immunoglobulin and mucin domaincontaining protein 3 (TIM-3) is expressed on the surfaces of various immune cells and is involved in regulating important biological processes. Understanding the structure and signaling pathways of TIM-3 and its interactions with ligands can provide insights into the pathogenesis and potential treatment of autoimmune diseases.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Health Care Sciences & Services
Yue Zhuang, Huan Wang, Jiang Su, Jing Zhang, Qian Wang, Yanan Chen, Huaping Che
Summary: This paper briefly reviews the features and regulatory mechanism of NLRP3 inflammasome, as well as its relationship with RA. It highlights the potential of NLRP3 inflammasome in RA treatment, enriching the therapeutic strategies for inflammatory diseases.
ANNALS OF PALLIATIVE MEDICINE
(2021)