Article
Cell Biology
Jianzhong Su, Jian Yuan, Liangde Xu, Shilai Xing, Mengru Sun, Yinghao Yao, Yunlong Ma, Fukun Chen, Longda Jiang, Kai Li, Xiangyi Yu, Zhengbo Xue, Yaru Zhang, Dandan Fan, Ji Zhang, Hui Liu, Xinting Liu, Guosi Zhang, Hong Wang, Meng Zhou, Fan Lyu, Gang An, Xiaoguang Yu, Yuanchao Xue, Jian Yang, Jia Qu
Summary: A whole-exome sequencing study on Han Chinese ancestry revealed three newly identified genetic loci associated with high myopia (HM), including a low-frequency variant in FKBP5 and a rare variant in FOLH1. Functional experiments showed that a single G-to-A transition disrupted the binding of the transcription activator KLF15 to the promoter of FKBP5, resulting in decreased transcription.
Article
Immunology
Penggang Lian, Xintao Du, Xiaodong Liu, Wenxia Ruan, Yonglin Liu, Haiying Wang
Summary: The study suggests that RORA polymorphisms may play a protective role in the development of allergic rhinitis (AR).
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Ophthalmology
Melissa Yao, Ken Kitayama, Fei Yu, Victoria L. Tseng, Anne L. Coleman
Summary: This study investigated the association between myopia and primary open-angle glaucoma (POAG) in the 2019 California Medicare population, and whether this association was modified by race and ethnicity. The results showed that individuals with myopia had higher odds of POAG compared to those without myopia, and this association was stronger among Asian, Black, and Hispanic patients compared to non-Hispanic White patients. These findings suggest disparities in glaucoma risk by race and ethnicity among individuals with myopia, highlighting the need for increased glaucoma screening in racial and ethnic minorities with myopia.
JAMA OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Haiying Wang, Hui Han, Yongliang Niu, Xiaobo Li, Xintao Du, Qiang Wang
Summary: This study found that certain variants of the LPP gene are associated with increased susceptibility to allergic rhinitis in the Chinese Han population. Additionally, the interaction of LPP polymorphisms with age, gender, and BMI was found to contribute to AR risk.
Article
Clinical Neurology
Dunzhu Mima, Li-ping Wang, Yun Zhai, Qing De, Song Ba, Ga Da, Bin-you Wang, Jing-bo Zhao, Ying Tang
Summary: This study investigated the prevalence and risk factors of dementia among the Tibetan population. The results showed that older age, unmarried status, lower education level, obesity, hypertension, diabetes, coronary heart disease, cerebral vascular disease, and high altitude sickness were independently associated with dementia. Additionally, social activities, such as religious activities, were found to be protective factors against dementia.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Ophthalmology
Xinxing Guo, Ahmed F. Shakarchi, Sandra S. Block, David S. Friedman, Michael X. Repka, Megan E. Collins
Summary: This study evaluated the differences between autorefraction measurements with and without cycloplegia among school-aged individuals, finding that there was a small difference in SE between noncycloplegic and cycloplegic autorefraction. Factors such as age, race, and refractive error were identified as key factors associated with these differences.
Article
Ophthalmology
Xinxing Guo, Ahmed F. Shakarchi, Sandra S. Block, David S. Friedman, Michael X. Repka, Megan E. Collins
Summary: The study aims to evaluate the differences between autorefraction measurements with and without cycloplegia among school-aged individuals and explore the factors associated with these differences. The results show that the majority of school-aged individuals have less than 1.00D difference in spherical equivalent between noncycloplegic and cycloplegic autorefraction. Age, race or ethnicity, and refractive error type have different effects on the differences.
Article
Ophthalmology
Fang Cheng, Li Shan, Wulian Song, Pan Fan, Lijuan Zhang, Xinyu Wang, Huiping Yuan
Summary: The prevalence of myopia, hyperopia, astigmatism, and anisometropia is high among adults aged 40 and older in Kailu, Inner Mongolia. Age is significantly associated with hyperopia, high myopia, astigmatism, and anisometropia. Myopia is more prevalent in females, and individuals with higher educational levels have a greater or lesser likelihood of myopia and astigmatism.
OPHTHALMIC AND PHYSIOLOGICAL OPTICS
(2021)
Article
Ophthalmology
Rohit Saxena, Vivek Gupta, Priyanka Prasad, Amit Bhardwaj, Praveen Vashist
Summary: A study in rural northern India found a 6.4% prevalence of myopia in children, with a strong inverse association with time spent outdoors especially in private schools. Awareness of modifiable risk factors, regular screenings, and lifestyle modifications are essential for addressing the increasing prevalence of myopia in rural areas.
Article
Multidisciplinary Sciences
Hideharu Fukasaku, Akira Meguro, Masaki Takeuchi, Nobuhisa Mizuki, Masao Ota, Kengo Funakoshi
Summary: This study investigated the association between PDGFRA gene polymorphisms and corneal astigmatism in a Japanese population. The results showed that certain SNPs in the upstream region of PDGFRA were significantly associated with the degree of corneal astigmatism.
SCIENTIFIC REPORTS
(2023)
Article
Public, Environmental & Occupational Health
Ji Liu, Qiaoyi Chen, Jingxia Dang
Summary: During the COVID-19 pandemic, increased use of digital devices among Chinese youth is significantly associated with higher risks of developing myopia symptoms, particularly when accompanied by heightened psychosocial stress levels.
JOURNAL OF GLOBAL HEALTH
(2021)
Article
Medicine, General & Internal
Natsuki Okabe, Airi Takahashi, Yumi Shigemoto, Chio Kogure, Tadao Ooka, Ryoji Shinohara, Sanae Otawa, Anna Kobayashi, Sayaka Horiuchi, Megumi Kushima, Zentaro Yamagata, Kenji Kashiwagi
Summary: This study investigated the distribution of visual acuity, refractive error, and axial length in 8-year-old children participating in the Japan Environmental Children's Study. The results showed that males had significantly longer axial length compared to females, and there was a significant correlation between axial length, spherical refractive error, and uncorrected visual acuity. Additionally, children with a parental history of eyeglasses or contact lens wear had significantly more myopic refractive error.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Haishuang Lin, Jing Sun, Nathan Congdon, Meiping Xu, Shanshan Liu, Yuanbo Liang, Hailin Wang, Shaodan Zhang
Summary: The study found a high prevalence of uncorrected refractive error in urban Chinese adults, with women, older individuals, and myopic individuals being at higher risk for uncorrected refractive error-related visual impairment. A health examination center-based screening model was shown to be an effective and cost-efficient way to improve refractive services in China.
FRONTIERS IN MEDICINE
(2021)
Article
Oncology
Shaoyan Lin, Hongnan Mo, Yiqun Li, Xiuwen Guan, Yimeng Chen, Zijing Wang, Peng Yuan, Jiayu Wang, Yang Luo, Ying Fan, Ruigang Cai, Qiao Li, Shanshan Chen, Pin Zhang, Qing Li, Fei Ma, Binghe Xu
Summary: This study conducted analyses on BCLM patients in the Han population and found that HR-/HER2+ and HR+/HER2+ subtypes, as well as patients with de novo stage IV breast cancer, had a higher risk of liver metastases, while patients with lung metastases had a lower risk. The median overall survival of BCLM patients was 31.4 months, with patients of HR+/HER2- subtype having the longest survival time of 38.2 months.
FRONTIERS IN ONCOLOGY
(2021)
Article
Ophthalmology
Annechien E. G. Haarman, Clair A. Enthoven, Milly S. Tedja, Jan R. Polling, J. Willem L. Tideman, Jan E. E. Keunen, Camiel J. F. Boon, Janine F. Felix, H. Raat, Annette J. M. Geerards, Gregorius P. M. Luyten, Gwyneth A. van Rijn, Virginie J. M. Verhoeven, Caroline C. W. Klaver
Summary: This study investigates the impact of the refractive error gene GJD2 on human myopia, finding that it affects ocular biometry, particularly axial length and anterior chamber depth. Children carrying two risk alleles show larger axial length/corneal radius ratio at ages 6 and 9. Education and environmental factors negatively influence myopia and biometric outcomes, though gene-environment interactions do not reach statistical significance.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)