4.3 Editorial Material

Dysplasia of the fibrous sheath with axonemal and centriolar defects combined with lack of mitochondrial activity as associated factors of ICSI failure in primary ciliary dyskinesia syndrome

Journal

INTERNATIONAL BRAZ J UROL
Volume 47, Issue 3, Pages 617-626

Publisher

BRAZILIAN SOC UROL
DOI: 10.1590/S1677-5538.IBJU.2019.0362

Keywords

-

Ask authors/readers for more resources

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.3
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Andrology

SARS-CoV-2 and its relationship with the genitourinary tract: Implications for male reproductive health in the context of COVID-19 pandemic

Jorge Hallak, Thiago A. Teixeira, Felipe S. Bernardes, Felipe Carneiro, Sergio A. S. Duarte, Juliana R. Pariz, Sandro C. Esteves, Esper Kallas, Paulo H. N. Saldiva

Summary: The rapid spread of the COVID-19 outbreak has led to a significant number needing hospitalization, with a small percentage of patients in critical conditions. This study aims to summarize the effects of SARS-CoV-2 infection on the male genitourinary tract, including impacts on the urinary system, kidney injury, and reproductive system. Further international scientific efforts are needed to understand the role of the urogenital system in clinical settings during the pandemic.

ANDROLOGY (2021)

Article Andrology

Radiological patterns of incidental epididymitis in mild-to-moderate COVID-19 patients revealed by colour Doppler ultrasound

Felipe Carneiro, Thiago A. Teixeira, Felipe S. Bernardes, Marcelo S. Pereira, Giovanna Milani, Amaro N. Duarte-Neto, Esper G. Kallas, Paulo H. N. Saldiva, Maria C. Chammas, Jorge Hallak

Summary: The study investigated testicular involvement in mild-to-moderate COVID-19 men and found that some men had epididymitis, with over half displaying epididymal head enlargement. The use of color Doppler ultrasound, even in the absence of symptoms, may help diagnose epididymitis early, potentially leading to fertility complications.

ANDROLOGIA (2021)

Article Andrology

Testicular pathology in fatal COVID-19: A descriptive autopsy study

Amaro N. Duarte-Neto, Thiago A. Teixeira, Elia G. Caldini, Cristina T. Kanamura, Michele S. Gomes-Gouvea, Angela B. G. dos Santos, Renata A. A. Monteiro, Joao R. R. Pinho, Thais Mauad, Luiz F. F. da Silva, Paulo H. N. Saldiva, Marisa Dolhnikoff, Katia R. M. Leite, Jorge Hallak

Summary: Pathological findings in testes from fatal COVID-19 cases showed a combination of orchitis, vascular changes, basal membrane thickening, Leydig and Sertoli cell scarcity, and reduced spermatogenesis associated with local SARS-CoV-2 infection, which may impair hormonal function and fertility in men.

ANDROLOGY (2022)

Article Biochemistry & Molecular Biology

Reactive Oxygen Species and Their Consequences on the Structure and Function of Mammalian Spermatozoa

Joel R. Drevet, Jorge Hallak, Mohammad-Hossein Nasr-Esfahani, Robert J. Aitken

Summary: This review explores the relationship between spermatozoa and reactive oxygen species (ROS), highlighting how spermatozoa rely on ROS for maturity but are highly susceptible to oxidative damage. Recent studies have shown the significant impact of oxidative damage on sperm structures and functions, particularly in terms of fertilization and embryonic development. Future research aims to investigate whether pro-oxidative situations can lead to epigenetic changes in spermatozoa.

ANTIOXIDANTS & REDOX SIGNALING (2022)

Article Andrology

Sperm motility in asthenozoospermic semen samples can be improved by incubation in a continuous single culture medium (CSCM®)

Caroline Ranea, Juliana Risso Pariz, Joel R. Drevet, Jorge Hallak

Summary: This study tested the most common incubation media used in Latin American andrology and micromanipulation laboratories and found that a 2-hour incubation in CSCM (R) medium led to the highest asthenozoospermic sperm motility. This simple protocol could be extremely useful for IVF clinics dealing with asthenozoospermic semen specimens.

SYSTEMS BIOLOGY IN REPRODUCTIVE MEDICINE (2022)

Article Physiology

SARS-CoV-2 Nucleocapsid Protein is Associated With Lower Testosterone Levels: An Experimental Study

Caio Henrique Lucio Carrasco, Paloma Noda, Ana Paula Barbosa, Everidiene Kinverlly Vieira Borges da Silva, Camila Gasque Bomfim, Bianca Helena Ventura Fernandes, Thiago Afonso Teixeira, Amaro Nunes Duarte Neto, Paulo Hilario Nascimento Saldiva, Kamal Achoa Filho, Cristiane Rodrigues Guzzo, Edison Luiz Durigon, Fernando Luiz Affonso Fonseca, Roseli Corazzini, Camilla Fanelli, Irene Lourdes Noronha, Jorge Hallak

Summary: The ongoing COVID-19 pandemic has put a significant burden on public and private health systems worldwide, prompting the urgent need for effective vaccines and treatments. Research has shown that the viral Nucleocapsid protein plays a crucial role as an antigen in vaccine development. Additionally, inoculation of this protein has been found to cause hormonal imbalance in the testes of rats and an increase in sperm production.

FRONTIERS IN PHYSIOLOGY (2022)

Review Andrology

Surgically retrieved spermatozoa for ICSI cycles in non-azoospermic males with high sperm DNA fragmentation in semen

Sandro C. Esteves, Igor Coimbra, Jorge Hallak

Summary: Intracytoplasmic sperm injection (ICSI) using surgically retrieved spermatozoa outside the classic context of azoospermia has shown improvement in pregnancy and miscarriage rates, possibly due to lower levels of DNA damage in testicular spermatozoa compared to ejaculated spermatozoa. However, data is limited and mainly focuses on males with confirmed sperm DNA damage. Further research is needed to assess the health of ICSI offspring resulting from surgically retrieved spermatozoa of non-azoospermic males. A comprehensive evaluation and treatment of underlying male infertility factors contributing to sperm DNA damage is crucial for safer and more effective ICSI utilization.

ANDROLOGY (2023)

Article Urology & Nephrology

Serum lipid profile levels and semen quality: new insights and clinical perspectives for male infertility and men's health

Gustavo Andrade, Ivan Iori, Mariana K. Hsieh, Giovanna Milani, Pedro C. E. Zandona, Thiago A. Teixeira, Joel R. Drevet, Elaine Maria Costa, Jorge Hallak

Summary: This study aimed to determine the relationship between serum lipid profile and testicular function. A retrospective study was conducted on 278 infertile men, and data on seminal analysis, lipid profile, and total serum testosterone were collected. The results showed that seminal creatine kinase activity was negatively related to HDL and triglycerides, while total testosterone and seminal volume were both negatively related to triglycerides. Therefore, a comprehensive assessment, including blood lipid profile, hormonal status, and routine seminal examinations, is recommended for infertile men.

INTERNATIONAL UROLOGY AND NEPHROLOGY (2023)

Meeting Abstract Urology & Nephrology

INTRACELLULAR SARS-COV-2 FOUNDIN THE SPERMATOZOA OF CONVALESCENT MEN WITH NEGATIVE PCR SEMEN SAMPLES REVEALED BY ELECTRON MICROSCOPY

Jorge Hallak, Elia Tamaso Espin Garcia Caldini, Maria Cassia Jacintho Mendes Correa, Marisa Dolhnikoff, Paulo Hilario Nascimento Saldiva, Esper Georges Kallas, Amaro Nunes Duarte Neto, Raul Segundo Sanchez Gutierrez, Joel R. Drevet, Thiago Afonso Carvalho Celestino Teixeira, Felipe Saraiva Bernardes, Heloisa Faquineti

JOURNAL OF UROLOGY (2022)

Meeting Abstract Urology & Nephrology

ELEVATED ROS LEVELS AND DNA FRAGMENTATION IN SPERM FROM CONVALESCENT MEN IN SARS-COV-2 INFECTION

Jorge Hallak, Felipe Bernardes, Thiago Afonso Carvalho Celestino Teixeira, Paulo Hilario Nascimento Saldiva, Esper Georges Kallas, Elia Tamaso Espin Garcia Caldini, Amaro Nunes Duarte Neto, Heloisa Faquineti, Vinicius Luiz Menezes Jesus, Raul Segundo Sanchez Gutierrez, Joel R. Drevet

JOURNAL OF UROLOGY (2022)

Article Medicine, General & Internal

Male sex rather than socioeconomic vulnerability as a determinant for COVID-19 death in Sao Paulo: A population-based study

Jorge Hallak, Thiago A. Teixeira, Ligia Barrozo, Julio Singer, Esper G. Kallas, Paulo H. N. Saldiva

Summary: This study explores the role of male sex as a risk factor for coronavirus disease deaths in Sao Paulo and investigates the impact of socioeconomic vulnerability and individual health issues. The findings suggest that male sex is an independent biological risk factor for coronavirus disease death, beyond the influence of comorbidities or social vulnerabilities.

SAGE OPEN MEDICINE (2022)

Letter Urology & Nephrology

Baggio-Yoshinari syndrome as a sexually transmitted infection: a possibly way of transmission?

Yasmin C. Oliveira, Mariana K. Hsieh, Thiago A. Teixeira, Caio H. Carrasco, Jorge Hallak

INTERNATIONAL UROLOGY AND NEPHROLOGY (2022)

Article Public, Environmental & Occupational Health

Marijuana Is Associated With a Hormonal Imbalance Among Several Habits Related to Male Infertility: A Retrospective Study

Thiago A. Teixeira, Ivan Iori, Gustavo Andrade, Paulo H. N. Saldiva, Joel R. Drevet, Elaine M. F. Costa, Jorge Hallak

Summary: This study investigated the impact of marijuana use and other habits on testicular function in infertile men seeking andrological evaluation. The findings suggest that marijuana use may cause hormonal imbalance by lowering estradiol levels and inhibiting aromatase function.

FRONTIERS IN REPRODUCTIVE HEALTH (2022)

Meeting Abstract Obstetrics & Gynecology

DETERMINATION OF MELATONIN CONCENTRATION IN SPERM CRYOPRESERVATION BY SLOW FREEZING METHOD.

Larissa Namie Chiba, Mayara Rodrigues, Ana Clara Monteiro Barduchi, Heloisa Faquineti, Juliana Risso Pariz, Jorge Hallak

FERTILITY AND STERILITY (2021)

Meeting Abstract Obstetrics & Gynecology

CRYOPRESERVED SEMINAL SAMPLES FROM PATIENTS WITH ACUTE COVID-19 HAVE THE WORST POST-THAW QUALITY WHEN COMPARED TO OTHER ANDROLOGICAL DISEASES.

Juliana Risso Pariz, Heloisa Faquineti, Mayara Rodrigues, Larissa Namie Chiba, Ana Clara Monteiro Barduchi, Felipe Saraiva Bernardes, Thiago Teixeira, Joel Drevet, Raul Segundo Sanchez, Jorge Hallak

FERTILITY AND STERILITY (2021)

No Data Available