Article
Medicine, General & Internal
Jun Kit He, Samuel Schick, Marshall Williams, Bradley Wills, Martim Pinto, Gean Viner, Eugene Brabston, Amit Momaya, X. Long Zheng, Brent Ponce
Summary: This study found that following TSA surgery, patients had decreased ADAMTS13 activity, increased VWF levels, and the lowest ADAMTS13/VWF ratio, suggesting that the highest risk for VTE may be on postoperative day 2. Proper anticoagulation treatment is recommended during this period.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Hematology
Masayuki Kubo, Kazuya Sakai, Masaki Hayakawa, Hirokazu Kashiwagi, Hideo Yagi, Yoshinobu Seki, Atsushi Hasegawa, Haruyuki Tanaka, Itsuto Amano, Yoshiaki Tomiyama, Masanori Matsumoto
Summary: This study investigated whether VWF degradation is enhanced in patients with ET. The results showed that patients with higher platelet counts had lower HMW-VWFM index and higher VWF-DP:VWF Ag ratio. Cytoreductive therapy increased the HMW-VWFM index and decreased the VWF-DP:VWF Ag ratio. In conclusion, an increased platelet count in ET patients is associated with enhanced cleavage of VWF, and cytoreductive therapy can reduce this cleavage and improve VWFM distributions.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Miruna Popa, Markus Hecker, Andreas H. Wagner
Summary: ADAMTS13 is a metalloprotease whose expression is inhibited by proinflammatory cytokines, potentially increasing the risk of arterial thrombosis. Factors associated with atherosclerosis do not seem to affect ADAMTS13 expression. There is a reciprocal correlation between the expression of ADAMTS13 and vWF in endothelial cells.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Stephen J. X. Murphy, Soon Tjin Lim, Fionnuala Hickey, Justin A. Kinsella, Deirdre R. Smith, Sean Tierney, Bridget Egan, T. Martin Feeley, Sinead M. Murphy, D. Ronan Collins, Tara Coughlan, Desmond O'Neill, Joseph A. Harbison, Prakash Madhavan, Sean M. O'Neill, Mary-Paula Colgan, James S. O'Donnell, Jamie M. O'Sullivan, George Hamilton, Dominick J. H. McCabe
Summary: The study found that VWF:Ag levels were higher and VWFpp/VWF:Ag ratios were lower in early symptomatic patients with carotid stenosis compared to asymptomatic patients, and these levels decreased over time. Additionally, there was a difference in VWF:Ag levels between patients with blood group O and those without blood group O.
THROMBOSIS AND HAEMOSTASIS
(2021)
Letter
Peripheral Vascular Disease
Aurelien Philippe, Nicolas Gendron, Olivier Bory, Agathe Beauvais, Tristan Mirault, Benjamin Planquette, Olivier Sanchez, Jean-Luc Diehl, Richard Chocron, David M. Smadja
Summary: The study found significant differences in VWF collagen-binding ability and ADAMTS13 activity in COVID-19 patients, with VWF:CB levels serving as a valuable clinical biomarker for microthrombosis and COVID-19 severity.
Article
Multidisciplinary Sciences
Kanwal Singh, Andrew C. Kwong, Hasam Madarati, Sharumathy Kunasekaran, Taylor Sparring, Alison E. Fox-Robichaud, Patricia C. Liaw, Colin A. Kretz
Summary: The study found that in septic patients, ADAMTS13 activity and antigen were reduced, while VWF antigen was elevated, with non-septic patients showing milder changes. These abnormalities persisted throughout the ICU stay and discharge in all patient cohorts, potentially contributing to a prothrombotic state in sepsis patients.
Editorial Material
Hematology
Colin A. Kretz
Summary: The study introduces a novel thrombolytic agent, Microlyse, which targets von Willebrand factor to activate plasminogen and has potential therapeutic applications for acute episodes of TTP.
Article
Hematology
Berangere S. Joly, Michael Darmon, Charlotte Dekimpe, Thibault Dupont, Guillaume Dumas, Elise Yvin, Nicolas Beranger, Karen Vanhoorelbeke, Elie Azoulay, Agnes Veyradier
Summary: Clinical features, hemostatic laboratory parameters, VWF/ADAMTS13 axis, and ADAMTS13 conformation were investigated in critically ill COVID-19 patients at admission. The study found that an imbalance between high VWF antigen levels and normal or slightly decreased ADAMTS13 activity levels correlated with mortality, suggesting that these markers may reflect inflammation and endothelial damage rather than driving the thrombotic process of COVID-19.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Hematology
Liang Zheng, Liyun Cao, X. Long Zheng
Summary: This study reveals the protective role of ADAMTS13 or lack of VWF in reducing irradiation and melanoma-induced thrombotic microangiopathy and mortality. The microenvironment created by plasma ADAMTS13 or lack of VWF may affect melanoma cell phenotypes through alteration of oxidation-reduction and lipid metabolic pathways.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Hematology
Shannen J. Deconinck, Christoph Nix, Svenja Barth, Eveline Bennek-Schoepping, Antoine Rauch, An-Sofie Schelpe, Elien Roose, Hendrik B. Feys, Inge Pareyn, Aline Vandenbulcke, Joshua Muia, Christophe Vandenbriele, Sophie Susen, Bart Meyns, Claudia Tersteeg, Steven Jacobs, Simon F. De Meyer, Karen Vanhoorelbeke
Summary: Acquired von Willebrand syndrome (aVWS) is common in patients with mechanical circulatory support devices and can lead to bleeding complications. Our study demonstrates that inhibiting ADAMTS13 with an anti-ADAMTS13 monoclonal antibody can prevent the degradation of von Willebrand factor (VWF) and improve hemostasis in these patients.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Review
Hematology
Dafna J. Groeneveld, Lauren G. Poole, James P. Luyendyk
Summary: Liver disease is associated with significant changes in the hemostatic system, with anticoagulants showing promise in slowing disease progression but also posing bleeding risks. Elevated levels of VWF may accelerate intrahepatic thrombosis, suggesting a potential link between VWF function and the progression of liver disease.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Cardiac & Cardiovascular Systems
Benjamin Reardon, Leonardo Pasalic, Emmanuel J. Favaloro
Summary: Von Willebrand factor (VWF) and ADAMTS13 play essential roles in hemostasis and thrombosis, and their balance can impact cardiac disease and other pathophysiological processes.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Review
Hematology
Xin Xu, Yao Feng, Yitong Jia, Xiao Zhang, Long Li, Xuesong Bai, Liqun Jiao
Summary: Abnormalities of VWF are associated with poor prognosis in COVID-19.
THROMBOSIS RESEARCH
(2022)
Review
Medicine, General & Internal
Parnian Alavi, Abhisha M. Rathod, Nadia Jahroudi
Summary: Endothelial cells have the capacity to express both pro and anticoagulant molecules, but they mainly function to maintain a non-thrombogenic surface under normal conditions. When stimulated, injured, or dysfunctional, endothelial cells release VWF, a procoagulant protein that plays a central role in platelet aggregation and thrombus formation. With aging, there is a significant increase in VWF levels, which correlates with a rise in thrombotic events, but the reasons for this age-related increase remain unclear.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Health Care Sciences & Services
Chanukya K. Colonne, Emmanuel J. Favaloro, Leonardo Pasalic
Summary: von Willebrand factor (VWF) and ADAMTS13 play important roles in normal hemostasis and can be involved in abnormal hemostasis in malignancy. VWF may also contribute to inflammation, angiogenesis, tumor biology, and tumor metastasis. VWF and ADAMTS13 have been explored as tumor biomarkers, but their clinical utility is currently limited. Further studies are needed to understand the relationships between VWF, ADAMTS13, and malignancy.
Article
Urology & Nephrology
Anna A. Bonenkamp, Anita van Eck van der Sluijs, Friedo W. Dekker, Dirk G. Struijk, Carola Wh de Fijter, Yolande M. Vermeeren, Frans J. van Ittersum, Marianne C. Verhaar, Brigit C. van Jaarsveld, Alferso C. Abrahams
Summary: This study aimed to identify modifiable causes and risk factors of technique failure in peritoneal dialysis. Results showed that infections, leakage, and catheter problems were important causes of technique failure. APD use was associated with a lower risk of technique failure.
PERITONEAL DIALYSIS INTERNATIONAL
(2023)
Article
Psychiatry
Els Nadort, Robbert W. Schouten, Rosa E. Boeschoten, Yves Smets, Prataap Chandie Shaw, Louis Jean Vleming, Marijke J. E. Dekker, Michiel Westerman, Ellen K. Hoogeveen, Willem J. W. Bos, Marcel Schouten, Karima Farhat, Friedo W. Dekker, Patricia van Oppen, Birit F. P. Broekman, Carl E. H. Siegert
Summary: This study investigated the effectiveness of a guided internet-based self-help intervention for hemodialysis patients with depressive symptoms. The results showed that this intervention did not seem to be effective in reducing depressive symptoms compared to usual care.
GENERAL HOSPITAL PSYCHIATRY
(2022)
Article
Transplantation
Esmee M. van der Willik, Fenna van Breda, Brigit C. van Jaarsveld, Marlon van de Putte, Isabelle W. Jetten, Friedo W. Dekker, Yvette Meuleman, Frans J. van Ittersum, Caroline B. Terwee
Summary: This study compared the content, validity, and reliability of PROMIS CATs and SF-12 in patients with chronic kidney disease. The results showed that PROMIS CATs had sufficient construct validity and test-retest reliability, and had a lower minimal detectable change compared to SF-12. The study suggests the need for further research on the feasibility of PROMIS CATs in nephrology care.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Edouard L. Fu, Josef Coresh, Morgan E. Grams, Catherine M. Clase, Carl-Gustaf Elinder, Julie Paik, Chava Ramspek, Lesley A. Inker, Andrew S. Levey, Friedo W. Dekker, Juan J. Carrero
Summary: Implementing the 2021 CKD-EPI equation in predominantly White European populations would slightly increase eGFR and reclassify a significant proportion of CKD patients to a higher eGFR category. eGFR by both equations strongly predicted outcomes.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Urology & Nephrology
Juan Jesus Carrero, Edouard L. Fu, Soren V. Vestergaard, Simon Kok Jensen, Alessandro Gasparini, Viyaasan Mahalingasivam, Samira Bell, Henrik Birn, Uffe Heide-Jorgensen, Catherine M. Clase, Faye Cleary, Josef Coresh, Friedo W. Dekker, Ron T. Gansevoort, Brenda R. Hemmelgarn, Kitty J. Jager, Tazeen H. Jafar, Csaba P. Kovesdy, Manish M. Sood, Benedicte Stengel, Christian F. Christiansen, Masao Iwagami, Dorothea Nitsch
Summary: The availability of electronic health records and routine measurements in kidney disease research provide opportunities but also pose challenges in terms of patient identification, marker usage, and outcome evaluation. The heterogeneity of definitions and the need to address biases are discussed, along with a proposed framework for reporting exposures and outcomes.
KIDNEY INTERNATIONAL
(2023)
Article
Sport Sciences
Floriana Samantha Luppino, Margien Elisabeth Den Hollander-Gijsman, Friedo Wilhelm Dekker, Kornelis Alexander Bartlema, Merel van Diepen
Summary: The study aimed to develop a validated instrument to accurately estimate the actual skills level of recreational skiers. The instrument was validated using multiple methods and proved to better reflect the actual skills levels compared with self-reportage.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS
(2023)
Article
Transplantation
Denise M. J. Veltkamp, Yiman Wang, Yvette Meuleman, Friedo W. Dekker, Wieneke M. Michels, Paul J. M. van der Boog, Aiko P. J. de Vries
Summary: This study investigated the relationship between symptom prevalence and burden with health-related quality of life (HRQOL) in kidney transplant recipients (KTRs). The results showed that female KTRs reported more symptoms and younger KTRs experienced more symptoms related to depression and changes in physical appearance.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Robin Lengton, Esmee M. van der Willik, Esther N. M. de Rooij, Yvette Meuleman, Saskia Le Cessie, Wieneke M. Michels, Marc Hemmelder, Friedo W. Dekker, Ellen K. Hoogeveen
Summary: This study investigated the association between residual estimated glomerular filtration rate (eGFR), dialysis adequacy, or serum phosphate level and chronic kidney disease-associated pruritus (CKD-aP) in incident dialysis patients. The results showed that higher residual eGFR and lower serum phosphate level, but not the dialysis dose, were related to a lower burden of CKD-aP in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Urology & Nephrology
Edouard L. Fu, Andrew S. Levey, Josef Coresh, Carl-Gustaf Elinder, Joris I. Rotmans, Friedo W. Dekker, Julie M. Paik, Peter Barany, Morgan E. Grams, Lesley A. Inker, Juan-Jesus Carrero
Summary: Cystatin C is recommended as a confirmatory test to eGFR when more precise estimates are needed for clinical decision making. However, it is uncertain whether eGFR(cr-cys) is the most accurate estimate in real-world settings, especially when there are large discordances between eGFR(cr) and eGFR(cys).
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Multidisciplinary Sciences
Mikko Haapio, Merel van Diepen, Retha Steenkamp, Jaakko Helve, Friedo W. Dekker, Fergus Caskey, Patrik Finne
Summary: Mortality prediction is crucial in long-term kidney replacement therapy (KRT) for treatment decisions and resource planning. Existing models have mostly been internally validated, but this study externally validated the performance of two previously constructed models in the Dutch and UK KRT populations. The models showed good performance and encourage widespread implementation in European KRT populations.
Article
Health Care Sciences & Services
Caroline B. Terwee, Esmee M. van der Willik, Fenna van Breda, Brigit C. van Jaarsveld, Marlon van de Putte, Isabelle W. Jetten, Friedo W. Dekker, Yvette Meuleman, Frans J. van Ittersum
Summary: This study evaluated the responsiveness and minimal important change of seven PROMIS CATs in Dutch patients. The results showed that PROMIS CATs had high responsiveness in physical function, fatigue, sleep disturbance, and depression domains, but did not perform as expected in anxiety and ability to participate in social roles and activities.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2023)
Article
Health Care Sciences & Services
Liselotte F. S. Langenhuijsen, Roemer J. Janse, Esmee Venema, David M. Kent, Merel van Diepen, Friedo W. Dekker, Ewout W. Steyerberg, Ype de Jong
Summary: Using the PROBAST, researchers explored the trends of risk of bias in prediction research and assessed the inter-rater agreement. They found that high bias was prevalent in the Analysis domain and the overall bias trends remained relatively stable over time. The inter-rater agreement was low and could potentially be improved by altering the PROBAST or providing training.
JOURNAL OF CLINICAL EPIDEMIOLOGY
(2023)
Article
Surgery
Yiman Wang, Paul van der Boog, Marc H. Hemmelder, Friedo W. Dekker, Aiko De Vries, Yvette Meuleman
Summary: The purpose of this article is to investigate the impact of symptom experience on health related quality of life (HRQOL) in kidney transplant recipients (KTRs) and whether illness perceptions mediated this impact. The findings suggest that worse symptom experiences could cause more unhelpful illness perceptions and consequently lead to lower HRQOL. The study highlights the importance of addressing symptom experiences and illness perceptions to improve HRQOL in kidney transplant recipients.
TRANSPLANT INTERNATIONAL
(2023)
Article
Urology & Nephrology
Esther N. M. de Rooij, Friedo W. Dekker, Saskia Le Cessie, Ewout J. Hoorn, Johan W. de Fijter, Ellen K. Hoogeveen
Summary: This study investigated the relationship between predialysis serum potassium level and death in hemodialysis patients and found a U-shaped relationship, with low serum potassium level associated with an increased risk of death.
Review
Urology & Nephrology
Nicholas C. Chesnaye, Vianda S. Stel, Giovanni Tripepi, Friedo W. Dekker, Edouard L. Fu, Carmine Zoccali, Kitty J. Jager
Summary: This article introduces the concept of inverse probability of treatment weighting (IPTW) and its application in adjusting for measured confounding in observational research, using a clinical example in nephrology. IPTW involves calculating the probability of exposure to the risk factor or intervention of interest based on individual characteristics (propensity score), and then calculating weights as the inverse of the propensity score. Application of these weights creates a pseudopopulation with balanced confounders across exposed and unexposed groups in studies, and it can also be applied in longitudinal studies to address informative censoring and time-dependent confounding.
CLINICAL KIDNEY JOURNAL
(2022)
