Article
Immunology
Lauren Goldschen, Jack Ellrodt, Hermioni L. Amonoo, Candace H. Feldman, Siobhan M. Case, Karestan C. Koenen, Laura D. Kubzansky, Karen H. Costenbader
Summary: Systemic lupus erythematosus (SLE) is a complex autoimmune disorder characterized by unpredictable disease flares. A connection between posttraumatic stress disorder (PTSD) and the development of SLE has been identified, suggesting that stress-related disorders alter susceptibility to SLE. Perturbations in the autonomic nervous system, neuroendocrine system, and at the genomic level may cause and sustain immune dysregulation, contributing to the development and propagation of SLE in those predisposed genetically.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Rheumatology
Mia T. Chandler, Leah M. Santacroce, Karen H. Costenbader, Seoyoung C. Kim, Candace H. Feldman
Summary: This study found that Black, Hispanic, and Asian individuals have higher odds of persistent high-dose steroid use compared to White individuals. Sustained access to outpatient care and the development of standardized steroid-tapering regimens from clinical trials with diverse populations may be targets for intervention to mitigate disparities in steroid-related adverse outcomes.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2023)
Article
Medicine, General & Internal
Lisa A. Brenner, Jeri E. Forster, Jaimie L. Gradus, Trisha A. Hostetter, Claire A. Hoffmire, Colin G. Walsh, Mary Jo Larson, Kelly A. Stearns-Yoder, Rachel Sayko Adams
Summary: This study aimed to identify the associations of military-related traumatic brain injury (TBI) with suicide and new-onset mental health conditions. The findings showed that soldiers with a history of TBI had higher rates of new-onset mental health conditions and were at greater risk of suicide. These results highlight the need for increased efforts to address the cumulative risk associated with multiple military-related exposures.
Article
Immunology
Haiping Xing, Haiyu Pang, Tian Du, Xufei Yang, Jing Zhang, Mengtao Li, Shuyang Zhang
Summary: In this study, atherosclerotic risk prediction model was built for SLE patients using RNA sequencing and differential expression analysis. The model, incorporating one gene and two clinical factors, demonstrated relatively high discrimination and calibration performance, providing valuable assistance for identifying atherosclerosis in SLE patients, especially asymptomatic ones.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Paul Curtiss, Amanda M. Walker, Benjamin F. Chong
Summary: This study reviewed patient cohorts and populations to investigate the progression of cutaneous lupus to systemic lupus. The study found variations in the progression rates between adult and pediatric groups, which were attributed to differences in patient populations, study design, diagnostic criteria, and follow-up time. Risk factors associated with the development of systemic lupus included positive anti-nuclear antibodies, hematologic abnormalities, and a higher number of lupus classification criteria at baseline.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Rheumatology
Xiaofeng Jiang, Jeffrey Sparks, Zachary Wallace, Xinjia Deng, Hui Li, Na Lu, Dongxing Xie, Yilun Wang, Chao Zeng, Guanghua Lei, Jie Wei, Yuqing Zhang
Summary: This study compares the risk of SARS-CoV-2 infection and severe sequelae in patients with systemic lupus erythematosus (SLE) and the general population, based on their COVID-19 vaccination status. It was found that unvaccinated patients with SLE had a higher risk of SARS-CoV-2 infection and severe sequelae compared to the general population. However, no significant differences were observed between vaccinated patients with SLE and the vaccinated general population during the 9-month follow-up.
Review
Biochemistry & Molecular Biology
Patricia Richter, Anca Cardoneanu, Ciprian Rezus, Alexandra Maria Burlui, Elena Rezus
Summary: Cardiovascular diseases are a leading cause of high mortality in SLE patients, and traditional risk factors are insufficient in predicting their risk. Inflammation has been found to play a crucial role in the development of atherosclerosis in SLE, highlighting the need for new biomarkers to assess subclinical CVD risk.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Rheumatology
Candace H. Feldman, Chang Xu, Karen H. Costenbader
Summary: It was found that Medicaid beneficiaries with SLE who are not vaccinated are at risk for potentially avoidable acute care use for vaccine-preventable illnesses, with higher risk among Black patients compared to White patients. Greater outpatient use was associated with reduced risk.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Multidisciplinary Sciences
Yuan-yuan Qi, Yan Cui, Hui Lang, Ya-ling Zhai, Xiao-xue Zhang, Xiao-yang Wang, Xin-ran Liu, Ya-fei Zhao, Xiang-hui Ning, Zhan-zheng Zhao
Summary: Genetic studies have linked the rs10947540 single-nucleotide polymorphism (SNP) in the ZNF76 gene with susceptibility to systemic lupus erythematosus (SLE) in Chinese populations. Carrier individuals of the C allele of rs10947540 were found to have a higher risk of developing SLE with elevated levels of serum creatinine. Bioinformatic analysis revealed a correlation between this SNP and decreased expression of ZNF76, suggesting a potential role in the pathogenesis of SLE.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Kaichi Kaneko, Hao Chen, Matthew Kaufman, Isaak Sverdlov, Emily M. Stein, Kyung-Hyun Park-Min
Summary: Osteonecrosis is a complex and devastating complication of systemic lupus erythematosus, with variable prevalence in SLE patients. The use of high-dose glucocorticoid therapy is strongly associated with the development of osteonecrosis in SLE patients, although the exact pathophysiology and risk factors for osteonecrosis in this population are not fully understood.
CLINICAL AND TRANSLATIONAL MEDICINE
(2021)
Letter
Medicine, General & Internal
Or Duek, Tobias R. Spiller, Arielle Rubenstein, Robert H. Pietrzak, Ilan Harpaz-Rotem
Summary: This study evaluates a new model of posttraumatic stress disorder, which categorizes symptoms as internally and externally cued, and compares it with existing models.
Review
Biochemistry & Molecular Biology
Valeria Rella, Cinzia Rotondo, Alberto Altomare, Francesco Paolo Cantatore, Addolorata Corrado
Summary: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with a wide range of clinical manifestations. Dysregulation of the immune system due to genetic, hormonal, and environmental factors can lead to various complications, including bone involvement such as osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Chien-Chih Lai, Yi-Syuan Sun, Fang-Chi Lin, Chih-Yu Yang, Chang-Youh Tsai
Summary: Analysis of bronchoalveolar lavage fluid (BALF) reveals high prevalence rates of PJP and CMV infections in SLE patients with pneumonia and respiratory failure. Thrombocytopenia, bacteremia, and PJP are identified as risk factors for increased 30-day mortality in SLE patients.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Review
Immunology
Christopher B. Oliveira, Mariana J. Kaplan
Summary: Patients with systemic lupus erythematosus (SLE) have a higher risk of cardiovascular diseases, and traditional risk factors cannot fully explain this increased risk. SLE-specific factors, such as immune dysregulation and inflammation, may contribute to the development of cardiovascular diseases in SLE patients.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Shunxiang Li, Huihua Ding, Ziheng Qi, Jing Yang, Jingyi Huang, Lin Huang, Mengji Zhang, Yuanjia Tang, Nan Shen, Kun Qian, Qiang Guo, Jingjing Wan
Summary: Serum metabolic fingerprints can be used for disease diagnosis and biomarker discovery. By analyzing the serum metabolic fingerprints of systemic lupus erythematosus (SLE) patients and healthy controls, early diagnosis and precision medicine for SLE can be achieved. This study identified the unique metabolic pattern of SLE patients and screened out a panel of metabolic biomarkers.
Article
Rheumatology
Cameron B. Speyer, Daniel Li, Hongshu Guan, Kazuki Yoshida, Emma Stevens, April M. Jorge, Brendan M. Everett, Candace H. Feldman, Karen H. Costenbader
RHEUMATOLOGY INTERNATIONAL
(2020)
Article
Rheumatology
Sonali P. Desai, Cianna Leatherwood, Malka Forman, Eunji Ko, Emma Stevens, Maura Iversen, Chang Xu, Bing Lu, Daniel H. Solomon
Summary: Using a quality improvement approach, this study integrated a treat-to-target approach for rheumatoid arthritis (RA) through routine electronic collection of patient-reported disease activity scores and a multidisciplinary learning collaborative for rheumatologists. The results showed a significant increase in treat-to-target implementation scores among intervention rheumatologists compared to the control group, with a lower likelihood of medication changes in the intervention group for patients with high RAPID3 scores.
ARTHRITIS CARE & RESEARCH
(2021)
Article
Rheumatology
Jing Cui, Soumya Raychaudhuri, Elizabeth W. Karlson, Cameron Speyer, Susan Malspeis, Hongshu Guan, Jeffrey A. Sparks, Hongru Ni, Xinyi Liu, Emma Stevens, Jessica N. Williams, Emma E. Davenport, Rachel Knevel, Karen H. Costenbader
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Brittany N. Weber, Emma Stevens, Lourdes M. Perez-Chada, Jenifer M. Brown, Sanjay Divakaran, Camden Bay, Courtney Bibbo, Jon Hainer, Sharmila Dorbala, Ron Blankstein, Viviany R. Taqueti, Joseph F. Merola, Elena Massarotti, Karen Costenbader, Katherine Liao, Marcelo F. Di Carli
JACC-CARDIOVASCULAR IMAGING
(2020)
Article
Rheumatology
Siobhan Case, Corine Sinnette, Courtnie Phillip, Claire Grosgogeat, Karen H. Costenbader, Cianna Leatherwood, Candace H. Feldman, Mary Beth Son
Summary: This study explored challenges faced by SLE and cSLE patients, identifying modifiable influences and coping strategies based on personal experiences. Participants identified five primary challenges with SLE, including diagnostic odyssey, public versus private face of SLE, SLE-related stresses, medication adherence, and transitioning from pediatric to adult care. Coping strategies and modifiable factors such as social support, open communication about SLE, and strong patient-provider relationships were highlighted.
Article
Rheumatology
May Y. Choi, Jill Hahn, Susan Malspeis, Emma F. Stevens, Elizabeth W. Karlson, Jeffrey A. Sparks, Kazuki Yoshida, Laura Kubzansky, Karen H. Costenbader
Summary: This study found that adherence to a combination of healthy lifestyle factors is associated with a lower risk of incident systemic lupus erythematosus (SLE). Women with more healthy lifestyle factors had the lowest risk of SLE. Assuming adherence to at least 4 healthy lifestyle behaviors in the entire population, the risk of developing SLE could be reduced by approximately 50%.
ARTHRITIS & RHEUMATOLOGY
(2022)
Letter
Rheumatology
May Y. Choi, Jill Hahn, Susan Malspeis, Emma F. Stevens, Elizabeth W. Karlson, Jeffrey A. Sparks, Kazuki Yoshida, Laura Kubzansky, Karen H. Costenbader
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Pediatrics
Siobhan M. Case, Peter A. Nigrovic
Summary: The classification of inflammatory arthritis separates childhood onset diseases from those that start in adulthood. However, it is now clear that most forms of arthritis transcend the pediatric/adult boundary and that drugs generally show comparable success, regardless of age of onset, which offers new opportunities in drug development and regulation focused on pharmacology and safety.
Article
Rheumatology
Siobhan M. Case, Gail S. Kerr, Mia Chandler, Valerie E. Stone, Irene Blanco, Candace H. Feldman
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Rheumatology
Emma Stevens, Michael E. Weinblatt, Elena Massarotti, Frances Griffin, Srinivas Emani, Sonali Desai
ACR OPEN RHEUMATOLOGY
(2020)
Article
Health Care Sciences & Services
Sonali Desai, Emma Stevens, Srinivas Emani, Peter Meyers, Maura Iversen, Daniel H. Solomon
JMIR FORMATIVE RESEARCH
(2020)