Journal
VIRUSES-BASEL
Volume 13, Issue 6, Pages -Publisher
MDPI
DOI: 10.3390/v13061037
Keywords
antibodies; Fc effector functions; emerging viruses
Categories
Funding
- Intramural Research Program of the NIH
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This review discusses recent studies that have identified the crucial role of Fc-FcγR interactions in antibody-based protection against emerging and re-emerging virus infections, primarily using mouse models.
Identification of therapeutics against emerging and re-emerging viruses remains a continued priority that is only reinforced by the recent SARS-CoV-2 pandemic. Advances in monoclonal antibody (mAb) isolation, characterization, and production make it a viable option for rapid treatment development. While mAbs are traditionally screened and selected based on potency of neutralization in vitro, it is clear that additional factors contribute to the in vivo efficacy of a mAb beyond viral neutralization. These factors include interactions with Fc receptors (FcRs) and complement that can enhance neutralization, clearance of infected cells, opsonization of virions, and modulation of the innate and adaptive immune response. In this review, we discuss recent studies, primarily using mouse models, that identified a role for Fc-Fc gamma R interactions for optimal antibody-based protection against emerging and re-emerging virus infections.
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