Journal
VIRUSES-BASEL
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/v13081514
Keywords
SARS-CoV-2; COVID-19; variant of concern; L452R; R346K; spike
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The spike protein of SARS-CoV-2 is evolving to increase transmissibility and evade immune responses, with genomic sequencing identifying single-point mutations and deletions. A strain of SARS-CoV-2 belonging to a previously unassociated lineage has been found to have decreased susceptibility to vaccine-induced neutralization.
SARS-CoV-2 spike is evolving to maximize transmissibility and evade the humoral response. The massive genomic sequencing of SARS-CoV-2 isolates has led to the identification of single-point mutations and deletions, often having the recurrence of hotspots, associated with advantageous phenotypes. We report the isolation and molecular characterization of a SARS-CoV-2 strain, belonging to a lineage (C.36) not previously associated with concerning traits, which shows decreased susceptibility to vaccine sera neutralization.
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