Journal
VIRUS GENES
Volume 57, Issue 4, Pages 358-368Publisher
SPRINGER
DOI: 10.1007/s11262-021-01854-9
Keywords
EBV; eIF4E; miRNA; BART11-3p; Gastric carcinoma
Categories
Funding
- National Natural Science Foundation of China [NSFC 81571995]
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eIF4E expression is lower in EBV-associated gastric carcinoma compared to other types of gastric carcinoma, and its downregulation can lead to increased apoptosis, S phase retardation, and decreased cell migration in gastric carcinoma. EBV-miR-BART11-3p directly targets eIF4E and is the key factor in its downregulation.
The eukaryotic translation initiation factor 4E (eIF4E) is a component of the eukaryotic translation initiation factor 4F, a significant complex in the protein translation process. It has been found to be closely related to many human tumors, such as gastric carcinoma. It is known that the Epstein-Barr virus (EBV) upregulates eIF4E in various ways in nasopharyngeal carcinoma. However, there are very few studies on eIF4E in EBV-associated gastric carcinoma. We found that the expression level of eIF4E in EBV-associated gastric carcinoma was lower than other types of gastric carcinoma, and the downregulation of eIF4E could lead to increased apoptosis of gastric carcinoma cells, retardation at S phase, and decreased cell migration. The dual luciferase reporter experiment showed that EBV-miR-BART11-3p could directly target the 3'-UTR region of eIF4E, and BART11-3p is the key factor leading to the downregulation of eIF4E. It could provide a new evidence for EBV-regulating host gene to affect the development of gastric carcinoma.
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