Article
Biochemistry & Molecular Biology
Zachery R. Reichert, Tadas Kasputis, Srinivas Nallandhighal, Sophia M. Abusamra, Amy Kasputis, Saloni Haruray, Yugang Wang, Shamara Williams, Udit Singhal, Ajjai Alva, Frank C. Cackowski, Megan E. V. Caram, Phillip L. Palmbos, Sarah E. Yentz, David C. Smith, Joshi J. Alumkal, Todd M. Morgan
Summary: The biological heterogeneity of metastatic prostate cancer affects personalized therapeutic approaches. A liquid biopsy approach can identify blood-based prognostic biomarkers for predicting disease progression and treatment response in patients with metastatic hormone-sensitive prostate cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Christian Thomas, Martin Baunacke, Holger H. H. Erb, Susanne Fuessel, Kati Erdmann, Juliane Putz, Angelika Borkowetz
Summary: Combination therapy of standard ADT plus docetaxel or androgen receptor-axis-targeted therapy prolongs survival in metastatic hormone-sensitive prostate cancer, and triple therapy with standard ADT plus docetaxel plus abiraterone shows superior results. Ongoing studies are exploring the potential of triple therapy to become the new standard treatment for mHSPC in the future.
Review
Biochemistry & Molecular Biology
Mirian Galliote Morale, Rodrigo Esaki Tamura, Ileana Gabriela Sanchez Rubio
Summary: Metformin is the most widely used drug for type 2 diabetes and has shown antitumor activity in various types of cancer cells. In vitro studies have demonstrated that metformin regulates almost all hallmarks of cancer and has the potential to synergize with other chemotherapeutic agents.
Article
Oncology
Min Joon Lee, Viranda H. Jayalath, Wei Xu, Lin Lu, Stephen J. Freedland, Neil E. Fleshner, Girish S. Kulkarni, Antonio Fineni, Theodorus H. van Der Kwast, Robert J. Hamilton
Summary: The relationship between metformin use and prostate cancer risk is controversial, with metformin use associated with increased risk of high-grade and overall prostate cancer. SNPs involved in metformin metabolism did not modify disease risk association, but two SNPs from the GWAS study did.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Oncology
Emuejevoke Olokpa, Sammed N. Mandape, Siddharth Pratap, La Monica Stewart
Summary: The study used RNA sequencing to identify the signaling pathways regulated by metformin in androgen-receptor positive, castration-resistant prostate cancer cells. Metformin was found to alter the expression of genes involved in metabolic pathways, the spliceosome, RNA transport, and protein processing within the endoplasmic reticulum, as well as in ErbB, insulin, mTOR, TGF-beta, MAPK, and Wnt signaling pathways. Some of the metformin-regulated genes are known to be direct transcriptional targets of p53 or AR, and metformin-induced reductions in AR mRNA and protein levels contributed to these alterations in gene expression.
Article
Oncology
Chunyang Chen, He Wang, Xinyu Geng, Dongze Zhang, Zhengyu Zhu, Guangbo Zhang, Jianquan Hou
Summary: This study confirmed the inhibitory effect of metformin on prostate cancer cell lines, with mechanisms involving autophagy and cell cycle arrest at G0/G1 phase. Metformin induced AMPK activation, promoted LC3II expression, and down-regulated p62/SQSTM1 expression. Animal experiments demonstrated that metformin reduced tumor volume, upregulated p-AMPK (Thr172) and LC3B, and downregulated Ki-67 levels without abnormal biochemical indicators.
CANCER CELL INTERNATIONAL
(2021)
Article
Cell Biology
Jiahong Chen, Yaqiang Huang, Zhenfeng Tang, Maozhang Li, Xiaohui Ling, Jinxian Liao, Xiaobo Zhou, Shumin Fang, Haibo Zhao, Weide Zhong, Xia Yuan
Summary: The study identified that activation of ECE1, ABCA12, BPY2, EEF1A1, RAD9A, and NIPSNAP1 genes can lead to resistance of prostate cancer cells to metformin, with RAD9A playing the most significant role in resistance. High levels of RAD9A may upregulate regulatory T cells in the tumor immune microenvironment to counterbalance the effects of metformin.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jianheng Ye, Shanghua Cai, Yuanfa Feng, Jinchuang Li, Zhiduan Cai, Yulin Deng, Ren Liu, Xuejin Zhu, Jianming Lu, Yangjia Zhuo, Yingke Liang, Jianjiang Xie, Yanqiong Zhang, Huichan He, Zhaodong Han, Zhenyu Jia, Weide Zhong
Summary: The therapeutic efficacy of metformin in prostate cancer (PCa) is uncertain, possibly due to transcriptional dysregulation and cell cycle reactivation leading to drug resistance. Super-enhancers (SEs) are associated with drug resistance in various cancers, and PTGR1 expression is significantly increased in metformin-resistant PCa cells. PTGR1 overexpression promotes cell cycle progression and reduces metformin sensitivity. Key transcription factors SRF and RUNX3 significantly increase PTGR1 expression, providing potential targets to address metformin resistance in PCa.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Medicine, General & Internal
Tomislav Omrcen
Summary: ADT has been the standard treatment for mHSPC for many years. However, recent studies have shown that combining ADT with docetaxel or ARTA can significantly improve survival. Future research might consider triple therapy as an option for mHSPC patients.
ACTA CLINICA CROATICA
(2022)
Article
Multidisciplinary Sciences
Hye Yeon Koo, Su-Min Jeong, Mi Hee Cho, Sohyun Chun, Dong Wook Shin, Jinsung Park
Summary: Aspirin and metformin use may be associated with lower prostate cancer incidence and mortality, while statins are not associated with either.
SCIENTIFIC REPORTS
(2021)
Review
Oncology
Giuseppe Napoli, Stefano Arcangeli, Bruno Fionda, Fernando Munoz, Umberto Tebano, Emilia Durante, Marcello Tucci, Roberto Bortolus, Marco Muraro, Giulia Rinaldi, Nicoletta Luca, Francesco Fiorica
Summary: This systematic review and meta-analysis aimed to estimate the probabilities of progression-free survival (PFS) and overall survival (OS) in patients with metastatic hormone-sensitive prostate cancer (mHSPC) treated with standard androgen deprivation treatment (ADT). The study found that PFS and OS varied greatly among patients, and high-volume disease and the presence of visceral metastases were associated with shorter survival.
CURRENT ONCOLOGY REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mike Sathekge, Frank Bruchertseifer, Mariza Vorster, Ismaheel O. Lawal, Kgomotso Mokoala, Janet Reed, Letjie Maseremule, Honest Ndlovu, Khanyi Hlongwa, Alex Maes, Alfred Morgenstern, Christophe Van de Wiele
Summary: In this retrospective study, we evaluated the treatment outcome of Ac-225-PSMA-617 radioligand therapy in patients with de novo metastatic hormone-sensitive prostate carcinoma (mHSPC). The results showed that this treatment option had a good anti-tumor effect, with a significant decline in PSA levels in the majority of patients and minimal side effects.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Hanan Goldberg, Faizan K. Mohsin, Alejandro Berlin, Thenappan Chandrasekar, Christopher J. D. Wallis, Zachary Klaassen, Ardalan E. Ahmad, Refik Saskin, Miran Kenk, Olli Saarela, Girish S. Kulkarni, Shabbir M. H. Alibhai, Neil Fleshner
Summary: The study found that diabetic men receiving metformin treatment had a lower risk of prostate cancer diagnosis, undergoing additional prostate biopsies, and receiving androgen deprivation therapy.
UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS
(2021)
Review
Medicine, General & Internal
Shahneen Sandhu, Caroline M. Moore, Edmund Chiong, Himisha Beltran, Robert G. Bristow, Scott G. Williams
Summary: Management of prostate cancer is rapidly evolving with advances in understanding the genomic landscape, improved imaging methods, and personalised therapeutics targeting DNA repair pathways. The therapeutic framework for metastatic disease has shifted, with oligometastatic disease being evaluated for metastatic-directed therapies, and novel androgen pathway inhibitors showing significant survival benefits as first-line therapy for metastatic disease. Emerging research into molecular characterisation and novel therapeutics, such as targeted radioisotopes and immunotherapy, hold promise for improving patient outcomes.
Article
Oncology
Carlos E. Stecca, Di Maria Jiang, Zachary Veitch, Sebastian J. Hotte, Nimira Alimohamed, Lori Wood, Srikala S. Sridhar
Summary: We conducted an online survey of genitourinary medical oncologists in Canada and found that the COVID-19 pandemic has led to an increased use of ARATs and a reduced use of docetaxel in the treatment of mHSPC, and this trend is expected to continue post-pandemic.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Oncology
S. Elsamany, A. Alzahrani, W. N. Abozeed, A. Rasmy, M. U. Farooq, M. A. Elbiomy, E. Rawah, K. Alsaleh, N. M. Abdel-Aziz
Article
Oncology
Salah Aref, El Sayed Kamel Areida, Mohamed Fathy Abdel Aaal, Ola Mohamed Adam, Mohamed Sabry El-Ghonemy, Mohamed Ali El-Baiomy, Tarek Abou Zeid
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2015)
Article
Oncology
Salah Aref, Nadia El Menshawy, Mohamed Sabry El-Ghonemy, Tarek Abou Zeid, Mohamed Ali El-Baiomy
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA
(2016)
Article
Oncology
Salaf Aref, Mohamed El-Ghonemy, Tarek Abouzeid, Amr El-Sabbagh, Mohamed El-Baiomy
Article
Oncology
Salah Aref, Mohamed Sabry El-Ghonemy, Tarek Elsayed Abouzeid, Amr Mohamed El-Sabbagh, Mohamed Ali El-Baiomy
Article
Oncology
M. A. Elbaiomy, Tamer Akl, Nadia Atwan, Ahmed Ali Elsayed, Maha Elzaafarany, S. Shamaa
JOURNAL OF ONCOLOGY
(2020)
Article
Oncology
Shereef Elsamany, Mohamed Elbaiomy, Ahmed Zeeneldin, Emad Tashkandi, Fayza Hassanin, Nafisa Abdelhafeez, Humaid O. Al-Shamsi, Nedal Bukhari, Omima Elemam
Summary: Managing breast cancer during the COVID-19 pandemic poses challenges due to the impact on patients' immune systems and treatment options. Survey results indicate support for modifications in treatment strategies, which should be adapted based on local infrastructure and resources.
Article
Oncology
M. A. Elbaiomy, T. Akl, R. Elhelaly, W. El-Beshbishi, M. S. El Ghonemy, R. Elzehery
Meeting Abstract
Oncology
M. El Baiomy, W. El Kashef, M. El Zafarany