Review
Biochemistry & Molecular Biology
Marco Terreni, Marina Taccani, Massimo Pregnolato
Summary: This paper examines the issue of antibiotic resistance and multidrug-resistant bacterial strains, analyzing possible strategies and listing the most promising new chemical compounds.
Article
Biochemistry & Molecular Biology
Marta Woroszylo, Daria Ciecholewska-Jusko, Adam Junka, Radoslaw Drozd, Marcin Wardach, Pawel Migdal, Patrycja Szymczyk-Ziolkowska, Daniel Styburski, Karol Fijalkowski
Summary: The combination of rotating magnetic field (RMF) with beta-lactam antibiotics shows promising results in enhancing the antibacterial effects against methicillin-resistant Staphylococcus aureus (MRSA) by causing morphological alterations in bacterial cells. This study provides potential new treatment options for MRSA infections by utilizing the disruptive effect of RMF on bacterial cell walls.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Engineering, Environmental
Ashish Kothari, Prashant Kumar, Amit Gaurav, Karanvir Kaushal, Atul Pandey, Shashi Ranjan Mani Yadav, Neeraj Jain, Balram Ji Omar
Summary: The emergence of multidrug-resistant bacteria poses a significant threat to global public health. Majority of clinical bacteria are found to be multidrug-resistant, with antibiotic resistance genes on their plasmids that can be horizontally transferred. The presence of optimal concentration of antibiotics or heavy metals facilitates horizontal gene transfer. High levels of arsenic in water were discovered in the Shukratal region of India, corresponding to high serum arsenic levels in infected individuals and increased antibiotic resistance in bacterial strains isolated from that area. This research highlights the imminent threats to global health due to improper waste disposal, increased antibiotic concentrations and human interference.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Review
Public, Environmental & Occupational Health
Guojun Sun, Qian Zhang, Zuojun Dong, Dashun Dong, Hui Fang, Chaojun Wang, Yichen Dong, Jiezhou Wu, Xuanzhe Tan, Peiyao Zhu, Yuehua Wan
Summary: This paper reviewed research on antibiotic-resistant bacteria (ARB) from 2010 to 2020 using bibliometrics. The analysis provided insights into the countries, institutions, journals, authors, research areas, and research trends in the field. The findings revealed an increasing number of studies over the years, with the USA and China being the most active research countries and environmental sciences and ecology being the most popular research areas.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Biochemistry & Molecular Biology
Azza Troudi, Jean Michel Bolla, Naouel Klibi, Jean Michel Brunel
Summary: Gram-negative bacteria pose a significant threat to public health due to the spread of drug resistance and the lack of effective alternative treatments. This study presents a promising strategy to combat resistant strains by combining a macrolide antibiotic with a polyaminoisoprenyl adjuvant derivative, resulting in a significant decrease in antibiotic resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
Adeoye John Kayode, Anthony Ifeanyi Okoh
Summary: Antimicrobial resistance poses a significant threat to the health sector and the management of microbial infections. This study analyzed the susceptibility of 194 Listeria monocytogenes isolates and investigated the risk of listeriosis associated with ready-to-eat foods and the empirical treatment of L. monocytogenes infections. The results showed high levels of antimicrobial resistance against prescribed and non-prescribed antimicrobials, indicating a potentially high risk of L. monocytogenes infection.
Article
Medicine, General & Internal
Sabrine Mzilem, Sadok Boukhchina
Summary: This study investigated the frequency of capsulated ampicillin-resistant Haemophilus influenzae strains, particularly capsular serotype b, isolated from children in Tunisia. The molecular mechanisms underlying ampicillin resistance were determined by PCR. The results showed that PCR can help decrease the transmission of these strains among children in Tunisia.
Review
Infectious Diseases
Jinzhou Ye, Xinhai Chen
Summary: Infections caused by antibiotic-resistant bacteria are a major global health challenge. This review compiles the most promising strategies currently under development to tackle antibiotic resistance, including the discovery of novel antibiotics, improvement of existing antibiotics, and the development of alternatives to conventional antibiotics. Clinical or preclinical studies show the great potential of these treatments against antibiotic-resistant bacteria, with some products expected to become commercially available soon.
Review
Environmental Sciences
Evdokia Syranidou, Nicolas Kalogerakis
Summary: This paper examines the interactions between microplastics and antibiotics, discussing the important factors influencing these interactions in different environments, as well as the relationships between microplastics, antibiotics, and antibiotic resistant bacteria in wastewater treatment plants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Environmental Sciences
Shuai Zhang, Yu Zhang, Yue Wang, Xingxiang Liu, Muyu Li, Hao Fang, Ming Kong
Summary: Surface runoff is a main pathway for emerging pollutants, including antibiotics, antibiotic-resistant bacteria, and antibiotic resistance genes, to enter marine sediments. This study investigates the impact of emerging pollutants on the fate of antibiotic resistance genes in marine sediments from different seas in China. The results show that antibiotic exposure generally decreases the relative abundance of most antibiotic resistance genes, but there are exceptions with increased abundance observed in certain conditions. The findings suggest that dosing with emerging pollutants does not increase antibiotic resistance gene abundance in marine sediments.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biotechnology & Applied Microbiology
Zhien He, Yongqiang Yang, Wei Li, Xiaoling Ma, Changfeng Zhang, Jingxiang Zhang, Baolin Sun, Tao Ding, Guo-Bao Tian
Summary: This study provides important information on Enterobacteriaceae bacteria carrying mcr-like genes and serves as a reference for the study of mcr-1 transmission in China and globally.
Article
Infectious Diseases
Paulina Paprocka, Bonita Durnas, Angelika Mankowska, Karol Sklodowski, Grzegorz Krol, Magdalena Zakrzewska, Michal Czarnowski, Patrycja Kot, Kamila Fortunka, Stanislaw Gozdz, Paul B. Savage, Robert Bucki
Summary: The study demonstrates that ceragenins exhibit high activity against clinical strains of Pseudomonas aeruginosa with low potential for resistance development. When used in conjunction with poloxamer 407, ceragenins show controlled toxicity, supporting their potential development as new antibiotics to combat infections caused by antibiotic resistant strains of Pseudomonas aeruginosa.
INFECTION AND DRUG RESISTANCE
(2021)
Article
Immunology
Katherine E. Goodman, Jonathan D. Baghdadi, Laurence S. Magder, Emily L. Heil, Mark Sutherland, Ryan Dillon, Laura Puzniak, Pranita D. Tamma, Anthony D. Harris
Summary: There is significant variability in the use of empiric gram-negative antibiotics among hospitalized adults in the United States, with potential disparities based on sex and race.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Microbiology
Daniel F. M. Monte, Matthew A. Nethery, Hanna Berman, Shivaramu Keelara, Nilton Lincopan, Paula J. Fedorka-Cray, Rodolphe Barrangou, Mariza Landgraf
Summary: This study characterized the resistome, phylogenetic structure, and CRISPR array composition of Salmonella enterica serovar Heidelberg strains isolated from the poultry production chain in Brazil. The results showed that these strains have a broad host range and are multidrug-resistant, with a widespread distribution of antibiotic-resistant strains from farm to market. The study also highlights the potential role of S. Heidelberg as a key pathogen disseminated from farm to fork and emphasizes the importance of CRISPR-based genotyping for salmonellae.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Engineering, Environmental
Oussama Baaloudj, Imen Assadi, Noureddine Nasrallah, Atef El Jery, Lotfi Khezami, Aymen Amin Assadi
Summary: The photocatalytic process has been proposed as an efficient and environmentally friendly method for treating water environment pollution, showing promising results in the removal of antibiotics and antibiotic-resistant bacteria. Recent studies have focused on process parameters and semiconductor photocatalysts to achieve impressive treatment efficiencies for both organic and microbial pollutants.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Article
Immunology
Caoimhe M. K. Lynch, Caitlin S. M. Cowan, Thomaz F. S. Bastiaanssen, Gerard M. Moloney, Nigel Theune, Marcel van de Wouw, Eva Florensa Zanuy, Ana Paula Ventura-Silva, Martin G. Codagnone, Francisca Villalobos-Manriquez, Matilde Segalla, Fatma Koc, Catherine Stanton, Paul Ross, Timothy G. Dinan, Gerard Clarke, John F. Cryan
Summary: Numerous studies have shown that the gut microbiota plays a crucial role in neurodevelopment and behavior. Early-life exposure to antibiotics has been associated with increased risk of immune and metabolic diseases. Targeted antibiotic-induced disruption of the microbiota during critical developmental periods has enduring effects on physiology and behavior. This study demonstrates that microbiota disruption during early life alters the structure and function of the caecal microbiome, as well as immune cells and neurophysiology in adolescence. However, the effects on behavior are limited and subtle, suggesting the importance of the gut microbiota during critical windows of development.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Amel Sami, Imad Elimairi, C. Anthony Ryan, R. Paul Ross, Catherine Stanton
Summary: This study investigates the impact of the smokeless tobacco product Toombak on the body's cortisol response and analyzes the psycho-dependency level of Toombak users. The results show that Toombak users have significantly lower hair cortisol levels compared to non-users, and they exhibit high levels of psycho-dependency and nicotine tolerance.
Article
Biochemistry & Molecular Biology
Mingjie Li, Jiuhong Ding, Catherine Stanton, R. Paul Ross, Jianxin Zhao, Bo Yang, Wei Chen
Summary: In this study, it was found that B. longum subsp. infantis FJSYZ1M3 could alleviate DSS-induced colitis through various mechanisms, including maintaining the intestinal barrier, regulating inflammatory cytokines, and modifying the gut microbiota.
Article
Biochemistry & Molecular Biology
Shane E. E. Somers, Gabrielle L. L. Davidson, Crystal N. N. Johnson, Michael S. S. Reichert, Jodie M. S. Crane, R. Paul Ross, Catherine Stanton, John L. L. Quinn
Summary: This study investigates the gut microbiota of wild great tits and finds that they are closely related to the host's state and the environment, especially for nestlings. The study also discovers that the gut microbiota is most sensitive during early development and is associated with environmental factors such as reproductive timing and hatching location. These findings are crucial for understanding the role of gut microbiota in the fitness of animals.
Article
Gastroenterology & Hepatology
Colin Buttimer, Ekaterina V. Khokhlova, Lisa Stein, Cara M. Hueston, Bianca Govi, Lorraine A. Draper, R. Paul Ross, Andrey N. Shkoporov, Colin Hill
Summary: This study isolates and characterizes six bacteriophages that can infect Ruminococcus gnavus, a gut microbe associated with inflammatory bowel disease. The phages have a temperate lifestyle and can coexist with the host bacterium without causing a significant reduction in its abundance. Analysis of gut virome data reveals a high abundance of these phages in individuals with IBD. This work provides insight into the interaction between phages and R. gnavus in the human gut microbiome.
Review
Gastroenterology & Hepatology
Susan Mills, Bo Yang, Graeme J. Smith, Catherine Stanton, R. Paul Ross
Summary: The colonization of Bifidobacterium in the neonatal gut highlights its significance to human health. Bifidobacterium longum is the most abundant species during early stages, but its levels decrease with age and in certain diseases. Research has revealed that B. longum produces bioactive molecules and can impact immune responses in various parts of the body. This review emphasizes the biological and clinical impacts of B. longum throughout different stages of human life, suggesting the need for further research and clinical trials to explore its potential in treating and preventing diseases.
Article
Microbiology
Ivan Sugrue, Daragh Hill, Paula M. O'Connor, Li Day, Catherine Stanton, Colin Hill, R. Paul Ross
Summary: This study describes a new variant of nisin, nisin E, produced by Streptococcus equinus strains isolated from sheep milk. The genome sequencing and analysis revealed similarities to nisin U, but with a unique rearrangement of the core peptide encoding gene. Nisin E showed antimicrobial activity against Lactobacillus, Bacillus, and Clostridiodes, and was immune to nisin U. The discovery of nisin E suggests its central role in the competitive nature of S. equinus.
Review
Food Science & Technology
Eleni Kamilari, Catherine Stanton, F. Jerry Reen, R. Paul Ross
Summary: This review highlights the biotechnological importance of the filamentous yeast-like fungus Geotrichum candidum, which is widely used as a starter in the dairy industry. The study found that aside from its role in the dairy and brewing industries, G. candidum has potential as a probiotic nutritional supplement in fish. Additionally, this species produces various biotechnologically important enzymes, antimicrobial compounds, and has bioremediation capabilities.
Article
Pediatrics
David B. Healy, Benjamin Campbell-Green, Vicki Livingstone, C. Anthony Ryan, R. Paul Ross, Catherine Stanton, Eugene M. Dempsey
Summary: The aim of this study was to evaluate the combined outcome of death and/or severe grade necrotising enterocolitis (NEC) in very preterm infants before and after the introduction of routine supplementation with Bifidobacterium bifidum and Lactobacillus acidophilus probiotics. The results showed a reduction in the composite outcome of severe grade NEC and/or death after the introduction of routine administration of probiotics.
Article
Chemistry, Medicinal
Shona Uniacke-Lowe, Fergus W. J. Collins, Colin Hill, R. Paul Ross
Summary: With the increase in antimicrobial resistance, the deep-sea fish microbiome can serve as a potential source of antimicrobials, including bacteriocins. In this study, bacterial isolates recovered from deep-sea fish were screened for antimicrobial activity and their genomic DNA was analyzed for bacteriocin and other antimicrobial metabolite genes. The study identified 147 candidate biosynthetic gene clusters, including 35 bacteriocin clusters, and discovered unique bacteriocin gene clusters encoding novel peptides. This dual approach provided insights into the bacteriocinogenic potential and antimicrobial molecules of the deep-sea isolates.
Review
Gastroenterology & Hepatology
Lauren Walsh, Colin Hill, R. Paul Ross
Summary: This review focuses on the potential effect of glyphosate exposure on the composition and functionality of the gut microbiome, highlighting the significance of gut microbiota to health.
Article
Infectious Diseases
Dhrati V. Patangia, Ghjuvan Grimaud, Kevin Linehan, R. Paul Ross, Catherine Stanton
Summary: This study investigated the impact of different drying off methods on the microbiota and resistome profile in colostrum and milk samples from cows. The results showed that the use of antibiotics during drying off increased microbial diversity and antibiotic resistance genes in milk. In contrast, the non-antibiotic group had a lower abundance of mastitis-causing pathogens and was associated with specific genera. These findings support the use of non-antibiotic alternatives for drying off in cows.
Review
Microbiology
Des Field, Miguel Fernandez de Ullivarri, R. Paul Ross, Colin Hill
Summary: Nisin, a highly post-translationally modified peptide, has been extensively studied over the past 100 years. While it has been used successfully as a food preservative, its potent activity against multidrug resistant microbes and potential for therapeutic use in treating bacterial infections has shifted the focus of research towards its biomedical applications. Recent developments have shed light on the biosynthesis, cellular location, and genetic regulation of nisin, and there is growing interest in its potential role in influencing the microbiome and in bioengineering novel variants for biomedical applications.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Nutrition & Dietetics
Xinqi Chen, Yang Chen, Catherine Stanton, Reynolds Paul Ross, Jianxin Zhao, Wei Chen, Bo Yang
Summary: This study aimed to investigate the dose-response effect of Bifidobacterium breve CCFM683 on relieving psoriasis and its underlying patterns. Specifically, the expression of keratin 16, keratin 17, and involucrin were substantially decreased by specific doses of the probiotic. Moreover, the gut microbiota in mice treated with the probiotic was rebalanced and the concentrations of colonic bile acids were positively correlated with the effectiveness of the strain in relieving psoriasis.
Article
Food Science & Technology
Kexue Chen, Xingya Zhou, Jianxin Zhao, R. Paul Ross, Catherine Stanton, Wei Chen, Bo Yang
Summary: This study explores the genetic diversity and functional gene features of L. johnsonii through comparative genomic analysis. The results show that L. johnsonii can be classified into two phylogenetic clusters, with differences in carbohydrate utilization genes, bacteriocin operon, extracellular polysaccharide gene cluster, and bile salt hydrolase encoding genes between the clusters.
