Journal
TRENDS IN CELL BIOLOGY
Volume 31, Issue 12, Pages 1019-1033Publisher
CELL PRESS
DOI: 10.1016/j.tcb.2021.06.011
Keywords
-
Categories
Funding
- Swiss National Science Foundation [310030_184801]
- German Research Foundation [AN377/3-3]
- Swiss National Science Foundation (SNF) [310030_184801] Funding Source: Swiss National Science Foundation (SNF)
Ask authors/readers for more resources
Nuclear pore complexes play a crucial role in higher eukaryotic cell division by rapidly disintegrating and reassembling, facilitating the progression of mitosis.
Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope (NE) that serve as selective gates for macromolecular transport between nucleus and cytoplasm. When higher eukaryotic cells prepare for division, they rapidly disintegrate NPCs during NE breakdown such that nuclear and cytoplasmic components mix to enable the formation of a cytoplasmic mitotic spindle. At the end of mitosis, reassembly of NPCs is coordinated with the establishment of the NE around decondensing chromatin. We review recent progress on mitotic NPC disassembly and reassembly, focusing on vertebrate cells. We highlight novel mechanistic insights into how NPCs are rapidly disintegrated into conveniently reusable building blocks, and put divergent models of (post-)mitotic NPC assembly into a spatial and temporal context.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available