Bioinspired materials and technology for advanced cryopreservation

Cryopreservation can help to meet the demand for biosamples of high medical value. However, it remains difficult to effectively cryopreserve some sensitive cells, tissues, and reproductive organs. A coordinated effort from the perspective of the whole frozen biological system is necessary to advance cryopreservation technology. Animals that survive in cold temperatures, such as hibernators and cold-tolerant insects, offer excellent natural models. Their anti-cold strategies, such as programmed suppression of metabolism and the synthesis of cryoprotec-tants (CPAs), warrant systematic study. Furthermore, the discovery and synthesis of metabolism-regulating and cryoprotective biomaterials, combined with biotechno-logical breakthroughs, can also promote the development of cryopreservation. Further advances in the quality and duration of biosample storage inspired by nature will promote the application of cryopreserved biosamples in clinical therapy.

Automated summary

Cryopreservation is important for meeting the demand for high value bio-samples, but remains challenging for sensitive cells and tissues. Coordinated efforts and studying natural anti-cold strategies are needed to advance cryopreservation technology. Discoveries in biomaterials and biotechnological breakthroughs can further promote the development of cryopreservation.