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Cryo-electron microscopy has enabled unprecedented progress in the quest to reveal the structure of the whole transcription preinitiation complex. Four recent studies pave the way for a complete description of how transcription is initiated at near-atomic level.

Automated summary

Cryo-electron microscopy has greatly advanced our understanding of the structure of the whole transcription preinitiation complex. Four recent studies have paved the way for a comprehensive description of transcription initiation at a near-atomic level.