4.7 Review

Nano-engineered screen-printed electrodes: A dynamic tool for detection of viruses

Journal

TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume 143, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.trac.2021.116374

Keywords

Screen-printed electrodes (SPEs); Nanomaterials; Immunoassays; Viruses; SARS CoV-2

Funding

  1. MIUR Grant Dipartimento di Eccellenza 2018-2022

Ask authors/readers for more resources

The article discusses the recent advancements in combining SPEs and various nanomaterials for detecting viral pathogens, highlighting the impact of nanomaterials on the analytical performance of portable SPE-based diagnostics. It provides insights into manufacturing methods and features, accompanied by a detailed table for readers to easily select based on the virus of interest.
There is a growing interest in the development of portable, cost-effective, and easy-to-use biosensors for the rapid detection of diseases caused by infectious viruses: COVID-19 pandemic has highlighted the central role of diagnostics in response to global outbreaks. Among all the existing technologies, screenprinted electrodes (SPEs) represent a valuable technology for the detection of various viral pathogens. During the last five years, various nanomaterials have been utilized to modify SPEs to achieve convincing effects on the analytical performances of portable SPE-based diagnostics. Herein we would like to provide the readers a comprehensive investigation about the recent combination of SPEs and various nanomaterials for detecting viral pathogens. Manufacturing methods and features advances are critically discussed in the context of early-stage detection of diseases caused by HIV-1, HBV, HCV, Zika, Dengue, and Sars-CoV-2. A detailed table is reported to easily guide readers toward the right choice depending on the virus of interest. (C) 2021 Elsevier B.V. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.7
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

Review Chemistry, Analytical

Point-of-Care for Evaluating Antimicrobial Resistance through the Adoption of Functional Materials

Sima Singh, Arshid Numan, Stefano Cinti

ANALYTICAL CHEMISTRY (2022)

Review Chemistry, Analytical

Advanced nanoengineered-customized point-of-care tools for prostate-specific antigen

Arshid Numan, Sima Singh, Yiqiang Zhan, Lijie Li, Mohammad Khalid, Kirsi Rilla, Sanjeev Ranjan, Stefano Cinti

Summary: This article discusses the prospects and challenges of integrating engineering sciences with cancer biology to develop nanotechnology-based tools for PCa diagnosis. The convergence of precision point-of-care diagnostic techniques provides sustainable solutions and real-time monitoring of changes in PSA levels in PCa diagnosis.

MICROCHIMICA ACTA (2022)

Article Chemistry, Analytical

Sweat urea bioassay based on degradation of Prussian Blue as the sensing architecture

Stefano Salatiello, Michele Spinelli, Chiara Cassiano, Angela Amoresano, Federico Marini, Stefano Cinti

Summary: Urea provides important pathophysiological information on renal and hepatic disorders. This study presents a rapid and reliable colorimetric urea bioassay that utilizes Prussian Blue as a pH sensing element. The method, optimized using design of experiments, can detect urea down to 0.05 mM with high accuracy.

ANALYTICA CHIMICA ACTA (2022)

Article Biophysics

Non-invasive electrochemistry-driven metals tracing in human biofluids

Aroosha Faheem, Stefano Cinti

Summary: Wearable analytical devices are the future of health monitoring, offering fast, decentralized, and human-centered solutions. Recent achievements focus on real-time, non-invasive monitoring of essential and toxic metals in bodily fluids.

BIOSENSORS & BIOELECTRONICS (2022)

Article Chemistry, Analytical

Plant Growth Monitoring: Design, Fabrication, and Feasibility Assessment of Wearable Sensors Based on Fiber Bragg Gratings

Daniela Lo Presti, Joshua Di Tocco, Sara Cimini, Stefano Cinti, Carlo Massaroni, Rosaria D'Amato, Michele A. A. Caponero, Laura De Gara, Emiliano Schena

Summary: Global climate change and population growth present challenges for agricultural outputs. Wearable sensors are being developed to monitor plant growth and microclimate parameters. This research proposes two wearable sensors based on fiber Bragg gratings, which have high sensitivity and can withstand various environmental factors. Experimental tests show that these sensors can effectively monitor dimensional changes in plants, offering promising applications in smart agriculture for improving crop quality, agricultural efficiency, and profits.

SENSORS (2023)

Article Chemistry, Analytical

Plant-Wear: A Multi-Sensor Plant Wearable Platform for Growth and Microclimate Monitoring

Joshua Di Tocco, Daniela Lo Presti, Carlo Massaroni, Stefano Cinti, Sara Cimini, Laura De Gara, Emiliano Schena

Summary: This study proposed a multi-sensor wearable platform for monitoring the growth of plant organs and microclimate. The platform consists of a custom flexible strain sensor and a commercial sensing unit, and showed promising results in preliminary tests.

SENSORS (2023)

Article Biochemical Research Methods

Design of a printed electrochemical strip towards miRNA-21 detection in urine samples: optimization of the experimental procedures for real sample application

Wanda Cimmino, Davide Migliorelli, Sima Singh, Antonella Miglione, Silvia Generelli, Stefano Cinti

Summary: MicroRNAs (miRNAs) are important clinical biomarkers for cancer diagnosis and prognosis. In this study, an electrochemical detection platform based on a screen-printed gold electrode was developed for the detection of miRNA. The platform showed high selectivity and sensitivity in both standard solutions and urine samples.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2023)

Article Chemistry, Multidisciplinary

Facile and Affordable Design of MXene-Co3O4-Based Nanocomposites for Detection of Hydrogen Peroxide in Cancer Cells: Toward Portable Tool for Cancer Management

Sima Singh, Arshid Numan, Mohammad Khalid, Ivana Bello, Elisabetta Panza, Stefano Cinti

Summary: This study presents a portable point-of-care electrochemical system based on MXene-Co3O4 nanocomposites to detect hydrogen peroxide (H2O2) in different cancer cell-lines. The developed sensor is affordable, disposable, and highly selective for H2O2 detection. The results show that this approach can monitor the variation of ROS in cancer cells, offering new perspectives for real-time monitoring of cancer progression and the efficacy of the therapy.

SMALL (2023)

Review Chemistry, Analytical

Towards sense and sensitivity-based electrochemical biosensors for liquid biopsy-based breast cancer detection

Sima Singh, Antonella Miglione, Ada Raucci, Arshid Numan, Stefano Cinti

Summary: Early diagnosis is crucial in the fight against breast cancer, with liquid biopsies offering a non-invasive approach. However, detecting non-invasive breast cancer remains challenging, and the lack of reliable screening methods hampers personalized therapy. Nanomaterials and electrochemical biosensors are being used in liquid biopsy-based detection, but they are still in the growth phase.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2023)

Review Chemistry, Analytical

Novel Approaches to Enzyme-Based Electrochemical Nanobiosensors

Nur Melis Kilic, Sima Singh, Gulsu Keles, Stefano Cinti, Sevinc Kurbanoglu, Dilek Odaci

Summary: Electrochemistry is an interdisciplinary science that has applications in various domains. The use of biosensors to measure biological or biochemical processes is critical in medical and biotechnological fields. There are electrochemical biosensors available for healthcare applications such as glucose, lactate, and nucleic acid detection. Enzyme-based biosensors using carbon-based nanomaterials are highly sensitive and selective, with fast reaction times. However, they can be influenced by environmental factors and the cost of enzymes and their immobilization can hinder their widespread use. This review discusses the design and applications of enzyme-based electrochemical nanobiosensors.

BIOSENSORS-BASEL (2023)

Review Chemistry, Multidisciplinary

Point-of-Care Testing for the Detection of MicroRNAs: Towards Liquid Biopsy on a Chip

Giulia Moro, Chiara Dalle Fratte, Nicola Normanno, Federico Polo, Stefano Cinti

Summary: Point-of-care (PoC) testing is revolutionizing healthcare by improving patient care and reaching remote areas. In the field of cancer management, the development of PoC devices for rapid detection of cancer markers, particularly focusing on stable blood-based markers like microRNAs, is urgently needed. This article highlights the potential impact of detecting circulating microRNAs on cancer management and emphasizes the importance of PoC testing devices, especially for low-income countries. It also discusses the challenges in promoting the technological transfer and clinical use of these tools, providing readers with a comprehensive overview of opportunities and limitations.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2023)

Review Chemistry, Analytical

Electrochemical Impedance Spectroscopy-Based Sensing of Biofilms: A Comprehensive Review

Sikander Ameer, Hussam Ibrahim, Muhammad Usama Yaseen, Fnu Kulsoom, Stefano Cinti, Mazhar Sher

Summary: Biofilms are complex communities of microorganisms that can form on various surfaces, and their presence can lead to infections, reduced efficiency, biofouling, and environmental damage. Electrochemical impedance sensing has emerged as a promising approach for real-time, non-destructive, and rapid monitoring of biofilms, with high sensitivity, versatility, and low cost.

BIOSENSORS-BASEL (2023)

Article Chemistry, Analytical

Development of a paper-based lateral flow prothrombin assay

Jerro Saidykhan, Louise Pointon, Stefano Cinti, Jennifer E. May, Anthony J. Killard

Summary: Disorders of haemostasis have significant impact on global health, with paper-based devices gaining attention as a simple and low-cost option for testing in low-resource settings.

ANALYTICAL METHODS (2022)

Article Chemistry, Analytical

Sustainable Copper Electrochemical Stripping onto a Paper-Based Substrate for Clinical Application

Antonella Miglione, Michele Spinelli, Angela Amoresano, Stefano Cinti

Summary: The electroanalytical field has made great progress in using paper-based substrates, but different types of paper substrates have their own characteristics and limitations. In this study, a novel two-dimensional merged paper-based device was developed for electrochemical copper ion detection in serum. This integrated device combined office paper, screen-printed electrochemical strips, and chromatographic disks to achieve an all-in-one electrochemical platform. The novel architecture allowed for sensitivity tuning and achieved a detection limit of 4 ppb for copper ions with a repeatability of approximately 10%.

ACS MEASUREMENT SCIENCE AU (2022)

Review Chemistry, Analytical

A critical review of biodegradable plastic mulch films in agriculture: Definitions, scientific background and potential impacts

Claudia Campanale, Silvia Galafassi, Francesca Di Pippo, Iulian Pojar, Carmine Massarelli, Vito Felice Uricchio

Summary: Biodegradable plastic mulches (BDMs) have the potential to be an eco-friendly alternative to conventional plastic mulches in agriculture. However, their long-term impacts on soil ecosystems are still uncertain, and further research is needed. Incorporating BDMs into the soil may stimulate microbial activity, but there is also a risk of incomplete degradation and release of residual microplastics and additives.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Performance enhancement of the lateral flow immunoassay by use of composite nanoparticles as signal labels

Xuechi Yin, Sijie Liu, Deepak Kukkar, Jianlong Wang, Daohong Zhang, Ki-Hyun Kim

Summary: The lateral flow immunoassay strip is a classic and dominant tool in point-of-care detection, known for its portability and simplicity. However, current colored nanomaterials used as signal labels in LFIA have limited sensing potential, leading to the recognition of composite nanoparticles as alternatives to enhance sensitivity, signal readout diversity, anti-matrix interference, and cost-effectiveness.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Anthropocene airborne microfibers: Physicochemical characteristics, identification methods and health impacts

Yaxin Cao, Longyi Shao, Timothy P. Jones, Wenjing Deng, M. Santosh, Pengju Liu, Cheng-Xue Yang, Yaowei Li, Daizhou Zhang, Kelly Berube

Summary: The toxicity of fibrous particles in ambient air can be higher than other types of particles. Microfibers can be organic or inorganic and their presence in the atmosphere as a result of human activity raises concerns for environmental and public health. Accurate collection, identification, and understanding of the health hazards associated with these fibers are crucial for mitigation strategies and protection of public health.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Progress in research on smartphone-assisted MIP optosensors for the on-site detection of food hazard factors

Chenchen Xie, Chen Meng, Huilin Liu, Baoguo Sun

Summary: The development of food hazard factor (FHF) detection has been moving towards on-site inspection and mobile law enforcement, calling for simple, fast, and affordable analysis technology to ensure food safety and quality. This review comprehensively summarizes the progress in research on smartphone-assisted MIP optosensors, focusing on the key issues of accuracy and sensitivity.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Miniaturization as a smart strategy to achieve greener sample preparation approaches: A view through greenness assessment

Guillem Peris-Pastor, Cristian Azorin, Jose Grau, Juan L. Benede, Alberto Chisvert

Summary: Green Analytical Chemistry plays an important role in every stage of method development, including sample preparation. Extraction techniques have evolved from conventional ones to a variety of miniaturized techniques in order to enhance analytical performance and ensure safety for operators and the environment. Green metric tools are used to evaluate the impact and sustainability of methods, with AGREEprep selected as the most suitable tool for evaluating published methods in various applications. The miniaturization of sample preparation strategies has led to the use of less and safer solvents, reduced waste generation and energy consumption, and improved portability and throughput.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Offline preparative separation methods based on electromigration: An overview and current trends

Helena Hruskova, Roman Reminek, Frantisek Foret

Summary: This review article summarizes the progress and recent studies in offline electromigration preparative techniques between 2018 and 2023. It covers various techniques including electrophoresis, free-flow electrophoresis, isoelectric focusing, and isotachophoresis, providing theoretical aspects, trends, and solutions to existing limitations in each technique.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Strategies to remove templates from molecularly imprinted polymer (MIP) for biosensors

Mayank Garg, Nicole Pamme

Summary: This review focuses on the removal strategies of templates from molecularly imprinted polymers (MIPs) used in diagnostic biosensors. Chemical-based and electrochemical-based template extraction approaches are summarized and evaluated, providing guidance for researchers in the fields of analytical chemistry, diagnostics, and materials science for the design of MIP-based sensors.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Passive breathomics for ultrasensitive characterization of acute and chronic respiratory diseases using electrochemical transduction mechanism

Ivneet Banga, Anirban Paul, Nathan Kodjo Mintah Churcher, Ruchita Mahesh Kumar, Sriram Muthukumar, Shalini Prasad

Summary: Breathomics is an emerging field that focuses on analyzing exhaled breath to diagnose and monitor respiratory diseases. Electrochemical sensors, with their high sensitivity, selectivity, and low cost, play a significant role in breathomics and can be integrated into portable devices for point-of-care diagnosis.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Elemental analysis of particulate matter by X-ray fluorescence methods: A green approach to air quality monitoring

Fabjola Bilo, Paola Cirelli, Laura Borgese

Summary: This review explores the application of X-ray fluorescence (XRF) spectrometry for elemental analysis of particulate matter (PM) in air quality monitoring. It discusses the fundamentals of XRF, experimental configurations, PM sampling devices and substrate, sample preparation strategies, qualitative and quantitative analysis, as well as the challenges faced by XRF in becoming a reliable analytical technique for PM analysis.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Advancements in overcoming challenges in dispersive liquid-liquid microextraction: An overview of advanced strategies

Hakim Faraji

Summary: The dispersive liquid-liquid microextraction (DLLME) technique is widely popular in analytical chemistry due to its high efficiency, cost-effectiveness, and simplicity. Recent advancements have addressed the limitations of DLLME, incorporating greener solvents, innovative dispersion strategies, and simplified procedures. These changes have made DLLME a more sustainable and efficient technique.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Metal organic framework-derived carbon nanomaterials and MOF hybrids for chemical sensing

Sherin F. Hammad, Inas A. Abdallah, Alaa Bedair, Reda M. Abdelhameed, Marcello Locatelli, Fotouh R. Mansour

Summary: Carbon nanomaterials (CNMs) have excellent capabilities in terms of adsorption, enhanced oxidation, and photocatalysis, attracting widespread attention in different fields. Metal-organic frameworks (MOFs) have been widely used due to their regular network structure, porous nature, and large specific surface area. However, the instability of MOFs in aqueous solutions limits their applications in chemical sensing. Recent studies have focused on increasing the stability of MOFs in water-based matrices through chemical modifications using CNMs.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Dielectric barrier discharge in mass spectrometry - An overview over plasma investigations and ion sources applications

Alexandra Pape, Oliver J. Schmitz

Summary: Low temperature plasmas based on dielectric barrier discharges have emerged as a recent development in ion source research. These ion sources are applicable to heat-sensitive analytes and can ionize a wide range of compounds. Despite intensive research on important parameters such as configuration, shape, size, and materials in the past two decades, the actual ionization mechanism for all plasma gases has not been fully elucidated. This review provides an overview of atmospheric pressure ion sources, with a focus on plasma and dielectric barrier discharge based ion sources, summarizing the reactions occurring in the plasma and discussing the applications developed by different research groups.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Recent and emerging trends of DNA/RNA hybridized COF nanoprobes for analytes detection and biomarkers imaging in clinical biomedicines

Hai Xiong, Fengli Li, Linyu Zeng, Qiyu Lei

Summary: This review provides an overview of the emerging trends in the use of functional COF nanomaterials as biosensors for DNA/RNA detection. It summarizes the construction of DNA/RNA hybridized COF nanoprobes and their potential applications in bioanalyte detection, biosensing, biomarker imaging, and clinical biomedicine.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Multiple luminescence responsive chemical sensing of lanthanide functionalized metal-organic frameworks hybrids for logic gate operation application to construct intelligent detecting platform

Bing Yan

Summary: This article summarizes the recent progress in logic gate computing and operation based on multiple luminescence response and chemical sensing for lanthanide functionalized MOF hybrid systems. The article first describes multi-color luminescence and the subsequent multiple luminescence response. The basic concept of logic gate operation and the advantages of lanthanide-based hybrid materials are then introduced. Reports on logic gate operation using pure lanthanide MOFs are provided, followed by a detailed summary of logic gate operations using lanthanide functionalized MOF hybrid materials. Additionally, the article discusses the practical luminescent detection of analytes by correlating the luminescence responsive signals and the concentration of different analytes. Finally, the article concludes with a prospect for this topic.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)

Review Chemistry, Analytical

Hydrogen-bonded organic frameworks (HOFs): Multifunctional material on analytical monitoring

Brij Mohan, Gurjaspreet Singh, Rakesh Kumar Gupta, Pawan Kumar Sharma, Alexander A. Solovev, Armando J. L. Pombeiro, Peng Ren

Summary: Porous materials, particularly hydrogen-bonded organic frameworks (HOFs), have gained significant attention due to their versatile applications and unique properties such as well-defined crystalline structure and easy regeneration processes. This article provides a comprehensive overview of HOFs, including synthesis methods, hydrogen bonding motifs, recent advancements, and potential applications, offering valuable guidance for further exploration in this dynamic field.

TRAC-TRENDS IN ANALYTICAL CHEMISTRY (2024)