Article
Pharmacology & Pharmacy
Mona F. Mahmoud, Shimaa Abdelaal, Heba Osama Mohammed, Assem M. El-Shazly, Rachid Daoud, Mohamed A. O. Abdelfattah, Mansour Sobeh
Summary: The extract of Syzygium aqueum (SA) has shown promising effects in preventing oxidative stress and inflammation in pancreatic beta cells, reducing glucose levels, increasing insulin secretion, and improving pancreatic damage caused by STZ in rats. Both SA and glibenclamide treatment decreased levels of TLR-4, MYD88, pro-inflammatory cytokines TNF-alpha, and TRAF-6 in pancreatic tissue homogenates, suggesting their anti-inflammatory properties. These findings indicate that SA may be a potential cost-effective alternative herbal remedy for treating type 2 diabetes mellitus.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Ei Ei Aung, Alfinda Novi Kristanti, Nanik Siti Aminah, Yoshiaki Takaya, Rico Ramadhan
Summary: Phytochemicals from medicinal plants are used for health benefits in humans. Syzygium aqueum, a species containing various phytochemicals, is used as a traditional medicine in Indonesia and Malaysia. In this study, three compounds were isolated from this species using chromatographic techniques and their structures were confirmed using spectroscopic methods. The compounds showed antidiabetic activity by inhibiting the α-glucosidase enzyme.
EGYPTIAN JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Khanh Hong Thi Hoang, Jaeyoon Lim, My Tuyen Thi Nguyen, Nan-Young Lee, Chang-Kyu Lee, Van Dao Nguyen, Hye-Lynn Kim, Jong-Tae Park, Jaehan Kim
Summary: This study investigated the potential of Syzygium formosum as a new cosmeceutical ingredient by analyzing the quantitative profile of phytochemicals in the leaf extract and studying the pharmacological mechanism of its skin relief functionality. The results showed that the leaf extract contains high levels of bioactive compounds which could be beneficial for skin care, making it a superior ingredient for cosmetic and pharmaceutical products.
APPLIED SCIENCES-BASEL
(2021)
Review
Multidisciplinary Sciences
Rony Abdi Adrian, Rony Abdi Syahputra, Nur Aira Juwita, Ririn Astyka, Muhammad Fauzan Lubis
Summary: Andaliman (Z. acanthopodium DC) is a flowering plant belonging to the Rutaceae family, native to North Sumatra, Indonesia. It is used in the culinary industry and traditional medicine, with reported antibacterial, antifungal, anti-inflammatory, anticancer, cardioprotective, hepatoprotective, nephroprotective, and wound healing properties. Previous studies have identified terpenoids, alkaloids, flavonoids, glycosides, tannins, and saponins as some of its phytochemical constituents. This review provides a summary of the existing research, facilitating further exploration of Andaliman.
Review
Chemistry, Medicinal
Sonu Mahawer, Ravendra Kumar, Om Prakash, Shailja Singh, Dharmendra Singh Rawat, Shiv Kumar Dubey, Mozaniel Oliveira
Summary: "Alpinia malaccensis, also known as Malacca ginger and Rankihiriya, is an important medicinal plant native to Indonesia and Malaysia, and is widely distributed in countries such as India, China, Peninsular Malaysia, and Java. This article provides a detailed study of its botanical characteristics, chemical compounds, ethnopharmacological values, therapeutic properties, as well as its potential pesticidal properties. The information was gathered from online journals using various combinations of terms such as Alpinia malaccensis, Malacca ginger, Rankihiriya, pharmacology, chemical composition, and ethnopharmacology. The study confirmed its traditional uses in treating nausea, vomiting, wounds, as well as its pharmacological activities such as antioxidant and antimicrobial effects. The authors believe that this review will contribute to further exploring the potential of A. malaccensis in preventing and treating various diseases."
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Nitis Smanthong, Ratree Tavichakorntrakool, Patcharaporn Tippayawat, Aroonlug Lulitanond, Porntip Pinlaor, Jureerut Daduang, Nattaya Sae-ung, Arunrat Chaveerach, Jutarop Phetcharaburanin, Patcharee Boonsiri
Summary: The ethanolic extract from Sida acuta leaves showed inhibitory effects on Proteus mirabilis and struvite crystal formation, suggesting potential for development as a new treatment for struvite stones induced by P. mirabilis. Phytochemical analysis identified bioactive compounds that contribute to these activities.
Article
Plant Sciences
Mihnea Paraschiv, Magda Csiki, Zorita Diaconeasa, Sonia Socaci, Ovidiu Balacescu, Elena Rakosy-Tican, Daniel Cruceriu
Summary: This study assessed the phytochemical profile and selective cytotoxicity of an extract from Solanum bulbocastanum against breast cancer cells. The extract showed high levels of phenolic compounds and flavanols, and demonstrated cytotoxicity towards breast cancer cell lines while exhibiting low toxicity towards healthy cell lines.
Article
Plant Sciences
Aleksandar Kocovic, Jovana Jeremic, Jovana Bradic, Miroslav Sovrlic, Jovica Tomovic, Perica Vasiljevic, Marijana Andjic, Nevena Draginic, Mirjana Grujovic, Katarina Mladenovic, Dejan Baskic, Suzana Popovic, Sanja Matic, Vladimir Zivkovic, Nevena Jeremic, Vladimir Jakovljevic, Nedeljko Manojlovic
Summary: The aim of this study was to identify the secondary metabolites in extracts of Xanthoparmelia stenophylla lichen and evaluate their antioxidant, antimicrobial, and cytotoxic activity. The study found that acetone extract had the highest phenolic and flavonoid content, as well as the best antioxidant activity. Hexanic extract showed the best antimicrobial activity, particularly against certain strains. Additionally, the acetonic extract exhibited strong cytotoxic effects.
Article
Plant Sciences
Miran El-Haggar, Lobna El-Hosseiny, Nabila M. Ghazy, Fathy Kandeel El-Fiky, Amr El-Hawiet
Summary: This study investigated tissue culture protocols for Lepidium sativum, finding that the calli extracts showed superior antimicrobial and cytotoxic activities compared to plant parts' extracts. LC/MS analysis revealed the presence of eleven secondary metabolites with varying concentrations in the ethanolic extracts of plant parts and calli.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Chemistry, Multidisciplinary
Narender Goel, Rahul L. Gajbhiye, Moumita Saha, Chennuru Nagendra, Araveeti Madhusudhana Reddy, V Ravichandiran, Krishna Das Saha, Parasuraman Jaisankar
Summary: This study compared the in vitro cytotoxic activity and phytochemical profiling of methanol extracts of Andrographis nallamalayana and Andrographis paniculata, finding significant cytotoxic effects on cancer cells, with programmed cell death induction. Additionally, various compounds such as phenolic acids and flavonoids were identified in the extracts through chemical analysis.
Article
Chemistry, Applied
Georon Ferreira de Sousa, Dayane Kelly Dias do Nascimento Santos, Ricardo Sergio da Silva, Barbara Rafaela da Silva Barros, Iranildo Jose da Cruz-Filho, Barbara de Azevedo Ramos, Tulio Diego da Silva, Persio Alexandre da Silva, Reginaldo Goncalves de Lima-Neto, Norma Buarque de Gusmao, Marcia Silva do Nascimento, Cristiane Moutinho Lagos de Melo
Summary: The extracts of P. edulis showed moderate antioxidant capacity and antifungal activity. In experiments on splenocytes, the extracts were found to promote the production of immune factors, demonstrating immunostimulatory action.
NATURAL PRODUCT RESEARCH
(2021)
Article
Plant Sciences
Selcuk Kucukaydin, Fatih Cayan, Gulsen Tel-Cayan, Mehmet Emin Duru
Summary: This study investigated the phytochemical compositions and biological activities of Thymus cariensis and T. cilicicus, and found that they exhibited high antioxidant and cytotoxic activities. A significant correlation was found between phenolic compounds and biological activities.
SOUTH AFRICAN JOURNAL OF BOTANY
(2021)
Article
Environmental Sciences
Navjot Kaur, Poonam Aggarwal, Vikas Kumar, Sukhpreet Kaur
Summary: This study optimized the extraction conditions of phytochemicals from java plum pomace using ultrasound-assisted extraction and compared it with conventional extraction. The results showed that ultrasound-assisted extraction yielded higher levels of phytochemicals and antioxidant activities compared to conventional extraction.
WASTE AND BIOMASS VALORIZATION
(2023)
Article
Chemistry, Analytical
Mohamed Marouane Saoudi, Jalloul Bouajila, Rami Rahmani, Khaled Alouani
Summary: The extracts of R. crispus are rich in phenolic compounds, showing antioxidant and anti-AChE activities, with the MeOH extract displaying strong activity against DPPH and AChE. The DCM extract exhibits high cytotoxic activity against cancer cells.
INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
M. A. Zarka, Amal Al Gendy
Summary: The essential oil extracted from Calothamnus quadrifidus leaves showed significant antioxidant, cytotoxic, and antimicrobial activities, with its cytotoxicity exceeding that of 1,8-cineole, except in one cell line. New compounds isolated from the leaves were identified and their molecular docking in peroxiredoxins showed conformation 2 to be the most stable with the best antioxidant effect.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
