Journal
GASTROENTEROLOGY CLINICS OF NORTH AMERICA
Volume 45, Issue 3, Pages 413-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.gtc.2016.04.002
Keywords
Gastric cancer; Helicobacter pylori; Atrophic gastritis; Intestinal metaplasia; Dysplasia
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Funding
- Puerto Rico Clinical and Translational Research Consortium from the National Institute on Minority Health and Health Disparities [U54MD007587]
- UPR/MDACC Partnership for Excellence in Cancer Research Program from the National Cancer Institute [U54 CA096297]
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Gastric cancer (GC) is the third leading cause of cancer-related death. Only 28.3% of new GC cases survive more than 5 years. Although incidence has declined in the United States, an increase is estimated for 2016. Risk factors include sex (risk is higher in men), Helicobacter pylori infection, heredity, and lifestyle. GC is usually diagnosed between the ages of 60-80 years. Prognosis of GC is largely dependent on the tumor stage at diagnosis and classification as intestinal or diffuse type; diffuse type GC has worse prognosis. Chemoprevention has been shown to decrease risk, but is currently not used clinically.
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