Journal
SEMINARS IN CANCER BIOLOGY
Volume 86, Issue -, Pages 58-63Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcancer.2021.08.001
Keywords
Tumor -associated macrophage; Extracellular vesicle; microRNA; Tumor microenvironment
Categories
Funding
- National Institutes of Health (NIH/NCI) [5P30CA071789-20]
- NIH/NCI [R01CA215753, R01CA219024]
- NCI/NIDCR [U01DE029759]
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This review article discusses the interaction between tumor-associated macrophages (TAMs) and cancer cells, with a focus on the pro-tumoral phenotype elicited by EV-contained miRNAs released by TAMs and transferred to cancer cells.
MicroRNAs (miRNAs) are central players in cancer biology. Their relevance in cancer development, progression and resistance to therapy has been further emphasized by the discovery that they are important cargo component of extracellular vesicles (EVs), which represent a prominent means of inter-cellular communication within the tumor microenvironment (TME). This review article focuses on the interaction between cancer cells and tumor -associated macrophages (TAMs) and in particular on the pro-tumoral phenotype elicited by EV-contained miRNAs released by TAMs and transferred to cancer cells. All main hallmarks of the malignant phenotype are affected by TAM-derived vesicular miRNAs, paving the road to the identification of such miRNAs as promising upcoming novel anti-cancer agents.
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