Drug repurposing: Misconceptions, challenges, and opportunities for academic researchers

A SARS-CoV-2 cytopathicity dataset generated by high-content screening of a large drug repurposing collection

(2021) Bernhard Ellinger et al.   Scientific Data

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Anti-HCV, nucleotide inhibitors, repurposing against COVID-19

(2020) Abdo A. Elfiky   LIFE SCIENCES

On-Label or Off-Label? Overcoming Regulatory and Financial Barriers to Bring Repurposed Medicines to Cancer Patients

(2020) Ciska Verbaanderd et al.   Frontiers in Pharmacology

Dosing will be a key success factor in repurposing antivirals for COVID‐19

(2020) Patrick F. Smith et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

In Vitro Antiviral Activity and Projection of Optimized Dosing Design of Hydroxychloroquine for the Treatment of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)

(2020) Xueting Yao et al.   CLINICAL INFECTIOUS DISEASES

Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial

(2020) Yeming Wang et al.   LANCET

Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors

(2020) Zhenming Jin et al.   NATURE

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

(2020) Joshua Geleris et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compassionate Use of Remdesivir for Patients with Severe Covid-19

(2020) Jonathan Grein et al.   NEW ENGLAND JOURNAL OF MEDICINE

Against pandemic research exceptionalism

(2020) Alex John London et al.   SCIENCE

Early treatment of COVID-19 patients with hydroxychloroquine and azithromycin: A retrospective analysis of 1061 cases in Marseille, France

(2020) Matthieu Million et al.   Travel Medicine and Infectious Disease

Ivermectin and COVID-19: A report in Antiviral Research, widespread interest, an FDA warning, two letters to the editor and the authors' responses

(2020) Mike Bray et al.   ANTIVIRAL RESEARCH

A medicinal chemistry perspective of drug repositioning: Recent advances and challenges in drug discovery

(2020) Thanigaimalai Pillaiyar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effect of High vs Low Doses of Chloroquine Diphosphate as Adjunctive Therapy for Patients Hospitalized With Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection

(2020) Mayla Gabriela Silva Borba et al.   JAMA Network Open

A preliminary assessment of oral monepantel’s tolerability and pharmacokinetics in individuals with treatment-refractory solid tumors

(2020) Anna Mislang et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Small molecules as central nervous system therapeutics: old challenges, new directions, and a philosophic divide

(2019) William A Banks et al.   Future Medicinal Chemistry

Moxidectin for deworming: from trials to implementation

(2018) Mathieu Maheu-Giroux et al.   LANCET INFECTIOUS DISEASES

Overcoming the legal and regulatory barriers to drug repurposing

(2018) Alasdair Breckenridge et al.   NATURE REVIEWS DRUG DISCOVERY

Emerging Understanding of the Mechanism of Action for Dimethyl Fumarate in the Treatment of Multiple Sclerosis

(2018) Elizabeth A. Mills et al.   Frontiers in Neurology

Effect of Aspirin on All-Cause Mortality in the Healthy Elderly

(2018) John J. McNeil et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing

(2018) Janis C. Weeks et al.   Scientific Reports

Drug repurposing: progress, challenges and recommendations

(2018) Sudeep Pushpakom et al.   NATURE REVIEWS DRUG DISCOVERY

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An update on Drug Repurposing: Re-written saga of the drug’s fate

(2018) Hema Sree GNS et al.   BIOMEDICINE & PHARMACOTHERAPY

The Essential Medicinal Chemistry of Curcumin

(2017) Kathryn M. Nelson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Drug Repurposing Hub: a next-generation drug library and information resource

(2017) Steven M Corsello et al.   NATURE MEDICINE

A standard database for drug repositioning

(2017) Adam S. Brown et al.   Scientific Data

Giving Drugs a Second Chance: Overcoming Regulatory and Financial Hurdles in Repurposing Approved Drugs As Cancer Therapeutics

(2017) J. Javier Hernandez et al.   Frontiers in Oncology

Can you teach old drugs new tricks?

(2016) Nicola Nosengo   NATURE

Dimethyl fumarate in multiple sclerosis: latest developments, evidence and place in therapy

(2016) Ralf A. Linker et al.   Therapeutic Advances in Chronic Disease

Recent trends in specialty pharma business model

(2015) Mannching Sherry Ku   JOURNAL OF FOOD AND DRUG ANALYSIS

An Aggregation Advisor for Ligand Discovery

(2015) John J. Irwin et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phytochemicals Perturb Membranes and Promiscuously Alter Protein Function

(2014) Helgi I. Ingólfsson et al.   ACS Chemical Biology

“New Drug” Designations for New Therapeutic Entities: New Active Substance, New Chemical Entity, New Biological Entity, New Molecular Entity

(2014) Sarah K. Branch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Functional Module Connectivity Map (FMCM): A Framework for Searching Repurposed Drug Compounds for Systems Treatment of Cancer and an Application to Colorectal Adenocarcinoma

(2014) Feng-Hsiang Chung et al.   PLoS One

Repurposing the FDA-Approved Pinworm Drug Pyrvinium as a Novel Chemotherapeutic Agent for Intestinal Polyposis

(2014) Bin Li et al.   PLoS One

Chloroquine Is a Zinc Ionophore

(2014) Jing Xue et al.   PLoS One

A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation

(2013) Jayme L. Dahlin et al.   PLoS One

A safe lithium mimetic for bipolar disorder

(2013) Nisha Singh et al.   Nature Communications

Computational Repositioning of the Anticonvulsant Topiramate for Inflammatory Bowel Disease

(2011) J. T. Dudley et al.   Science Translational Medicine

Drug repurposing and adverse event prediction using high-throughput literature analysis

(2011) Spyros N. Deftereos et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Challenges in the Search for Drugs to Treat Central Nervous System Disorders

(2009) S. J. Enna et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS