Article
Multidisciplinary Sciences
Viviane Fongaro Botosso, Soraia Attie Calil Jorge, Renato Mancini Astray, Ana Marcia de Sa Guimaraes, Monica Beatriz Mathor, Patricia dos Santos de Carneiro, Edison Luiz Durigon, Dimas Covas, Danielle Bruna Leal de Oliveira, Ricardo das Neves Oliveira, Durvanei Augusto Maria, Silas Fernandes Eto, Neuza Maria Frazatti Gallina, Giselle Pidde, Carla Cristina Squaiella-Baptistao, Dilza Trevisan Silva, Isadora Maria Villas-Boas, Dayanne Carla Fernandes, Aline Vivian Vatti Auada, Alexandre Campos Banari, Antonio Francisco de Souza Filho, Camila Bianconi, Carla Lilian de Agostini Utescher, Denise Cristina Andre Oliveira, Douglas Oscar Ceolin Mariano, Flavia Ferreira Barbosa, Giuliana Rondon, Josana Kapronezai, Juliana Galvao da Silva, Mauricio Barbugiani Goldfeder, Priscila Comone, Regis Edgar Castilho Junior, Taiana Taina Silva Pereira, Fan Hui Wen, Denise Tambourgi, Ana Marisa Chudzinski-Tavassi
Summary: The new outbreak of COVID-19 has caused millions of deaths worldwide. Efforts are being made to find effective treatments, such as using immunoglobulin from immunized animals or plasma from convalescent patients. Clinical trials using anti-SARS-CoV-2 immunoglobulins from horses immunized with spike protein are underway. Researchers have developed an anti-SARS-CoV-2 equine F(ab ')(2) immunoglobulin that successfully neutralizes the virus, is safe in animal models, and reduces the severity of the disease in a hamster model of SARS-CoV-2 infection.
SCIENTIFIC REPORTS
(2022)
Article
Immunology
Nhu Ngoc Nguyen, Linda Houhamdi, Van Thuan Hoang, Jeremy Delerce, Lea Delorme, Philippe Colson, Philippe Brouqui, Pierre-Edouard Fournier, Didier Raoult, Philippe Gautret
Summary: The reinfection rate of SARS-CoV-2 is low, and the severity of the first and second episodes of infection is similar. The severity of the second episode of COVID-19 is not higher than that of the first infection, even for patients with antibodies.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Microbiology
Christina M. Kackos, Sherri L. Surman, Bart G. Jones, Robert E. Sealy, Trushar Jeevan, Christopher J. H. Davitt, Sergei Pustylnikov, Tamarand L. Darling, Adrianus C. M. Boon, Julia L. Hurwitz, Marcelo M. Samsa, Richard J. Webby
Summary: SARS-CoV-2 continues to disrupt everyday life and cause excess morbidity and mortality worldwide. Vaccination has been key to quelling the impact of this respiratory pathogen, and mRNA vaccines have led the charge on this front. The emergence of SARS-CoV-2 variants has threatened vaccine efficacy, but the mRNA vaccines developed by GreenLight Biosciences have shown robust protective efficacy against the wild-type virus and its variants.
MICROBIOLOGY SPECTRUM
(2023)
Review
Microbiology
Jessica A. Plante, Brooke M. Mitchell, Kenneth S. Plante, Kari Debbink, Scott C. Weaver, Vineet D. Menachery
Summary: Despite the development of vaccines, COVID-19 caused by SARS-CoV-2 continues to be a global concern due to the emergence of new variants, raising worries about increased spread and potential impacts on immunity.
CELL HOST & MICROBE
(2021)
Article
Multidisciplinary Sciences
Salmaan Sharif, Aamer Ikram, Adnan Khurshid, Muhammad Salman, Nayab Mehmood, Yasir Arshad, Jamal Ahmed, Rana Muhammad Safdar, Lubna Rehman, Ghulam Mujtaba, Jaffar Hussain, Johar Ali, Mehar Angez, Muhammad Masroor Alam, Ribqa Akthar, Muhammad Wasif Malik, Mirza Zeeshan Iqbal Baig, Muhammad Suleman Rana, Muhammad Usman, Muhammad Qaisar Ali, Abdul Ahad, Nazish Badar, Massab Umair, Sana Tamim, Asiya Ashraf, Faheem Tahir, Nida Ali
Summary: The study found 27% of wastewater samples tested positive for SARs-CoV-2, indicating the potential for monitoring viral spread through wastewater surveillance. Additionally, the detection of virus sequence data in wastewater highlights the importance of surveillance for early warning signs.
Review
Endocrinology & Metabolism
Salvatore Corrao, Karen Pinelli, Martina Vacca, Massimo Raspanti, Christiano Argano
Summary: This review discusses the prevalence, pathophysiological mechanisms, and outcomes of COVID-19 infection in people with diabetes, proposing a rationale for using drugs prescribed in patients with diabetes and providing pragmatic clinical recommendations for dealing with COVID-19 in this patient population.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Heather P. McLaughlin, Brian C. Hiatt, Denny Russell, Christina M. Carlson, Jesica R. Jacobs, Ailyn C. Perez-Osorio, Michelle L. Holshue, Sung W. Choi, Romesh K. Gautom
Summary: The paper discusses the collaboration between the Washington State Public Health Laboratory and the Centers for Disease Control and Prevention in responding to the COVID-19 outbreak, highlighting factors contributing to an effective laboratory response and discussing challenges, successful steps, and lessons learned.
AMERICAN JOURNAL OF PUBLIC HEALTH
(2021)
Review
Microbiology
Maria Karoliny da Silva Torres, Carlos David Araujo Bichara, Maria de Nazare do Socorro de Almeida, Mariana Cayres Vallinoto, Maria Alice Freitas Queiroz, Izaura Maria Vieira Cayres Vallinoto, Eduardo Jose Melo dos Santos, Carlos Alberto Marques de Carvalho, Antonio Carlos R. Vallinoto
Summary: This article conducts an extensive literature review on the impact of SARS-CoV-2 pandemic in terms of biology, sociology, genetics, diagnostics, therapeutics, immunology, and socioeconomics. It aims to provide a comprehensive understanding of the major aspects related to the ongoing pandemic.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiaojuan Peng, Qi Liu, Zhaolin Chen, Guiyan Wen, Qing Li, Yanfang Chen, Jie Xiong, Xinzhou Meng, Yuanjin Ding, Ying Shi, Shaohui Tang
Summary: Patients with moderate cases of SARS-CoV-2 have a good prognosis with active treatment, but a small proportion of recovered patients may still be virus carriers, necessitating additional rounds of viral detection.
Review
Chemistry, Analytical
Rabia Asghar, Madiha Rasheed, Jalees ul Hassan, Mohsin Rafique, Mashooq Khan, Yulin Deng
Summary: This review discusses the diagnostic platforms for COVID-19, including imaging, molecular-based detection, serological testing, and biosensors. Each platform's principle, advancement, and challenges are discussed in detail, along with an overview of the impact of variants on detection, commercially available kits, and readout signal analysis.
Article
Virology
Nikolaos Spanakis, Katerina Kassela, Nikolas Dovrolis, Maria Bampali, Elisavet Gatzidou, Athanasia Kafasi, Elisavet Froukala, Anastasia Stavropoulou, Konstantinos Lilakos, Stavroula Veletza, Sotirios Tsiodras, Athanasios Tsakris, Ioannis Karakasiliotis
Summary: This study analyzed different variants of SARS-CoV-2 responsible for the outbreak in Athens before the pandemic, showing a variety of spread chains in the area, including a dominant variant and rare variants, some of which had implications for the virus's pathogenesis.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Gastroenterology & Hepatology
Tarik Asselah, David Durantel, Eric Pasmant, George Lau, Raymond F. Schinazi
Summary: COVID-19 started in Wuhan in 2019 and has become a global pandemic. The virus responsible, SARS-CoV-2, shares a high sequence identity with bat- and pangolin-derived coronaviruses. Risk factors for SARS-CoV-2 infection include age, obesity, diabetes, and hypertension.
JOURNAL OF HEPATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Himanshu G. Toor, Devjani I. Banerjee, Soumya Lipsa Rath, Siddhi A. Darji
Summary: The global COVID-19 pandemic has caused over a million deaths, leading to intense research on potential therapeutic strategies targeting the spike glycoprotein of SARS-CoV-2. Multiple known drug candidates have shown significant interactions with the virus, indicating potential for designing novel combinatorial therapy formulations.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Md Tanveer Adil, Rumana Rahman, Douglas Whitelaw, Vigyan Jain, Omer Al-Taan, Farhan Rashid, Aruna Munasinghe, Periyathambi Jambulingam
Summary: SARS-CoV-2, the virus responsible for COVID-19, has caused a global pandemic with high mortality rates. Treatment is primarily supportive, and preventive strategies focus on reducing transmission through contact tracing and hygiene practices.
POSTGRADUATE MEDICAL JOURNAL
(2021)
Review
Pharmacology & Pharmacy
Thales Kronenberger, Stefan A. Laufer, Thanigaimalai Pillaiyar
Summary: This article discusses the rationale for inhibitors targeting SARS-CoV-2 Mpro. Small molecules and peptidomimetic inhibitors are two types of inhibitors with different modes of action. Novel inhibitors discovered during the COVID-19 pandemic are highlighted, focusing on their binding modes and structures.
DRUG DISCOVERY TODAY
(2023)
Article
Environmental Sciences
Lucas Rocha-Melogno, Katherine Crank, Michael H. Bergin, Gregory C. Gray, Kyle Bibby, Marc A. Deshusses
Summary: An increasing body of literature suggests that aerosol inhalation plays a primary role in COVID-19 transmission, particularly in indoor settings. In response to this, the authors developed a model and web application to assess and mitigate the risk of aerosol transmission. Their findings showed that the risk of transmission significantly increased when masks were not worn and the room was poorly ventilated, but it could be reduced with proper ventilation and relative humidity.
ENVIRONMENTAL TECHNOLOGY
(2023)
Article
Polymer Science
Madeline G. Jensen, Patrick T. O'Shaughnessy, Marlee Shaffer, Sooyoun Yu, Yun Young Choi, Megan Christiansen, Charles O. Stanier, Michael Hartley, Joey Huddle, Jed Johnson, Kyle Bibby, Nosang V. Myung, David M. Cwiertny
Summary: During the global spread of COVID-19, the high demand and limited availability of melt-blown filtration material led to a manufacturing backlog of N95 Filtering Facepiece Respirators (FFRs). An alternative filter material, consisting of electrospun polystyrene (PS) microfibers, showed favorable performance in terms of filtration efficiency and antibacterial activity, potentially making it a suitable option for use in N95 FFRs.
JOURNAL OF APPLIED POLYMER SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Pedro F. P. Brandao-Dias, Daniel M. C. Hallack, Elise D. D. Snyder, Jennifer L. L. Tank, Diogo Bolster, Sabrina Volponi, Arial J. J. Shogren, Gary A. A. Lamberti, Kyle Bibby, Scott P. P. Egan
Summary: Environmental DNA (eDNA) analysis is a powerful tool for detecting target organisms remotely. This study explores the possibility of obtaining longitudinal dynamics information on targets by separating different size components of eDNA within a sample. The results show that medium-sized particles decay more slowly and increase in proportion over time. Different sizes of eDNA particles do not decay independently, but a parsimonious mathematical model best explains the data. A framework for discerning target distance and abundance with eDNA data is proposed.
MOLECULAR ECOLOGY RESOURCES
(2023)
Review
Environmental Sciences
Ananda Tiwari, Sangeet Adhikari, Devrim Kaya, Md. Aminul Islam, Bikash Malla, Samendra P. Sherchan, Ahmad I. Al-Mustapha, Manish Kumar, Srijan Aggarwal, Prosun Bhattacharya, Kyle Bibby, Rolf U. Halden, Aaron Bivins, Eiji Haramoto, Sami Oikarinen, Annamari Heikinheimo, Tarja Pitkaenen
Summary: Monkeypox disease, caused by the monkeypox virus, has become a global concern. Wastewater-based surveillance can be a useful tool for early detection of the virus, but there are challenges to overcome.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Brooke Stemple, Djuna Gulliver, Kara Tinker, Preom Sarkar, Josh Miller, Kyle Bibby
Summary: This study characterizes the impact of long-term storage of supercritical CO2 in depleted oil reservoirs on subsurface biogeochemistry, focusing on the geochemical and microbial composition of produced water from CO2 enhanced oil recovery (CO2 EOR) wells in the Niagaran Pinnacle Reef. The results indicate that high salinity and supercritical CO2 conditions select for stress-tolerant microbial communities adapted to these environments.
ACS EARTH AND SPACE CHEMISTRY
(2022)
Article
Engineering, Environmental
Olivia Ginn, Jennifer L. Tank, Andrei Badilla-Aguilar, Elise Snyder, Pedro F. P. Brandao-Dias, Emma Thrift, Diogo Bolster, Kyle Bibby
Summary: Environmental factors play a critical role in understanding the fate and transport of antibiotic resistance in impacted streams. This study examines the impact of stream characteristics and particle size association on the removal of antimicrobial resistance genes over time. The findings suggest that both substrate and particle size influence the behavior and removal rates of antibiotic resistance genes in surface waters.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Environmental Sciences
Rasha Maal-Bared, Michael McCracken, Bharatee Busawon, Darlyce Simpson
Summary: This study conducted an extensive adenosine triphosphate (ATP) monitoring campaign in an urban, chloraminated drinking water system. The results showed temporal and spatial variation in ATP concentrations, but they did not exceed the proposed 10 pg/mL corrective action limit. ATP concentrations were able to inform outlying reservoir management decisions and could serve as a useful indicator of biological stability in the drinking water distribution system (DWDS) for the utility of the future.
Article
Environmental Sciences
William Chen, Kyle Bibby
Summary: Wastewater-based epidemiology (WBE) is a community-level monitoring technique used to track diseases, but its feasibility for monitoring vector-borne pathogens like Zika virus is uncertain. Monte Carlo simulation was used to generate distributions for total Zika RNA shedding and the process limit of detection (PLOD), and the probability of detecting Zika RNA in wastewater was calculated. Results suggest that successful Zika WBE application is unlikely in the United States but likely in Zika-endemic countries with decreased wastewater treatment plant (WWTP) per capita flows. However, the great discrepancy between true and reported clinical cases suggests that Zika WBE may be feasible even in the absence of outbreaks in endemic countries.
Article
Engineering, Environmental
Pedro F. P. Brandao-Dias, Jennifer L. Tank, Elise D. Snyder, Ursula H. Mahl, Brett Peters, Diogo Bolster, Arial J. Shogren, Gary A. Lamberti, Kyle Bibby, Scott P. Egan
Summary: eDNA in aquatic systems is a complex mixture that includes dissolved DNA, intracellular DNA, and particle-adsorbed DNA. Understanding the composition and interactions of eDNA is crucial for determining the abundance and location of target organisms. This study found that eDNA rapidly adsorbs to other materials in the water column, affecting its concentration and particle size distribution. Only particulate organic matter affected the removal rate of eDNA. The removal of larger eDNA components was influenced by physical processes, while the removal of smaller eDNA components was driven by biological degradation.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Engineering, Environmental
William Chen, Kyle Bibby
Summary: This paper discusses the importance of wastewater-based surveillance in understanding the occurrence and spread of infectious diseases and proposes a framework to assess the suitability of novel diseases for wastewater monitoring. The paper also explores five primary factors that influence the detection probability in wastewater-based surveillance and emphasizes the need for further research on these factors.
Article
Engineering, Environmental
Emily Clements, Christopher Irwin, Jacob Koestner, Alexandros Taflanidis, Kyle Bibby, Robert Nerenberg
Summary: This research proposes using statistical tools to assess water age distributions and highlights that average water age is not a reliable indicator of water quality. The study demonstrates that changes in occupancy have a greater impact on water age than changes in average water demand.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2023)
Article
Environmental Sciences
Rasha Maal-Bared, Charles Gerba, Kyle Bibby, Naoko Munakata, Anna S. Mehrotra, Kari Fitzmorris Brisolara, Charles Haas, Lee Gary, Bina Nayak, Jay Swift, Samendra Sherchan, Leonard Casson, Lola Olabode, Albert Rubin, Robert Reimers, Mark Sobsey
Summary: Recent safety concerns in the water sector during the COVID-19 pandemic have emphasized the importance of industry-focused reviews on emerging pathogens to support evidence-based decision-making. This study provides a summary of the available evidence on monkeypox virus (MPXV) and related orthopoxviruses and offers sector-wide recommendations. Based on the current information, there is no evidence to suggest that infectious MPXV is present in wastewater or biosolids, and the outbreak is unlikely to pose a transmission risk from these sources.
Article
Engineering, Environmental
Justin Greaves, Devin North, Kyle Bibby
Summary: The molecular viral fecal pollution indicators have emerged as leading candidates for water quality monitoring. This study investigates the associations of six molecular fecal pollution targets with particles in wastewater and finds that the targets have the highest concentrations on suspended particles, suggesting that particle association dictates their transport in environmental waters.
ENVIRONMENTAL SCIENCE-WATER RESEARCH & TECHNOLOGY
(2022)
Article
Environmental Sciences
Warish Ahmed, Wendy J. M. Smith, Suzanne Metcalfe, Greg Jackson, Phil M. Choi, Mary Morrison, Daniel Field, Pradip Gyawali, Aaron Bivins, Kyle Bibby, Stuart L. Simpson
Summary: This study compared the performance of RT-qPCR and RT-dPCR platforms in detecting SARS-CoV-2 RNA in low-prevalence locations in Queensland, Australia. The results showed that RT-dPCR had a lower limit of detection and a higher detection rate than RT-qPCR in both eluate and pellet samples.
Correction
Public, Environmental & Occupational Health
Sean Cavany, Aaron Bivins, Zhenyu Wu, Devin North, Kyle Bibby, T. Alex Perkins
EPIDEMIOLOGY AND INFECTION
(2022)
Article
Environmental Sciences
Toshimi Nakajima, Mao Kuragano, Makoto Yamada, Ryo Sugimoto
Summary: This study compared the contribution of submarine groundwater discharge (SGD) to river nutrient budgets at nearshore and embayment scales, and found that SGD-derived nutrients become more important at larger spatial scales.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Fan Liu, Lei Zhang, Chongyang Zhang, Ziguang Chen, Jingguang Li
Summary: NO2 emissions from wall-mounted gas stoves used for household heating have become a significant source of indoor pollution in Chinese urban areas. The high indoor concentration of NO2 poses potential health risks to residents. It is urgently necessary to establish relevant regulations and implement emission reduction technologies to reduce NO2 emissions from wall-mounted gas stoves.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Letter
Environmental Sciences
Hans Peter H. Arp, Raoul Wolf, Sarah E. Hale, Sivani Baskaran, Juliane Gluege, Martin Scheringer, Xenia Trier, Ian T. Cousins, Harrie Timmer, Roberta Hofman-Caris, Anna Lennquist, Andre D. Bannink, Gerard J. Stroomberg, Rosa M. A. Sjerps, Rosa Montes, Rosario Rodil, Jose Benito Quintana, Daniel Zahn, Herve Gallard, Tobias Mohr, Ivo Schliebner, Michael Neumann
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Philomina Onyedikachi Peter, Binessi Edouard Ifon, Francois Nkinahamira, Kayode Hassan Lasisi, Jiangwei Li, Anyi Hu, Chang-Ping Yu
Summary: This study investigates the relationship between dissolved organic matter (DOM) and Rare Earth Elements (REEs) in sediments from Yundang Lagoon, China. The results show four distinct fluorescent components, with protein-like substances being the most prevalent. Additionally, the total fluorescence intensity and LREE concentrations exhibit a synchronized increase from Outer to Inner to Songbai Lake core sediments. The findings demonstrate a strong correlation between DOM content and pollution levels.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Surya Gupta, Pasquale Borrelli, Panos Panagos, Christine Alewell
Summary: The objective of this study is to incorporate soil hydraulic properties into the erodibility factor (K) of USLE-type models. By modifying and improving the existing equations for soil texture and permeability, the study successfully included information on saturated hydraulic conductivity (Ksat) into the calculation of K factor. Using the Random Forest machine learning algorithm, two independent K factor maps with different spatial resolutions were generated. The results show that the decrease in K factor values has a positive impact on the modeling of soil erosion rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jesmin Akter, Wendy J. M. Smith, Yawen Liu, Ilho Kim, Stuart L. Simpson, Phong Thai, Asja Korajkic, Warish Ahmed
Summary: The choice of workflow in wastewater surveillance has a significant impact on SARS-CoV-2 concentrations, while having minimal effects on HF183 and no effect on HAdV 40/41 concentrations. Certain components in the workflow can be interchangeable, but factors such as buffer type, chloroform, and homogenization speed can affect the recovery of viruses and bacteria.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yu Luo, Xueting Yang, Diwei Wang, Hongmei Xu, Hongai Zhang, Shasha Huang, Qiyuan Wang, Ningning Zhang, Junji Cao, Zhenxing Shen
Summary: Atmospheric PM2.5, which can generate reactive oxygen species (ROS), is associated with cardiorespiratory morbidity and mortality. The study found that both the mass concentration of PM2.5 and the DTT activity were higher during the heating season than during the nonheating season. Combustion sources were the primary contributors to DTT activity during the heating season, while secondary formation dominated during the nonheating season. The study also revealed that biomass burning had the highest inherent oxidation potential among all sources investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Erin L. Murphy, Leah R. Gerber, Chelsea M. Rochman, Beth Polidoro
Summary: Plastic pollution has devastating consequences for marine organisms. This study uses a trait-based framework to develop a vulnerability index for marine mammals, seabirds, and sea turtles in Hawai'i. The index ranks 63 study species based on their vulnerability to macroplastic pollution, providing valuable information for species monitoring and management priorities.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Kenji Maurice, Amelia Bourceret, Sami Youssef, Stephane Boivin, Liam Laurent-Webb, Coraline Damasio, Hassan Boukcim, Marc-Andre Selosse, Marc Ducousso
Summary: Growing pressure from climate change and agricultural land use is destabilizing soil microbial community interactions. Little is known about microbial community resistance and adaptation to disturbances, hindering our understanding of recovery latency and implications for ecosystem functioning. This study found that anthropic disturbance and natural disturbance have different effects on the topology and stability of soil microbial networks.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Yunhao Li, Yali Feng, Haoran Li, Yisong Yao, Chenglong Xu, Jinrong Ju, Ruiyu Ma, Haoyu Wang, Shiwei Jiang
Summary: Deep-sea mining poses a serious threat to marine ecosystems and human health by disturbing sediment and transmitting metal ions through the food chain. This study developed a new regenerative adsorption material, OMN@SA, which effectively removes metal ions. The adsorption mechanism and performance of the material for metal ion fixation were investigated.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Antonio Medici, Margherita Lavorgna, Marina Isidori, Chiara Russo, Elena Orlo, Giovanni Luongo, Giovanni Di Fabio, Armando Zarrelli
Summary: Valsartan, a widely used antihypertensive drug, has been detected in high concentrations in surface waters due to its unchanged excretion and incomplete degradation in wastewater treatment plants. This study investigated the degradation of valsartan and identified 14 degradation byproducts. The acute and chronic toxicity of these byproducts were evaluated in key organisms in the freshwater trophic chain.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Jiang Lin, Lianbao Chi, Qing Yuan, Busu Li, Mingbao Feng
Summary: This study investigated the photodegradation behavior and product formation of two representative pharmaceuticals in simulated estuary water. The study found that the formed transformation products of these pharmaceuticals have potential toxicity on marine organisms, including oxidative stress and damage to cellular components.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Hua Fang, Dongdong Jiang, Ye He, Siyi Wu, Yuehong Li, Ziqi Zhang, Haoting Chen, Zixin Zheng, Yan Sun, Wenxiang Wang
Summary: This study revealed that exposure to lower levels of air pollutants led to decreased pregnancy rates, with PM10, NO2, SO2, and CO emerging as the four most prominent pollutants. Individuals aged 35 and above exhibited heightened susceptibility to pollutants.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Ali Shaan Manzoor Ghumman, Rashid Shamsuddin, Amin Abbasi, Mohaira Ahmad, Yoshiaki Yoshida, Abdul Sami, Hamad Almohamadi
Summary: In this study, inverse vulcanized polysulfides (IVP) were synthesized by reacting molten sulfur with 4-vinyl benzyl chloride, and then functionalized using N-methyl D-glucamine (NMDG). The functionalized IVP showed a high mercury adsorption capacity and a machine learning model was developed to predict the amount of mercury removed. Furthermore, the functionalized IVP can be regenerated and reused, providing a sustainable and cost-effective adsorbent.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Environmental Sciences
Rita Bonfiglio, Renata Sisto, Stefano Casciardi, Valeria Palumbo, Maria Paola Scioli, Erica Giacobbi, Francesca Servadei, Gerry Melino, Alessandro Mauriello, Manuel Scimeca
Summary: This study investigated the presence of aluminum in human colon cancer samples and its potential association with biological processes involved in cancer progression. Aluminum was found in tumor areas of 24% of patients and was associated with epithelial to mesenchymal transition (EMT) and cell death. Additional analyses revealed higher tumor mutational burden and mutations in genes related to EMT and apoptosis in aluminum-positive colon cancers. Understanding the molecular mechanisms of aluminum toxicity may improve strategies for the management of colon cancer patients.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
