Article
Biochemistry & Molecular Biology
Lucas M. N. Silva, Wilza W. M. Franca, Victor H. B. Santos, Renan A. F. Souza, Adriana M. Silva, Emily G. M. Diniz, Thierry W. A. Aguiar, Joao V. R. Rocha, Mary A. A. Souza, Wheverton R. C. Nascimento, Reginaldo G. Lima Neto, Iranildo J. Cruz Filho, Eulalia C. P. A. Ximenes, Hallysson D. A. Araujo, Andre L. Aires, Monica C. P. A. Albuquerque
Summary: This study evaluated the schistosomicidal potential of Plumbagin (PLUM) against Schistosoma mansoni and its pharmacokinetic parameters. The results showed that PLUM significantly reduced the worm and egg load, as well as demonstrated good pharmacokinetic profiles in silico.
Article
Chemistry, Medicinal
Omary Mashiku Minzi, Rajabu Hussein Mnkugwe, Eliford Ngaimisi, Safari Kinung'hi, Anna Hansson, Anton Pohanka, Appolinary Kamuhabwa, Eleni Aklillu
Summary: The study found that co-administration of dihydroartemisinin-piperaquine significantly increases systemic exposure of praziquantel, which may contribute to the increased effectiveness of praziquantel + dihydroartemisinin-piperaquine combination therapy compared to praziquantel alone in treating schistosomiasis.
Article
Biology
Mona M. El-Derbawy, Hala S. Salem, Mona Raboo, Ibrahim R. Baiuomy, Sana A. Fadil, Haifa A. Fadil, Sabrin R. M. Ibrahim, Walaa A. El Kholy
Summary: This study aimed to investigate the anti-schistosomal potential of ginger-loaded chitosan nanoparticles on experimentally infected mice. The results showed that the nanoparticles significantly reduced the infection and improved the liver tissue.
Article
Infectious Diseases
Erik Koehne, Nina Zander, Miriam Rodi, Jana Held, Wolfgang Hoffmann, Rella Zoleko-Manego, Michael Ramharter, Ghyslain Mombo-Ngoma, Peter G. Kremsner, Andrea Kreidenweiss
Summary: The study results indicate that pyronaridine and methylene blue have potential for the treatment of schistosomiasis. Both drugs show certain efficacy against different physiological stages of schistosomes, with the combination drug pyronaridine-artesunate already demonstrating treatment potential in clinical settings.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Article
Parasitology
Khanh Pham, Gideon S. Mtalitinya, Christine Aristide, Efeose A. Airewele, Deborah K. Nyakaru, Paige McMahon, Gerald Mulaki Mulaki, Paul L. A. M. Corstjens, Claudia J. . de Dood, Govert J. van Dam, John M. Changalucha, Humphrey D. Mazigo, Myung Hee Lee, Hyasinta Jaka, Jennifer A. Downs
Summary: Schistosoma mansoni infection is associated with mild-to-moderate lower gastrointestinal mucosal abnormalities that are visible during sigmoidoscopy, and these abnormalities partially improve 6 months after effective praziquantel treatment.
Article
Parasitology
Neveen Adel Madbouly, Mohammed Emam, Malak Ayman, Mohammed Ayman, Ibraheem Rabia, Azza El Amir
Summary: This study evaluated the antischistosomal effects of Nifedipine (NIF) and Diltiazem (DTZ), widely used antihypertensive drugs, as well as their combinations with Praziquantel (PZQ) on early and late Schistosoma mansoni infections in vitro and in vivo. The results showed that combined treatment of NIF and PZQ improved the parasite reduction efficacy in mice compared to PZQ monotherapy, leading to a decrease in anti-SEA antibody levels.
EXPERIMENTAL PARASITOLOGY
(2022)
Article
Multidisciplinary Sciences
Valentina Z. Petukhova, Sammy Y. Aboagye, Matteo Ardini, Rachel P. Lullo, Francesca Fata, Margaret E. Byrne, Federica Gabriele, Lucy M. Martin, Luke N. M. Harding, Vamshikrishna Gone, Bikash Dangi, Daniel D. Lantvit, Dejan Nikolic, Rodolfo Ippoliti, Gregory Effantin, Wai Li Ling, Jeremy J. Johnson, Gregory R. J. Thatcher, Francesco Angelucci, David L. Williams, Pavel A. Petukhov
Summary: This study identifies noncovalent TGR inhibitors that are effective against schistosome infections in mice, surpassing praziquantel in treating juvenile worms.
NATURE COMMUNICATIONS
(2023)
Editorial Material
Parasitology
Yohann Le Govic, Benjamin Gourbal, Jerome Boissier
Summary: Researchers have decoded the functions of genes necessary for worm survival and pathogenesis using postgenomic technologies, paving the way for the development of innovative parasite-targeted therapies in the effort to eliminate schistosomiasis, which is hindered by the incomplete efficacy of the only FDA-approved anti-schistosomal drug, praziquantel.
TRENDS IN PARASITOLOGY
(2021)
Article
Microbiology
Andreas J. Stroehlein, Pasi K. Korhonen, V. Vern Lee, Stuart A. Ralph, Margaret Mentink-Kane, Hong You, Donald P. McManus, Louis-Albert Tchuem Tchuente, J. Russell Stothard, Parwinder Kaur, Olga Dudchenko, Erez Lieberman Aiden, Bicheng Yang, Huanming Yang, Aidan M. Emery, Bonnie L. Webster, Paul J. Brindley, David Rollinson, Bill C. H. Chang, Robin B. Gasser, Neil D. Young
Summary: Urogenital schistosomiasis, caused by the blood fluke Schistosoma haematobium, affects over 100 million people globally. Research on the genome of S. haematobium reveals important biological and disease traits, which can contribute to improved control of the disease.
Article
Pharmacology & Pharmacy
Tayo A. Adekiya, Pradeep Kumar, Pierre P. D. Kondiah, Yahya E. Choonara
Summary: This study employed nanotechnological techniques to design and develop a praziquantel nanoliposomal (NLP) system. The study successfully surface-functionalized the NLP with anti-calpain antibody for targeted praziquantel delivery in the treatment of schistosomiasis. The results showed that the anti-calpain-NLP system had stable physicochemical parameters and satisfactory drug release rate. In vitro and in vivo experiments demonstrated that the system had no significant cytotoxic effects and exhibited hepatoprotective effects. Parasitological analysis confirmed the improved effectiveness of oral anti-calpain-NLP in targeting schistosomes in the liver and porto-mesenteric locations.
Article
Parasitology
Ho Yin Pekkle Lam, Po-Ching Cheng, Shih-Yi Peng
Summary: The combination therapy of PZQ and Sch B demonstrates beneficial effects in treating schistosomiasis by improving hepatosplenomegaly, fibrosis, lung and intestinal injuries, and survival rate, while partially improving neurological function.
INTERNATIONAL JOURNAL FOR PARASITOLOGY
(2022)
Article
Chemistry, Medicinal
Flavio C. Lombardo, Paolo S. Ravaynia, Mario M. Modena, Andreas Hierlemann, Jennifer Keiser
Summary: Human liver microtissues (hLiMTs) have the potential to be used in anti-schistosomal drug discovery, as they express all human P450 enzymes and can evaluate the metabolic conversion capacity and toxicity of compounds.
ACS INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Ramy Mohamed Ghazy, Walid Ismail Ellakany, Mai M. Badr, Nehad E. M. Taktak, Heba Elhadad, Sarah M. Abdo, Ayat Hagag, Abdel Rahman Hussein, Mohamed Mostafa Tahoun
Summary: This study investigated the factors contributing to the maintenance of Schistosoma mansoni infection transmission in hotspots in Egypt. The results showed that in addition to environmental and malacological factors, human practices play a significant role in sustaining the infection. This implies that an integrated control approach is necessary for eliminating schistosomiasis in hotspots.
INFECTIOUS DISEASES OF POVERTY
(2022)
Article
Chemistry, Medicinal
Dana M. Klug, Eftychia M. Mavrogiannaki, Katherine C. Forbes, Lisseth Silva, Rosario Diaz-Gonzalez, Guiomar Perez-Moreno, Gloria Ceballos-Perez, Raquel Garcia-Hernandez, Cristina Bosch-Navarrete, Carlos Cordon-Obras, Claudia Gomez-Linan, Andreu Saura, Jeremiah D. Momper, Maria Santos Martinez-Martinez, Pilar Manzano, Ali Syed, Nelly El-Sakkary, Conor R. Caffrey, Francisco Gamarro, Luis Miguel Ruiz-Perez, Dolores Gonzalez Pacanowska, Lori Ferrins, Miguel Navarro, Michael P. Pollastri
Summary: The study identified a series of new compounds for combating human African trypanosomiasis and developed a potent antitrypanosomal compound with promising pharmacokinetic parameters. However, this compound was not further investigated for stage 2 HAT treatments due to its inability to penetrate the blood-brain barrier.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Infectious Diseases
Julie Hoermann, Esther Kuenzli, Carmen Schaefer, Daniel H. Paris, Silja Buehler, Peter Odermatt, Somphou Sayasone, Andreas Neumayr, Beatrice Nickel
Summary: This study evaluated the sensitivity and specificity of a rapid diagnostic test (Schistosoma ICT IgG-IgM) for the detection of specific IgG and IgM antibodies against Schistosoma spp. in serum. The test showed a sensitivity of 100% in patients with confirmed schistosomiasis, and a specificity of 100% in healthy individuals and patients with rheumatoid arthritis. However, some cross-reactivity was observed in serum samples of patients with other helminth infections, resulting in a specificity of 85%. The Schistosoma ICT IgG-IgM test is a suitable screening tool for Schistosoma specific antibodies, but confirmatory testing is necessary in populations at risk of co-infection with other tissue invasive parasites.
PLOS NEGLECTED TROPICAL DISEASES
(2022)
Article
Agronomy
Mathias Reginatto Wrzesinski, Marcelo Luis Schwab, Denis Antonio Ferrarin, Angel Ripplinger, Julia da Silva Rauber, Marcia Cristina da Silva, Maria Angelica Miglino, Gustavo de Sa Schiavo Matias, Alexandre Mazzanti
Summary: Hypertrophic feline muscular dystrophy (HFMD) is a rare genetic disease linked to the X chromosome, primarily affecting young male cats and characterized by progressive tongue protrusion. This case study presented the clinical aspects, dietary management, and clinical progression of a seven-year-old mixed-breed cat diagnosed with HFMD.
Article
Chemistry, Physical
Camila Marcovicz, Guilherme dos Anjos Camargo, Bianca Scharr, Larissa Sens, Mariana Negrelli Levandowski, Thiago De Castro Rozada, Patricia Castellen, Juliana Inaba, Rosimeire Nunes De Oliveira, Julio Cesar Mine, Sheila de Andrade Penteado Correa, Silmara Marques Allegretti, Barbara Celnia Fiorin
Summary: This study synthesized Chalcones with nitro and bromo substituents in different positions and investigated their conformation and schistosomicidal effects. The results showed that Chalcones had a preference for s-cis geometry and exhibited significant effects on adult Schistosoma mansoni. Chalcones reduced the motor activity, caused mortality, and suppressed egg production in a concentration-dependent manner. These findings indicate the potential of Chalcones as schistosomicidal drugs and contribute to the understanding of the relationship between molecular conformation and biological effects.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Agriculture, Dairy & Animal Science
Catia H. de Almeida Lima Massari, Adriano Ferreira-Silva, Henrique Riceti-Magalhaes, Dara R. Souza-Silva, Maria A. Miglino
Summary: The present study investigated the role of computed tomography in identifying the os cordis and characterizing its anatomical structure in sheep. The results showed the presence of a 6.39 mm osseous structure in the aortic valve region of the heart, along with fibrous connective tissue, cancellous bone tissue, and calcified hyaline cartilage. It was concluded that computed tomography is an effective tool for visualizing the os cordis in lambs.
REVISTA MVZ CORDOBA
(2022)
Article
Biotechnology & Applied Microbiology
Gustavo de Sa Schiavo Matias, Ana Claudia O. Carreira, Vitoria Frias Batista, Hianka Jasmyne Costa de Carvalho, Maria Angelica Miglino, Paula Fratini
Summary: Decellularized extracellular matrix can be used as a biomaterial for tissue engineering, particularly for partial trachea replacement. In this study, acellular canine tracheal scaffolds with preserved ECM structure and proteins were obtained and evaluated for cell adhesion and proliferation. The results showed successful recellularization of the scaffolds with canine tracheal epithelial cells and yolk sac endothelial progenitor cells. In vivo implantation in mice confirmed the preserved tissue and absence of fibrotic tissue process. This study demonstrates the potential of recellularized scaffolds for future applications in tissue engineering.
Article
Parasitology
Allan Daniel Ribeiro Sotelo Montanhaur, Estela de Oliveira Lima, Jeany Delafiori, Cibele Zanardi Esteves, Cesar Corat Ribeiro Prado, Silmara Marques Allegretti, Marlene Tiduko Ueta, Carlos Emilio Levy, Rodrigo Ramos Catharino
Summary: Strongyloidiasis, caused by Strongyloides stercoralis infection, is a common parasitic disease in tropical or subtropical areas. Due to the lack of a gold-standard diagnostic tool, this study used metabolomics to evaluate metabolic changes in stool samples and identified 5 potential biomarkers, indicating the involvement of microbiota remodeling, parasite constitution, and host response in the intestinal metabolism of S. stercoralis infection.
Article
Anatomy & Morphology
Monica Duarte da Silva, Ricardo Martins de Azevedo Castro Guglielmi, Andressa Daronco Cereta, Henrique Inhauser Riceti Magalhaes, Rafaela Rodrigues Ribeiro, Jose Miguel Velasquez Salazar, Maria Angelica Miglino
Summary: Due to the limitations imposed by the COVID-19 pandemic, new technologies were used to facilitate teaching and learning activities. This research developed a digital platform that connects the knowledge of the central nervous system anatomy in feline, equine, and sheep models. The platform includes modules with explanatory documents, video lectures, and descriptive atlases. This is the first veterinary neuroanatomy platform that addresses the CNS anatomy of felines, equines, and sheep simultaneously.
ANATOMIA HISTOLOGIA EMBRYOLOGIA
(2023)
Article
Parasitology
Paula Berna da Silva Medeiros, Tiago Manuel Fernandes Mendes, Vera Lucia Garcia, Rosimeire Nunes De Oliveira, Leticia Bastos Duart, Silmara Marques Allegretti
Summary: In this study, the ethanolic extract of Spondias mombin L. was tested for its in vitro effect against Strongyloides venezuelensis. The results showed that the extract and its fractions had a better in vitro effect than ivermectin. Fraction 4 exhibited the best results, causing 100% mortality in a short period of time. Scanning electron microscopy and gas chromatography analysis provided insights into the mechanism of action, suggesting that monoaromatic phenolic lipids may be responsible for the antiStrongyloides effect. The use of polyvinylpyrrolidone reduced the efficiency of the extract.
Article
Veterinary Sciences
Maria Jose Monroy-Cendales, Juan Fernando Velez-Garcia, Roman David Castaneda-Serrano, Maria Angelica Miglino
Summary: This study investigated the gross anatomy of the scapular and brachial muscles in the robust brown capuchin monkey (Sapajus apella), revealing adaptations for arboreal and terrestrial locomotion that are similar to other primates.
JOURNAL OF MEDICAL PRIMATOLOGY
(2023)
Article
Anatomy & Morphology
Juan Fernando Velez-Garcia, Maria Angelica Miglino
Summary: This study describes the attachments and innervations of the extrinsic thoracic limb muscles in three procyonid species. It reveals intra- and interspecific anatomical variations in muscle attachments and evolutionary derivations based on innervation. The functions of these muscles may be associated with locomotor habits and phylogenetic relationships among procyonids.
ANATOMICAL SCIENCE INTERNATIONAL
(2023)
Article
Anatomy & Morphology
Francisco Acuna, Julieta Carril, Enrique L. L. Portiansky, Mirta A. A. Flamini, Maria A. Miglino, Claudio G. G. Barbeito
Summary: This study determined the expression of different glycosidic residues (Gr) in the placenta of the plains viscacha using lectin histochemistry, and constructed a matrix to analyze and infer phylogenetic and evolutionary relationships. The results showed variations in the pattern expression of different Gr in different stages of placenta development, and a high diversity of Gr in the near-term placenta.
JOURNAL OF MORPHOLOGY
(2023)
Article
Veterinary Sciences
Patricia Christiane O. C. Jezler, Henrique I. R. Magalhaes, Monica D. Silva, Lucas A. Ribeiro, Maria Angelica Miglino, Andrea A. Pereira
Summary: The study evaluated the ratio of major and trace elements in dog cataract lenses using X-ray fluorescence spectrometry, contributing to diagnostic, non-surgical, and ophthalmological preventive data. Results showed that the concentrations of Ca, Fe, Cu, and Zn in dog cataract lenses were associated with the reabsorption mechanism of hypermature cataracts. These findings may support the development of therapeutic strategies for cataracts in dogs. The Ca concentrations differed in different stages of cataract development, and the Fe concentration was higher in males than females. This research provides valuable insights into cataract formation and prevention.
VETERINARY OPHTHALMOLOGY
(2023)
Article
Veterinary Sciences
Cristina E. de Albuquerque, Monica D. da Silva, Henrique I. Riceti Magalhaes, Hianka J. C. de Carvalho, Maria A. Miglino, Marco A. Gioso
Summary: The study aimed to describe the innervation and vascularization of the stomatognathic system in dogs. The distribution patterns of arteries, veins, and nerves were observed in dogs with different skull types. The findings revealed variations in the blood vessels and neural structures of the stomatognathic system among different skull types. This data is important for clinical practice, surgical planning, and interpretation of clinical dysfunctions.
JOURNAL OF VETERINARY DENTISTRY
(2023)
Article
Veterinary Sciences
Adriano Dall'Olio, Gustavo Matias, Hianka Carvalho, Ana Claudia O. Carreira, Thais Campanelli, Vitoria Batista, Julia Dantas, Paulo Fratini, Maria A. Miglino
Summary: Cleft palates are serious oral deformities that mostly affect puppies. Surgical treatment using decellularized scaffolds has been found to be effective in achieving total closure and healing of the cleft palate in dogs.
JOURNAL OF VETERINARY DENTISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Tarley Santos Oliveira, Igor Smirnow, Kadija Mohamed Santee, Maria Angelica Miglino, Rodrigo da Silva Nunes Barreto
Summary: This study aims to achieve the artificial development of blood vessels through the recellularization of vascular scaffolds derived from bovine placental vessels. The results showed that the decellularization process maintained the natural structure and elastin content of the vessels, and endothelial precursor cells were attached to the lumen and external surface of the decellularized vessels. Therefore, this biomaterial holds potential for use in cardiovascular medicine.
ARQUIVOS BRASILEIROS DE CARDIOLOGIA
(2023)
Review
Zoology
Juan Fernando Velez-Garcia, Lucia Marin-Gonzalez, Maria Jose Monroy-Cendales, Maria Angelica Miglino
Summary: This study analyzes the interspecific and intraspecific differences of the craniolateral forearm muscles of Procyon cancrivorus, providing detailed descriptions of their anatomical characteristics. It is of great significance for understanding the anatomy of crab-eating raccoons and potential anatomical variations in related species.
IHERINGIA SERIE ZOOLOGIA
(2022)
Article
Parasitology
Gabriela Martinez Moura Tavares, Hannar Angelica de Melo Alverga, Estela Moraes Felix, Giovana de Oliveira Dichman, Gabriel Monteiro Pinheiro, Yara Juliano, Priscila Paruci, Dennis Minoru Fujita, Lucas Melo Neves, Marina Tiemi Shio, Luiz Henrique da Silva Nali
Summary: This study investigated the frequency of N. gonorrhoeae infection in women in a poor area of São Paulo and found that most of the strains detected showed resistance to one or more antimicrobials.
Article
Parasitology
Qian Yao, Ying-Ying Fan, Shuang Huang, Gui-Rong Hu, Jun-Ke Song, Xin Yang, Guang-Hui Zhao
Summary: This study found that the expression of miR-4521 was upregulated during C. parvum infection, and this upregulation was related to the TLR/NF-kappa B signal pathway. Additionally, miR-4521 promoted the propagation of C. parvum in HCT-8 cells by regulating BCL2-mediated cell apoptosis through targeting foxm1.
Article
Parasitology
Cho Naing, Maxine A. Whittaker, Wong Siew Tung, Htar Aung, Joon Wah Mak
Summary: This study aimed to estimate the prevalence of zoonotic brugian filariasis in animals and compare it with the prevalence in humans in the same area. The findings suggest that cats, dogs, and leaf-eating monkeys may serve as potential reservoirs for human brugian filariasis.
Review
Parasitology
Raissa Nogueira de Brito, Susan Tanner, Julie Velasquez Runk, Juliana Hoyos
Summary: This study conducted a scoping review to identify major research themes and knowledge gaps in the social science literature on leishmaniases or Chagas disease. The findings showed that research in this field mainly focuses on the sociocultural, economic, historical, and political dimensions of the diseases. Future research should pay more attention to how social institutions and economic factors shape disease education, control measures, healthcare access, and quality of life of affected individuals.
Article
Parasitology
Minghao Zheng, Mengyao Zhang, Hao Li, Shipo Wu, Yuee Zhao, Jinlong Zhang, Yunyue Zhou, Mohamed Boie Jalloh, Kun Zhang, Lina Chen, Zhiqiang Mi, Yong Cui, Lihua Hou
Summary: Rapid and convenient detection of Plasmodium falciparum, the deadliest malaria parasite in Africa, is crucial for malaria eradication efforts in medical resource-limited settings. A CRISPR-based diagnostic method that can detect P. falciparum without nucleic acid extraction was developed and showed high sensitivity and consistency with qPCR test. It can also detect artemisinin-resistant strains and other laboratory-cultured strains. This method has great potential for clinical testing and large-scale community screening in Africa and other regions.
Article
Parasitology
Fabian Correa-Morales, Cassandra Gonzalez-Acosta, David Ibarra-Ojeda, Miguel Moreno-Garcia
Summary: Since 2002, West Nile Virus (WNV) has been reported in 18 states in Mexico. This paper discusses the proposed hypotheses for the absence of WNV outbreaks in Latin America and provides a context-specific explanation for Mexico.
Article
Parasitology
Umberto Molini, Lauren M. Coetzee, Vernon Christians, Maria Y. Hemberger, Bernard Chiwome, Maria Amukwaya, Siegfried Khaiseb, Giovanni Cattoli, William G. Dundon, Giovanni Franzo
Summary: Porcine circovirus 3 (PCV-3) has been reported globally since its first identification in 2015. Limited data on PCV-3 in Africa led to a study in Namibia, which found a high prevalence of PCV-3 in backyard piggeries, but not in commercial farms with higher biosecurity measures. The source of viral introduction and factors such as semen importation, feeding backyard pigs with human food waste, pig exchanges, and wildlife movements may be involved in the dispersal of PCV-3 within Namibia. Further studies are needed to understand the epidemiology and impact of PCV-3 on pig productivity and wildlife health.
Article
Parasitology
Chutchai Piewbang, Panida Poonsin, Pattiya Lohavicharn, Panitnan Punyathi, Sawang Kesdangsakonwut, Tanit Kasantikul, Somporn Techangamsuwan
Summary: This study provides insights into the pathology of natural SARS-CoV-2 infection in dogs, revealing severe damage to the lungs and involvement of multiple organs. The findings suggest the potential utility of dogs as a model for studying SARS-CoV-2 infection in humans, highlighting the need for further investigation.
Article
Parasitology
Julian Avila-Jimenez, Juan David Gutierrez, Mariano Altamiranda-Saavedra
Summary: Leishmaniasis is a parasitic disease transmitted to humans by sandfly vectors and vertebrate hosts. This study used ecological niche modeling to investigate the potential distribution of host and vector species associated with cutaneous leishmaniasis transmission, revealing different distribution patterns under varying climatic conditions.
Article
Parasitology
Luis A. Gomez-Puerta, Juan Olazabal, Santiago Paredes, Juan Lopez, Miguel Anampa, Angelica Mondragon, Ana Vargas-Calla, Hugo Castillo
Summary: This study reports the first detection of Candidatus M. haemolamae infection in vicunas from the Pampa Galeras National Reserve in Peru, using molecular diagnosis. Tick-infested vicunas had a higher likelihood of being infected with Candidatus M. haemolamae compared to tick-free vicunas. Gender and age were not associated with infection.
Article
Parasitology
Berlin Londono-Renteria, Zakaria Seidu, Helena Lamptey, Michael F. Ofori, Lars Hviid, Mary Lopez-Perez
Summary: Heterozygous carriers of HbAS and HbAC have a reduced risk of severe malaria, but not immunity against Plasmodium falciparum infection. Antibody levels against gSG6-P1 peptide in Anopheles mosquito saliva can serve as a serological biomarker for exposure to Plasmodium infection. This study highlights the importance of studying the role of hemoglobinopathies in malaria transmission for improving control interventions.
Article
Parasitology
Imane Belbacha, Meryem El Azzouzi, Rajae Bensghir, Kamal Filali Marhoum, Khadija Hajjout, El Mir Elharti, Khalid Sadki, Hicham Oumzil
Summary: This study investigates the association of three SNPs in the APOBEC3G gene with disease outcomes in Moroccan HIV-1 infected patients. The rs2294367 CG genotype is strongly associated with protection against HIV-1 infection, particularly in older individuals.
Article
Parasitology
Tan Luong, Do Kien Tran, Anh Hung Pham, Thi Thu-Ha Hoang, Van Khang Pham, Quang Thai Pham, Thi Mai Hung Tran, Minh Hoa Luong, Thanh Long Pham, Jason K. Blackburn
Summary: This study examined the epidemiology of anthrax in Lai Chau province, Vietnam, using historical data. Spatial clusters of human and livestock anthrax were identified, and the characteristics of the disease were described. The study found that there were distinct differences between the high-risk areas for human and livestock anthrax, and most human cases occurred during specific seasons. Additionally, the decrease in livestock anthrax vaccine coverage was associated with an increase in disease incidence.
Article
Parasitology
Jin-tao Chen, Jian-bo Zhan, Ming-chao Zhu, Kai-ji Li, Man-qing Liu, Bin Hu, Kun Cai, Hai-rong Xiong, Shu-liang Chen, Wei-long Tan, Liang-jun Chen, Wei Hou
Summary: This study investigated the prevalence and variation of orthohantavirus in rodents and humans in Hubei province, China. It identified the diversity of orthohantaviruses circulating in the region, with the HV004-like subtype being the main genotype in rodents and patients. This highlights the importance of continued attention and research on orthohantaviruses, especially newly identified strains.