Article
Nanoscience & Nanotechnology
Polina Ivanova, Konrad Dziegielewski, Marcin Drozd, Sandra Skorupska, Ilona Grabowska-Jadach, Mariusz Pietrzak
Summary: Reactive oxygen species (ROS) are important in physiological processes but can pose a threat to health with increased concentrations. Different defense systems in plants, invertebrates, and vertebrates including humans combat ROS, but environmental conditions and lifestyle can interfere with enzyme activity. Therefore, finding alternative ROS scavengers is crucial, with nanozymes being a proposed solution to mimic essential enzyme activities and prevent excessive ROS activity.
Article
Nanoscience & Nanotechnology
Yuan Gao, Shihong Liu, Xinchun Zeng, Zhixiong Guo, Da Chen, Sanzhong Li, Zhimin Tian, Yongquan Qu
Summary: Endothelial dysfunction induced by severe oxidative stress damage plays a critical role in the pathogenesis and progression of atherosclerosis. This study demonstrates that gadolinium-doped CeO2 nanozymes effectively scavenge reactive oxygen species (ROS) and show promising antiatherosclerosis performance. The Gd/CeO2 nanozymes reduce vascular lesions and lipid accumulation in macrophages, decrease inflammatory factor levels, and can serve as T1-weighted magnetic resonance imaging contrast agents for plaque localization.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Engineering, Environmental
Pei Wang, Lianguo Wang, Yilan Zhan, Yifan Liu, Ziqiang Chen, Jia Xu, Jun Guo, Jun Luo, Junchao Wei, Fei Tong, Zhihua Li
Summary: Given the limitations of clinical curettage for periodontitis, improved medical therapy is needed for thorough removal of dental plaque and periodontal tissue repair. The development of local drug delivery systems (LDDSs) for adjuvant periodontitis therapy has faced challenges such as low anti-biofilm effect and tissue damage caused by excessive reactive oxygen species (ROS). In this study, versatile nanocomposites (PPM NPs) were fabricated using polydopamine-coated Prussian blue nanoparticles (PB NPs) loaded with minocycline (Mino), which showed enhanced antibacterial and anti-inflammatory effects for periodontitis treatment.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Engineering, Biomedical
Bijun Zhu, Jiangjiexing Wu, Tong Li, Songtao Liu, Junheng Guo, Yijun Yu, Xinyi Qiu, Yue Zhao, Haoran Peng, Jinli Zhang, Leiying Miao, Hui Wei
Summary: In this study, the use of MVF nanozyme as a precise regulator of ROS in periodontitis is proposed. By selectively eliminating H2O2, the most prominent ROS, MVF contributes to limiting inflammation, regulating immune microenvironment, promoting periodontal regeneration, and stimulating osteogenic differentiation of periodontal stem cells. MVF regulates ROS through the Nrf2/HO-1 pathway and promotes osteogenic differentiation through the PI3K/Akt pathway. Nanozymes have the potential to be an important precision medicine tool in periodontitis therapy.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Chemistry, Analytical
Li Liu, Yayu Lai, Jinming Cao, Yu Peng, Tian Tian, Wensheng Fu
Summary: A Ni0.1Cu0.9S nanoflower with excellent antibacterial activity was successfully synthesized through a one-step hydrothermal method. Based on this nanoflower, a colorimetric technique for rapid and accurate detection of ascorbic acid (AA) by the unaided eye was designed.
Article
Engineering, Environmental
Liying Zhang, Pei Xie, Hang Wu, Jiulong Zhao, Shige Wang
Summary: In this study, a two-dimensional MoSe2@PVP nanosheets were fabricated as an artificial enzyme to treat acute pancreatitis (AP) by eliminating reactive oxygen species (ROS) and reactive nitrogen species (RNS). The nanosheets showed good biocompatibility and demonstrated excellent ROS and RNS scavenging abilities. In vivo experiments on an animal model of AP confirmed the therapeutic effect of the nanosheets in reducing the levels of certain inflammatory factors.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biotechnology & Applied Microbiology
Zhuobin Xu, Yufei Zhu, Mengke Xie, Kankan Liu, Liangliang Cai, Huihui Wang, Dandan Li, Hao Chen, Lizeng Gao
Summary: This study synthesized mackinawite nanozymes (GFeSNs) from glutathione and iron ions, and found that GFeSNs have broad-spectrum antioxidant properties and can significantly improve the treatment outcomes of acute kidney injury (AKI) by scavenging reactive oxygen species (ROS).
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Feng Wang, Qinghe Wu, Chunfu Zhang, Lingchi Kong, Rongtai Zuo, Kai Feng, Guoping Jia, Mengfei Hou, Jianhua Zou, Yimin Chai, Jia Xu, Xiaoyuan Chen, Qinglin Kang
Summary: The management of diabetic wounds is challenging due to bacterial infections and chronic inflammation. This study proposes a two-phase treatment strategy using reactive oxygen species (ROS) to combat infection and promote wound regeneration. The strategy effectively eliminates bacteria and stimulates wound healing.
Article
Engineering, Biomedical
Fuchun Nan, Qingyan Jia, Xiaokuang Xue, Shuai Wang, Weimin Liu, Jian Wang, Jiechao Ge, Pengfei Wang
Summary: This study presents a new type of high-performance nanozyme for multifunctional nanotheranostic use. The nanozyme, assembled with iron phthalocyanine and a polymer, shows multiple enzyme-like activities and can generate dual reactive oxygen species. It also demonstrates enhanced catalytic therapy under the influence of the tumor microenvironment and near-infrared light-responsive photothermal effect.
Article
Chemistry, Multidisciplinary
Meng-Meng Pan, Yu Ouyang, Yong-Li Song, Lu-Qin Si, Ming Jiang, Xu Yu, Li Xu, Itamar Willner
Summary: In this study, the synthesis and characterization of Au3+-modified UiO-67 metal-organic framework nanoparticles were described. The Au3+-NMOFs showed dual oxidase-like and peroxidase-like activities, and acted as an effective catalyst for the generation of ROS agents for antibacterial and wound healing applications.
Article
Nanoscience & Nanotechnology
Jialuo Ding, Yanhui Du, Xinying Hu, Mengyuan Zhao, Yeying Li, Le Li, Yu Su, Zhenkun Lin
Summary: Excessive reactive oxygen species (ROS) can cause oxidative stress and dysfunction of white adipocytes and white fat. Nanozymes, specifically aptamer-modified atomically precise gold Au-25 nanoclusters (Apt-Au-25 NCs), have shown potential in scavenging ROS and treating ROS-related diseases. The study demonstrates that Apt-Au-25 NCs have high targeting capability towards white adipocytes, exhibit SOD-like and CAT-like activity, and are efficient in scavenging ROS in white adipocytes, suggesting their potential for obesity and related disease treatment.
Article
Chemistry, Multidisciplinary
Longwei Wang, Xiaodi Zhang, Zhen You, Zhongwei Yang, Mengyu Guo, Jiawei Guo, He Liu, Xiaoyu Zhang, Zhuo Wang, Aizhu Wang, Yawei Lv, Jian Zhang, Xin Yu, Jing Liu, Chunying Chen
Summary: The deficient catalytic activity of nanozymes and insufficient endogenous H2O2 in the tumor microenvironment (TME) are major obstacles for nanozyme-mediated catalytic tumor therapy. We explored the contributing factors of enzymatic activity based on positive and negative charges, which are experimentally and theoretically demonstrated to enhance the peroxidase (POD)-like activity of a MoS2 nanozyme. Hence, an acidic tumor microenvironment-responsive and ultrasound-mediated cascade nanocatalyst (BTO/MoS2@CA) is presented that enables effective tumor ferroptosis with minimal side effects.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Nanoscience & Nanotechnology
Longxiyu Meng, Jiayuan Feng, Jie Gao, Yihong Zhang, Wenjing Mo, Xiaozhi Zhao, Hui Wei, Hongqian Guo
Summary: Mn3O4 nanoflowers with scavenging activities for reactive oxygen species and cell-free DNA have been developed, providing better protection and treatment for acute kidney injury (AKI), as well as real-time imaging capabilities.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Developmental Biology
R. Emily Martin, Eliana Marzol, Jose M. Estevez, Gloria K. Muday
Summary: Research shows that ethylene and its precursor regulate root hair formation by increasing ROS accumulation. Ethylene-sensitive mutants have increased root hair number and ROS accumulation, while ethylene-insensitive mutants show the opposite effect.
Article
Nanoscience & Nanotechnology
Hsin-Lun Lee, Yao Chen Chuang, Jo-Ting Tsai, Yu-Chen Chen, Ping-Hsiu Wu, Leu-Wei Lo, Jeng-Fong Chiou, Yao-An Shen
Summary: Gold nanomaterials have gained attention in biomedical applications due to their biocompatibility and unique properties. In this study, a gold nanodandelion-based system for scavenging reactive oxygen species (ROS) was developed. The system showed excellent antioxidant properties and could mitigate oxidative stress. The size and surface characteristics of the gold nanomaterials influenced their efficiency in scavenging ROS.
ACS APPLIED NANO MATERIALS
(2023)
Article
Microbiology
Zhi-Lai Chi, Xiang-Yang Zhao, Ya-Ling Chen, Jia-Long Hao, Guang-Hui Yu, Bernard A. Goodman, Geoffrey Michael Gadd
Summary: Fungal-mineral interactions can produce biogenic nano-size minerals with high peroxidase-like activity. Analysis revealed that the unique properties of magnetite nanoparticles mainly come from surface non-lattice oxygen, challenging traditional Fenton reaction theories. Additionally, nanoSIMS and synchrotron-based micro-FTIR spectra demonstrated the presence of oxygen film and groups on fungal hyphae surfaces.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Soil Science
Xiaolei Huang, Lei Wang, Yiran Mei, Zhixin Jia, Tingliang Li, Guanghui Yu, Wei Ran
Summary: This study demonstrates that partially substituting chemical fertilizer with compost can enhance the topsoil carbon sequestration efficiency in a rice-wheat cropping system, primarily by increasing microbial biomass and Fe-bound organic carbon, and indirectly by improving microbial substrate-use efficiency.
APPLIED SOIL ECOLOGY
(2022)
Article
Engineering, Environmental
Zhi-Lai Chi, Guang-Hui Yu, Andreas Kappler, Cong-Qiang Liu, Geoffrey Michael Gadd
Summary: Our study reveals that fungi have a robust defect engineering strategy to modulate the POD-like activity of iron minerals, decreasing the activity of poorly ordered ferrihydrite but enhancing that of well-crystallized hematite. The dynamics of POD-like activity involve trade-offs between lattice oxygen and oxygen vacancies in the iron nanoparticles, which may be located in a cytoprotective fungal exoskeleton.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Engineering, Environmental
Yingnan Huang, Fei Dang, Yongguang Yin, Guodong Fang, Yujun Wang, Guanghui Yu, Dongmei Zhou, Baoshan Xing
Summary: Microplastics (MPs) are commonly found in the environment, and research has shown that they can alter the chemical speciation of coexisting contaminants. This study demonstrates that upon solar irradiation, polystyrene (PS) is able to photoreduce dissolved silver (Ag(I)) to metallic silver nanoparticles (Ag(0)-NPs), with carbonyl groups on weathered PS playing a key role in the reduction process. These findings reveal the chemical reactivity of weathered PS and highlight the potential impact of microplastics in the natural environment.
ENVIRONMENTAL SCIENCE & TECHNOLOGY LETTERS
(2022)
Article
Engineering, Environmental
Zhi-Lai Chi, Guang-Hui Yu, H. Henry Teng, Hai-Gang Liu, Jian Wang, Cong-Qiang Liu, Qi-Rong Shen, Geoffrey Michael Gadd
Summary: Fungal-mineral interactions that alleviate stress from organic pollutants have been studied, and it was found that fungal biomineralization can trigger the formation of an ultrathin exoskeleton enriched with iron oxides and biomolecules. This nanobiohybrid system enhances the fungal degradation of bisphenol A through molecular-level trade-offs. The study provides important insights into fungal biomineralization and the coevolution of the Earth's lithosphere and biosphere.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Soil Science
Caiqing Qin, Si-Liang Li, Guang-Hui Yu, Adrian M. Bass, Fu-Jun Yue, Sheng Xu
Summary: Soil in karst zones plays a crucial role in balancing the global carbon budget and regulating climate change. This study investigates the vertical variation of soil carbon and its response to land-use change in a typical karst region in SW China. The results highlight the dynamic nature of soil carbon in karst zones and the need to consider it in estimating carbon sink and global carbon budget.
Article
Engineering, Environmental
Dan Wan, Fei-Fei Liu, Jiu-Bin Chen, Andreas Kappler, Yakov Kuzyakov, Cong-Qiang Liu, Guang-Hui Yu
Summary: The generation of reactive oxygen species (ROS) mediated by minerals and/or microorganisms has a significant impact on carbon and nutrient cycles at soil-water interfaces. Microorganisms primarily drive the production of hydroxyl radical (HO') by modulating iron redox transformation, rather than directly producing ROS. Certain genera, such as Geobacter, Paucimonas, Rhodocyclaceae_K82, and Desulfotomaculum, play a crucial role in HO' production.
Article
Engineering, Environmental
Ruixia Han, Zhe Wang, Jitao Lv, Zhe Zhu, Guang-Hui Yu, Gang Li, Yong-Guan Zhu
Summary: Microbially mediated iron redox processes play a significant role in biogeochemical cycles. Soil organic matter (SOM) affects these processes, but a comprehensive understanding is still lacking. This study examined the role of SOM in microbial iron reduction and hydroxyl radical production. The results show that SOM inhibits the transformation of ferrihydrite to crystalline iron oxides and affects Fe(II) and center dot OH production through different mechanisms.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2022)
Article
Environmental Sciences
Yu Liu, Yucheng Hu, Chengxun Yu, Yuqi Gao, Zhenying Liu, Khan M. G. Mostofa, Siliang Li, Yumei Hu, Guanghui Yu
Summary: This study investigated the spatiotemporal variation of water quality parameters and optical properties of dissolved organic matter (DOM) in the Haihe River in Tianjin, China. It found that both salinity gradients and trophic state gradients have significant effects on the water body, influencing the abundance of chromophoric DOM (CDOM) and the fluorescence optical characteristics.
JOURNAL OF ENVIRONMENTAL SCIENCES
(2023)
Article
Environmental Sciences
Zhixin Jia, Xiaolei Huang, Lina Li, Tingliang Li, Yonghong Duan, Ning Ling, Guanghui Yu
Summary: The study investigates the roles of the 'enzyme latch' and 'Fe gate' mechanisms in regulating soil organic carbon (SOC) sequestration in a rice-wheat cropping system. The findings suggest that organic fertilization can strengthen the effects of these mechanisms and accelerate SOC sequestration in the system.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biodiversity Conservation
Huan Li, Guang-Hui Yu, Liping Hao, Yunpeng Qiu, Shuijin Hu
Summary: Soil organic carbon is crucial for sustaining terrestrial productivity and climate stability. Arbuscular mycorrhizal fungi (AMF) play a critical role in modulating soil carbon dynamics. However, it is still unknown how AMF-root associations interact with soil minerals to affect soil carbon cycling.
GLOBAL CHANGE BIOLOGY
(2023)
Article
Engineering, Environmental
Fu-Sheng Sun, Chao Ma, Guang-Hui Yu, Yakov Kuzyakov, Yun-Chao Lang, Ping-Qing Fu, Li-Jun Guo, Hui Henry Teng, Cong-Qiang Liu
Summary: The sequestration of organic carbon in wetland sediments is affected by oxygen availability. The mechanisms underlying the sequestration, particularly the co-mediation of reactive iron protection and thermodynamic limitations by the energetics of the organic carbon, are not well understood. Field surveys and remote sensing images have shown a significant decline in wetland areas in Tianjin over the past 26 years, which could be attributed to anthropogenic activities. High oxygen availability promotes reactive iron protection for organic carbon, while in anoxic environments, thermodynamic constraints limit its oxidation.
Review
Environmental Sciences
Hailiang Dong, Qiang Zeng, Yizhi Sheng, Chunmei Chen, Guanghui Yu, Andreas Kappler
Summary: Soils and sediments are important reservoirs of organic matter, and understanding the interactions between iron minerals and organic matter is crucial for carbon cycling and ecosystem functions. This review highlights the mechanisms and importance of coupled iron-carbon cycles, including the role of oxygenation of iron minerals, Fe(III) reduction, and the impact of organic matter on the redox properties of Fe minerals.
NATURE REVIEWS EARTH & ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Tao Wen, Guang-Hui Yu, Wen-Dan Hong, Jun Yuan, Guo-Qing Niu, Peng-Hao Xie, Fu-Sheng Sun, Lao-Dong Guo, Yakov Kuzyakov, Qi-Rong Shen
Summary: The chemical composition of root exudates has contrasting effects on soil carbon release and rhizosphere microorganisms. Amino acids promote organic carbon release and alteration of bacterial communities, while carboxylic acids increase the prevalence of Actinobacteria and carbon mobilization. Sugar application reduces microbial diversity without significantly impacting soil carbon dynamics.
FUNDAMENTAL RESEARCH
(2022)
Article
Soil Science
Guang-Hui Yu, Sha Liu
Summary: The long-term application of manure fertilizer has been found to increase the concentrations of soluble aluminum and iron in soil, and potentially enhance the stability of organic carbon and nitrogen. The findings were supported by synchrotron radiation based FTIR spectromicroscopy, which showed the co-localization of manure fertilizer with secondary minerals and organic compounds.
FRONTIERS IN SOIL SCIENCE
(2022)
