Review
Medicine, General & Internal
D. O. T. Alawode, A. J. Heslegrave, N. J. Ashton, T. K. Karikari, J. Simren, L. Montoliu-Gaya, J. Pannee, A. O'Connor, P. S. J. Weston, J. Lantero-Rodriguez, A. Keshavan, A. Snellman, J. Gobom, R. W. Paterson, J. M. Schott, K. Blennow, N. C. Fox, H. Zetterberg
Summary: Alzheimer's disease is increasingly prevalent worldwide, with a need for earlier and more secure diagnosis techniques. Current biomarker-based guidelines for AD diagnosis heavily rely on neuroimaging and CSF sampling, while blood-based biomarkers show potential for more accessible and cost-effective testing. Plasma neurofilament light chain and phosphorylated tau exhibit promise, but further comparisons are needed for p-tau to differentiate AD from non-AD dementias reliably. Plasma amyloid beta could serve as an early screening tool, but requires precise tests and robust pre-analytical protocols.
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Medicine, Research & Experimental
Katarzyna Potyrak, Benita Wiatrak, Edward Krzyzak, L. Lukasz Szczukowski, Piotr Swiatek, Adam Szelag
Summary: Alzheimer's disease remains a serious disorder with no effective therapy. However, certain compounds show potential for beneficial effects on damaged neuronal cells and are capable of crossing the blood-brain barrier.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Shiuan-Haur Su, Yujing Song, Michael W. Newstead, Tao Cai, MengXi Wu, Andrew Stephens, Benjamin H. Singer, Katsuo Kurabayashi
Summary: The digital Phenoplate (dPP) is an integrated platform that allows ultra-sensitive measurement of cellular cytokine secretory profiles, making it suitable for high precision and high throughput characterization of cellular phenotypes.
Article
Clinical Neurology
Ying Xu, Htein Linn J. Aung, Randall J. S. Bateman, William S. Brooks, Jasmeer S. Chhatwal, Gregory S. M. Day, Anne M. R. Fagan, Martin R. Farlow, Brian G. Gordon, Patrick G. Kehoe, Johannes Levin, Hiroshi C. Mori, John C. Morris, Whitney Wharton, Peter R. Humburg, Peter R. Schofield, Ruth Peters
Summary: This study investigated the relationship between blood pressure and cognition in individuals with autosomal-dominant Alzheimer's disease mutations. The findings suggest that higher systolic blood pressure is associated with poorer cognition, particularly in mutation carriers.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Adolfo Lopez-Ornelas, Adriana Jimenez, Gilberto Perez-Sanchez, Citlali Ekaterina Rodriguez-Perez, Alejandro Corzo-Cruz, Ivan Velasco, Enrique Estudillo
Summary: Alzheimer's disease is a common neurodegenerative disorder with increasing prevalence. Understanding its pathophysiology is crucial for developing effective treatment. Despite recent efforts in drug development, the neuronal damage caused by Amyloid beta peptide and Tau protein abnormalities remains a challenge. Peripheral inflammation is closely associated with the onset and progression of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Jennifer Kim, Sebastian W. Ahn, Kyle Deans, Devon Thompson, Benjamin Ferland, Prajan Divakar, Christine Dominas, Oliver Jonas
Summary: The study developed an IMD platform that can be directly inserted into the brain to simultaneously measure the effects of multiple drugs on native brain tissue, providing evidence of therapeutic responses through data analysis. The results demonstrate that the platform is helpful in confirming the effects of drugs on brain tissues and facilitating rapid testing of treatment hypotheses.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Clinical Neurology
Clara Vila-Castelar, Yinghua Chen, Stephanie Langella, Francisco Lopera, Henrik Zetterberg, Oskar Hansson, Jeffrey L. Dage, Shorena Janelidzde, Yi Su, Kewei Chen, Celina Pluim McDowell, Jairo E. Martinez, Liliana Ramirez-Gomez, Gloria Garcia, David Aguillon, Ana Baena, Margarita Giraldo-Chica, Hillary D. Protas, Valentina Ghisays, Silvia Rios-Romenets, Pierre N. Tariot, Kaj Blennow, Eric M. Reiman, Yakeel T. Quiroz
Summary: This study found that female carriers of Presenilin-1 E280A mutation had higher levels of plasma phosphorylated tau at threonine 217 (P-tau217) than male carriers when their cognitive abilities were intact, but as the disease progressed, female carriers showed a greater increase in plasma neurofilament light (NfL) levels than male carriers. However, among non-carriers, there were no significant differences in sex and plasma biomarkers.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Hiroyuki Shimada, Keitaro Makino, Takashi Kato, Kengo Ito
Summary: This study aimed to identify suitable computer-based cognitive tests and cut-off values for estimating amyloid burden in preclinical Alzheimer's disease drug trials. The results showed that computer-based memory and processing speed tests have the potential to reduce failure rates while screening individuals with A beta accumulation in community settings.
Article
Social Sciences, Interdisciplinary
Richard Milne, Alessia Costa, Natassia Brenman
Summary: This paper examines the practice and potential benefits of digital phenotyping, focusing on Alzheimer's disease research. Drawing on research with researchers and developers, the metaphor of the "data shadow" is used to explore the intersection of hopes and concerns related to digital tools and Alzheimer's disease. The potential of the data shadow to capture the dynamic and distorted nature of data representations and the unease associated with encounters between individuals or groups and their data is discussed. The paper also considers the representation of cognitive state and dementia risk produced by digital tools, as well as the empowering, enabling, and threatening aspects of digital phenotyping practices in the dementia field discussed by researchers and practitioners.
BIG DATA & SOCIETY
(2022)
Article
Clinical Neurology
Haoshen Shi, Yosef Koronyo, Dieu-Trang Fuchs, Julia Sheyn, Ousman Jallow, Krishna Mandalia, Stuart L. Graham, Vivek K. Gupta, Mehdi Mirzaei, Andrei A. Kramerov, Alexander V. Ljubimov, Debra Hawes, Carol A. Miller, Keith L. Black, Roxana O. Carare, Maya Koronyo-Hamaoui
Summary: This study found that vascular amyloid beta (Aβ) protein deposits were detected in retinas of mild cognitively impaired (MCI) and Alzheimer's disease (AD) patients, and these deposits were linked to disease status. The study also revealed that the components of retinal vascular tight junctions (TJs) and Aβ expression were correlated with neuropathology. The severe decreases in retinal vascular zonula occludens-1 (ZO-1) and claudin-5 were identified in MCI and AD patients, which correlated with arteriolar Aβ(40) deposition and cerebral pathology and cognitive deficits.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Robin Ziyue Zhou, Davide Liborio Vetrano, Giulia Grande, Frida Duell, Linus Jonsson, Erika J. Laukka, Claudia Fredolini, Bengt Winblad, Lars Tjernberg, Sophia Schedin-Weiss
Summary: This study suggests that the levels of bisecting N-acetylglucosamine and total tau in blood are associated with Alzheimer's disease (AD). Individuals with an intermediate tau/bisecting N-acetylglucosamine ratio have an elevated risk of AD. Furthermore, a combined model including this ratio, apolipoprotein E (APOE) e4 status, and Mini-Mental State Examination score can predict future AD.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Jun Wang, Ming Chen, Colin L. L. Masters, Yan-Jiang Wang
Summary: Early and accurate diagnosis of Alzheimer's disease (AD) is crucial for effective treatment. Blood biomarker assays are a promising tool for clinical diagnosis due to their non-invasive nature, cost-effectiveness, and accessibility. However, challenges in using blood biomarkers for AD diagnosis in community-based populations include confounding factors, small changes in biomarker levels, and difficulty in detecting early changes. This article analyzes these challenges and provides perspectives on strategies to overcome them, facilitating the translation of blood biomarker research into clinical practice.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Hualong Wang, Ying Xu, Rujing Ren, Feng Yao, Mei Chen, Zhihua Sheng, Xin Guo, Yan Li, Shengdi Chen, Gang Wang
Summary: The study on 106 Alzheimer's disease patients revealed different blood pressure characteristics in patients at different stages, with some having high blood pressure or low blood pressure, which correlated with cognitive performance. Additionally, patients in the mild stage showed a higher prevalence in certain characteristics compared to those in the severe stage.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Jinghan Huang, Thor D. Stein, Yixuan Wang, Ting Fang Alvin Ang, Qiushan Tao, Kathryn L. Lunetta, Joseph Massaro, Samia C. Akhter-Khan, Jesse Mez, Rhoda Au, Lindsay A. Farrer, Xiaoling Zhang, Wei Qiao Qiu
Summary: Elevated blood levels of monocyte chemoattractant protein-1 (MCP-1) are associated with increased risk of Alzheimer's disease (AD) in certain genotypes, possibly through the blood-brain barrier (BBB) pathways.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Carlos M. Hernandez, Rachel E. Barkey, Kristen M. Craven, Karin A. Pedemonte, Bernadette Alisantosa, Jonathan O. Sanchez, Jane M. Flinn
Summary: Alzheimer's disease is characterized by plaque and tangle buildup in the brain. Previous research showed that plasma transfusion from young donor mice improved memory and synaptic function in old transgenic APP/PS1 mice. In the current study, plasma transfusion from young wildtype mice to tau-expressing mice resulted in reduced phosphorylated tau levels and fewer tau tangles, suggesting potential therapeutic effects.
