Article
Physiology
Jacob A. Goldsmith, Raymond E. Lai, Ryan S. Garten, Qun Chen, Edward J. Lesnefsky, Robert A. Perera, Ashraf S. Gorgey
Summary: This study investigated the predictors of mitochondrial health in individuals with chronic spinal cord injury (SCI), focusing on visceral adiposity, inflammatory biomarkers, testosterone, and circulating serum growth factors. The results showed that increased visceral adiposity and associated inflammatory signaling, along with reduced testosterone levels, predicted mitochondrial dysfunction following SCI. Specifically, lower visceral adiposity and higher testosterone levels or lower visceral adiposity and lower inflammation levels positively predicted mitochondrial mass and enzyme activity in individuals with chronic SCI.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Sean R. Millar, Ivan J. Perry, Catherine M. Phillips
Summary: This study found that predicted VAT equations explained a greater proportion of variance in inflammatory biomarkers compared to traditional anthropometric measures, suggesting that equations for assessing VAT levels may be useful for characterizing metabolic health. Further research is recommended to investigate the relationships between predicted VAT levels and disease and mortality outcomes.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2023)
Review
Cardiac & Cardiovascular Systems
Monika Gawalko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev
Summary: Obesity is a significant contributing factor to atrial fibrillation (AF) by causing systemic changes and affecting different adipose tissue depots. Adipose tissue secretes various mediators that promote AF and cardiac remodeling. This review discusses the role of obesity-related factors, specific adipose tissue depots, and molecular mechanisms in AF, highlighting gaps in current knowledge and implications for clinical management.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Kuo-Tzu Sung, Jen-Yuan Kuo, Chun-Ho Yun, Yueh-Hung Lin, Jui-Peng Tsai, Chi-In Lo, Chih-Chung Hsiao, Yau-Huei Lai, Cheng-Ting Tsai, Charles Jia-Yin Hou, Cheng-Huang Su, Hung- Yeh, Chen-Yen Chien, Ta-Chuan Hung, Chung-Lieh Hung
Summary: Region-specific visceral adiposity may not equally discriminate baseline dysglycemia or diabetes, and showed differential predictive performance in new-onset diabetes. Our data suggested that interatrial fat may serve as a potential marker for new-onset diabetes.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Hila Zelicha, Nora Kloting, Alon Kaplan, Anat Yaskolka Meir, Ehud Rinott, Gal Tsaban, Yoash Chassidim, Matthias Bluher, Uta Ceglarek, Berend Isermann, Michael Stumvoll, Rita Nana Quayson, Martin von Bergen, Beatrice Engelmann, Ulrike E. Rolle-Kampczyk, Sven-Bastiaan Haange, Kieran M. Tuohy, Camilla Diotallevi, Ilan Shelef, Frank B. Hu, Meir J. Stampfer, Iris Shai
Summary: Through an 18-month study, it was found that a green-MED diet, enriched with plant-based polyphenols and lower in red meat intake, may be a potent intervention to promote visceral adipose tissue regression.
Article
Multidisciplinary Sciences
Yuki Komatsu, Kiyoshi Aoyama, Mamoru Yoneda, Shogo Ito, Yusuke Sano, Yumeno Kawai, Xixi Cui, Yuichiro Yamada, Nozomi Furukawa, Katsuhide Ikeda, Kohzo Nagata
Summary: The removal of interscapular brown adipose tissue (iBAT) attenuated the exacerbation of cardiac inflammation and fibrosis induced by salt loading in DS/obese rats, but did not affect the development of hypertension. Salt loading led to adipocyte hypertrophy and increased inflammation in white adipose tissue, while the conversion of iBAT to white adipose tissue-like tissue contributed to elevated levels of circulating interleukin-6, exacerbating cardiac pathology.
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2021)
Article
Nutrition & Dietetics
Chao Zhang, Jonathan Salamon, Ren Zhang
Summary: This study investigated the relationship between fibrinogen and tissue plasminogen activator levels and changes in adipose tissue, finding that tissue plasminogen activator levels were more affected during weight loss, while fibrinogen levels remained relatively stable.
Article
Cell Biology
Jianrui Song, Diana Farris, Paola Ariza, Smriti Moorjani, Mita Varghese, Muriel Blin, Judy Chen, Daniel Tyrrell, Min Zhang, Kanakadurga Singer, Morgan Salmon, Daniel R. Goldstein
Summary: This study reveals that aging enhances atherosclerosis through the increased inflammation of visceral fat. The transplantation of aged fat onto the carotid artery of mice resulted in larger atherosclerotic plaques with increased macrophage numbers. Inflammatory factors secreted by adipose tissue macrophages, including TNF alpha, CXCL2, and CCL2, were found to contribute to the enhancement of atherosclerosis in aging fat transplants.
Review
Endocrinology & Metabolism
Israelle Netto Freitas, Joel Alves da Silva Jr, Kenia Moreno de Oliveira, Bruna Lourenconi Alves, Thiago Dos Reis Araujo, Joao Paulo Camporez, Everardo Magalhaes Carneiro, Ana Paula Davel
Summary: Adipose tissue, an organ with metabolic and endocrine activity, undergoes morphological, functional, and molecular changes during obesity. The ER stress inhibitor TUDCA has shown therapeutic potential in minimizing adipose tissue dysfunction and metabolic alterations associated with obesity. Specifically, TUDCA has been demonstrated to inhibit ER stress, inflammation, and apoptosis in adipocytes, and may have cardiovascular protective effects through its influence on perivascular adipose tissue (PVAT) function and adiponectin release.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Neha Tawar, Basu Dev Banerjee, Sri Venkata Madhu, Vivek Agrawal, Sanjay Gupta
Summary: This study found the presence of organochlorine pesticides (OCPs) and their metabolites in visceral adipose tissue of subjects with type 2 diabetes mellitus (T2DM). The levels of delta-HCH, heptachlor, endrin, and p,p ' DDT were higher in the T2DM group and correlated with fasting and postprandial plasma glucose levels. There was also a positive association between OCPs and central adiposity and ER stress markers.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Aldo Scafoglieri, Jona Van den Broeck, Erik Cattrysse, Ivan Bautmans, Steven B. Heymsfield
Summary: This study found that the distribution ratios of visceral adipose tissue (VAT) show curvilinear relationships with age and anthropometry. Interpreting changes in body composition based on linear extrapolations in clinical practice can be challenging.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Magdalena Sylwia Kaminska, Anna Lubkowska, Mariusz Panczyk, Ireneusz Walaszek, Szymon Grochans, Elzbieta Grochans, Anna Maria Cybulska
Summary: This study aimed to assess the relationship between different measures of obesity (BMI, WC, RFM, VAI, WHtR) and parameters of chronic inflammation (CRP, TNF-α, IL-6) in perimenopausal women. The results showed that BMI, WC, RFM, VAI, and WHtR are clearly related to selected parameters of chronic inflammation.
Article
Endocrinology & Metabolism
Henry S. Kahn
Summary: BMI does not provide information about the relative size of adipose tissue depots, while SAD is associated with visceral fat accumulation, which may contribute to the estimation of cardiometabolic risk. SADHtR is more strongly associated with intermediary predictors of cardiometabolic disease.
Article
Endocrinology & Metabolism
Giuseppe Petito, Federica Cioffi, Elena Silvestri, Rita De Matteis, Davide Lattanzi, Pieter de Lange, Assunta Lombardi, Maria Moreno, Fernando Goglia, Antonia Lanni, Rosalba Senese
Summary: This study demonstrates that T2 is able to counteract some adverse effects caused by a long-lasting HFD and to produce beneficial effects on inflammation. Irisin and SIRT1 pathway may represent a mechanism underlying the above described effects.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Dentistry, Oral Surgery & Medicine
M. Alikhani, B. Alyami, I. S. Lee, S. Almoammar, T. Vongthongleur, M. Alikhani, S. Alansari, C. Sangsuwon, M. Y. Chou, E. Khoo, A. Boskey, C. C. Teixeira
ORTHODONTICS & CRANIOFACIAL RESEARCH
(2015)
Article
Dentistry, Oral Surgery & Medicine
Mani Alikhani, Sarah Alansari, Chinapa Sangsuwon, Mona Alikhani, Michelle Yuching Chou, Bandar Alyami, Jeanne M. Nervina, Cristina C. Teixeira
SEMINARS IN ORTHODONTICS
(2015)
Article
Multidisciplinary Sciences
Mani Alikhani, Sarah Alansari, Mohammad A. Hamidaddin, Chinapa Sangsuwon, Bandar Alyami, Soumya N. Thirumoorthy, Serafim M. Oliveira, Jeanne M. Nervina, Cristina C. Teixeira
Article
Dentistry, Oral Surgery & Medicine
Mani Alikhani, Markos Raptis, Billie Zoldan, Chinapa Sangsuwon, Yoo B. Lee, Bandar Alyami, Corey Corpodian, Luz M. Barrera, Sarah Alansari, Edmund Khoo, Cristina Teixeira
AMERICAN JOURNAL OF ORTHODONTICS AND DENTOFACIAL ORTHOPEDICS
(2013)
Article
Dentistry, Oral Surgery & Medicine
M. Alikhani, E. Khoo, B. Alyami, M. Raptis, J. M. Salgueiro, S. M. Oliveira, A. Boskey, C. C. Teixeira
JOURNAL OF DENTAL RESEARCH
(2012)
Article
Dentistry, Oral Surgery & Medicine
Bandar Alyami, Mutaz Ali-Hassan, Ramat Braimah, Mansur Al-Mahri, Fahad Alyami, Saeed Alharieth
CLEFT PALATE-CRANIOFACIAL JOURNAL
(2020)
Article
Dentistry, Oral Surgery & Medicine
Bandar Alyami
Summary: This study evaluated dental malocclusion among 326 patients seeking orthodontic treatment in Najran, Saudi Arabia. The prevalence of Class I, Class II, and Class III malocclusion was found to be 72.7%, 11.6%, and 15.6% respectively, with a higher incidence of increased overjet and crowding observed.
SAUDI DENTAL JOURNAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Bandar Alyami, Ramat Braimah, Saeed Alharieth
SAUDI DENTAL JOURNAL
(2020)
Review
Dentistry, Oral Surgery & Medicine
Bandar Alyami
CASE REPORTS IN DENTISTRY
(2020)