Article
Pharmacology & Pharmacy
Junyi Bai, Tingting Xiong, Xiao Wang, Yanfen Cheng, Ruifeng Luo, Xiangdong Yang, Chaomei Fu
Summary: This study investigates the therapeutic effects and potential mechanisms of Lian-Zhi-Fan (LZF) decoction in the treatment of ulcerative colitis (UC) using a metabolomics approach. The results demonstrate that LZF ameliorates weight loss, disease activity index (DAI) score, and colon inflammation in UC rats. Metabolomics analysis identifies 14 potential biomarkers, five of which have diagnostic significance. These biomarkers are mainly involved in amino acid metabolism, fat metabolism, and energy production.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
C. Seifarth, N. Slavova, C. Degro, K. S. Lehmann, M. E. Kreis, B. Weixler
Summary: This study evaluated the use of sacral nerve stimulation (SNS) in patients with high stool frequency or fecal incontinence after proctocolectomy with IPAA. The results showed that SNS improved symptoms in over two-thirds of patients, suggesting its feasibility as a therapeutic option in this patient population.
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE
(2021)
Article
Plant Sciences
Armita Farid, Mohammad Sheibani, Asie Shojaii, Mitra Noori, Manijeh Motevalian
Summary: The leaf extract of Plantago major exhibits anti-inflammatory effects and protects against mucosal damage in rats with ulcerative colitis, especially when administered in high doses. The seed extract of P. major has minimal protective effects on ulcerative colitis.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ines Silva, Priscila Mendes, Sofia Guerra, Rui Pinto, Vanessa Mateus
Summary: Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory response in the gastrointestinal tract. Current treatments do not cure the underlying pathogenic mechanism, leading to a need for new and effective pharmacological approaches. Preclinical studies show that topiramate has potential anti-inflammatory effects. This study investigates the effect of topiramate in a chronic TNBS-induced colitis model in rodents, demonstrating its ability to reduce colonic damage and normalize stool consistency and anus appearance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Vrushali R. Hambardikar, Deepa S. Mandlik
Summary: The study demonstrated that treatment with NG effectively alleviated TNBS-induced colitis in rats by improving body weight, hematological parameters, reducing spleen and colon weight, alleviating symptoms, as well as decreasing inflammatory response and repairing tissue damage.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2022)
Article
Immunology
Maryam Ranjbar Bushehri, Nahid Babaei, Hadi Esmaeili Gouvarchin Ghaleh, Gholamreza Khamisipour, Gholamreza Farnoosh
Summary: This study investigates the anti-inflammatory effects of peiminine on ulcerative colitis. The results demonstrate that peiminine treatment can alleviate inflammatory manifestations, reduce intestinal tissue damage, and affect gene expression. Peiminine holds potential as a therapeutic adjunct for the management of ulcerative colitis.
INFLAMMOPHARMACOLOGY
(2023)
Article
Cell Biology
Ahmed Kouki, Wafa Ferjani, Pham My-Chan Dang, Neziha Ghanem-Boughanmi, Abdelaziz Souli, Mossadok Ben-Attia, Jamel El-Benna
Summary: This study demonstrates the preventive effect of apocynin on acetic acid-induced ulcerative colitis in rats. Apocynin reduces pro-oxidant markers, preserves colonic cytoarchitecture, and decreases systemic inflammatory markers. These findings suggest that apocynin could be a promising therapeutic option for the prevention of ulcerative colitis.
Article
Biochemistry & Molecular Biology
Gaolong Lin, Jiaojiao Yang, Jiayi Liu, Jianxun Shangguan, Hanxiao Pan, Yingying Zhang, Kunjie Ran, Dingwei Li, Fengnan Yu, Helin Xu
Summary: In this study, an in situ hydrogel (PE) with mucoadhesive ability was successfully constructed using temperature-sensitive poloxamer and EGCG as hydrogel-forming material and adhesive enhancer, respectively. The incorporation of EGCG improved the stability of KGF and shortened the gelled time of PE hydrogel. KGF@PE demonstrated promising therapeutic effects on ulcerative colitis, including recovering body weight, repairing colonic morphology and function, and upregulating tight junction proteins, with no obvious side effects observed in mice models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Plant Sciences
Daxing Gu, Huiting Wang, Mingen Yan, Yaoxing Li, Shijing Yang, Dayou Shi, Shining Guo, Li Wu, Cui Liu
Summary: Echinacea purpurea (L.) Moench (EP) is a medicinal plant commonly used to treat skin inflammation and gastrointestinal diseases. In this study, the protective effect of Echinacea purpurea extract (EE) on ulcerative colitis (UC) was evaluated in a rat model. The results showed that EE could reduce weight loss and diarrhea, improve intestinal epithelial barrier integrity, and inhibit inflammation and oxidation. EE may achieve therapeutic effect by inhibiting the C3a/C3aR signal pathway, suggesting its potential as a medicinal plant to alleviate UC.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Ittetsu Kin, Tatsuya Sasaki, Takao Yasuhara, Masahiro Kameda, Takashi Agari, Mihoko Okazaki, Kakeru Hosomoto, Yosuke Okazaki, Satoru Yabuno, Satoshi Kawauchi, Ken Kuwahara, Jun Morimoto, Kyohei Kin, Michiari Umakoshi, Yousuke Tomita, Naoki Tajiri, Cesario Borlongan, Isao Date
Summary: This study examined the efficacy of vagus nerve stimulation (VNS) on Parkinson's disease model rats using a wireless controllable electrical stimulator. The results showed that VNS with 0.25-0.5 mA intensity significantly improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. Further research confirmed the practicality and effectiveness of the new experimental device.
Article
Pharmacology & Pharmacy
Kehan Rao, Shumin Qin, Yuanming Yang, Kai Zhan, Haomeng Wu, Huan Zheng, Shaogang Huang
Summary: The study found that shenling baizhu powder (SBP) has therapeutic effects on TNBS-induced colitis and potential value in treating and maintaining remission of colitis. SBP effectively strengthens the epithelial barrier integrity in colitis patients by increasing the secretion of mucin and tight junction proteins while inhibiting apoptosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Nutrition & Dietetics
Ammar Hassanzadeh Keshteli, Rosica Valcheva, Cheryl Nickurak, Heekuk Park, Rupasri Mandal, Kendall van Diepen, Karen I. Kroeker, Sander Veldhuyzen van Zanten, Brendan Halloran, David S. Wishart, Karen L. Madsen, Levinus A. Dieleman
Summary: The study reveals that dietary modifications, including increased intake of anti-inflammatory foods and decreased intake of pro-inflammatory foods, are associated with metabolic and microbial changes in ulcerative colitis patients in clinical remission, effectively preventing subclinical inflammation.
Article
Immunology
Deepa K. Ingawale, Satish K. Mandlik, Snehal S. Patel
Summary: The study demonstrated that treatment with hecogenin and a combination of hecogenin and fluticasone significantly improved symptoms of ulcerative colitis in the rat model, including increased body weight and colon length, reduced inflammation, decreased spleen weight, and restoration of antioxidant levels.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Plant Sciences
Qian Xie, Hongyan Li, Rong Ma, Mihong Ren, Yong Li, Jinxiu Li, Hai Chen, Zhuoping Chen, Daoyin Gong, Jian Wang
Summary: In this study, the therapeutic effects of Coptis chinensis Franch and Magnolia officinalis on TNBS-induced ulcerative colitis in rats were investigated. It was found that these herbal medicines could improve disease indicators, reduce colonic mucosal damage, and regulate intestinal flora. They also showed anti-inflammatory effects and protected the integrity of the tight junction, indicating their potential in preventing intestinal barrier damage.
Article
Gastroenterology & Hepatology
Alka A. Potdar, Shishir Dube, Takeo Naito, Katherine Li, Gregory Botwin, Talin Haritunians, Dalin Li, David Casero, Shaohong Yang, Janine Bilsborough, Jacqueline G. Perrigoue, Lee A. Denson, Mark Daly, Stephan R. Targan, Phillip Fleshner, Jonathan Braun, Subra Kugathasan, Thaddeus S. Stappenbeck, Dermot P. B. McGovern
Summary: The study identified differences in intestinal ACE2 expression levels in patients with Crohn's disease and ulcerative colitis, associated with inflammation and disease severity. Treatment with anti-cytokine therapy restored ACE2 expression, potentially impacting outcomes of severe acute respiratory syndrome coronavirus 2 infection.
