Review
Neurosciences
Jianfeng Liu
Summary: The stress system in the brain plays a crucial role in protecting humans and animals from harmful stimuli. Excessive stress can lead to maladaptive changes in the stress system and result in depression. Recent evidence suggests that PKM zeta is involved in stress response and depressive-like behavior, and it could be a molecular target for developing novel antidepressants.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Neurosciences
Niloufar Amini, Reza Roosta Azad, Fereshteh Motamedi, Hadi Mirzapour-Delavar, Soheil Ghasemi, Shayan Aliakbari, Hamid Gholami Pourbadie
Summary: The overexpression of hippocampal PKM zeta can restore memory dysfunction induced by amyloidopathy in the early phase of AD, partly through preserving GluA2-containing AMPA receptors in the hippocampus. This suggests that PKM zeta's signaling pathway could be a potential therapeutic target for combating memory deficits in AD.
BRAIN RESEARCH BULLETIN
(2021)
Article
Multidisciplinary Sciences
Joel Lee, Xiumin Chen, Roger A. Nicoll
Summary: Activation of Ca2+/calmodulin-dependent kinase II (CaMKII) plays a critical role in long-term potentiation (LTP), but how LTP and memories survive the turnover of synaptic proteins remains a mystery. In this study, it was found that constitutive Ca2+-independent CaMKII activity acquired before slice preparation provides a lasting memory trace at synapses, which remains stable over a 2-week period in slice culture.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Neurosciences
Hamish Patel, Reza Zamani
Summary: This paper reviews the role of PKM zeta in the maintenance of long-term memory, highlighting its mechanism in preventing AMPA receptor endocytosis for synaptic potentiation. While inhibition of PKM zeta can reverse LTP and impair established long-term memories, a deficit in memory retrieval cannot be ruled out.
REVIEWS IN THE NEUROSCIENCES
(2021)
Article
Neurosciences
Todd Charlton Sacktor
Summary: Karim Nader's research explores memory reconsolidation and memory maintenance by PKM zeta. He found that inhibiting PKM zeta or blocking reconsolidation can erase long-term memory. The study also revealed a connection between PKM zeta's regulation of AMPAR trafficking and memory maintenance. PKM zeta inhibition erases all memories stored by the kinase, while reconsolidation blockade disrupts specific recalled memories by preventing the resynthesis of PKM zeta.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Matteo Bernabo, Josue Haubrich, Karine Gamache, Karim Nader
Summary: The study found that NMDAR activation and proteasome activity can lead to a temporary reduction in PKM xi protein after memory retrieval, while new PKM xi protein is synthesized during memory reconsolidation to restore memory. Failure to synthesize new PKM xi during memory reconsolidation impairs memory, but continuous synthesis of PKM xi is not necessary for maintenance itself.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Dongyang Cui, Xiaodong Jiang, Ming Chen, Huan Sheng, Da Shao, Li Yang, Xinli Guo, Yingqi Wang, Bin Lai, Ping Zheng
Summary: Rac1 activation has opposite effects on the induction and maintenance of LTP in the hippocampus, modulating different signaling pathways during the different stages; activation of Rac1 during LTP induction leads to PKC ι/λ activation, while activation of Rac1 during LTP maintenance leads to PKM zeta inhibition.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Dimitrius Tansini Pramio, Felipe Monteleone Vieceli, Elisa Varella-Branco, Carolina Purcell Goes, Gerson Shigeru Kobayashi, Diogo Vieira da Silva Pelegrina, Beatriz Caroline de Moraes, Aicha El Allam, Bony De Kumar, Gabriel Jara, Jose Marcelo Farfel, David Alan Bennett, Somanath Kundu, Mariano S. Viapiano, Eduardo Moraes Reis, Paulo Sergio Lopes de Oliveira, Maria Rita dos Santos Passos-Bueno, Carla V. Rothlin, Sourav Ghosh, Deborah Schechtman
Summary: This study identified an epigenetic mechanism regulating the expression of Protein kinase M zeta (PKMζ) in the human brain. DNA methylation at the internal promoter and CREB binding were found to play a critical role in PKMζ expression and its function in neuronal differentiation and Alzheimer's disease.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2023)
Article
Pharmacology & Pharmacy
Majid Reza Farokhi, Erfan Taherifard, Roksana SoukhakLari, Leila Moezi, Fatema Pirsalami, Amir Savardashtaki, Maryam Moosavi
Summary: This study found that Agmatine has a dose-dependent effect on passive avoidance memory in mice. Low doses impaired memory, while high doses improved memory. Agmatine had no effect on nociception. Additionally, the modulation of CaMKII-alpha and ERK signaling pathways by Agmatine may be related to its dose-dependent effect on memory.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Shayan Aliakbari, Mohammad Sayyah, Hadi Mirzapourdelavar, Niloufar Amini, Naser Naghdi, Hamid Gholami Pourbadie
Summary: EC amyloidopathy leads to impaired synaptic transmission and memory deficits, while overexpression of PKM zeta in DG enhances synaptic responses and improves memory performance, suggesting PKM zeta may serve as a potential therapeutic target for early stage AD.
NEUROBIOLOGY OF AGING
(2021)
Article
Neurosciences
Changchi Hsieh, Panayiotis Tsokas, Alejandro Grau-Perales, Edith Lesburgueres, Joseph Bukai, Kunal Khanna, Joelle Chorny, Ain Chung, Claudia Jou, Nesha S. Burghardt, Christine A. Denny, Rafael E. Flores-Obando, Benjamin Rush Hartley, Laura Melissa Rodriguez Valencia, A. Ivan Hernandez, Peter J. Bergold, James E. Cottrell, Juan Marcos Alarcon, Andre Antonio Fenton, Todd Charlton Sacktor
Summary: Research has shown that PKM zeta plays a crucial role in long-term memory storage and LTP maintenance, with its differential expression at different stages reflecting the location of information storage in the brain. By tagging memory cells and increasing PKM zeta expression in certain regions, the long-term storage of information in the CA3-to-CA1 pathway can be revealed.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Economics
Tai-Wei Hu
Summary: This article examines the behavior pattern of decision-makers after receiving informative signals, uncovering two robust predictions regarding optimal behavior and introducing a new behavioral bias called "information stubbornness".
Article
Psychology, Mathematical
Nicholas P. Maxwell, Mark J. Huff, Erin M. Buchanan
Summary: This article introduces lrd, an open-source tool for processing lexical response data in recall studies. Validation studies showed high reliability, sensitivity, and specificity of lrd in comparison to human-coded data, indicating consistent results between data processed by lrd and a human coder.
BEHAVIOR RESEARCH METHODS
(2022)
Review
Clinical Neurology
Xiaoling Zhou, Yifei Zhou, Jianian Hua, Qun Xue
Summary: This meta-analysis explored the association between myasthenia gravis (MG) and memory, revealing that patients with MG had significantly lower performance in immediate and delayed recall abilities compared to healthy controls. The severity of MG did not show a significant association with memory performance.
FRONTIERS IN NEUROLOGY
(2021)
Article
Psychology, Multidisciplinary
Eric Y. Mah, Kelly E. L. Grannon, Alison Campbell, Nicholas Tamburri, Randall K. Jamieson, D. Stephen Lindsay
Summary: Research has shown that people tend to recall names of animate concepts, such as animals, better than names of inanimate objects. However, a study by Popp and Serra in 2016 found a reverse animacy effect where participants performed better in recalling names of inanimate-inanimate pairs compared to animate-animate pairs. This study aimed to replicate this effect and explore the role of semantic similarity.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Andressa Radiske, Maria Carolina Gonzalez, Diana A. Noga, Janine Rossato, Lia R. M. Bevilaqua, Martin Cammarota
Summary: Research on adult male Wistar rats showed that different subunits of NMDARs in the hippocampus play distinct roles in the stability and destabilization of extinction memory. GluN2B-containing NMDARs are necessary for extinction memory destabilization, while GluN2A-containing NMDARs are involved in its restabilization. Pharmacological modulation of these receptor subtypes around the time of extinction memory recall may regulate the dominance of extinction memory over the original memory trace.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Andressa Radiske, Maria Carolina Gonzalez, Janine Rossato, Genedy Apolinario, Joao R. de Oliveira, Lia R. M. Bevilaqua, Martin Cammarota
Summary: The research found that hippocampal CaMKII is essential for the restabilization of avoidance memory, and inhibiting CaMKII can erase learned avoidance responses.
Article
Neurosciences
Maria Carolina Gonzalez, Andressa Radiske, Janine I. Rossato, Sergio Conde-Ocazionez, Lia R. M. Bevilaqua, Martin Cammarota
Summary: In this study, it was found that training adult male Wistar rats in a long-term object recognition memory (ORM)-inducing learning task increased hippocampal theta power. In addition, suppressing theta via optogenetic medial septum (MS) inactivation caused amnesia specifically for the object being explored at the time of inactivation. These findings suggest that the MS is necessary for long-term ORM formation and that hippocampal theta activity is causally linked to this process.
Article
Behavioral Sciences
Janine I. Rossato, Andressa Radiske, Maria Carolina Gonzalez, Lia R. M. Bevilaqua, Martin Cammarota
Summary: Hippocampal JNK activity is necessary for the consolidation and reconsolidation of object recognition memory, but not for memory recall or short-term retention.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Neurosciences
Maria Carolina Gonzalez, Andressa Radiske, Sergio Conde-Ocazionez, Janine Rossato, Lia R. M. Bevilaqua, Martin Cammarota
Summary: The destabilization of hippocampal dopamine D1/D5 receptor is necessary for object recognition memory (ORM) updating through reconsolidation. Hippocampal theta-gamma coupling (hPAC) controls ORM destabilization, and its modulation could increase the efficacy of reconsolidation-based psychotherapy.
Article
Neurosciences
Andressa Radiske, Maria Carolina Gonzalez, Diana A. Noga, Janine I. Rossato, Lia R. M. Bevilaqua, Martin Cammarota
Summary: Fear-motivated avoidance extinction memory is reconsolidated upon recall through hippocampal BDNF-dependent pathway, which involves activation of mTOR in dorsal CA1. Inhibition of mTOR post-recall hinders memory persistence, while coadministration of recombinant BDNF impedes mTOR inhibition from affecting the memory trace. This suggests that mTOR signaling is essential for fear-motivated avoidance extinction memory reconsolidation and BDNF may act downstream mTOR in a protein synthesis-independent manner.