Article
Chemistry, Multidisciplinary
Satu Hakkinen, Joji Tanaka, Ramon Garcia Maset, Stephen C. L. Hall, Steven Huband, Julia Y. Rho, Qiao Song, Sebastien Perrier
Summary: This study reports the polymerisation-induced self-assembly of copolymers during RAFT grafting, showing the formation of various morphologies of micelles in the polymerisation process, providing new avenues for controlling polymer structure and material properties.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Polymer Science
Daniel M. Day, Lian R. Hutchings
Summary: A series of polyisoprene-block-poly(methyl methacrylate) block copolymers self-assemble in aliphatic hydrocarbon solvents, forming varying nanostructures such as spherical micelles, wormlike micelles or vesicles. The self-assembly behavior is dependent on the molar mass and composition of the block copolymers, allowing for the construction of phase-diagrams. The resulting structures exhibit thermal responsiveness and may undergo morphological changes upon heating.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Vincenzo Taresco, Isotta Tulini, Iolanda Francolini, Antonella Piozzi
Summary: Nanoparticles based on polyglycerol adipate (PGA) grafted with polycaprolactone (PCL) were developed as carriers for usnic acid, showing prolonged antimicrobial activity. The drug release profile and mechanism could be controlled by varying the length of PCL arms. This study is of great significance in the prevention and treatment of various infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Polymer Science
Selvaraj Nagarajan, Chi-Hsuan Su, Eamor M. Woo
Summary: Poly(ethylene adipate) can crystallize into either ring-banded spherulites or ringless spherulites, depending on the temperature conditions. The internal structures and polymorphism of these two morphologies differ, with the ring-banded spherulites primarily containing alpha-form crystals and the ringless spherulites containing a combination of alpha and beta crystals. Dissection analysis reveals that the interior of the banded spherulites consists of concentric-shell structures resembling cut onions. By designing optimized regularly-banded morphologies, the PEA banded spherulites demonstrate prominent photonic iridescence and the capability to structure light with circular patterns through laser interference.
Article
Polymer Science
Isabella R. Dorsman, Matthew J. Derry, Victoria J. Cunningham, Steven L. Brown, Clive N. Williams, Steven P. Armes
Summary: The study discovered an unexpected reduction in dispersion viscosity when heating block copolymer vesicles above a critical temperature, with a thermal transition from vesicles to worms and then to spheres observed. Moreover, the addition of a suitable comonomer was found to lower the critical onset temperature required for the vesicle-to-worm transition, as confirmed by rheology and small-angle X-ray scattering experiments. The thermal transitions observed were irreversible on normal experimental timescales.
Article
Engineering, Biomedical
Wenjun Zhan, Ge Gao, Zhiyu Liu, Xiaoyang Liu, Lingling Xu, Manli Wang, Hai-Dong Xu, Runqun Tang, Jingyuan Cao, Xianbao Sun, Gaolin Liang
Summary: A rationally designed peptide conjugate that self-assembles into fibrous structures upon activation of bacterial alkaline phosphatase has been developed to combat Staphylococcus aureus infection. The assemblies interact with the cell lipid membrane and disrupt membrane integrity, leading to the killing of S. aureus.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Polymer Science
Wen Lin, Yujin Zhao, Tingting Su, Zhanyong Wang
Summary: The degradation behavior of PBAT films by different concentrations of Fusarium solani cutinase (FsC) was investigated. It was found that FsC could degrade both the amorphous region and the crystalline region of PBAT films, and its degradation activity was concentration-dependent. High concentration of FsC resulted in significant degradation of PBAT films, while low concentration had less apparent effect. FsC concentration and degradation time did not significantly affect the molecular weight of degraded PBAT.
POLYMER DEGRADATION AND STABILITY
(2023)
Article
Chemistry, Multidisciplinary
Richard H. Huang, Nazia Nayeem, Ye He, Jorge Morales, Duncan Graham, Rafal Klajn, Maria Contel, Stephen O'Brien, Rein Ulijn
Summary: The study demonstrates the use of zwitterionic tetrapeptide modalities to direct nanoparticle assembly under physiological conditions, allowing for the reduction of cell growth in cancer cells through enzyme-responsive self-assembly. Customizing the peptide sequence can program the enzyme responsiveness and cellular uptake pathway.
ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Xuejiao Yang, Honglei Lu, Yinghua Tao, Laicheng Zhou, Huaimin Wang
Summary: The study presents an efficient and general platform for controlling the formation of assemblies in living cells, using a protective strategy to resist hydrolysis and enable selective unmasking in the lysosomes. Demonstrated in vitro and in living cells, this spatiotemporal control of chemical assembly may have applications in various fields including supramolecular chemistry, materials science, synthetic biology, and chemical biology.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Materials Science, Multidisciplinary
Chang Wei, Peng Guo, Mingfu Lyu, Bo Wang, Chao Li, Lin Sang, Zhiyong Wei
Summary: In this study, high-barrier poly(butylene adipate-terephthalate)/polyglycolic acid (PBAT/PGA) blending films were prepared using melt-compounding and extrusion-blowing techniques with the addition of antioxidant compounds. The incorporation of PGA improved the mechanical properties and water vapor barrier performance of the films. The use of a chain extender achieved good compatibility between PBAT and PGA. Antioxidant compounds enhanced the thermal stability of the films. UV-accelerated degradation was observed, but the water vapor barrier permeability remained well-maintained due to the high crystallinity of the PGA region. These findings highlight the potential of PBAT/PGA films as mulching films.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Raghu Pradeep Narayanan, Abhay Prasad, Alex Buchberger, Lei Zou, Julio Bernal-Chanchavac, Tara Macculloch, Nour Eddine Fahmi, Hao Yan, Fei Zhang, Matthew J. Webber, Nicholas Stephanopoulos
Summary: The combination of multiple orthogonal interactions enables hierarchical complexity in self-assembled nanoscale materials. This study demonstrates the efficient supramolecular polymerization of DNA origami nanostructures using a multivalent display of small molecule host-guest interactions, and exploits high-affinity CB[7]-adamantane interactions to enable responsive enzymatic actuation.
Article
Chemistry, Physical
Saul J. Hunter, Steven P. Armes
Summary: In this Feature Article, the authors review their recent progress in designing shape-shifting thermoresponsive diblock copolymer nano-objects. Unlike traditional thermoresponsive polymers, these nano-objects undergo thermally driven transitions between different morphologies in aqueous solution. The shape-shifting behavior is attributed to a subtle change in the hydration level of the insoluble thermoresponsive block. The authors characterized these nano-objects using various techniques and briefly discussed their potential applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Xianbao Sun, Manli Wang, Xiaoyang Liu, Wenjun Zhan, Guangqiong Xu, Qiaochu Jiang, Hai-Dong Xu, Fuqiang Wang, Gaolin Liang
Summary: This study proposed an enzymatic self-assembly/disassembly strategy to regulate the mimetic hydrolase activities. By designing a peptide molecule and reacting it with phosphatase or kinase, the activity of the artificial enzyme could be turned ON or OFF. This work provides a feasible strategy for the fabrication of artificial enzymes with controllable and superior activities.
SCIENCE CHINA-CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Xuejiao Yang, Bihan Wu, Jiong Zhou, Honglei Lu, Hongyue Zhang, Feihe Huang, Huaimin Wang
Summary: This study demonstrates that host-guest complexation can efficiently regulate enzymatic self-assembly, leading to controlled cancer cell death.
Article
Chemistry, Applied
Aurelie A. Adam, Jordane Jasniewski, Marie E. Vuillemin, Blandine Simard, Jennifer Burgain, Regis Badin, Lionel Muniglia, Florentin Michaux
Summary: The study modified the structure of gum arabic by using a laccase and a phenolic compound in aqueous solution, leading to an increase in molecular mass and significant changes in properties such as thermal behavior, hydrophilicity, and hygroscopicity. The modified gum arabic also exhibited antioxidant properties and spontaneously formed spherical monodisperse micrometric particles in water.
FOOD HYDROCOLLOIDS
(2022)
Article
Chemistry, Multidisciplinary
Jisun Im, Yaan Liu, Qin Hu, Gustavo F. Trindade, Christopher Parmenter, Michael Fay, Yinfeng He, Derek J. Irvine, Christopher Tuck, Ricky D. Wildman, Richard Hague, Lyudmila Turyanska
Summary: This study successfully fabricates complex 3D metal nanoparticle-polymer nanocomposites using two-photon polymerization (2PP). Three complementary strategies are described: in situ formation of metal nanoparticles (MeNPs) through a single-step photoreduction process, integration of pre-formed MeNPs into 2PP resin, and site-selective MeNPs decoration of 3D 2PP structures. These strategies offer exciting opportunities for the fabrication of MeNP composites with sub-micron resolution for various applications.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Valentina Cuzzucoli Crucitti, Aleksandar Ilchev, Jonathan C. Moore, Harriet R. Fowler, Jean-Frederic Dubern, Olutoba Sanni, Xuan Xue, Bethany K. Husband, Adam A. Dundas, Sean Smith, Joni L. Wildman, Vincenzo Taresco, Paul Williams, Morgan R. Alexander, Steven M. Howdle, Ricky D. Wildman, Robert A. Stockman, Derek J. Irvine
Summary: This study utilized the alpha parameter, a molecular descriptor, to design terpene-based polymers resistant to biofilm formation by Pseudomonas aeruginosa. The potential biofilm resistance of terpene-derived monomers was predicted and ranked using the alpha parameter. The monomers from commercially available terpenes were polymerized and confirmed to have biofilm resistance properties. The scaled-up monomers were successfully printed and used to create bio-instructive microparticles. The observations in this study have significant potential to produce bio-resistant coatings, packaging materials, fibers, and medical devices.
Article
Engineering, Chemical
Felipe Morais Bolner, Yashmin Rafante Blazzio, Barbara Rezende Lara, Fabricio Machado, Timothy F. L. McKenna
Summary: Several commercial silicas were used to support metallocene active centres, and their impact on polymerization kinetics and resulting polymer properties were studied. It was found that pore volume distribution played a major role in the fragmentation of silica-supported catalysts, where mesoporous silicas with a narrow distribution obtained higher activities and faster fragmentation. Care must be taken when using standard information on particle porosity, as it can be misleading.
CANADIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Polymer Science
Harriet R. Fowler, Dara M. O'Brien, Daniel J. Keddie, Cameron Alexander, Derek J. Irvine, Robert A. Stockman, Steven M. Howdle, Vincenzo Taresco
Summary: Polyols and polyacrylates are widely used in polymer synthesis and can be used as monomers, initiators, or building blocks. Finding bio-based/renewable sources for these compounds is crucial due to the increasing need to reduce dependency on fossil fuels. By functionalizing the alkene moieties of common terpenes through oxidation, the toolbox of bio-based diols and triols is expanded. These polyols can be easily converted into terpene-derived diacrylates under mild conditions. As demonstrated, these monomers can be used in aza-Michael polymerizations to form new (bio)degradable poly-beta-amino esters.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2023)
Article
Biochemical Research Methods
Bruno L. Nogueira, Argimiro R. Secchi, Fabricio Machado, Carime V. S. Rodrigues, Rossano Gambetta, Dasciana S. Rodrigues
Summary: A modification of the conventional batch organosolv process is proposed to separate solid biomass from the liquid phase, resulting in a higher glucose yield during enzymatic hydrolysis. The modified process removes lignin fragments from cellulose fibers, leading to a higher cellulose content in the solid phase. This study provides a simple and rapid protocol for isolating the main components of lignocellulosic biomass, which can be used for further chemical transformations or pretreatment studies.
BIOTECHNOLOGY JOURNAL
(2023)
Article
Engineering, Chemical
Eduardo Ulisses Xavier Peres, Paulo Roberto R. de Matos, Fabricio Machado, Paulo Anselmo Ziani Suarez
Summary: A new biolubricant was prepared by oligo-esterification of ricinoleic acid, oxalic acid, and ethylene glycol. The new compound was characterized using FT-IR and H-1-NMR spectroscopies. The new oligomer showed good performance as a lubricant, with potential to replace petrochemical lubricants.
BRAZILIAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Engineering, Chemical
Anthony F. Glenn, Gabriel F. S. Brito, Graciane Resende, Lumena L. Jaques, Raissa G. M. R. Barroso, Thaina Araruna, Fabricio Machado
Summary: This study focuses on the comparative synthesis of alkyd resins from renewable resources using the alcoholysis-polycondensation process. The resulting resins are analyzed using FTIR, H-1 NMR, and C-13 NMR. The study evaluates the molecular weight and physicochemical properties of the resins using intrinsic viscosity and GPC assays. The results show that chia oil alkyd resin has potential as a surface coating agent.
MACROMOLECULAR REACTION ENGINEERING
(2023)
Article
Engineering, Chemical
Tamara Agner, Amadeo Zimermann, Fabricio Machado, Brenno A. D. Neto, Pedro H. H. de Araujo, Claudia Sayer
Summary: In this study, iron-containing imidazolium-based ionic liquids were used as catalysts for the homogeneous polymerization of n-butyl vinyl ether to investigate the conditions that lead to high molecular weights. The Lewis acidic IL proved to be highly efficient, even at low catalyst concentrations, suggesting its potential for industrial applications. In contrast, the neutral iron-containing IL showed no catalytic activity.
MACROMOLECULAR REACTION ENGINEERING
(2023)
Article
Polymer Science
Maarten A. Mees, Thomas D. McAllister, Silvio Curia, Steven M. Howdle, Richard Hoogenboom
Summary: This study reports on a feasible method to introduce carbamate and fluorescent zwitterionic groups into linear polyethylenimine (L-PEI) by reacting with supercritical CO2, thus expanding the chemical toolbox of L-PEI and providing a new tool for the preparation of fluorescent L-PEI and PEtOx.
Article
Engineering, Manufacturing
Geoffrey Rivers, Jonathan S. Austin, Yinfeng He, Adam Thompson, Negar Gilani, Nathan Roberts, Peng Zhao, Christopher J. Tuck, Richard J. M. Hague, Ricky D. Wildman, Lyudmila Turyanska
Summary: The development of conductive polymer ink formulations for 3D printing of electronics at a large scale is important. In this study, a new ink formulation using bio-renewable solvents instead of commonly used DMSO is introduced. The use of these green organic co-solvents improves the printing stability and electrical properties of the ink. The inkjet-based 3D printing method allows for the production of large-area and high-fidelity electronic devices with reproducible electrical performance.
ADDITIVE MANUFACTURING
(2023)
Article
Chemistry, Physical
Philippa L. Jacob, Benedetta Brugnoli, Alessandra Del Giudice, Hien Phan, Veeren M. Chauhan, Laura Beckett, Richard B. Gillis, Cara Moloney, Robert J. Cavanagh, Eduards Krumins, Morgan Reynolds -Green, Joachim C. Lentz, Claudia Conte, Valentina Cuzzucoli Crucitti, Benoit Couturaud, Luciano Galantini, Iolanda Francolini, Steven M. Howdle, Vincenzo Taresco
Summary: Sustainably derived poly(glycerol adipate) (PGA) possesses desirable features for drug delivery, such as biodegradability, biocompatibility, self-assembly into nanoparticles, and functionalizable pendant groups. However, PGA suffers from poor amphiphilic balance, resulting in weak drug-polymer interactions, low drug-loading in nanoparticles, and low stability. To overcome these drawbacks, the polyester backbone was significantly modified while maintaining mild and sustainable polymerization conditions. Novel poly(diglycerol adipate) (PDGA) variants with hydrophilic diglycerol and hydrophobic hexanediol showed improved water solubility, diminished self-assembling ability, and enhanced features as nanocarriers. The PDGAHex nanoparticles exhibited stability in different environments and enhanced drug loading, as well as good biocompatibility in vitro and in vivo experiments.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2023)
Review
Biochemical Research Methods
Brenno A. D. Neto, Jenny E. P. Sorto, Alexandre A. M. Lapis, Fabricio Machado
Summary: This review provides a comprehensive overview of recent advancements and applications of fluorescence imaging probes synthesized via multicomponent reactions (MCRs). It discusses the applications of these probes in biological imaging, particularly in cellular imaging, and explores the challenges and future perspectives in the field. The review also highlights the historical perspective and pioneering works in this area of research.
Article
Chemistry, Multidisciplinary
Kristoffer Kortsen, Morgan Reynolds-Green, Bradley Hopkins, Alison McLellan, Matthew J. Derry, Paul D. Topham, Jeremy J. Titman, Daniel J. Keddie, Vincenzo Taresco, Steven M. Howdle
Summary: A new and robust methodology is reported for the synthesis of PS-PMMA core-shell particles using seeded dispersion polymerization in supercritical carbon dioxide. The core-shell ratio can be predictably controlled by manipulating the reagent stoichiometry. The key development is the iterative addition of the MMA shell monomer to the pre-prepared PS core, resulting in isolated single particle populations with distinct and controllable core-shell morphologies.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Raissa G. M. R. Barroso, Jamille R. C. Lima, Leia C. L. Favaro, Fabricio Machado, Silvia B. Goncalves
Summary: A lactic-acid-producing strain was isolated from Brazilian soil and found to have the ability to convert glycerol into lactic acid. By adjusting fermentation variables such as temperature and pH, the production of lactic acid can be maximized while reducing the formation of 1,3-propanediol.
FERMENTATION-BASEL
(2022)
Article
Polymer Science
Yuanzhang Jiang, Xuyi Wang, Yanting Han, Dakai Gong, Yingchun Gu, Lin Tan
Summary: In this study, FeCl3 and poly(acrylic acid) (PAA) were doped into waterborne polyurethanes (WPUs) to create multifunctional materials with self-healing and antimicrobial properties. WPU/Fe/PAA-5.5, containing 5.5 wt % PAA, exhibited excellent mechanical properties, strong self-healing capabilities, and an impressive antimicrobial rate of over 90%. These supramolecular films were also highly recyclable through hot-pressing.
Article
Polymer Science
Longyu Tian, Min Wang, Guangming Liao, Baoliang Liu, Sujuan Zhang, Yucheng Sun, Zhen Meng, Jintao Zhang, Zaijun Lu
Summary: Two kinds of benzoxazine monomers were synthesized and used to prepare polybenzoxazine anion exchange membranes (AEMs) with quaternary ammonium functionalization. The LQPBZ AEM exhibited better ion conductivity and alkaline stability.
Article
Polymer Science
Claire A. Lemarchand
Summary: This study investigates the shock behavior of three different polymers through molecular dynamics simulations. The results reveal specificities in the shock behavior of polymers, including deviations from the linear relation between shock velocity and particle velocity, as well as differences in shear stress relaxation behind the shock front. It is found that the deviation of the Hugoniot locus is related to the change in the relative contribution of bonding and non-bonding potential energies, while polymers with higher glass transition temperatures exhibit slower shear stress relaxation.
Article
Polymer Science
Zengquan Liu, Xiaochun Yin, He Zhang, Shuo Gao, Qinglin Kuang, Yanhong Feng
Summary: A powder solid-state extension (PSSE) technology was proposed to address the high melt viscosity issue of UHMWPE. By uniaxial extension and sintering in the solid state, a highly self-reinforced material was prepared. X-ray diffraction and scattering techniques were used to study the structural evolution during the PSSE process, and a solid-phase induced transformation model was established.
Article
Polymer Science
Zhike Li, Anyu Luo, Rui Zhou, Xin Li, Haiyan Li
Summary: A novel high temperature resistance IL@SiO2 nanocapsules were successfully prepared and their friction and wear properties in PA6 composites were studied. The addition of IL@SiO2 nanocapsules reduced the friction coefficient and wear rate without affecting the mechanical properties of PA6. The synergy between the IL core and SiO2 wall in the nanocapsules improved the self-lubricating performance of the PA6 composites.
Article
Polymer Science
Xin Liu, Xuhong Guo, Qi Liao
Summary: In this study, an algorithm for accurately estimating viscosity is developed using molecular dynamics simulations and the Green-Kubo formula. This algorithm can be applied to complex systems with long correlations, such as macromolecular and biological simulation systems.
Article
Polymer Science
Hao Pu, Yun-Lei Hou, Jing -Zhou Chen, Dong -Lin Zhao
Summary: The use of modified graphene improves the interfacial adherence of carbon fibers to epoxy resin, resulting in enhanced interfacial and bending properties of CF and matrix in CF/EP composites, as well as increased interlaminar shear strength and flexural strength.
Article
Polymer Science
Wei-Chung Ke, Jin-Wei Lin, Manohar Reddy Busireddy, Yueh-Hsing Lee, Jiun-Tai Chen, Chain-Shu Hsu
Summary: This study introduces a crosslinkable monomer, TAIC, to synthesize three crosslinked polyimide films, which exhibit improved thermal, mechanical, and dielectric properties. The introduction of TAIC enhances the tensile strength, reduces the dielectric constant and dielectric loss, and decreases the coefficient of thermal expansion of the polyimide films.
Article
Polymer Science
Alex Kwasi Kumi, Ruiling Fan, Ye Chen, Yumei Zhang
Summary: The difference in leaching of amylopectin from cellulose/amylopectin/1-butyl-3-methylimidazolium chloride ([Bmim][Cl]) blends during regeneration in water and aqueous ethanol has been studied. Molecular dynamics simulations showed that the dissolution and regeneration mechanisms of amylopectin in [Bmim][Cl] are similar to cellulose in ionic liquids. Water regeneration leads to weak electrostatic interactions, resulting in high leaching of amylopectin. In contrast, ethanol-water interactions enhance electrostatic interactions among amylopectin chains, limiting amylopectin leaching in aqueous ethanol.
Article
Polymer Science
Xi Zeng, Junwei Zhou, Junbiao Peng, Chunsheng Zhang, Danling Wang, Yihu Song, Qiang Zheng
Summary: This study utilizes an oligomer deep eutectic solvent (DES) based on polyethylene glycol to regulate the vulcanization kinetics of rubber. The results show that the DES can accelerate vulcanization at low temperatures without affecting the crosslinking density and Mullins effect.
Article
Polymer Science
Qianqian Yue, Yongfei Peng, Xingjian Liu, Aihua He, Huarong Nie
Summary: The addition of metal deactivators can effectively suppress the aging of TBIR, prolong its lifespan, and have no negative effects on its physical and processing properties. These research findings are of great importance for improving the stability and aging resistance of polymers.
Article
Polymer Science
J. Gomez-Caturla, J. Ivorra-Martinez, R. Tejada-Oliveros, V Moreno, D. Garcia-Garcia, R. Balart
Summary: This work focuses on the development of environmentally friendly PLA formulations by using different esters derived from geraniol as plasticizers. The results show that these esters have good compatibility with PLA, and they can effectively enhance the elongation and plasticity of PLA, reduce its glass transition temperature, and slightly improve its water absorption capabilities.
Article
Polymer Science
Dandan Li, Zhaohui Lu, Zhao Ke, Ke Xu, Fengna Dai, Youhai Yu, Guangtao Qian, Chunhai Chen
Summary: In this study, cross-linked PI aerogel membranes with low dielectric constant and high moisture resistance were prepared by co-polymerization and scraping coating technology. The incorporation of fluorinated blocks and benzimidazole ring structures resulted in novel PI aerogel membranes with fascinating dielectric properties and outstanding moisture resistance.
Article
Polymer Science
Zhaoyang Chu, Qing Zhang, Haihua Luo, Han Zhou, Fapei Zhang, Wei Chen, Wenhua Zhang
Summary: Multi-physical fields solution processing strategy is a universal and facile method for preparing various conjugated polymer films and high-performance devices. In this study, we employed a combined microfluidic flow and ultrasonication strategy (FU) for processing CP solutions, and found a pronounced synergetic effect in promoting the pre-ordering of chains in solution. The conformation order and anisotropy of the solution were revealed through various characterizations. A non-classical nucleation model for polymer crystallization in non-equilibrium solution processing was confirmed. The roles of microfluidic flow and ultrasonication in chain aggregation and crystallization were addressed through multi-physical simulations. Compared to pristine solutions, the FU strategy showed improved solution anisotropy and crystallization kinetics, resulting in higher crystallinity in films and increased mobilities in OFET devices. The FU processing strategy provides a universal approach for regulating chain conformation and aggregation in conjugated polymer solutions.