Article
Polymer Science
Mathieu Madau, Gaelle Morandi, Vincent Lapinte, Didier Le Cerf, Virginie Dulong, Luc Picton
Summary: HA-based thermo-responsive hydrogels were obtained through functionalization with PiPrOx-co-PnBuOx copolymers. The hydrogel transition temperature can be controlled by varying the monomeric composition.
Review
Materials Science, Biomaterials
Lucca Trachsel, Marcy Zenobi-Wong, Edmondo M. Benetti
Summary: PAOXAs, as starting materials for tissue engineering supports and cell culture platforms, have gained popularity due to their biocompatibility, chemical versatility, and potential to fabricate multifunctional biomaterials with a broad spectrum of properties.
BIOMATERIALS SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Tim R. Dargaville, Damien G. Harkin, Jong-Ryul Park, Amanda Cavalcanti, Eleonore C. L. Bolle, Flavia Medeiros Savi, Brooke L. Farrugia, Bryn D. Monnery, Yann Bernhard, Joachim F. R. Van Guyse, Annelore Podevyn, Richard Hoogenboom
Summary: A rapid photo-curing system based on poly(2-ethyl-2-oxazoline-co-2-allylamidopropyl-2-oxazoline) and its in vivo compatibility were investigated, showing mild foreign body responses in a murine subdermal model. The study paves the way for future investigations into the use of these highly tailorable materials for implantable hydrogel devices.
Article
Chemistry, Multidisciplinary
Paola A. Benitez-Duif, Marina Breisch, Daniel Kurka, Karlina Edel, Semra Goekcay, Dominic Stangier, Wolfgang Tillmann, Montasser Hijazi, Joerg C. Tiller
Summary: The exceptional properties of double-network hydrogels make them suitable for mimicking complex biomaterials, such as cartilage. The stability of these hydrogels is maintained even at physiological conditions. A specific type of double-network hydrogel based on poly(2-methyl-2-oxazoline) exhibits biomechanical properties similar to cartilage and high strength.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Zivani Varanaraja, Nathan Hollingsworth, Ross Green, C. Remzi Becer
Summary: This study investigates the thermal properties and solution behavior of 21 tunable copolymers in both aqueous and nonaqueous media. Their ability to disperse carbonized materials in nonaqueous medium is evaluated.
ACS APPLIED POLYMER MATERIALS
(2023)
Article
Chemistry, Organic
Jipeng Zhu, Min Zhou, Weinan Jiang, Yang Zhou, Gonghua Song, Runhui Liu
Summary: We have developed a facile one-pot synthesis method for 2-oxazolines. This method can tolerate a wide range of functional groups under mild reaction conditions and provide diverse 2-oxazoline products with good yields. The chirality of the isocyanate at position 1 can be preserved, and microwave-assisted synthesis can further enhance the reaction yield and reduce the reaction time. This method is of great significance for the synthesis of 2-oxazoline-derived polymers and materials.
TETRAHEDRON LETTERS
(2022)
Article
Chemistry, Physical
C. Le Coeur, C. Lorthioir, A. Feoktystov, B. Wu, G. Volet, C. Amiel
Summary: The study investigated the adsorption behavior and local structures within nanocomposite gels based on Laponite and POXA, revealing the unique evolution of the storage modulus G' with POXA concentration. In contrast to PEO, the stronger affinity of POXA chains for clay surfaces reduced the inhomogeneities for Laponite disks within the gels, leading to the strengthening of POXA-based hydrogels.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Polymer Science
Tatyana Kirila, Anna Smirnova, Alla Razina, Andrey Tenkovtsev, Alexander Filippov
Summary: The study investigated the water-salt solutions of star-shaped six-arm poly-2-alkyl-2-oxazines and poly-2-alkyl-2-oxazolines using light scattering and turbidimetry. It was found that the sensitivity of the investigated stars to salt in solution depends on the structure of the salt and polymer, as well as the salt concentration. Additionally, an increase in hydrophobicity led to a decrease in phase separation temperature, with a non-monotonic relationship between phase separation temperature and salt concentration observed in solutions with methylpyridinium p-toluenesulfonate.
Article
Biochemistry & Molecular Biology
Maria J. Sanchez-Fernandez, Jens Rutjes, Rosa P. Felix Lanao, Johan C. M. E. Bender, Jan C. M. van Hest, Sander C. G. Leeuwenburgh
Summary: The development of dual crosslinked hydrogels with tunable stiffness, ductility, and self-healing capacity for bone adhesive applications is successful. These hydrogels show superior mechanical and bone adhesive properties, making them suitable for use as bone adhesive glues.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Polymer Science
Malik Salman Haider, Taufiq Ahmad, Mengshi Yang, Chen Hu, Lukas Hahn, Philipp Stahlhut, Jurgen Groll, Robert Luxenhofer
Summary: The study presents a thermosensitive diblock copolymer with reversible sol-gel transition and ideal rheological properties, suitable for biofabrication applications.
Article
Polymer Science
Lucca Trachsel, Matteo Romio, Marcy Zenobi-Wong, Edmondo M. Benetti
Summary: Cyclic macromolecules exhibit enhanced mechanical strength and greater hydration in hydrogels, compared to their linear counterparts, due to the higher effective intramolecular repulsion between polymer segments and the topology effects.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Engineering, Biomedical
Dominik Hahn, Jannick M. Sonntag, Steffen Luck, Manfred F. Maitz, Uwe Freudenberg, Rainer Jordan, Carsten Werner
Summary: Poly(ethylene glycol) (PEG)-glycosaminoglycan (GAG) hydrogel networks are established as versatile biomaterials, with varying stiffness and swelling properties achieved through the systematic combination of different poly(2-alkyl-2-oxazolines) (POx) and heparin. The choice of POx and its temperature-dependent conformation can modulate the release of GAG-binding growth factors, while the hydrophobicity of the gel-incorporated POx influences fibronectin adsorption, fibroblast growth, and bacterial adhesion. In vitro hemocompatibility tests demonstrate advantages of POx-based gels over PEG-based reference materials. Biohybrid POx hydrogels have the potential to meet the requirements of biomedical technologies with customizable physicochemical characteristics.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Polymer Science
Dominik Segiet, Annika Stockmann, Jan Sadowski, Frank Katzenberg, Joerg C. Tiller
Summary: By studying the cloud point temperatures and thermo-responsive swelling behavior of polymers, hydrogels with a narrow thermal transition can be achieved. The cloud point temperature of polymers in water is independent of concentration, while the salt solution does not affect the hydrogels.
MACROMOLECULAR CHEMISTRY AND PHYSICS
(2021)
Article
Polymer Science
Annelore Podevyn, Sandra Van Vlierberghe, Peter Dubruel, Richard Hoogenboom
Summary: The combination of natural and synthetic polymers to form hybrid hydrogels offers the potential of fabricating new materials with dual polymer properties. This study synthesized two alkene-functionalized poly(2-alkyl/aryl-2-oxazoline) (PAOx) copolymers and one gelatin derivative, thiolated gelatin (gel-SH), as precursors for hybrid hydrogels through a photo-induced radical thiol-ene crosslinking process. The results showed that hydrogels with an excess amount of PAOx precursor exhibited increased mechanical stability. The thermo-responsive properties of a specific hydrogel film were also investigated, showing promise for developing hybrid poly(2-oxazoline)-gelatin hydrogels with predictable properties.
Article
Chemistry, Physical
Wen -Li Wang, Kousuke Kawai, Hiroaki Sigemitsu, Ren-Hua Jin
Summary: In this work, comb polymers with grafted-on-graft side chains (c-PEI-g-Acyl) were synthesized via an effective acylation reaction. The resulting films showed good crystalline features and formed honeycomb structures supported by crystalline lamellae frames.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Physical
Y. Prykhodko, A. Martin, H. Oulyadi, Ya L. Kobzar, S. Marais, K. Fatyeyeva
Summary: The thermal properties of imidazolium-based protic ionic liquids (PILs) with different perfluorinated anions were studied by synthesizing 21 PILs with various alkyl and fluorinated side chains. The results showed that an increase in the length of alkyl side chains led to a decrease in melting point temperature, while an increase in the amount of fluorine atoms in the cation chemical structure led to higher crystallinity and lower thermal stability. The best thermal stability was observed in monofluorinated- and butyl-TFSI PILs in liquid state, while the lowest thermal stability was found in trifluorinated- and vinyl-TFA PILs in solid state.
JOURNAL OF MOLECULAR LIQUIDS
(2022)
Article
Chemistry, Multidisciplinary
Amandine Pons, Jonathan Decaens, Riham Najjar, Nansalmaa Otog, Mathieu Arribat, Sandrine Jolly, Samuel Couve-Bonnaire, Muriel Sebban, Gael Coadou, Hassan Oulyadi, David Speybrouck, Seiji Iwasa, Andre B. Charette, Thomas Poisson, Philippe Jubault
Summary: In order to fine-tune the effects of proline on bioactive compounds, various modifications have been made to its structure over the years. Notably, the introduction of a cyclopropane ring or a fluorine atom has shown interesting results. In this study, a proline containing fluorocyclopropane was synthesized and inserted into a tripeptide, and its conformation was analyzed using nuclear magnetic resonance and density functional theory calculations.
Article
Chemistry, Physical
Celine Jaudoin, Isabelle Grillo, Fabrice Cousin, Maria Gehrke, Malika Ouldali, Ana-Andreea Arteni, Luc Picton, Christophe Rihouey, Fanny Simeliere, Amelie Bochot, Florence Agnely
Summary: The microstructure and interactions of hybrid systems formed by mixtures of hyaluronic acid and liposomes were investigated, and it was found that the surface properties of liposomes play a crucial role in determining their structure.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Matthieu Hedouin, Anne-Laure Barthelemy, Nicolas Vanthuyne, Hend Besrour, Jacques Maddaluno, Emmanuel Magnier, Hassan Oulyadi
Summary: This work explains the importance of using an excess of butyllithium in the directed ortho-lithiation of a trifluoromethyl sulfoximine. The study shows that the presence of excess n-BuLi leads to deprotonation on the ortho-position of the aromatic, resulting in the formation of six different aggregates. DFT calculations provide optimized solvated structures for these aggregates that are consistent with the experimental NMR data.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Biochemistry & Molecular Biology
Mengli Ding, Jingwen Qiu, Stephan Rouziere, Christophe Rihouey, Luc Picton, Ruxandra Gref
Summary: Due to their flexible composition, large surface areas, versatile surface properties, and degradability, nanoscale metal organic frameworks (nano MOFs) are drawing significant attention in nanomedicine. In particular, iron trimesate MIL-100 (Fe) is extensively studied in drug delivery. The challenging synthesis of room-temperature (RT) MIL100 has been addressed by using acetic acid as a modulator and non-toxic cyclodextrin-based coatings for stability. RT MIL100 obtained using acetic acid showed good colloidal stability, low cytotoxicity, and high drug payload efficiency, making it suitable for cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Medicinal
Meriem Aitouguinane, Zainab El Alaoui-Talibi, Halima Rchid, Imen Fendri, Slim Abdelkafi, Mohamed Didi Ould El-Hadj, Zakaria Boual, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Pascal Dubessay, Philippe Michaud, Guillaume Pierre, Cedric Delattre, Cherkaoui El Modafar
Summary: The study investigated the ability of alginates extracted from two Moroccan brown seaweeds and their derivatives to induce phenolic metabolism in tomato seedlings. Elicitation was done by foliar spraying the seaweed alginates on tomato seedlings and evaluating their effects on PAL activity, polyphenol, and lignin production. It was found that low-molecular-weight alginates were more effective in inducing natural defenses in tomato seedlings compared to the alginate polymers. These findings suggest that low-molecular-weight alginates may have potential as a stimulant for plant natural defenses.
Article
Polymer Science
Guillaume Bretel, Duc-Trung Tran, Gaelle Morandi, Vincent Lapinte, Stephane Marais, Louise Hespel
Summary: In this study, thermo-sensitive polyoxazoline copolymers containing photo-sensitive azobenzene moieties were synthesized. The presence of azobenzene moieties significantly affected the properties of the resulting copolymers, including the glass transition temperature, cloud point temperature, and water uptake capacity. UV radiation-induced trans-cis isomerization of the azobenzene moieties allowed for the tuning of these properties. This photo-sensitive copolymer has great potential for various applications.
Article
Polymer Science
Gwendoline Christophe, Xiaoyang Hou, Emmanuel Petit, Mounir Traikia, Didier Le Cerf, Christophe Rihouey, Christine Gardarin, Cedric Delattre, Philippe Michaud, Guillaume Pierre, Pascal Dubessay
Summary: This study identified Peteryoungia rosettifformans as a wild producer of an exopolysaccharide related to glucuronan. Structural and biochemical analyses revealed that the polysaccharide had a molecular mass of 1.85 x 10(5) Da and was partially O-acetylated at C-2 and/or C-3 positions. The concentration of Mg2+ ions in the cultivation medium was found to impact the structure of the polysaccharide.
Article
Pharmacology & Pharmacy
Huu Van Le, Virginie Dulong, Luc Picton, Didier Le Cerf
Summary: The lyophilization of nanogels allows for long-term conservation and adjustment of their concentration and dispersant type. This study investigated the effects of formulation aspects on the integrity of polyelectrolyte complex nanogels after lyophilization and reconstitution. The best approach for freeze-drying thermoresponsive PEC-NGs was determined, and it was found that freeze-drying PEC-NG suspensions prepared at a relatively low polymer concentration with trehalose as a cryoprotectant allowed for homogeneous redispersion of PEC-NGs without significant aggregation.
Article
Biochemistry & Molecular Biology
Manel Sfar, Ghada Souid, Fahad M. M. Alminderej, Zeineb Mzoughi, Yassine El-Ghoul, Christophe Rihouey, Didier Le Cerf, Hatem Majdoub
Summary: This study investigated the extraction of polysaccharides from coriander seeds and evaluated their antioxidant and hepatoprotective effects. The structural characterization of the polysaccharide was performed, showing its composition and properties. Results demonstrated that the polysaccharide exhibited significant inhibition of cadmium-induced oxidation damage and protection against Cd hepatocytotoxicity by reducing MDA production and increasing CAT and SOD enzyme levels.
Article
Biotechnology & Applied Microbiology
Claire Toucheteau, Valentine Deffains, Clement Gaignard, Christophe Rihouey, Celine Laroche, Guillaume Pierre, Olivier Lepine, Ian Probert, Didier Le Cerf, Philippe Michaud, Ingrid Arnaudin-Fruitier, Nicolas Bridiau, Thierry Maugard
Summary: This study isolated and depolymerized exopolysaccharides (EPS) from different microalgae, characterized their structural features, and investigated their effects on collagen activity. The depolymerized EPS forms enhanced collagen production, and the inhibition of collagenase activity was strongly correlated to the sulfate group content of EPS. These findings provide new insights into the dermo-cosmetic potential of microalgae EPS.
Article
Chemistry, Organic
Hend Besrour, Matthieu Hedouin, Lina Truong, Sami Lakhdar, Hassan Oulyadi
Summary: In this study, the interaction between a diphenyliodonium salt and trivalent phosphorus compounds was investigated using {H-1, F-19, P-31} NMR and DFT calculations. The importance of blue light in the reaction was highlighted, and the formation of a phosphonium intermediate was identified. The formation of an EDA complex was characterized, and the significance of acetonitrile for the formation of this complex was demonstrated. The study was further extended to other phosphonium salt formation reactions, and the stability and photoreactivity of the complexes were investigated using DFT calculations.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Batoul Rkein, Romain Coffinier, Marian Powderly, Maxime Manneveau, Morgane Sanselme, Muriel Durandetti, Muriel Sebban, Ghanem Hamdoun, Hassan Oulyadi, David Harrowven, Julien Legros, Isabelle Chataigner
Summary: This article investigates the reaction of nitroarenes with silyloxydienes under high pressure and demonstrates the successful dearomatizing [4+2] cycloadditions at room temperature, resulting in highly functionalized compounds with tetrasubstituted carbon centers.
CHEMICAL COMMUNICATIONS
(2022)
Article
Polymer Science
Yuanzhang Jiang, Xuyi Wang, Yanting Han, Dakai Gong, Yingchun Gu, Lin Tan
Summary: In this study, FeCl3 and poly(acrylic acid) (PAA) were doped into waterborne polyurethanes (WPUs) to create multifunctional materials with self-healing and antimicrobial properties. WPU/Fe/PAA-5.5, containing 5.5 wt % PAA, exhibited excellent mechanical properties, strong self-healing capabilities, and an impressive antimicrobial rate of over 90%. These supramolecular films were also highly recyclable through hot-pressing.
Article
Polymer Science
Longyu Tian, Min Wang, Guangming Liao, Baoliang Liu, Sujuan Zhang, Yucheng Sun, Zhen Meng, Jintao Zhang, Zaijun Lu
Summary: Two kinds of benzoxazine monomers were synthesized and used to prepare polybenzoxazine anion exchange membranes (AEMs) with quaternary ammonium functionalization. The LQPBZ AEM exhibited better ion conductivity and alkaline stability.
Article
Polymer Science
Claire A. Lemarchand
Summary: This study investigates the shock behavior of three different polymers through molecular dynamics simulations. The results reveal specificities in the shock behavior of polymers, including deviations from the linear relation between shock velocity and particle velocity, as well as differences in shear stress relaxation behind the shock front. It is found that the deviation of the Hugoniot locus is related to the change in the relative contribution of bonding and non-bonding potential energies, while polymers with higher glass transition temperatures exhibit slower shear stress relaxation.
Article
Polymer Science
Zengquan Liu, Xiaochun Yin, He Zhang, Shuo Gao, Qinglin Kuang, Yanhong Feng
Summary: A powder solid-state extension (PSSE) technology was proposed to address the high melt viscosity issue of UHMWPE. By uniaxial extension and sintering in the solid state, a highly self-reinforced material was prepared. X-ray diffraction and scattering techniques were used to study the structural evolution during the PSSE process, and a solid-phase induced transformation model was established.
Article
Polymer Science
Zhike Li, Anyu Luo, Rui Zhou, Xin Li, Haiyan Li
Summary: A novel high temperature resistance IL@SiO2 nanocapsules were successfully prepared and their friction and wear properties in PA6 composites were studied. The addition of IL@SiO2 nanocapsules reduced the friction coefficient and wear rate without affecting the mechanical properties of PA6. The synergy between the IL core and SiO2 wall in the nanocapsules improved the self-lubricating performance of the PA6 composites.
Article
Polymer Science
Xin Liu, Xuhong Guo, Qi Liao
Summary: In this study, an algorithm for accurately estimating viscosity is developed using molecular dynamics simulations and the Green-Kubo formula. This algorithm can be applied to complex systems with long correlations, such as macromolecular and biological simulation systems.
Article
Polymer Science
Hao Pu, Yun-Lei Hou, Jing -Zhou Chen, Dong -Lin Zhao
Summary: The use of modified graphene improves the interfacial adherence of carbon fibers to epoxy resin, resulting in enhanced interfacial and bending properties of CF and matrix in CF/EP composites, as well as increased interlaminar shear strength and flexural strength.
Article
Polymer Science
Wei-Chung Ke, Jin-Wei Lin, Manohar Reddy Busireddy, Yueh-Hsing Lee, Jiun-Tai Chen, Chain-Shu Hsu
Summary: This study introduces a crosslinkable monomer, TAIC, to synthesize three crosslinked polyimide films, which exhibit improved thermal, mechanical, and dielectric properties. The introduction of TAIC enhances the tensile strength, reduces the dielectric constant and dielectric loss, and decreases the coefficient of thermal expansion of the polyimide films.
Article
Polymer Science
Alex Kwasi Kumi, Ruiling Fan, Ye Chen, Yumei Zhang
Summary: The difference in leaching of amylopectin from cellulose/amylopectin/1-butyl-3-methylimidazolium chloride ([Bmim][Cl]) blends during regeneration in water and aqueous ethanol has been studied. Molecular dynamics simulations showed that the dissolution and regeneration mechanisms of amylopectin in [Bmim][Cl] are similar to cellulose in ionic liquids. Water regeneration leads to weak electrostatic interactions, resulting in high leaching of amylopectin. In contrast, ethanol-water interactions enhance electrostatic interactions among amylopectin chains, limiting amylopectin leaching in aqueous ethanol.
Article
Polymer Science
Xi Zeng, Junwei Zhou, Junbiao Peng, Chunsheng Zhang, Danling Wang, Yihu Song, Qiang Zheng
Summary: This study utilizes an oligomer deep eutectic solvent (DES) based on polyethylene glycol to regulate the vulcanization kinetics of rubber. The results show that the DES can accelerate vulcanization at low temperatures without affecting the crosslinking density and Mullins effect.
Article
Polymer Science
Qianqian Yue, Yongfei Peng, Xingjian Liu, Aihua He, Huarong Nie
Summary: The addition of metal deactivators can effectively suppress the aging of TBIR, prolong its lifespan, and have no negative effects on its physical and processing properties. These research findings are of great importance for improving the stability and aging resistance of polymers.
Article
Polymer Science
J. Gomez-Caturla, J. Ivorra-Martinez, R. Tejada-Oliveros, V Moreno, D. Garcia-Garcia, R. Balart
Summary: This work focuses on the development of environmentally friendly PLA formulations by using different esters derived from geraniol as plasticizers. The results show that these esters have good compatibility with PLA, and they can effectively enhance the elongation and plasticity of PLA, reduce its glass transition temperature, and slightly improve its water absorption capabilities.
Article
Polymer Science
Dandan Li, Zhaohui Lu, Zhao Ke, Ke Xu, Fengna Dai, Youhai Yu, Guangtao Qian, Chunhai Chen
Summary: In this study, cross-linked PI aerogel membranes with low dielectric constant and high moisture resistance were prepared by co-polymerization and scraping coating technology. The incorporation of fluorinated blocks and benzimidazole ring structures resulted in novel PI aerogel membranes with fascinating dielectric properties and outstanding moisture resistance.
Article
Polymer Science
Zhaoyang Chu, Qing Zhang, Haihua Luo, Han Zhou, Fapei Zhang, Wei Chen, Wenhua Zhang
Summary: Multi-physical fields solution processing strategy is a universal and facile method for preparing various conjugated polymer films and high-performance devices. In this study, we employed a combined microfluidic flow and ultrasonication strategy (FU) for processing CP solutions, and found a pronounced synergetic effect in promoting the pre-ordering of chains in solution. The conformation order and anisotropy of the solution were revealed through various characterizations. A non-classical nucleation model for polymer crystallization in non-equilibrium solution processing was confirmed. The roles of microfluidic flow and ultrasonication in chain aggregation and crystallization were addressed through multi-physical simulations. Compared to pristine solutions, the FU strategy showed improved solution anisotropy and crystallization kinetics, resulting in higher crystallinity in films and increased mobilities in OFET devices. The FU processing strategy provides a universal approach for regulating chain conformation and aggregation in conjugated polymer solutions.