Article
Environmental Sciences
Fang Wang, Yuying Wang, Yu Wang, Teng Jia, Li Chang, Jie Ding, Li Zhou
Summary: This study investigated the relationship between exposure to polycyclic aromatic hydrocarbons (PAHs) and hypertension, and found a positive dose-response relationship between high exposure to certain PAH metabolites and the risk of hypertension. Obese individuals with high PAH exposure were at greater risk for hypertension than individuals with low PAH exposure and normal BMI.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Manthar Ali Mallah, Li Changxing, Mukhtiar Ali Mallah, Muhammad Naveed, Yang Liu, Sobia Noreen, He Xi, Wei Wang, Feifei Feng, Qiao Zhang
Summary: This study aimed to investigate the association between urinary PAHs and cardiovascular diseases. The results showed a positive correlation between urinary PAHs and the prevalence of coronary heart disease, angina, heart attack, and stroke.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Boying Liu, Yanyan Chen, Siyao Li, Yuanyuan Xu, Yi Wang
Summary: Exposure to polycyclic aromatic hydrocarbons (PAHs) may increase the risk of thyroid nodular goiter (NG)/papillary thyroid carcinoma (PTC), with a gender-specific effect observed. Elevated concentrations of specific OH-PAHs in NG and PTC patients are associated with increased disease risk.
ENVIRONMENTAL POLLUTION
(2021)
Article
Endocrinology & Metabolism
Qiming Yuan, Kun Jin, Xianghong Zhou, Zhimei Qiu, Jiakun Li, Di Jin, Zilong Zhang, Chichen Zhang, Lu Yang, Yu Zhan, Shi Qiu, Qiang Wei
Summary: This study found that exposure to polycyclic aromatic hydrocarbons (PAHs) is associated with changes in levels of sexual hormones. Specifically, urinary 2-hydroxynapthalene and 3-hydroxyfluorene were associated with increased testosterone levels in males, while urinary 1-hydroxyphenanthrene was associated with increased estradiol levels in females.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Engineering, Environmental
Manthar Ali Mallah, Zhu Ying, Mukhtiar Ali, Junwei Guo, Feifei Feng, Wei Wang, Pingping Shang, Qiao Zhang
Summary: This study aims to examine the association between urinary polycyclic aromatic hydrocarbons (PAHs) and liver function parameters among the US population. Data from the National Health and Nutritional Examination Survey (NHANES) 2003-2016 were used, and a total of 2515 participants were included. Logistic regression analysis showed that increased 9-hydroxyfluorene was associated with elevated GGT levels. In conclusion, 9-hydroxyfluorene is associated with elevated GGT levels, and its effect is modified by other PAHs.
ENVIRONMENTAL GEOCHEMISTRY AND HEALTH
(2023)
Article
Environmental Sciences
Esther M. John, Jocelyn Koo, Sue A. Ingles, Theresa H. Keegan, Jenny T. Nguyen, Catherine Thomsen, Mary Beth Terry, Regina M. Santella, Khue Nguyen, Beizhan Yan
Summary: Urinary PAH exposure was found to be widespread in girls aged 6-16 years, with concentrations varying by age, race/ethnicity, body mass index percentile, as well as outdoor, indoor, and dietary sources of exposure.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Yan Lin, Xueyao Gao, Xinghua Qiu, Jinming Liu, Chi-Hong Tseng, Junfeng Jim Zhang, Jesus A. Araujo, Yifang Zhu
Summary: This study found that traveling from Los Angeles to Beijing led to significant increases in the concentrations of alkyl-naphthalene and alkyl-phenanthrene metabolites in urine samples, with different concentration ratios indicating relative exposure contributions from petrogenic and pyrogenic sources. These results suggest that 2-PHECA to hydroxy-phenanthrene ratio could be used as an index to reflect the sources of exposure to PAHs.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Environmental Sciences
Mengmeng Fu, Huimin Wang, QianXiang Bai, Juanjuan Du, Qiao Niu, Jisheng Nie
Summary: This study investigated the relationship between polycyclic aromatic hydrocarbon (PAH) metabolites and mild cognitive impairment (MCI) in coke oven workers, and explored whether plasma p-tau231 can be used as a potential biomarker for MCI. The results showed that the urinary levels of PAH metabolites were positively associated with MCI and plasma p-tau231 levels in coke oven workers.
Article
Environmental Sciences
Zhiyu Yang, Shouyi Chen, Si Zhou, Conghui Xu, Chunxia Jing, Chongshan Guo, Xinhong Pan, Lixi Zeng, Lei Tan
Summary: This study evaluated the association between internal exposure to polycyclic aromatic hydrocarbons (PAHs) and urinary iodine concentration with thyroid volume in school-age children in Guangzhou, China. The results showed a significant positive association between urinary hydroxylated PAHs and thyroid volume. Additionally, urinary PAHs were also linked to urinary iodine, and iodine mediated the relationship between PAHs and thyroid volume.
ENVIRONMENTAL POLLUTION
(2023)
Article
Pharmacology & Pharmacy
Humairat H. Rahman, Danielle Niemann, Stuart H. Munson-McGee
Summary: This study found that urinary polycyclic aromatic hydrocarbons (PAHs) and metals were associated with an increased risk of emphysema in smokers, while certain arsenic species and metals showed an inverse relationship. Additionally, several demographic factors were significantly associated with emphysema in smokers.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2022)
Article
Environmental Sciences
Yan-Ling Deng, Pan Yang, Yi-Xin Wang, Chong Liu, Qiong Luo, Tian Shi, Jia-Yue Zeng, Ting-Ting Lu, Pan-Pan Chen, Yu Miao, Min Zhang, Fei-Peng Cui, Wen-Qing Lu, Qiang Zeng
Summary: Previous studies have found associations between exposure to phthalates and polycyclic aromatic hydrocarbons (PAHs) and altered semen quality, but no studies have evaluated their combined effects. This study aimed to investigate the associations between urinary metabolite mixtures of phthalates and PAHs and semen quality.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Miao Liu, Lei Zhao, Linlin Liu, Wenting Guo, Huihua Yang, Jie Yu, Shuang Chen, Meng Li, Qin Fang, Xuefeng Lai, Liangle Yang, Rui Zhu, Xiaomin Zhang
Summary: This study found a positive association between urinary polycyclic aromatic hydrocarbon (PAH) metabolites and children's blood pressure, with 9-hydroxyphenanthrene (9-OHPh) and 4-hydroxyphenanthrene (4-OHPh) as the major contributors. The relationship was modified by passive smoking status and stronger in passive smokers. The metabolites were also related to the elevation of multiple cytokines, with platelet-derived growth factor (PDGF) playing a role in the blood pressure elevation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Xiaobing Feng, Ruyi Liang, Da Shi, Dongming Wang, Yanjun Guo, Weihong Qiu, Man Cheng, Tao Xu, Chaoqian Dong, Min Zhou, Weihong Chen
Summary: This study found that exposure to polycyclic aromatic hydrocarbons (PAHs) may increase the risk of depression among US adults. Specific urinary PAH metabolites were positively associated with the risk of depression, particularly in smokers. Further research is needed to investigate the underlying mechanism by which PAHs induce the development of depression.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Environmental Sciences
Ram B. Jain
Summary: The associations between urinary concentrations of oxidant polycyclic aromatic hydrocarbon (PAH) metabolites and serum concentrations of anti-oxidant alpha-klotho were examined in US adults aged 40-79 years. The study found that increased PAH metabolite concentrations were associated with decreased alpha-klotho concentrations in individuals with normal or near normal kidney function. However, the associations were not significant in individuals with albuminuria. These findings suggest that exposure to PAH may lead to reduced alpha-klotho concentrations.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemical Research Methods
Marie Marques, Anne Maitre, Luc Choisnard, Christine Demeilliers, Renaud Persoons
Summary: A new gas chromatography-tandem mass spectrometry method was developed and validated for determining metabolites of polycyclic aromatic hydrocarbons in urine. Utilizing a two-stage derivatization approach and SPE extraction, the method successfully detected 11 target compounds with low limits of quantification and high precision. Application to workers in aluminum production confirmed the effectiveness of the method in assessing carcinogenic occupational exposures.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Oncology
Alexandra J. White, Allyson M. Gregoire, Kyla W. Taylor, Carolyn Eberle, Symielle Gaston, Katie M. O'Brien, Chandra L. Jackson, Dale P. Sandler
Summary: The study suggests that using hair products, particularly perms and straighteners, during adolescence may be associated with a higher risk of premenopausal breast cancer. Overall, the frequency of permanent hair dye use during adolescence was low, but there may be an association with increased breast cancer risk among black women.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Public, Environmental & Occupational Health
Abee L. Boyles, Brandiese E. Beverly, Suzanne E. Fenton, Chandra L. Jackson, Anne Marie Z. Jukic, Vicki L. Sutherland, Donna D. Baird, Gwen W. Collman, Darlene Dixon, Kelly K. Ferguson, Janet E. Hall, Elizabeth M. Martin, Thaddeus T. Schug, Alexandra J. White, Kelly J. Chandler
Summary: Environmental factors, such as chemical exposures and nonchemical stressors, can impact maternal health during pregnancy. Studies indicate that racial/ethnic minorities are more vulnerable to adverse effects from both chemicals and nonchemical stressors, leading to disparities in maternal health outcomes.
JOURNAL OF WOMENS HEALTH
(2021)
Letter
Environmental Sciences
Alexander P. Keil, Jessie P. Buckley, Katie M. O'Brien, Kelly K. Ferguson, Shanshan Zhao, Alexra J. White
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Article
Environmental Sciences
Alexandra J. White, Allyson M. Gregoire, Nicole M. Niehoff, Kimberly A. Bertrand, Julie R. Palmer, Patricia F. Coogan, Traci N. Bethea
Summary: Overall, no association between air pollution and increased breast cancer risk was observed among Black women, except potentially among women living in the Midwestern US.
ENVIRONMENTAL RESEARCH
(2021)
Article
Environmental Sciences
Suril S. Mehta, Tamarra James-Todd, Katie M. Applebaum, Andrea Bellavia, Kimberly Coleman-Phox, Nancy Adler, Barbara Laraia, Elissa Epel, Emily Parry, Miaomiao Wang, June-Soo Park, Ami R. Zota
Summary: This study investigated the associations between individual and mixture of POPs exposure and measures of prenatal fasting glucose, insulin, and insulin resistance in overweight women during pregnancy. The findings revealed varied associations between certain POPs exposures and glucose metabolism during pregnancy, with individual PCB exposures positively associated with fasting insulin and HOMA-IR, and all PFAS inversely associated with glucose and insulin levels. Further research on the relationship between POPs exposure and glycemic outcomes in a larger population of pregnant women is warranted.
ENVIRONMENTAL RESEARCH
(2021)
Article
Oncology
Nicole M. Niehoff, Mary Beth Terry, Deborah B. Bookwalter, Joel D. Kaufman, Katie M. O'Brien, Dale P. Sandler, Alexandra J. White
Summary: This study suggests that there is an association between NO2 exposure and increased breast cancer risk in women with higher familial risk, while the association with PM2.5 did not vary. The impact of different pollutants on breast cancer risk may vary among individuals with different levels of familial risk.
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2022)
Article
Environmental Sciences
Allyson M. Gregoire, Trang VoPham, Francine Laden, Rina Yarosh, Katie M. O'Brien, Dale P. Sandler, Alexandra J. White
Summary: This study found no association between living in areas with higher levels of UV radiation and overall breast cancer risk. Higher UV levels were inversely associated with ER- breast cancer risk, but not with ER+. The inverse association was only evident in women who did not regularly take vitamin D supplements for ER- breast cancer.
ENVIRONMENT INTERNATIONAL
(2022)
Article
Public, Environmental & Occupational Health
Katie M. O'Brien, Alexander P. Keil, Quaker E. Harmon, Chandra L. Jackson, Alexandra J. White, Mary Diaz-Santana, Jack A. Taylor, Dale P. Sandler
Summary: The use of vitamin D supplements, particularly recent use, is inversely associated with breast cancer risk, especially for ductal carcinoma in situ.
Letter
Environmental Sciences
Alexandra J. White, Allyson M. Gregoire, Jared A. Fisher, Danielle N. Medgyesi, Longxiang Li, Petros Koutrakis, Dale P. Sandler, Rena R. Jones
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Environmental Sciences
Evans K. Lodge, Chantel L. Martin, Rebecca C. Fry, Alexandra J. White, Cavin K. Ward-Caviness, Sandro Galea, Allison E. Aiello
Summary: Vacant, aged, and poorly maintained housing may contribute to low-level lead exposure among adults in older cities like Detroit. US Census and neighborhood quality data can be used to identify population-level lead exposure among US adults.
JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY
(2023)
News Item
Oncology
Margaret R. Karagas, Amy Wang, David C. Dorman, Amy L. Hall, Jingbo Pi, Consolato M. Sergi, Elaine Symanski, Elizabeth M. Ward, Victoria H. Arrandale, Kenichi Azuma, Eduardo Brambila, Gloria M. Calaf, Jason M. Fritz, Shoji Fukushima, Joanna M. Gaitens, Tom K. Grimsrud, Lei Guo, Elsebeth Lynge, Amelia P. Marinho-Reis, Melissa A. McDiarmid, Daniel R. S. Middleton, Thomas P. Ong, David A. Polya, Betzabet Quintanilla-Vega, Georgia K. Roberts, Tiina Santonen, Riitta Sauni, Maria J. Silva, Pascal Wild, Changwen W. Zhang, Qunwei Zhang, Yann Grosse, Lamia Benbrahim-Tallaa, Aline de Conti, Nathan L. DeBono, Fatiha El Ghissassi, Federica Madia, Bradley Reisfeld, Leslie T. Stayner, Eero Suonio, Susana Viegas, Roland Wedekind, Shukrullah Ahmadi, Heidi Mattock, William M. Gwinn, Mary K. Schubauer-Berigan
Article
Oncology
Ruth M. Lunn, Suril S. Mehta, Gloria D. Jahnke, Amy Wang, Mary S. Wolfe, Brian R. Berridge
Summary: The National Toxicology Program aims to increase awareness of cancer hazards in the environment and promote primary prevention, public health decision-making, and reducing the global cancer burden. The latest report added 8 new substances, including Helicobacter pylori, antimony trioxide, and 6 haloacetic acids found in water disinfection by-products. The program also conducted a cancer hazard assessment on circadian disruption, revealing that night shift work and certain lighting conditions may cause cancer. Their approaches are evolving to address modern challenges, focusing on real-world exposures and refining methods for cancer hazard assessments.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Environmental Sciences
Suril S. Mehta, M. Elizabeth Hodgson, Ruth M. Lunn, Claire E. Ashley, Whitney D. Arroyave, Dale P. Sandler, Alexandra J. White
Summary: Indoor wood-burning fireplaces and stoves are associated with an increased risk of lung cancer, even among non-smokers, according to a nationwide cohort study of US women. The study highlights the importance of considering the health risks of using wood-burning devices indoors.
ENVIRONMENT INTERNATIONAL
(2023)
Review
Public, Environmental & Occupational Health
Nicole M. Niehoff, Mandy Goldberg, Alexandra J. White
Summary: This article reviews the evidence from the past 5 years on environmental exposures during childhood/adolescence through first birth and the risk of breast and other cancers during adulthood. The studies found associations between environmental factors such as tobacco smoke, pesticides, and living on high traffic roads and breast cancer risk. However, research on other cancers is limited. The article suggests that future studies should focus on exploring the relationship between early-life environmental exposures and cancer risk.
CURRENT EPIDEMIOLOGY REPORTS
(2022)