Article
Gastroenterology & Hepatology
Patricia P. Bloom, Eric A. Meyerowitz, Zoe Reinus, Michael Daidone, Jenna Gustafson, Arthur Y. Kim, Esperance Schaefer, Raymond T. Chung
Summary: In COVID-19 patients, abnormalities in liver biochemistries, particularly AST and ALT, are common on admission and throughout the course of illness. Aminotransferases are frequently elevated, while alkaline phosphatase and total bilirubin elevations are rare. AST-dominant aminotransferase elevation seems to correlate with disease severity and reflects true hepatic injury.
Article
Immunology
Isaac Nunez, Angel A. Priego-Ranero, H. Benjamin Garcia-Gonzalez, Brenda Jimenez-Franco, Rebeca Bonilla-Hernandez, Guillermo Dominguez-Cherit, Javier Merayo-Chalico, Jose C. Crispin, Ana Barrera-Vargas, Sergio Ivan Valdes-Ferrer
Summary: The study found that hematological and biochemical markers taken on admission can help predict the severity of COVID-19 patients, including the risk of death or admission to critical care. These simple blood tests can play an important role in the early stages of the disease, helping to identify severe patients early and allocate resources appropriately.
CLINICAL IMMUNOLOGY
(2021)
Article
Clinical Neurology
Wei Zhu, Yangjing Bai, Simin Li, Meng Zhang, Jian Chen, Peishan Xie, Xuejiao Bai, Dong Zhou, Yan Jiang
Summary: This study aimed to investigate the prevalence of delirium and its risk factors in hospitalized COVID-19 patients. The study found that delirium was a frequent complication among hospitalized COVID-19 patients, and it was associated with unfavorable outcomes. It is crucial to reduce delirium and its long-term effects by addressing the modifiable risk factors.
JOURNAL OF NEUROLOGY
(2023)
Article
Medicine, General & Internal
Laura C. Myers, Patricia Kipnis, John Greene, Brian Lawson, Gabriel J. Escobar, Bruce H. Fireman, Nicola P. Klein, Vincent X. Liu
Summary: The in-hospital mortality rate of COVID-19 patients is lower among those who are fully vaccinated compared to those who are unvaccinated, according to a retrospective cohort study.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Infectious Diseases
Oscar Moreno-Perez, Isabel Ribes, Vicente Boix, Maria Angeles Martinez-Garcia, Silvia Otero-Rodriguez, Sergio Reus, Rosario Sanchez-Martinez, Jose Manuel Ramos, Pablo Chico-Sanchez, Esperanza Merino
Summary: This study aimed to describe breakthrough COVID-19 infections in hospitalized patients and identify factors associated with poor outcomes. The results showed that patients hospitalized with breakthrough infections tend to be older individuals with comorbidities and have a higher mortality rate.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Geriatrics & Gerontology
Liron Sinvani, Allison Marziliano, Alex Makhnevich, Sergey Tarima, Yan Liu, Michael Qiu, Meng Zhang, Suzanne Ardito, Maria Carney, Michael Diefenbach, Karina Davidson, Edith Burns
Summary: This study utilized administrative data to build a model predicting mortality in hospitalized older adults with COVID-19, finding associations between various factors like male sex, Asian race, chronic kidney disease, and mechanical ventilation with mortality. While age was not an independent predictor, interactions with hypertension, early Do-Not-Resuscitate preferences, and illness severity were observed.
Article
Immunology
Giuseppe Lapadula, Roberto Leone, Davide Paolo Bernasconi, Andrea Biondi, Emanuela Rossi, Mariella D'Angio, Barbara Bottazzi, Laura Rachele Bettini, Ilaria Beretta, Cecilia Garlanda, Maria Grazia Valsecchi, Alberto Mantovani, Paolo Bonfanti
Summary: The study assessed the prognostic value of PTX3 in patients hospitalized with COVID-19. The results showed that high levels of PTX3 were associated with a worse outcome, and the evaluation of this marker could be useful in prognostic stratification and identification of patients who could benefit from immunomodulant therapy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Mohammad Hossein Imanieh, Fatemeh Amirzadehfard, Sina Zoghi, Faezeh Sehatpour, Peyman Jafari, Hamidreza Hassanipour, Maryam Feili, Maryam Mollaie, Pardis Bostanian, Samrad Mehrabi, Reyhaneh Dashtianeh, Afrooz Feili
Summary: This study aimed to develop a predictive scoring model for early detection of high risk COVID-19 patients by analyzing clinical and laboratory data. A simple scoring system incorporating CRP, oxygen saturation variation, PT, diastolic blood pressure, BUN, and LDH was derived. The scoring system can help identify patients at higher risk of mortality.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)
Article
Medicine, General & Internal
Jeong Yun Yang, Michael D. Parkins, Andrew Canakis, Olga C. Aroniadis, Dhiraj Yadav, Rebekah E. Dixon, B. Joseph Elmunzer, Nauzer Forbes
Summary: The study found that healthcare worker status is not associated with poorer outcomes among COVID-19 hospitalized patients. In fact, healthcare workers had a shorter hospitalization length and were less likely to be admitted to the intensive care unit. Further research is needed to understand the proportion of healthcare worker infections acquired in the workplace and their impact on outcomes.
Article
Multidisciplinary Sciences
Eva Maria Andres-Esteban, Manuel Quintana-Diaz, Karen Lizzette Ramirez-Cervantes, Irene Benayas-Pena, Alberto Silva-Obregon, Rosa Magallon-Botaya, Ivan Santolalla-Arnedo, Raul Juarez-Vela, Vicente Gea-Caballero
Summary: The study found that frailty in COVID-19 patients can significantly affect the prognosis, leading to higher mortality and other complications. Therefore, assessing frailty in COVID-19 patients is crucial for better management and outcomes.
Article
Medicine, General & Internal
Leszek Gromadzinski, Maciej Zechowicz, Beata Moczulska, Michal Kasprzak, Klaudyna Grzelakowska, Paulina Nowek, Dominika Stepniak, Natalia Jaje-Rykowska, Aleksandra Klosinska, Mikolaj Pozarowszczyk, Aleksandra Wochna, Adam Kern, Jerzy Romaszko, Agata Sobacka, Przemyslaw Podhajski, Aldona Kubica, Jacek Krys, Maciej Piasecki, Piotr Lackowski, Malgorzata Jasiewicz, Eliano Pio Navarese, Jacek Kubica
Summary: This study identified independent risk factors for in-hospital mortality in COVID-19 patients, including age ≥70 years, admission saturation without oxygen ≤87%, presence of typical COVID-19-related lung abnormalities ≥40% on chest CT, and concomitant diagnosis of coronary artery disease.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Jingwen Li, Hu Luo, Gang Deng, Jinying Chang, Xiaoming Qiu, Chen Liu, Bo Qin
Summary: Deceased COVID-19 patients were older, predominantly male, and had common symptoms such as nausea and dyspnea. They also had higher levels of biochemical markers and received more frequent treatments compared to recovered patients.
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2021)
Article
Neurosciences
Leszek Drabik, Justyna Derbisz, Zaneta Chatys-Bogacka, Iwona Mazurkiewicz, Katarzyna Sawczynska, Tomasz Kesek, Jacek Czepiel, Pawel Wrona, Joanna Szaleniec, Malgorzata Wojcik-Bugajska, Aleksander Garlicki, Maciej Malecki, Ralph Jozefowicz, Agnieszka Slowik, Marcin Wnuk
Summary: This study aimed to investigate the association between neurological symptoms or signs (NSS) and in-hospital mortality or oxygen requirement in COVID-19 patients. The presence of high-risk NSS increased the risk of in-hospital mortality, while the presence of low-risk NSS decreased the risk. Additionally, high-risk NSS also increased the risk of oxygen requirement during hospitalization.
Article
Urology & Nephrology
Steven Menez, Steven G. Coca, Dennis G. Moledina, Yumeng Wen, Lili Chan, Heather Thiessen-Philbrook, Wassim Obeid, Brian T. Garibaldi, Evren U. Azeloglu, Ugochukwu Ugwuowo, C. John Sperati, Lois J. Arend, Avi Z. Rosenberg, Madhurima Kaushal, Sanjay Jain, F. Perry Wilson, Chirag R. Parikh
Summary: The study found that sTNFR1 and sTNFR2 are independently associated with MAKE in patients hospitalized with COVID-19, and both can serve as predictors for adverse kidney outcomes.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2023)
Article
Multidisciplinary Sciences
Vera Wilke, Mihaly Sulyok, Maria-Ioanna Stefanou, Vivien Richter, Benjamin Bender, Ulrike Ernemann, Ulf Ziemann, Nisar Malek, Katharina Kienzle, Constantin Klein, Stefanie Bunk, Siri Goepel, Annerose Mengel
Summary: This study evaluated the incidence and risk factors of delirium in hospitalized COVID-19 patients and its impact on clinical outcomes. The study found that disease severity, advanced age, neurodegenerative disease history, and elevated infection and renal parameters were the strongest predictors for the occurrence of delirium.